CN105051027A - 作为转染期间重排(ret)激酶抑制剂的吡啶衍生物 - Google Patents
作为转染期间重排(ret)激酶抑制剂的吡啶衍生物 Download PDFInfo
- Publication number
- CN105051027A CN105051027A CN201480015907.3A CN201480015907A CN105051027A CN 105051027 A CN105051027 A CN 105051027A CN 201480015907 A CN201480015907 A CN 201480015907A CN 105051027 A CN105051027 A CN 105051027A
- Authority
- CN
- China
- Prior art keywords
- alkyl
- ethoxy
- fluorophenyl
- trifluoromethyl
- acetamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CCOc1cc(Br)cnc1* Chemical compound CCOc1cc(Br)cnc1* 0.000 description 13
- MDXJETOWOWMSCZ-UHFFFAOYSA-N C=C1C(C2NC2)=CC(c2n[nH]nn2)=CC1C(F)(F)F Chemical compound C=C1C(C2NC2)=CC(c2n[nH]nn2)=CC1C(F)(F)F MDXJETOWOWMSCZ-UHFFFAOYSA-N 0.000 description 1
- KLJLJJHZGGEDSD-ARJAWSKDSA-O CC(C)(C(F)(F)F)/C(/O)=C/C(N)=[NH2+] Chemical compound CC(C)(C(F)(F)F)/C(/O)=C/C(N)=[NH2+] KLJLJJHZGGEDSD-ARJAWSKDSA-O 0.000 description 1
- WRVDTUPCCSPFCR-RLXIPSCYSA-O CC(C)(C(F)(F)F)C(/C=C(/N)\[OH2+])=N Chemical compound CC(C)(C(F)(F)F)C(/C=C(/N)\[OH2+])=N WRVDTUPCCSPFCR-RLXIPSCYSA-O 0.000 description 1
- YHUBZKCLPILRCF-UHFFFAOYSA-N CC(C)(C)OC(C(c(c(C(F)(F)F)c1)ncc1NC)C#N)=O Chemical compound CC(C)(C)OC(C(c(c(C(F)(F)F)c1)ncc1NC)C#N)=O YHUBZKCLPILRCF-UHFFFAOYSA-N 0.000 description 1
- YOEQJXRIVMDKOM-UHFFFAOYSA-N CC(c(c(C(F)(F)F)c1)ncc1N=O)C#N Chemical compound CC(c(c(C(F)(F)F)c1)ncc1N=O)C#N YOEQJXRIVMDKOM-UHFFFAOYSA-N 0.000 description 1
- LTMFTLRZOQJNRP-UHFFFAOYSA-N CC1(C)OS(c2ccc(CC(OC)=O)c(F)c2)OC1(C)C Chemical compound CC1(C)OS(c2ccc(CC(OC)=O)c(F)c2)OC1(C)C LTMFTLRZOQJNRP-UHFFFAOYSA-N 0.000 description 1
- DHKCPXUJXBEYIP-UHFFFAOYSA-N CCCC1=CC(c2ccc(CC(Nc3ccc(CC(C)(C)CO)c(C(F)(F)F)c3)=O)cc2F)=CNC1=O Chemical compound CCCC1=CC(c2ccc(CC(Nc3ccc(CC(C)(C)CO)c(C(F)(F)F)c3)=O)cc2F)=CNC1=O DHKCPXUJXBEYIP-UHFFFAOYSA-N 0.000 description 1
- XEPCZNYKJKQIAG-UHFFFAOYSA-N CCOC(C(c1cc(F)c(CC(Nc2cnc(C(C)(C)CO)c(C(F)(F)F)c2)=O)cc1)=CN1)=CC1=O Chemical compound CCOC(C(c1cc(F)c(CC(Nc2cnc(C(C)(C)CO)c(C(F)(F)F)c2)=O)cc1)=CN1)=CC1=O XEPCZNYKJKQIAG-UHFFFAOYSA-N 0.000 description 1
- ZWTYBYLWIRPFSZ-UHFFFAOYSA-N CCOC(C(c1ccc(CC(Nc(cc2C(F)(F)F)cnc2OCCN(C)C)=O)c(F)c1)=CN1)=CC1=O Chemical compound CCOC(C(c1ccc(CC(Nc(cc2C(F)(F)F)cnc2OCCN(C)C)=O)c(F)c1)=CN1)=CC1=O ZWTYBYLWIRPFSZ-UHFFFAOYSA-N 0.000 description 1
- YDGUKGOCDBDHSY-UHFFFAOYSA-O CCOC1=CC(B2OC(C)(C)C(C)O2)=CNC1[OH2+] Chemical compound CCOC1=CC(B2OC(C)(C)C(C)O2)=CNC1[OH2+] YDGUKGOCDBDHSY-UHFFFAOYSA-O 0.000 description 1
- IAFQHMRLFASZKN-UHFFFAOYSA-N CCOC1=CC(c2cc(F)c(CC(Nc(cc3C(F)(F)F)ccc3OCCO)=O)c(F)c2)=CNC1=O Chemical compound CCOC1=CC(c2cc(F)c(CC(Nc(cc3C(F)(F)F)ccc3OCCO)=O)c(F)c2)=CNC1=O IAFQHMRLFASZKN-UHFFFAOYSA-N 0.000 description 1
- JZVWPDCTWNMSBO-UHFFFAOYSA-N CCOC1=CC(c2ccc(CC(Nc3ccc(CC(CO)(F)F)c(C(F)(F)F)c3)=O)c(F)c2)=CNC1=O Chemical compound CCOC1=CC(c2ccc(CC(Nc3ccc(CC(CO)(F)F)c(C(F)(F)F)c3)=O)c(F)c2)=CNC1=O JZVWPDCTWNMSBO-UHFFFAOYSA-N 0.000 description 1
- LNLPJHXWJXGBEV-UHFFFAOYSA-N CCc(cc1C(F)(F)F)cnc1O Chemical compound CCc(cc1C(F)(F)F)cnc1O LNLPJHXWJXGBEV-UHFFFAOYSA-N 0.000 description 1
- WWTGXYAJVXKEKL-UHFFFAOYSA-N Cc(nc1)c[n]1-c1cc(C(F)(F)F)cc(N)c1 Chemical compound Cc(nc1)c[n]1-c1cc(C(F)(F)F)cc(N)c1 WWTGXYAJVXKEKL-UHFFFAOYSA-N 0.000 description 1
- JHLCLALPGFWTGY-UHFFFAOYSA-N N#CCc(c(C(F)(F)F)c1)ncc1[N+]([O-])=O Chemical compound N#CCc(c(C(F)(F)F)c1)ncc1[N+]([O-])=O JHLCLALPGFWTGY-UHFFFAOYSA-N 0.000 description 1
- LAQFPQSYKMWFAW-UHFFFAOYSA-N N#CCc(c(F)cc(Br)c1)c1F Chemical compound N#CCc(c(F)cc(Br)c1)c1F LAQFPQSYKMWFAW-UHFFFAOYSA-N 0.000 description 1
- RCEMMXVNSKICPW-UHFFFAOYSA-N Nc1c(C[Zn])ccc(C(F)(F)F)c1N Chemical compound Nc1c(C[Zn])ccc(C(F)(F)F)c1N RCEMMXVNSKICPW-UHFFFAOYSA-N 0.000 description 1
- LSRHFWSNUFIKER-UHFFFAOYSA-N OCc(c(F)cc(Br)c1)c1F Chemical compound OCc(c(F)cc(Br)c1)c1F LSRHFWSNUFIKER-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/69—Two or more oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201480015907.3A CN105051027A (zh) | 2013-03-15 | 2014-03-14 | 作为转染期间重排(ret)激酶抑制剂的吡啶衍生物 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013072683 | 2013-03-15 | ||
| CN2013090059 | 2013-12-20 | ||
| CN2014072449 | 2014-02-24 | ||
| CN201480015907.3A CN105051027A (zh) | 2013-03-15 | 2014-03-14 | 作为转染期间重排(ret)激酶抑制剂的吡啶衍生物 |
| PCT/IB2014/059817 WO2014141187A1 (en) | 2013-03-15 | 2014-03-14 | Pyridine derivatives as rearranged during transfection (ret) kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105051027A true CN105051027A (zh) | 2015-11-11 |
Family
ID=50390154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480015907.3A Pending CN105051027A (zh) | 2013-03-15 | 2014-03-14 | 作为转染期间重排(ret)激酶抑制剂的吡啶衍生物 |
Country Status (33)
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109096264A (zh) * | 2018-08-28 | 2018-12-28 | 山东理工职业学院 | Ret抑制剂及其制备方法、组合物和用途 |
| CN110036007A (zh) * | 2016-09-29 | 2019-07-19 | 第一三共株式会社 | 吡啶化合物 |
| WO2022017524A1 (zh) * | 2020-07-23 | 2022-01-27 | 深圳晶泰科技有限公司 | 吡啶酮类化合物及其制备方法和应用 |
| CN115626880A (zh) * | 2022-11-15 | 2023-01-20 | 常州大学 | 3-硝基-5-氰基三氟甲苯的合成方法 |
| CN115667253A (zh) * | 2020-04-27 | 2023-01-31 | 伊莱利利公司 | 可用于抑制ret激酶的化合物 |
| CN116438179A (zh) * | 2020-11-06 | 2023-07-14 | 伊莱利利公司 | 作为ret激酶抑制剂的吡唑衍生物 |
| CN116925023A (zh) * | 2023-07-18 | 2023-10-24 | 江苏桐孚高新材料有限公司 | 2-全氟烷基-4h-吡喃-4-酮衍生物的改进合成方法 |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE044025T2 (hu) | 2010-05-20 | 2019-09-30 | Array Biopharma Inc | Makrociklusos vegyületek mint TRK-kináz inhibitorok |
| CN107148418A (zh) * | 2014-09-08 | 2017-09-08 | 葛兰素史密斯克莱知识产权发展有限公司 | 2‑(4‑(4‑乙氧基‑6‑氧代‑1,6‑二氢吡啶‑3‑基)‑2‑氟苯基)‑n‑(5‑(1,1,1‑三氟‑2‑甲基丙‑2‑基)异噁唑‑3‑基)乙酰胺的晶型 |
| UA122213C2 (uk) * | 2014-09-10 | 2020-10-12 | Глаксосмітклайн Інтеллектьюел Проперті Девелопмент Лімітед | Сполуки як інгібітори кінази, реаранжованої під час трансфекції (ret) |
| UA123084C2 (uk) * | 2014-09-10 | 2021-02-17 | Глаксосмітклайн Інтеллектьюел Проперті Девелопмент Лімітед | Сполуки як інгібітори кінази, реаранжованої під час трансфекції (ret) |
| WO2016127074A1 (en) | 2015-02-06 | 2016-08-11 | Blueprint Medicines Corporation | 2-(pyridin-3-yl)-pyrimidine derivatives as ret inhibitors |
| PL3322706T3 (pl) | 2015-07-16 | 2021-07-19 | Array Biopharma, Inc. | Podstawione związki pirazolo[1,5-a]pirydynowe jako inhibitory kinazy ret |
| WO2017019804A2 (en) | 2015-07-28 | 2017-02-02 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| RS65069B1 (sr) | 2015-11-02 | 2024-02-29 | Blueprint Medicines Corp | Inhibitori ret-a |
| WO2017145050A1 (en) | 2016-02-23 | 2017-08-31 | Glaxosmithkline Intellectual Property Development Limited | Pyridylpyridone derivative useful as a ret kinase inhibitor in the treatment of ibs and cancer |
| AU2017232610B2 (en) | 2016-03-16 | 2021-07-22 | Plexxikon Inc. | Compounds and methods for kinase modulation and indications therefore |
| US10183928B2 (en) | 2016-03-17 | 2019-01-22 | Blueprint Medicines Corporation | Inhibitors of RET |
| KR20190008891A (ko) | 2016-05-13 | 2019-01-25 | 인스티튜토 데 메디시나 몰레큘라 | Ｉｌｃ３ 세포와 연관된 질환을 치료하는 방법 |
| WO2018017983A1 (en) | 2016-07-22 | 2018-01-25 | Blueprint Medicines Corporation | Compounds useful for treating disorders related to ret |
| TWI704148B (zh) | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
| JOP20190077A1 (ar) | 2016-10-10 | 2019-04-09 | Array Biopharma Inc | مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret |
| WO2018136663A1 (en) | 2017-01-18 | 2018-07-26 | Array Biopharma, Inc. | Ret inhibitors |
| US11168090B2 (en) | 2017-01-18 | 2021-11-09 | Array Biopharma Inc. | Substituted pyrazolo[1,5-a]pyrazines as RET kinase inhibitors |
| JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
| JP2020519672A (ja) | 2017-05-15 | 2020-07-02 | ブループリント メディシンズ コーポレイション | ＲＥＴ阻害剤とｍＴＯＲＣ１阻害剤との組合せ及び異常なＲＥＴ活性によって媒介されるがんを処置するためのその使用 |
| US10093648B1 (en) * | 2017-09-22 | 2018-10-09 | Celgene Corporation | Crystalline 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione hemihydrate, compositions and methods of use thereof |
| TWI791053B (zh) | 2017-10-10 | 2023-02-01 | 美商亞雷生物製藥股份有限公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物 |
| TWI876442B (zh) | 2017-10-10 | 2025-03-11 | 美商絡速藥業公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物 |
| EP3740486A1 (en) | 2018-01-18 | 2020-11-25 | Array Biopharma, Inc. | Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors |
| CA3087578C (en) | 2018-01-18 | 2023-08-08 | Array Biopharma Inc. | Substituted pyrazolo[3,4-d]pyrimidine compounds as ret kinase inhibitors |
| EP3740491A1 (en) | 2018-01-18 | 2020-11-25 | Array Biopharma, Inc. | Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors |
| FI3773589T3 (fi) | 2018-04-03 | 2024-02-01 | Blueprint Medicines Corp | Ret-estäjä käytettäväksi ret-muunnoksen sisältävän syövän hoidossa |
| WO2020055672A1 (en) | 2018-09-10 | 2020-03-19 | Array Biopharma Inc. | Fused heterocyclic compounds as ret kinase inhibitors |
| AU2020257301B2 (en) | 2019-04-18 | 2025-10-23 | The Johns Hopkins University | Substituted 2-amino-pyrazolyl-(1,2,4)triazolo(1,5a) pyridine derivatives and use thereof |
| WO2021164742A1 (zh) * | 2020-02-20 | 2021-08-26 | 广州白云山医药集团股份有限公司白云山制药总厂 | 喹啉类化合物 |
| US12448366B2 (en) | 2020-05-29 | 2025-10-21 | Rigel Pharmaceuticals, Inc. | Solid forms of pralsetinib |
| US20240270855A1 (en) | 2021-06-03 | 2024-08-15 | Fundação D. Anna De Sommer Champalimaud E Dr. Carlos Montez Champalimaud | Neuro-mesenchyme units control ilc2 and obesity via a brain-adipose circuit |
| EP4650002A1 (en) * | 2024-05-15 | 2025-11-19 | Ludwig-Maximilians-Universität | Aniline-based modulators of the nuclear receptor tlx (nr2e1) |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0203542A3 (en) | 1999-08-12 | 2003-07-28 | Upjohn Co | 3(5)-amino-pyrazole derivatives, process for their preparation, their use and pharmaceutical compositions containing the same |
| AU2002215053A1 (en) * | 2000-11-27 | 2002-06-24 | Pharmacia Italia S.P.A. | Phenylacetamido- pyrazole derivatives and their use as antitumor agents |
| DE10201764A1 (de) | 2002-01-18 | 2003-07-31 | Bayer Cropscience Ag | Substituierte 4-Aminopyridin-Derivate |
| US7968574B2 (en) | 2004-12-28 | 2011-06-28 | Kinex Pharmaceuticals, Llc | Biaryl compositions and methods for modulating a kinase cascade |
| CA2666116A1 (en) * | 2006-10-16 | 2008-04-24 | Novartis Ag | Phenylacetamides useful as protein kinase inhibitors |
| SI2848610T1 (en) * | 2006-11-15 | 2018-02-28 | Ym Biosciences Australia Pty Ltd | Inhibitors of kinase activity |
| EP2467137A1 (en) | 2009-08-19 | 2012-06-27 | Ambit Biosciences Corporation | Biaryl compounds and methods of use thereof |
| JP6097998B2 (ja) | 2010-12-16 | 2017-03-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン生成のビアリールアミドインヒビター |
| US8937071B2 (en) | 2013-03-15 | 2015-01-20 | Glaxosmithkline Intellectual Property Development Limited | Compounds as rearranged during transfection (RET) inhibitors |
-
2014
- 2014-03-14 EP EP14713598.2A patent/EP2970191B1/en active Active
- 2014-03-14 CA CA2905627A patent/CA2905627A1/en not_active Abandoned
- 2014-03-14 EA EA201591738A patent/EA029296B1/ru not_active IP Right Cessation
- 2014-03-14 SG SG11201506695UA patent/SG11201506695UA/en unknown
- 2014-03-14 WO PCT/IB2014/059817 patent/WO2014141187A1/en not_active Ceased
- 2014-03-14 SI SI201430170A patent/SI2970191T1/sl unknown
- 2014-03-14 DK DK14713598.2T patent/DK2970191T3/en active
- 2014-03-14 PE PE2015001878A patent/PE20151538A1/es not_active Application Discontinuation
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| CN110036007B (zh) * | 2016-09-29 | 2021-10-15 | 第一三共株式会社 | 吡啶化合物 |
| CN113788824A (zh) * | 2016-09-29 | 2021-12-14 | 第一三共株式会社 | 吡啶化合物 |
| CN109096264A (zh) * | 2018-08-28 | 2018-12-28 | 山东理工职业学院 | Ret抑制剂及其制备方法、组合物和用途 |
| CN115667253A (zh) * | 2020-04-27 | 2023-01-31 | 伊莱利利公司 | 可用于抑制ret激酶的化合物 |
| WO2022017524A1 (zh) * | 2020-07-23 | 2022-01-27 | 深圳晶泰科技有限公司 | 吡啶酮类化合物及其制备方法和应用 |
| TWI786742B (zh) * | 2020-07-23 | 2022-12-11 | 大陸商深圳晶泰科技有限公司 | 吡啶酮類化合物及其製備方法和應用 |
| CN115803316B (zh) * | 2020-07-23 | 2024-12-06 | 深圳晶泰科技有限公司 | 吡啶酮类化合物及其制备方法和应用 |
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| CN116438179A (zh) * | 2020-11-06 | 2023-07-14 | 伊莱利利公司 | 作为ret激酶抑制剂的吡唑衍生物 |
| CN115626880B (zh) * | 2022-11-15 | 2023-11-14 | 常州大学 | 3-硝基-5-氰基三氟甲苯的合成方法 |
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| WO2025016082A1 (zh) * | 2023-07-18 | 2025-01-23 | 江苏桐孚高新材料有限公司 | 2-全氟烷基-4h-吡喃-4-酮衍生物的改进合成方法 |
| CN116925023B (zh) * | 2023-07-18 | 2025-11-21 | 江苏桐孚高新材料有限公司 | 2-全氟烷基-4h-吡喃-4-酮衍生物的改进合成方法 |
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