CN105263503A - 含有类肝素、急效麻醉剂及缓冲液的稳定组合物 - Google Patents
含有类肝素、急效麻醉剂及缓冲液的稳定组合物 Download PDFInfo
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- CN105263503A CN105263503A CN201480018245.5A CN201480018245A CN105263503A CN 105263503 A CN105263503 A CN 105263503A CN 201480018245 A CN201480018245 A CN 201480018245A CN 105263503 A CN105263503 A CN 105263503A
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- buffer
- heparinoid
- anesthetis
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- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 229960004492 suprofen Drugs 0.000 description 1
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- LXIKEPCNDFVJKC-QXMHVHEDSA-N tenidap Chemical compound C12=CC(Cl)=CC=C2N(C(=O)N)C(=O)\C1=C(/O)C1=CC=CS1 LXIKEPCNDFVJKC-QXMHVHEDSA-N 0.000 description 1
- 229960002871 tenoxicam Drugs 0.000 description 1
- WZWYJBNHTWCXIM-UHFFFAOYSA-N tenoxicam Chemical compound O=C1C=2SC=CC=2S(=O)(=O)N(C)C1=C(O)NC1=CC=CC=N1 WZWYJBNHTWCXIM-UHFFFAOYSA-N 0.000 description 1
- XYKWNRUXCOIMFZ-UHFFFAOYSA-N tepoxalin Chemical compound C1=CC(OC)=CC=C1N1C(C=2C=CC(Cl)=CC=2)=CC(CCC(=O)N(C)O)=N1 XYKWNRUXCOIMFZ-UHFFFAOYSA-N 0.000 description 1
- 229950009638 tepoxalin Drugs 0.000 description 1
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 229960001312 tiaprofenic acid Drugs 0.000 description 1
- HTJXMOGUGMSZOG-UHFFFAOYSA-N tiaramide Chemical compound C1CN(CCO)CCN1C(=O)CN1C(=O)SC2=CC=C(Cl)C=C21 HTJXMOGUGMSZOG-UHFFFAOYSA-N 0.000 description 1
- 229950010302 tiaramide Drugs 0.000 description 1
- 229960004659 ticarcillin Drugs 0.000 description 1
- OHKOGUYZJXTSFX-KZFFXBSXSA-N ticarcillin Chemical compound C=1([C@@H](C(O)=O)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)C=CSC=1 OHKOGUYZJXTSFX-KZFFXBSXSA-N 0.000 description 1
- 229950002345 tiopinac Drugs 0.000 description 1
- YEZNLOUZAIOMLT-UHFFFAOYSA-N tolfenamic acid Chemical compound CC1=C(Cl)C=CC=C1NC1=CC=CC=C1C(O)=O YEZNLOUZAIOMLT-UHFFFAOYSA-N 0.000 description 1
- 229960002905 tolfenamic acid Drugs 0.000 description 1
- 229960001017 tolmetin Drugs 0.000 description 1
- UPSPUYADGBWSHF-UHFFFAOYSA-N tolmetin Chemical compound C1=CC(C)=CC=C1C(=O)C1=CC=C(CC(O)=O)N1C UPSPUYADGBWSHF-UHFFFAOYSA-N 0.000 description 1
- 229960005294 triamcinolone Drugs 0.000 description 1
- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
- 229920000428 triblock copolymer Polymers 0.000 description 1
- 229960002268 triflusal Drugs 0.000 description 1
- FQCQGOZEWWPOKI-UHFFFAOYSA-K trisalicylate-choline Chemical compound [Mg+2].C[N+](C)(C)CCO.OC1=CC=CC=C1C([O-])=O.OC1=CC=CC=C1C([O-])=O.OC1=CC=CC=C1C([O-])=O FQCQGOZEWWPOKI-UHFFFAOYSA-K 0.000 description 1
- JACRWUWPXAESPB-UHFFFAOYSA-M tropate Chemical compound OCC(C([O-])=O)C1=CC=CC=C1 JACRWUWPXAESPB-UHFFFAOYSA-M 0.000 description 1
- 210000001113 umbilicus Anatomy 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
- 229940096998 ursolic acid Drugs 0.000 description 1
- PLSAJKYPRJGMHO-UHFFFAOYSA-N ursolic acid Natural products CC1CCC2(CCC3(C)C(C=CC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1C)C(=O)O PLSAJKYPRJGMHO-UHFFFAOYSA-N 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 229950000707 ximoprofen Drugs 0.000 description 1
- 229950004227 zaltoprofen Drugs 0.000 description 1
- 229950007802 zidometacin Drugs 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Communicable Diseases (AREA)
- Anesthesiology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Gynecology & Obstetrics (AREA)
- Inorganic Chemistry (AREA)
- Endocrinology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361757592P | 2013-01-28 | 2013-01-28 | |
| US61/757592 | 2013-01-28 | ||
| PCT/US2014/013352 WO2014171986A1 (en) | 2013-01-28 | 2014-01-28 | Stable compositions comprising heparinoid, acute-acting anesthetic, and buffer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105263503A true CN105263503A (zh) | 2016-01-20 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480018245.5A Pending CN105263503A (zh) | 2013-01-28 | 2014-01-28 | 含有类肝素、急效麻醉剂及缓冲液的稳定组合物 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20150359816A1 (enExample) |
| EP (1) | EP2948154A4 (enExample) |
| JP (2) | JP2016517390A (enExample) |
| KR (1) | KR20160008496A (enExample) |
| CN (1) | CN105263503A (enExample) |
| AU (2) | AU2014254472A1 (enExample) |
| BR (1) | BR112015018047A8 (enExample) |
| CA (1) | CA2899636C (enExample) |
| IL (1) | IL240194B (enExample) |
| MX (1) | MX2015009696A (enExample) |
| SG (1) | SG11201505853RA (enExample) |
| WO (1) | WO2014171986A1 (enExample) |
| ZA (1) | ZA201505814B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10117847B2 (en) * | 2015-12-04 | 2018-11-06 | Ventis Pharma | Extended duration local anesthetic formulation |
| CA3090767A1 (en) | 2017-02-27 | 2018-08-30 | Urigen N.A. | Treatment of lower urinary tract epithelium with glucagon like peptide 2 |
| CN111787915A (zh) | 2017-04-12 | 2020-10-16 | 尤里根制药股份有限公司 | 注射器中包含局部麻醉剂、缓冲剂和糖胺聚糖的稳定性提高的制品 |
| EP3400951B1 (de) * | 2017-05-12 | 2019-12-11 | Farco-Pharma GmbH | Blaseninstillationszusammensetzung enthaltend chondoitinsulfat (4,5 mg/ml), hyaluronsäure (16 mg/ml) und phosphatpuffer (ph 6,1 bis 7,9) mit erhöhter lagerstabiliät zur behandlung von cystitis |
| EP3415163B1 (de) * | 2017-06-13 | 2023-02-22 | Farco-Pharma GmbH | Zusammensetzung mit lokalanästhetischer wirkung und deren verwendung |
| ES2968164T3 (es) * | 2019-04-26 | 2024-05-08 | Tcm Biotech Int Corp | Composición farmacéutica para la prevención de infección urinaria recurrente |
| TWI887239B (zh) * | 2019-05-17 | 2025-06-21 | 日商半導體能源研究所股份有限公司 | 發光元件、發光裝置、電子機器及照明裝置 |
| AU2020315353A1 (en) | 2019-07-18 | 2022-03-10 | C. Lowell Parsons | Alkalization of urinary bladder wall prior to treatment with intravesical heparin and alkalinized lidocaine to enhance relief of bladder pain symptoms |
| CN115814099B (zh) * | 2022-12-19 | 2024-04-26 | 成都蓉生药业有限责任公司 | 一种人凝血因子ix的干热处理稳定剂及其制剂与制备方法 |
| MX2023012862A (es) * | 2023-10-27 | 2023-11-09 | Mar Mariana Guerrero | Composicion topica de agentes esclerosantes en portadores acuosos. |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5603695A (en) * | 1995-06-07 | 1997-02-18 | Erickson; Kim | Device for alkalizing local anesthetic injection medication |
| WO2007073397A1 (en) * | 2005-12-19 | 2007-06-28 | Urigen, Inc. | Kits and improved compositions for treating lower urinary tract discorders |
| WO2012094515A1 (en) * | 2011-01-06 | 2012-07-12 | Parsons C Lowell | Method for manufacturing composition comprising local anesthetic, heparinoid, and buffer |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1708722T1 (sl) * | 2004-01-28 | 2014-10-30 | The Regents Of The University Of California | Nova intersticijska terapija za takojšnje simptome sprostitve in kronična terapija pri intersticijskem cistitisu |
| EP2839830B1 (en) * | 2005-01-14 | 2019-05-15 | Urigen, Inc. | Kits and compositions for treating lower urinary tract disorders |
| US8357795B2 (en) * | 2008-08-04 | 2013-01-22 | Allergan, Inc. | Hyaluronic acid-based gels including lidocaine |
| ES2634505T3 (es) * | 2009-08-13 | 2017-09-28 | Lubris Llc | Tratamiento de PRG4 para la cistitis intersticial |
| US9486747B2 (en) * | 2014-08-12 | 2016-11-08 | The Curators Of The University Of Missouri | Nanocomposite membranes with advanced antifouling properties under visible light irradiation |
-
2014
- 2014-01-28 EP EP14785471.5A patent/EP2948154A4/en not_active Ceased
- 2014-01-28 JP JP2015555403A patent/JP2016517390A/ja active Pending
- 2014-01-28 BR BR112015018047A patent/BR112015018047A8/pt not_active Application Discontinuation
- 2014-01-28 US US14/763,369 patent/US20150359816A1/en not_active Abandoned
- 2014-01-28 AU AU2014254472A patent/AU2014254472A1/en not_active Abandoned
- 2014-01-28 MX MX2015009696A patent/MX2015009696A/es unknown
- 2014-01-28 KR KR1020157023381A patent/KR20160008496A/ko not_active Ceased
- 2014-01-28 SG SG11201505853RA patent/SG11201505853RA/en unknown
- 2014-01-28 CA CA2899636A patent/CA2899636C/en active Active
- 2014-01-28 WO PCT/US2014/013352 patent/WO2014171986A1/en not_active Ceased
- 2014-01-28 CN CN201480018245.5A patent/CN105263503A/zh active Pending
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2015
- 2015-07-28 IL IL240194A patent/IL240194B/en unknown
- 2015-08-13 ZA ZA2015/05814A patent/ZA201505814B/en unknown
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2018
- 2018-08-13 JP JP2018152223A patent/JP2019006783A/ja active Pending
- 2018-10-11 AU AU2018247284A patent/AU2018247284A1/en not_active Abandoned
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5603695A (en) * | 1995-06-07 | 1997-02-18 | Erickson; Kim | Device for alkalizing local anesthetic injection medication |
| WO2007073397A1 (en) * | 2005-12-19 | 2007-06-28 | Urigen, Inc. | Kits and improved compositions for treating lower urinary tract discorders |
| WO2012094515A1 (en) * | 2011-01-06 | 2012-07-12 | Parsons C Lowell | Method for manufacturing composition comprising local anesthetic, heparinoid, and buffer |
| CN103747790A (zh) * | 2011-01-06 | 2014-04-23 | C·洛维尔·帕森斯 | 制造包含局部麻醉剂、类肝素和缓冲剂的组合物的方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| BR112015018047A2 (pt) | 2017-07-18 |
| IL240194A0 (en) | 2015-09-24 |
| CA2899636C (en) | 2021-05-25 |
| SG11201505853RA (en) | 2015-08-28 |
| AU2014254472A1 (en) | 2015-08-20 |
| US20150359816A1 (en) | 2015-12-17 |
| WO2014171986A1 (en) | 2014-10-23 |
| CA2899636A1 (en) | 2014-10-23 |
| AU2018247284A1 (en) | 2018-11-01 |
| JP2019006783A (ja) | 2019-01-17 |
| EP2948154A4 (en) | 2016-09-14 |
| JP2016517390A (ja) | 2016-06-16 |
| EP2948154A1 (en) | 2015-12-02 |
| ZA201505814B (en) | 2016-11-30 |
| IL240194B (en) | 2021-12-01 |
| KR20160008496A (ko) | 2016-01-22 |
| MX2015009696A (es) | 2016-03-31 |
| BR112015018047A8 (pt) | 2019-11-05 |
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