CN105189456B - Kras g12c的共价抑制剂 - Google Patents

Kras g12c的共价抑制剂 Download PDF

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CN105189456B
CN105189456B CN201480025340.8A CN201480025340A CN105189456B CN 105189456 B CN105189456 B CN 105189456B CN 201480025340 A CN201480025340 A CN 201480025340A CN 105189456 B CN105189456 B CN 105189456B
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ras
compound
substituted
unsubstituted
hydrocarbyl
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CN105189456A (zh
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任平达
刘毅
李连升
方俊
吴涛
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Araxes Pharma LLC
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
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    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pyridine Compounds (AREA)
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201480025340.8A 2013-03-15 2014-03-14 Kras g12c的共价抑制剂 Active CN105189456B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201361852123P 2013-03-15 2013-03-15
US61/852,123 2013-03-15
US201361889480P 2013-10-10 2013-10-10
US61/889,480 2013-10-10
JO98/2014 2014-03-13
JOP20140098 2014-03-13
PCT/US2014/027504 WO2014152588A1 (en) 2013-03-15 2014-03-14 Covalent inhibitors of kras g12c

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CN105189456A CN105189456A (zh) 2015-12-23
CN105189456B true CN105189456B (zh) 2017-12-19

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AU (2) AU2014239542A1 (https=)
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MX (1) MX364438B (https=)
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CN110698378B (zh) * 2019-11-19 2021-03-19 上海皓元生物医药科技有限公司 2-(羟基-(甲基环丙基)苯基氨基)-1-哌嗪基乙酮衍生物的制备方法

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US9227978B2 (en) 2013-03-15 2016-01-05 Araxes Pharma Llc Covalent inhibitors of Kras G12C
US9745319B2 (en) 2013-03-15 2017-08-29 Araxes Pharma Llc Irreversible covalent inhibitors of the GTPase K-Ras G12C
JO3805B1 (ar) 2013-10-10 2021-01-31 Araxes Pharma Llc مثبطات كراس جي12سي
MX387055B (es) 2014-06-06 2025-03-19 Res Triangle Inst Agonistas del receptor de apelina (apj) y usos de los mismos.
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WO2016049568A1 (en) 2014-09-25 2016-03-31 Araxes Pharma Llc Methods and compositions for inhibition of ras
CA2976741C (en) 2015-03-30 2023-01-17 Mission Therapeutics Limited 1-cyano-pyrrolidine compounds as usp30 inhibitors
ES2898765T3 (es) 2015-04-10 2022-03-08 Araxes Pharma Llc Compuestos de quinazolina sustituidos y métodos de uso de los mismos
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