BR112015018047A8 - método para preparar composições estáveis que compreendem heparinoide, anestésico de ação aguda e tampão e as mesmas - Google Patents

método para preparar composições estáveis que compreendem heparinoide, anestésico de ação aguda e tampão e as mesmas Download PDF

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Publication number
BR112015018047A8
BR112015018047A8 BR112015018047A BR112015018047A BR112015018047A8 BR 112015018047 A8 BR112015018047 A8 BR 112015018047A8 BR 112015018047 A BR112015018047 A BR 112015018047A BR 112015018047 A BR112015018047 A BR 112015018047A BR 112015018047 A8 BR112015018047 A8 BR 112015018047A8
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BR
Brazil
Prior art keywords
heparinoid
buffer
compositions
acute
acting anesthetic
Prior art date
Application number
BR112015018047A
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English (en)
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BR112015018047A2 (pt
Inventor
Lowell Parsons C
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Urigen Pharmaceuticals Inc
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Publication date
Application filed by Urigen Pharmaceuticals Inc filed Critical Urigen Pharmaceuticals Inc
Publication of BR112015018047A2 publication Critical patent/BR112015018047A2/pt
Publication of BR112015018047A8 publication Critical patent/BR112015018047A8/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Anesthesiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Gynecology & Obstetrics (AREA)
  • Inorganic Chemistry (AREA)
  • Endocrinology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

resumo “composições estáveis que compreendem heparinoide, anestésico de ação aguda e tampão” a presente invenção refere-se a métodos aprimorados para preparar composições que incluem um heparinoide, um anestésico de ação aguda e um tampão. esses métodos resultam em composições em que o heparinoide e o anestésico de ação aguda são pelo menos 90% estáveis por um ano. as composições preparadas por esses métodos e que têm tais propriedades de estabilidade aprimoradas são também descritos, assim como métodos para uso dessas composições para tratar, melhorar ou impedir distúrbios do trato urinário inferior, tal como cistite intersticial. 1/1
BR112015018047A 2013-01-28 2014-01-28 método para preparar composições estáveis que compreendem heparinoide, anestésico de ação aguda e tampão e as mesmas BR112015018047A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361757592P 2013-01-28 2013-01-28
PCT/US2014/013352 WO2014171986A1 (en) 2013-01-28 2014-01-28 Stable compositions comprising heparinoid, acute-acting anesthetic, and buffer

Publications (2)

Publication Number Publication Date
BR112015018047A2 BR112015018047A2 (pt) 2017-07-18
BR112015018047A8 true BR112015018047A8 (pt) 2019-11-05

Family

ID=51731742

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015018047A BR112015018047A8 (pt) 2013-01-28 2014-01-28 método para preparar composições estáveis que compreendem heparinoide, anestésico de ação aguda e tampão e as mesmas

Country Status (13)

Country Link
US (1) US20150359816A1 (pt)
EP (1) EP2948154A4 (pt)
JP (2) JP2016517390A (pt)
KR (1) KR20160008496A (pt)
CN (1) CN105263503A (pt)
AU (2) AU2014254472A1 (pt)
BR (1) BR112015018047A8 (pt)
CA (1) CA2899636C (pt)
IL (1) IL240194B (pt)
MX (1) MX2015009696A (pt)
SG (1) SG11201505853RA (pt)
WO (1) WO2014171986A1 (pt)
ZA (1) ZA201505814B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10117847B2 (en) 2015-12-04 2018-11-06 Ventis Pharma Extended duration local anesthetic formulation
EP3609483A4 (en) * 2017-04-12 2021-01-20 Urigen Pharmaceuticals, Inc. ITEM OF MANUFACTURING CONSISTING OF LOCAL ANESTHETICS, BUFFER AND GLYCOSAMINOGLYCANE IN A SYRINGE OF IMPROVED STABILITY
ES2775673T3 (es) * 2017-05-12 2020-07-27 Farco Gmbh Composición para el tratamiento de enfermedades inflamatorias del tracto urogenital que contiene sulfato de condonita (4,5 mg/ml), ácido hialurónico (16 mg/ml) y tampón de fosfato (pH 6,1 a 7,9) con mayor estabilidad de almacenamiento para tratar la cistitis
EP3415163B1 (de) * 2017-06-13 2023-02-22 Farco-Pharma GmbH Zusammensetzung mit lokalanästhetischer wirkung und deren verwendung
ES2968164T3 (es) * 2019-04-26 2024-05-08 Tcm Biotech Int Corp Composición farmacéutica para la prevención de infección urinaria recurrente
TW202105790A (zh) * 2019-05-17 2021-02-01 日商半導體能源研究所股份有限公司 發光元件、發光裝置、電子機器及照明裝置
EP3998932A4 (en) * 2019-07-18 2023-08-16 C. Lowell Parsons ALKALINIZATION OF THE URINARY BLADDER WALL BEFORE TREATMENT WITH INTRAVESICAL HEPARIN AND ALKALIZED LIDOCAINE TO ENHANCE SYMPTOMS RELIEF OF PAIN BLADDER
CN115814099B (zh) * 2022-12-19 2024-04-26 成都蓉生药业有限责任公司 一种人凝血因子ix的干热处理稳定剂及其制剂与制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5603695A (en) * 1995-06-07 1997-02-18 Erickson; Kim Device for alkalizing local anesthetic injection medication
DK1708722T3 (da) * 2004-01-28 2014-08-25 Univ California Ny interstitiel terapi til øjeblikkelig symptomlindring og kronisk terapived interstitiel cystit
AU2006204769A1 (en) * 2005-01-14 2006-07-20 Urigen, Inc. Kits and improved compositions for treating lower urinary tract
WO2007073397A1 (en) * 2005-12-19 2007-06-28 Urigen, Inc. Kits and improved compositions for treating lower urinary tract discorders
US8450475B2 (en) * 2008-08-04 2013-05-28 Allergan, Inc. Hyaluronic acid-based gels including lidocaine
ES2634505T3 (es) * 2009-08-13 2017-09-28 Lubris Llc Tratamiento de PRG4 para la cistitis intersticial
EA201391014A1 (ru) * 2011-01-06 2014-01-30 С. Лоуэлл Парсонс Способ производства композиции, содержащей местный анестетик, гепариноид и буфер
US9486747B2 (en) * 2014-08-12 2016-11-08 The Curators Of The University Of Missouri Nanocomposite membranes with advanced antifouling properties under visible light irradiation

Also Published As

Publication number Publication date
BR112015018047A2 (pt) 2017-07-18
AU2018247284A1 (en) 2018-11-01
JP2019006783A (ja) 2019-01-17
JP2016517390A (ja) 2016-06-16
IL240194A0 (en) 2015-09-24
EP2948154A1 (en) 2015-12-02
CN105263503A (zh) 2016-01-20
EP2948154A4 (en) 2016-09-14
AU2014254472A1 (en) 2015-08-20
ZA201505814B (en) 2016-11-30
KR20160008496A (ko) 2016-01-22
SG11201505853RA (en) 2015-08-28
WO2014171986A1 (en) 2014-10-23
CA2899636A1 (en) 2014-10-23
CA2899636C (en) 2021-05-25
IL240194B (en) 2021-12-01
MX2015009696A (es) 2016-03-31
US20150359816A1 (en) 2015-12-17

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements