CN105612153B - 用作trpa1调节剂的取代的杂环磺酰胺化合物 - Google Patents

用作trpa1调节剂的取代的杂环磺酰胺化合物 Download PDF

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CN105612153B
CN105612153B CN201480053713.2A CN201480053713A CN105612153B CN 105612153 B CN105612153 B CN 105612153B CN 201480053713 A CN201480053713 A CN 201480053713A CN 105612153 B CN105612153 B CN 105612153B
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alkyl
haloalkyl
phenyl
halogen
group
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CN105612153A (zh
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陈慧芬
初燕燕
史蒂芬·多
安东尼·埃斯特拉德
胡百华
亚历山大·科列斯尼科夫
林星雨
约瑟夫·P·利丝卡托斯
丹尼尔·肖尔
维沙尔·维尔马
王兰
吴国胜
袁步伟
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F Hoffmann La Roche AG
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    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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  • Plural Heterocyclic Compounds (AREA)
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CN201480053713.2A 2013-10-11 2014-10-09 用作trpa1调节剂的取代的杂环磺酰胺化合物 Active CN105612153B (zh)

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US201361890127P 2013-10-11 2013-10-11
US61/890,127 2013-10-11
CN2014086380 2014-09-12
CNPCT/CN2014/086380 2014-09-12
CN201480053713.2A CN105612153B (zh) 2013-10-11 2014-10-09 用作trpa1调节剂的取代的杂环磺酰胺化合物
PCT/EP2014/071593 WO2015052264A1 (en) 2013-10-11 2014-10-09 Substituted heterocyclic sulfonamide compounds useful as trpa1 modulators

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JP6975515B2 (ja) * 2016-07-20 2021-12-01 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft Ｔｒｐａ１モデュレーターとしてのスルホニルシクロアルキルカルボキサミド化合物
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JP7071959B2 (ja) * 2016-08-12 2022-05-19 エフ．ホフマン－ラ ロシュ アーゲー スルホニルピリジルｔｒｐ阻害剤
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FR3114235A1 (fr) 2020-09-18 2022-03-25 Université Grenoble Alpes Inhibition du canal trpa1 astrocytaire comme nouvelle cible therapeutique neuroprotectrice dans les phases prodromales de la maladie d’alzheimer
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IT202100015098A1 (it) 2021-06-09 2022-12-09 Flonext S R L Composto antagonista del canale trpa1 per uso in patologie degenerative della retina
CN116478076A (zh) * 2023-04-26 2023-07-25 南京优氟医药科技有限公司 一种(2s,4s)-1-叔丁氧羰基-2-(二氟甲基)-4-羟基吡咯烷的制备方法
TW202542165A (zh) 2023-12-19 2025-11-01 瑞士商愛杜西亞製藥有限公司 大環食慾素激動劑
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