CA2899636C - Stable compositions comprising heparinoid, acute-acting anesthetic, and buffer - Google Patents

Stable compositions comprising heparinoid, acute-acting anesthetic, and buffer Download PDF

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Publication number
CA2899636C
CA2899636C CA2899636A CA2899636A CA2899636C CA 2899636 C CA2899636 C CA 2899636C CA 2899636 A CA2899636 A CA 2899636A CA 2899636 A CA2899636 A CA 2899636A CA 2899636 C CA2899636 C CA 2899636C
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CA
Canada
Prior art keywords
buffer
heparinoid
lidocaine
composition
heparin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2899636A
Other languages
English (en)
French (fr)
Other versions
CA2899636A1 (en
Inventor
C. Lowell Parsons
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Urigen Pharmaceuticals Inc
Original Assignee
Urigen Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Urigen Pharmaceuticals Inc filed Critical Urigen Pharmaceuticals Inc
Publication of CA2899636A1 publication Critical patent/CA2899636A1/en
Application granted granted Critical
Publication of CA2899636C publication Critical patent/CA2899636C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Anesthesiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Inorganic Chemistry (AREA)
  • Endocrinology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2899636A 2013-01-28 2014-01-28 Stable compositions comprising heparinoid, acute-acting anesthetic, and buffer Active CA2899636C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361757592P 2013-01-28 2013-01-28
US61/757,592 2013-01-28
PCT/US2014/013352 WO2014171986A1 (en) 2013-01-28 2014-01-28 Stable compositions comprising heparinoid, acute-acting anesthetic, and buffer

Publications (2)

Publication Number Publication Date
CA2899636A1 CA2899636A1 (en) 2014-10-23
CA2899636C true CA2899636C (en) 2021-05-25

Family

ID=51731742

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2899636A Active CA2899636C (en) 2013-01-28 2014-01-28 Stable compositions comprising heparinoid, acute-acting anesthetic, and buffer

Country Status (13)

Country Link
US (1) US20150359816A1 (enExample)
EP (1) EP2948154A4 (enExample)
JP (2) JP2016517390A (enExample)
KR (1) KR20160008496A (enExample)
CN (1) CN105263503A (enExample)
AU (2) AU2014254472A1 (enExample)
BR (1) BR112015018047A8 (enExample)
CA (1) CA2899636C (enExample)
IL (1) IL240194B (enExample)
MX (1) MX2015009696A (enExample)
SG (1) SG11201505853RA (enExample)
WO (1) WO2014171986A1 (enExample)
ZA (1) ZA201505814B (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10117847B2 (en) * 2015-12-04 2018-11-06 Ventis Pharma Extended duration local anesthetic formulation
CA3090767A1 (en) 2017-02-27 2018-08-30 Urigen N.A. Treatment of lower urinary tract epithelium with glucagon like peptide 2
CN111787915A (zh) 2017-04-12 2020-10-16 尤里根制药股份有限公司 注射器中包含局部麻醉剂、缓冲剂和糖胺聚糖的稳定性提高的制品
EP3400951B1 (de) * 2017-05-12 2019-12-11 Farco-Pharma GmbH Blaseninstillationszusammensetzung enthaltend chondoitinsulfat (4,5 mg/ml), hyaluronsäure (16 mg/ml) und phosphatpuffer (ph 6,1 bis 7,9) mit erhöhter lagerstabiliät zur behandlung von cystitis
EP3415163B1 (de) * 2017-06-13 2023-02-22 Farco-Pharma GmbH Zusammensetzung mit lokalanästhetischer wirkung und deren verwendung
ES2968164T3 (es) * 2019-04-26 2024-05-08 Tcm Biotech Int Corp Composición farmacéutica para la prevención de infección urinaria recurrente
TWI887239B (zh) * 2019-05-17 2025-06-21 日商半導體能源研究所股份有限公司 發光元件、發光裝置、電子機器及照明裝置
AU2020315353A1 (en) 2019-07-18 2022-03-10 C. Lowell Parsons Alkalization of urinary bladder wall prior to treatment with intravesical heparin and alkalinized lidocaine to enhance relief of bladder pain symptoms
CN115814099B (zh) * 2022-12-19 2024-04-26 成都蓉生药业有限责任公司 一种人凝血因子ix的干热处理稳定剂及其制剂与制备方法
MX2023012862A (es) * 2023-10-27 2023-11-09 Mar Mariana Guerrero Composicion topica de agentes esclerosantes en portadores acuosos.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5603695A (en) * 1995-06-07 1997-02-18 Erickson; Kim Device for alkalizing local anesthetic injection medication
SI1708722T1 (sl) * 2004-01-28 2014-10-30 The Regents Of The University Of California Nova intersticijska terapija za takojšnje simptome sprostitve in kronična terapija pri intersticijskem cistitisu
EP2839830B1 (en) * 2005-01-14 2019-05-15 Urigen, Inc. Kits and compositions for treating lower urinary tract disorders
WO2007073397A1 (en) * 2005-12-19 2007-06-28 Urigen, Inc. Kits and improved compositions for treating lower urinary tract discorders
US8357795B2 (en) * 2008-08-04 2013-01-22 Allergan, Inc. Hyaluronic acid-based gels including lidocaine
ES2634505T3 (es) * 2009-08-13 2017-09-28 Lubris Llc Tratamiento de PRG4 para la cistitis intersticial
US20140194380A1 (en) * 2011-01-06 2014-07-10 Lowell C. Parsons Method of manufacturing composition comprising local anesthetic, heparinoid, and buffer
US9486747B2 (en) * 2014-08-12 2016-11-08 The Curators Of The University Of Missouri Nanocomposite membranes with advanced antifouling properties under visible light irradiation

Also Published As

Publication number Publication date
BR112015018047A2 (pt) 2017-07-18
CN105263503A (zh) 2016-01-20
IL240194A0 (en) 2015-09-24
SG11201505853RA (en) 2015-08-28
AU2014254472A1 (en) 2015-08-20
US20150359816A1 (en) 2015-12-17
WO2014171986A1 (en) 2014-10-23
CA2899636A1 (en) 2014-10-23
AU2018247284A1 (en) 2018-11-01
JP2019006783A (ja) 2019-01-17
EP2948154A4 (en) 2016-09-14
JP2016517390A (ja) 2016-06-16
EP2948154A1 (en) 2015-12-02
ZA201505814B (en) 2016-11-30
IL240194B (en) 2021-12-01
KR20160008496A (ko) 2016-01-22
MX2015009696A (es) 2016-03-31
BR112015018047A8 (pt) 2019-11-05

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CA2899636C (en) Stable compositions comprising heparinoid, acute-acting anesthetic, and buffer
US20120196830A1 (en) Kits and improved compositions for treating lower urinary tract disorders
US12491207B2 (en) Article of manufacture comprising local anesthetic, buffer, and glycosaminoglycan in syringe with improved stability
CA2823949C (en) Method for manufacturing composition comprising local anesthetic, heparinoid, and buffer
EP3998932A1 (en) Alkalization of urinary bladder wall prior to treatment with intravesical heparin and alkalinized lidocaine to enhance relief of bladder pain symptoms
WO2007073397A1 (en) Kits and improved compositions for treating lower urinary tract discorders
HK40014943A (en) Method for manufacturing composition comprising local anesthetic, heparinoid, and buffer

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