BR112015028493A2 - Métodos para preparar células t para imunoterapia, célula t isolada, seu uso e composição farmacêutica - Google Patents

Métodos para preparar células t para imunoterapia, célula t isolada, seu uso e composição farmacêutica

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Publication number
BR112015028493A2
BR112015028493A2 BR112015028493A BR112015028493A BR112015028493A2 BR 112015028493 A2 BR112015028493 A2 BR 112015028493A2 BR 112015028493 A BR112015028493 A BR 112015028493A BR 112015028493 A BR112015028493 A BR 112015028493A BR 112015028493 A2 BR112015028493 A2 BR 112015028493A2
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BR
Brazil
Prior art keywords
cells
methods
immunotherapy
isolated
pharmaceutical composition
Prior art date
Application number
BR112015028493A
Other languages
English (en)
Inventor
Gouble Agnes
Poirot Laurent
Scharenberg Andrew
Smith Julianne
SCHIFFER-MANNIOUI Cècile
Galetto Roman
Grosse Stephanie
Original Assignee
Cellectis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2013/040766 external-priority patent/WO2013176916A1/en
Application filed by Cellectis filed Critical Cellectis
Publication of BR112015028493A2 publication Critical patent/BR112015028493A2/pt

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    • A61K35/14—Blood; Artificial blood
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    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
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    • C12N9/14—Hydrolases (3)
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Abstract

MÉTODOS PARA PREPARAR CÉLULAS T PARA IMUNOTERAPIA, CÉLULA T ISOLADA, SEU USO E COMPOSIÇÃO FARMACÊUTICA. A presente invenção refere-se a métodos para desenvolver células T geneticamente modificadas para imunoterapia que são nãoalorreativas. A presente invenção refere-se a métodos para modificar células T inativando ambos os genes codificando o receptor de células T e um gene de ponto de controle imunológico para desatrelar o potencial da resposta imunológica. Este método envolve o uso de endonucleases de corte raro específicas, em particular TALEnucleases (endonuclease efetora de TAL) e polinucleotídeos codificando tais polipeptídios, para atingir com precisão uma seleção de genes essenciais nas células T, que estão disponíveis a partir de doadores e a partir de cultura de células primárias. A invenção abre caminho para estratégias de imunoterapia adotiva tradicionais e acessíveis para o tratamento de câncer e infecções virais.
BR112015028493A 2013-05-13 2014-05-13 Métodos para preparar células t para imunoterapia, célula t isolada, seu uso e composição farmacêutica BR112015028493A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
PCT/US2013/040766 WO2013176916A1 (en) 2012-05-25 2013-05-13 Use of pre t alpha or functional variant thereof for expanding tcr alpha deficient t cells
US13/892,805 US11603539B2 (en) 2012-05-25 2013-05-13 Methods for engineering allogeneic and immunosuppressive resistant T cell for immunotherapy
PCT/US2013/040755 WO2013176915A1 (en) 2012-05-25 2013-05-13 Methods for engineering allogeneic and immunosuppressive resistant t cell for immunotherapy
US13/942,191 US20150017136A1 (en) 2013-07-15 2013-07-15 Methods for engineering allogeneic and highly active t cell for immunotherapy
PCT/IB2014/061409 WO2014184741A1 (en) 2013-05-13 2014-05-13 Methods for engineering allogeneic and highly active t cell for immunotheraphy

Publications (1)

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BR112015028493A2 true BR112015028493A2 (pt) 2017-09-19

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BR112015028493A BR112015028493A2 (pt) 2013-05-13 2014-05-13 Métodos para preparar células t para imunoterapia, célula t isolada, seu uso e composição farmacêutica

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US (2) US20150017136A1 (pt)
EP (2) EP2997132B1 (pt)
JP (3) JP6875124B2 (pt)
KR (3) KR102329704B1 (pt)
CN (1) CN105378068A (pt)
AU (1) AU2014266830B2 (pt)
BR (1) BR112015028493A2 (pt)
CA (1) CA2912373A1 (pt)
DK (1) DK2997132T3 (pt)
ES (1) ES2828669T3 (pt)
MX (1) MX2015015639A (pt)
RU (1) RU2736616C2 (pt)
WO (1) WO2014184741A1 (pt)

Families Citing this family (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2853829C (en) 2011-07-22 2023-09-26 President And Fellows Of Harvard College Evaluation and improvement of nuclease cleavage specificity
US20150017136A1 (en) * 2013-07-15 2015-01-15 Cellectis Methods for engineering allogeneic and highly active t cell for immunotherapy
US20150044192A1 (en) 2013-08-09 2015-02-12 President And Fellows Of Harvard College Methods for identifying a target site of a cas9 nuclease
US9359599B2 (en) 2013-08-22 2016-06-07 President And Fellows Of Harvard College Engineered transcription activator-like effector (TALE) domains and uses thereof
US9340800B2 (en) 2013-09-06 2016-05-17 President And Fellows Of Harvard College Extended DNA-sensing GRNAS
US9388430B2 (en) 2013-09-06 2016-07-12 President And Fellows Of Harvard College Cas9-recombinase fusion proteins and uses thereof
US9526784B2 (en) 2013-09-06 2016-12-27 President And Fellows Of Harvard College Delivery system for functional nucleases
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