CN1053658C - 氨基芪唑衍生物和药 - Google Patents

氨基芪唑衍生物和药 Download PDF

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Publication number
CN1053658C
CN1053658C CN95192423A CN95192423A CN1053658C CN 1053658 C CN1053658 C CN 1053658C CN 95192423 A CN95192423 A CN 95192423A CN 95192423 A CN95192423 A CN 95192423A CN 1053658 C CN1053658 C CN 1053658C
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CN
China
Prior art keywords
carbon atoms
group
amino
compound
vinyl
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN95192423A
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English (en)
Chinese (zh)
Other versions
CN1145066A (zh
Inventor
日高弘义
松浦明
松田真人
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Shinyaku Co Ltd
D Western Therapeutics Institute Inc
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Nippon Shinyaku Co Ltd
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Publication of CN1145066A publication Critical patent/CN1145066A/zh
Application granted granted Critical
Publication of CN1053658C publication Critical patent/CN1053658C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
CN95192423A 1994-04-06 1995-04-05 氨基芪唑衍生物和药 Expired - Lifetime CN1053658C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP6825294 1994-04-06
JP68252/1994 1994-04-06
JP68252/94 1994-04-06

Publications (2)

Publication Number Publication Date
CN1145066A CN1145066A (zh) 1997-03-12
CN1053658C true CN1053658C (zh) 2000-06-21

Family

ID=13368389

Family Applications (1)

Application Number Title Priority Date Filing Date
CN95192423A Expired - Lifetime CN1053658C (zh) 1994-04-06 1995-04-05 氨基芪唑衍生物和药

Country Status (14)

Country Link
US (1) US5972976A (enExample)
EP (1) EP0754682B9 (enExample)
JP (1) JP3080405B2 (enExample)
KR (1) KR100293867B1 (enExample)
CN (1) CN1053658C (enExample)
AT (1) ATE207057T1 (enExample)
CA (1) CA2187214C (enExample)
DE (1) DE69523298T2 (enExample)
DK (1) DK0754682T3 (enExample)
ES (1) ES2165911T3 (enExample)
PT (1) PT754682E (enExample)
RU (1) RU2138482C1 (enExample)
TW (1) TW308586B (enExample)
WO (1) WO1995027699A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69824895T2 (de) * 1998-04-15 2005-06-30 Hidaka, Hiroyoshi, Nagoya Verfahren zur bestimmung des gens eines zielproteins mit hilfe eines medikamentes
WO1999058142A1 (en) * 1998-05-12 1999-11-18 Chen Wen Y Use of anti-prolactin agents to treat proliferative conditions
WO2000064875A1 (en) * 1999-04-23 2000-11-02 Nippon Shinyaku Co., Ltd. Method for pulvirizing to fine powder
US6521658B1 (en) 1999-05-28 2003-02-18 Abbott Laboratories Cell proliferation inhibitors
MXPA02005866A (es) * 1999-12-14 2002-10-23 Nippon Shinyaku Co Ltd Derivados de heterociclo y drogas.
JP2004359545A (ja) * 2001-03-08 2004-12-24 D Western Therapeutics Institute 抗癌剤耐性克服剤
CN1237969C (zh) 2001-04-10 2006-01-25 日本新药株式会社 慢性关节风湿病的治疗剂
WO2002087577A1 (en) * 2001-04-26 2002-11-07 Nippon Shinyaku Co., Ltd. Medicines
US6951875B2 (en) * 2001-10-29 2005-10-04 Hoffmann-La Roche Inc. Conjugated aromatic compounds with a pyridine substituent
FR2838437B1 (fr) * 2002-04-11 2004-06-04 Aventis Pharma Sa Procedes de preparation de combretastatines
JP5149482B2 (ja) * 2002-09-06 2013-02-20 株式会社デ・ウエスタン・セラピテクス研究所 悪性腫瘍を処置するための医薬組成物、方法および使用
WO2006078941A2 (en) * 2005-01-20 2006-07-27 Sirtris Pharmaceuticals, Inc. Novel sirtuin activating compounds and methods of use thereof
WO2007137196A2 (en) * 2006-05-19 2007-11-29 Threshold Pharmaceuticals, Inc. Tubulin binding anti cancer compounds and prodrugs thereof
US20100198262A1 (en) * 2009-01-30 2010-08-05 Mckinley Laurence M Axial offset bone fastener system
BR112015026048A2 (pt) 2013-04-19 2017-07-25 Univ Arkansas análogos de combretastatina
DK3623362T3 (da) 2013-12-13 2023-01-30 Eurochem Agro Gmbh Gødningsmiddelblanding, der indeholder en nitrifikationshæmmer
WO2015153635A1 (en) 2014-03-31 2015-10-08 Board Of Trustees Of The University Of Arkansas Disubstituted triazole analogs
DE102017201608A1 (de) 2017-02-01 2018-08-02 Eurochem Agro Gmbh 3,4-Dimethylpyrazol enthaltende Mischung und ihre Verwendung
CN112110829B (zh) * 2019-06-19 2023-08-01 复旦大学 一种能结合α-突触核蛋白聚集体的小分子化合物、其制备方法及其用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0570596A1 (en) * 1991-12-09 1993-11-24 Daikin Industries, Ltd. Power feeder of air conditioner

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69129611T2 (de) * 1990-08-20 1998-12-17 Eisai Co., Ltd., Tokio/Tokyo Sulfonamid-Derivate
JP2790926B2 (ja) * 1990-08-20 1998-08-27 エーザイ株式会社 スルホンアミド誘導体
EP0570594B1 (en) * 1991-12-10 1997-07-30 Shionogi & Co., Ltd. Hydroxamic acid derivative based on aromatic sulfonamide

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0570596A1 (en) * 1991-12-09 1993-11-24 Daikin Industries, Ltd. Power feeder of air conditioner

Also Published As

Publication number Publication date
WO1995027699A1 (en) 1995-10-19
MX9604540A (es) 1997-09-30
JP3080405B2 (ja) 2000-08-28
ATE207057T1 (de) 2001-11-15
EP0754682B1 (en) 2001-10-17
US5972976A (en) 1999-10-26
KR970702253A (ko) 1997-05-13
EP0754682A1 (en) 1997-01-22
KR100293867B1 (ko) 2001-09-17
PT754682E (pt) 2002-03-28
EP0754682A4 (en) 1998-03-04
CN1145066A (zh) 1997-03-12
RU2138482C1 (ru) 1999-09-27
CA2187214A1 (en) 1995-10-19
TW308586B (enExample) 1997-06-21
DE69523298T2 (de) 2002-06-27
DK0754682T3 (da) 2002-02-04
ES2165911T3 (es) 2002-04-01
DE69523298D1 (de) 2001-11-22
CA2187214C (en) 2002-03-12
EP0754682B9 (en) 2003-09-17

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Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
ASS Succession or assignment of patent right

Owner name: JAPAN NEW MEDICINE CO., LTD.; D.WESTERN THERAPEUT

Free format text: FORMER OWNER: NIPPON SHINYAKU CO LTD; HIDAKA HIROSHI

Effective date: 20010911

C41 Transfer of patent application or patent right or utility model
TR01 Transfer of patent right

Effective date of registration: 20010911

Patentee after: NIPPON SHINYAKU Co.,Ltd.

Patentee after: D*Western Therapeutics Institute

Patentee before: NIPPON SHINYAKU Co.,Ltd.

Patentee before: Hidaka Hiroyoshi

C17 Cessation of patent right
CX01 Expiry of patent term

Expiration termination date: 20150405

Granted publication date: 20000621