CN105378068A - 用于免疫治疗的同种异体且高活性的t细胞的工程化方法 - Google Patents

用于免疫治疗的同种异体且高活性的t细胞的工程化方法 Download PDF

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Publication number
CN105378068A
CN105378068A CN201480039917.0A CN201480039917A CN105378068A CN 105378068 A CN105378068 A CN 105378068A CN 201480039917 A CN201480039917 A CN 201480039917A CN 105378068 A CN105378068 A CN 105378068A
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cells
tcr
cell
gene
tale
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Pending
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CN201480039917.0A
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Chinese (zh)
Inventor
罗曼·加莱托
阿涅丝·古布勒
斯蒂芬妮·格罗斯
塞西尔·希费尔-曼尼维
劳伦特·普瓦罗
安德鲁·沙伦贝格
朱莉安娜·史密斯
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Cellectis SA
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Cellectis SA
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Priority claimed from PCT/US2013/040755 external-priority patent/WO2013176915A1/en
Application filed by Cellectis SA filed Critical Cellectis SA
Publication of CN105378068A publication Critical patent/CN105378068A/zh
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CN201480039917.0A 2013-05-13 2014-05-13 用于免疫治疗的同种异体且高活性的t细胞的工程化方法 Pending CN105378068A (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
PCT/US2013/040755 WO2013176915A1 (en) 2012-05-25 2013-05-13 Methods for engineering allogeneic and immunosuppressive resistant t cell for immunotherapy
USPCT/US2013/040755 2013-05-13
US13/892,805 2013-05-13
US13/892,805 US11603539B2 (en) 2012-05-25 2013-05-13 Methods for engineering allogeneic and immunosuppressive resistant T cell for immunotherapy
PCT/US2013/040766 WO2013176916A1 (en) 2012-05-25 2013-05-13 Use of pre t alpha or functional variant thereof for expanding tcr alpha deficient t cells
USPCT/US2013/040766 2013-05-13
US13/942,191 2013-07-15
US13/942,191 US20150017136A1 (en) 2013-07-15 2013-07-15 Methods for engineering allogeneic and highly active t cell for immunotherapy
PCT/IB2014/061409 WO2014184741A1 (en) 2013-05-13 2014-05-13 Methods for engineering allogeneic and highly active t cell for immunotheraphy

Publications (1)

Publication Number Publication Date
CN105378068A true CN105378068A (zh) 2016-03-02

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CN201480039917.0A Pending CN105378068A (zh) 2013-05-13 2014-05-13 用于免疫治疗的同种异体且高活性的t细胞的工程化方法

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US (2) US20150017136A1 (enExample)
EP (2) EP3936612A1 (enExample)
JP (3) JP6875124B2 (enExample)
KR (3) KR20210143926A (enExample)
CN (1) CN105378068A (enExample)
AU (1) AU2014266830B2 (enExample)
BR (1) BR112015028493A2 (enExample)
CA (1) CA2912373A1 (enExample)
DK (1) DK2997132T3 (enExample)
ES (1) ES2828669T3 (enExample)
MX (1) MX380738B (enExample)
RU (1) RU2736616C2 (enExample)
WO (1) WO2014184741A1 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113412520A (zh) * 2019-02-07 2021-09-17 皇家飞利浦有限公司 标识对放射免疫组合治疗的反应性
CN113906054A (zh) * 2018-12-24 2022-01-07 埃泰美德(香港)有限公司 能够结合cd19和cd3的多特异性抗原结合蛋白及其用途
WO2024088401A1 (en) * 2022-10-28 2024-05-02 CorrectSequence Therapeutics Co., Ltd Gene editing systems and methods for reducing immunogenicity and graft versus host response
US12460000B2 (en) 2018-09-07 2025-11-04 Itabmed (Hk) Limited Anti-CD19 and anti-CD3 bispecific antigen binding proteins and uses thereof

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* Cited by examiner, † Cited by third party
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EP3613852A3 (en) 2011-07-22 2020-04-22 President and Fellows of Harvard College Evaluation and improvement of nuclease cleavage specificity
US20150017136A1 (en) * 2013-07-15 2015-01-15 Cellectis Methods for engineering allogeneic and highly active t cell for immunotherapy
US20230050345A1 (en) * 2013-05-13 2023-02-16 Cellectis Methods for engineering allogeneic and highly active t cell for immunotheraphy
US20150044192A1 (en) 2013-08-09 2015-02-12 President And Fellows Of Harvard College Methods for identifying a target site of a cas9 nuclease
US9359599B2 (en) 2013-08-22 2016-06-07 President And Fellows Of Harvard College Engineered transcription activator-like effector (TALE) domains and uses thereof
US9388430B2 (en) 2013-09-06 2016-07-12 President And Fellows Of Harvard College Cas9-recombinase fusion proteins and uses thereof
US9228207B2 (en) 2013-09-06 2016-01-05 President And Fellows Of Harvard College Switchable gRNAs comprising aptamers
US9737604B2 (en) 2013-09-06 2017-08-22 President And Fellows Of Harvard College Use of cationic lipids to deliver CAS9
CN111218447B (zh) 2013-11-07 2024-10-11 爱迪塔斯医药有限公司 使用统治型gRNA的CRISPR相关方法和组合物
US10357515B2 (en) * 2013-11-22 2019-07-23 Cellectis Method for generating batches of allogeneic T-cells with averaged potency
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