CN104614302B - 在声细胞计中的颗粒分析 - Google Patents

在声细胞计中的颗粒分析 Download PDF

Info

Publication number
CN104614302B
CN104614302B CN201510064850.2A CN201510064850A CN104614302B CN 104614302 B CN104614302 B CN 104614302B CN 201510064850 A CN201510064850 A CN 201510064850A CN 104614302 B CN104614302 B CN 104614302B
Authority
CN
China
Prior art keywords
particle
flowing
stream
sound
flow
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201510064850.2A
Other languages
English (en)
Chinese (zh)
Other versions
CN104614302A (zh
Inventor
G.卡杜查克
M.D.沃德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Los Alamos National Security LLC
Original Assignee
Los Alamos National Security LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Los Alamos National Security LLC filed Critical Los Alamos National Security LLC
Publication of CN104614302A publication Critical patent/CN104614302A/zh
Application granted granted Critical
Publication of CN104614302B publication Critical patent/CN104614302B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/14—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object using acoustic emission techniques
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/4833—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48735—Investigating suspensions of cells, e.g. measuring microbe concentration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0636—Focussing flows, e.g. to laminate flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B01L2300/0838—Capillaries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0433—Moving fluids with specific forces or mechanical means specific forces vibrational forces
    • B01L2400/0439—Moving fluids with specific forces or mechanical means specific forces vibrational forces ultrasonic vibrations, vibrating piezo elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G01N15/1433—Signal processing using image recognition
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
    • G01N2001/4094—Concentrating samples by other techniques involving separation of suspended solids using ultrasound
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1028—Sorting particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G01N2015/1415—Control of particle position
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G01N2015/142—Acoustic or ultrasonic focussing

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Acoustics & Sound (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Fluid Mechanics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Separation Of Solids By Using Liquids Or Pneumatic Power (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
CN201510064850.2A 2007-12-19 2008-12-19 在声细胞计中的颗粒分析 Active CN104614302B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US842207P 2007-12-19 2007-12-19
US61/008422 2007-12-19
US12/283491 2008-09-11
US12/283,491 US8266951B2 (en) 2007-12-19 2008-09-11 Particle analysis in an acoustic cytometer
US12/283,461 US8266950B2 (en) 2007-12-19 2008-09-11 Particle analysis in an acoustic cytometer
US12/283461 2008-09-11
CN200880127473.0A CN102089635B (zh) 2007-12-19 2008-12-19 在声细胞计中的颗粒分析

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN200880127473.0A Division CN102089635B (zh) 2007-12-19 2008-12-19 在声细胞计中的颗粒分析

Publications (2)

Publication Number Publication Date
CN104614302A CN104614302A (zh) 2015-05-13
CN104614302B true CN104614302B (zh) 2018-05-04

Family

ID=40787028

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201510064850.2A Active CN104614302B (zh) 2007-12-19 2008-12-19 在声细胞计中的颗粒分析
CN200880127473.0A Active CN102089635B (zh) 2007-12-19 2008-12-19 在声细胞计中的颗粒分析

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN200880127473.0A Active CN102089635B (zh) 2007-12-19 2008-12-19 在声细胞计中的颗粒分析

Country Status (12)

Country Link
US (7) US8266951B2 (OSRAM)
EP (1) EP2232212B1 (OSRAM)
JP (5) JP2011508220A (OSRAM)
KR (2) KR101817410B1 (OSRAM)
CN (2) CN104614302B (OSRAM)
AU (1) AU2008343033B2 (OSRAM)
BR (1) BRPI0821646A8 (OSRAM)
CA (1) CA2709765C (OSRAM)
EA (1) EA022506B1 (OSRAM)
IL (1) IL206331A (OSRAM)
WO (1) WO2009086043A2 (OSRAM)
ZA (1) ZA201004306B (OSRAM)

Families Citing this family (141)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7340957B2 (en) 2004-07-29 2008-03-11 Los Alamos National Security, Llc Ultrasonic analyte concentration and application in flow cytometry
US7835000B2 (en) 2006-11-03 2010-11-16 Los Alamos National Security, Llc System and method for measuring particles in a sample stream of a flow cytometer or the like
EP2479552B1 (en) * 2007-04-02 2015-09-02 Acoustic Cytometry Systems, Inc. Methods for enhanced analysis of acoustic field focused cells and particles
US7837040B2 (en) * 2007-04-09 2010-11-23 Los Alamos National Security, Llc Acoustic concentration of particles in fluid flow
US8083068B2 (en) 2007-04-09 2011-12-27 Los Alamos National Security, Llc Apparatus for separating particles utilizing engineered acoustic contrast capture particles
US8263407B2 (en) 2007-10-24 2012-09-11 Los Alamos National Security, Llc Method for non-contact particle manipulation and control of particle spacing along an axis
US8528406B2 (en) * 2007-10-24 2013-09-10 Los Alamos National Security, LLP Method for non-contact particle manipulation and control of particle spacing along an axis
US8266951B2 (en) 2007-12-19 2012-09-18 Los Alamos National Security, Llc Particle analysis in an acoustic cytometer
US8714014B2 (en) * 2008-01-16 2014-05-06 Life Technologies Corporation System and method for acoustic focusing hardware and implementations
US20100009333A1 (en) * 2008-07-08 2010-01-14 Beckman Coulter, Inc. Methods for Acoustic Particle Focusing in Biological Sample Analyzers
US8865003B2 (en) * 2008-09-26 2014-10-21 Abbott Laboratories Apparatus and method for separation of particles suspended in a liquid from the liquid in which they are suspended
US20100140185A1 (en) * 2008-12-05 2010-06-10 John Hill Wastewater treatment
JP5487638B2 (ja) * 2009-02-17 2014-05-07 ソニー株式会社 微小粒子分取のための装置及びマイクロチップ
JP5502655B2 (ja) * 2009-09-30 2014-05-28 シスメックス株式会社 試料調製装置、細胞分析装置及び分析物の濃縮方法
US8691145B2 (en) 2009-11-16 2014-04-08 Flodesign Sonics, Inc. Ultrasound and acoustophoresis for water purification
EP2507639B1 (en) * 2009-12-04 2020-04-01 Life Technologies Corporation Apparatuses, systems, methods, and computer readable media for acoustic flow cytometry
US8830451B1 (en) * 2010-05-07 2014-09-09 Stc.Unm Multinode acoustic focusing for parallel flow cytometry analysis applications
US9074977B2 (en) 2010-05-07 2015-07-07 Stc.Unm Multinode acoustic focusing for parallel flow cytometry analysis applications
EP2582631A4 (en) 2010-06-16 2016-05-25 Flodesign Sonics Inc PHONONIC CRYSTAL DESALINATION SYSTEM AND METHOD OF USE
US9421553B2 (en) 2010-08-23 2016-08-23 Flodesign Sonics, Inc. High-volume fast separation of multi-phase components in fluid suspensions
US8679338B2 (en) 2010-08-23 2014-03-25 Flodesign Sonics, Inc. Combined acoustic micro filtration and phononic crystal membrane particle separation
US8460607B2 (en) 2010-10-22 2013-06-11 Abbott Laboratories Microfluidic device having a flow channel
US8980106B2 (en) 2010-12-15 2015-03-17 Abbott Laboratories Apparatus and method for separation of whole blood into plasma or serum and cells
CA2826655C (en) 2011-02-04 2018-09-18 Cidra Corporate Services Inc. Sonic filter for measuring and capturing particles having a particular particle size in a fluid, mixture or process flow
MX338778B (es) 2011-02-15 2016-05-02 Microbix Biosystems Inc Metodos, sistemas y aparato para realizar citometrias de flujo.
SG193283A1 (en) 2011-03-03 2013-10-30 Life Technologies Corp Sampling probes, systems, apparatuses, and methods
USD698038S1 (en) 2011-03-03 2014-01-21 Life Technologies Corporation Plate loader
CA2827226C (en) 2011-04-27 2019-02-12 Becton Dickinson And Company Devices and methods for separating magnetically labeled moieties in a sample
EP2724160A2 (en) 2011-06-27 2014-04-30 Life Technologies Corporation Acoustic cytometry methods and protocols
CA2842359A1 (en) * 2011-08-01 2013-02-07 Denovo Sciences Cell capture system and method of use
US10466160B2 (en) 2011-08-01 2019-11-05 Celsee Diagnostics, Inc. System and method for retrieving and analyzing particles
EP2761291B1 (en) * 2011-09-28 2016-06-29 Acousort AB System and method to separate cells and/or particles
JP2015512766A (ja) 2012-01-31 2015-04-30 ザ・ペン・ステート・リサーチ・ファンデーション 可変定常的表面弾性波を用いたマイクロ流体操作及び粒子の分類
EP2623589A1 (en) * 2012-02-06 2013-08-07 Centre National de la Recherche Scientifique Method of forming a multilayer aggregate of objects
US9752114B2 (en) 2012-03-15 2017-09-05 Flodesign Sonics, Inc Bioreactor using acoustic standing waves
US9416344B2 (en) 2012-03-15 2016-08-16 Flodesign Sonics, Inc. Bioreactor using acoustic standing waves
US9340435B2 (en) 2012-03-15 2016-05-17 Flodesign Sonics, Inc. Separation of multi-component fluid through ultrasonic acoustophoresis
US9422328B2 (en) 2012-03-15 2016-08-23 Flodesign Sonics, Inc. Acoustic bioreactor processes
US10689609B2 (en) 2012-03-15 2020-06-23 Flodesign Sonics, Inc. Acoustic bioreactor processes
US9458450B2 (en) 2012-03-15 2016-10-04 Flodesign Sonics, Inc. Acoustophoretic separation technology using multi-dimensional standing waves
US9272234B2 (en) 2012-03-15 2016-03-01 Flodesign Sonics, Inc. Separation of multi-component fluid through ultrasonic acoustophoresis
US9745548B2 (en) 2012-03-15 2017-08-29 Flodesign Sonics, Inc. Acoustic perfusion devices
US9783775B2 (en) 2012-03-15 2017-10-10 Flodesign Sonics, Inc. Bioreactor using acoustic standing waves
US9950282B2 (en) 2012-03-15 2018-04-24 Flodesign Sonics, Inc. Electronic configuration and control for acoustic standing wave generation
US10953436B2 (en) 2012-03-15 2021-03-23 Flodesign Sonics, Inc. Acoustophoretic device with piezoelectric transducer array
US9822333B2 (en) 2012-03-15 2017-11-21 Flodesign Sonics, Inc. Acoustic perfusion devices
US10967298B2 (en) 2012-03-15 2021-04-06 Flodesign Sonics, Inc. Driver and control for variable impedence load
US10322949B2 (en) 2012-03-15 2019-06-18 Flodesign Sonics, Inc. Transducer and reflector configurations for an acoustophoretic device
US9457302B2 (en) 2014-05-08 2016-10-04 Flodesign Sonics, Inc. Acoustophoretic device with piezoelectric transducer array
US10040011B2 (en) 2012-03-15 2018-08-07 Flodesign Sonics, Inc. Acoustophoretic multi-component separation technology platform
US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
US9567559B2 (en) 2012-03-15 2017-02-14 Flodesign Sonics, Inc. Bioreactor using acoustic standing waves
US9623348B2 (en) 2012-03-15 2017-04-18 Flodesign Sonics, Inc. Reflector for an acoustophoretic device
US9688958B2 (en) 2012-03-15 2017-06-27 Flodesign Sonics, Inc. Acoustic bioreactor processes
US10370635B2 (en) 2012-03-15 2019-08-06 Flodesign Sonics, Inc. Acoustic separation of T cells
US9796956B2 (en) 2013-11-06 2017-10-24 Flodesign Sonics, Inc. Multi-stage acoustophoresis device
US9752113B2 (en) 2012-03-15 2017-09-05 Flodesign Sonics, Inc. Acoustic perfusion devices
US10737953B2 (en) 2012-04-20 2020-08-11 Flodesign Sonics, Inc. Acoustophoretic method for use in bioreactors
US11324873B2 (en) 2012-04-20 2022-05-10 Flodesign Sonics, Inc. Acoustic blood separation processes and devices
US10748278B2 (en) 2012-06-18 2020-08-18 Sobru Solutions, Inc. Organism evaluation system and method of use
US9644229B2 (en) 2012-06-18 2017-05-09 Sobru Solutions, Inc. Microorganism evaluation system
US11446660B2 (en) 2012-06-18 2022-09-20 Scanlogx, Inc Organism evaluation system and method of use
EP2877832B1 (en) * 2012-07-27 2020-10-28 Engender Technologies Limited System for microfluidic orientation and sorting of particles
JP6025982B2 (ja) 2012-08-01 2016-11-16 ザ・ペン・ステート・リサーチ・ファンデーション 粒子および細胞の高効率分離およびマニピュレーション
WO2014046605A1 (en) * 2012-09-21 2014-03-27 Acousort Ab A method for separating cells-bead complexes
CN110595987A (zh) 2012-10-26 2019-12-20 贝克顿·迪金森公司 用于操纵流体样品中的组分的装置和方法
WO2014085627A1 (en) 2012-11-27 2014-06-05 The Penn State Research Foundation Spatiotemporal control of chemical microenvironment using oscillating microstructures
US9121800B2 (en) 2012-12-13 2015-09-01 David Stucker Internally reflective chamber for fluorescent radiation collection and concentration, and method for using the same
KR101356933B1 (ko) * 2012-12-28 2014-01-29 고려대학교 산학협력단 표면탄성파를 이용한 미세유동 크로마토 그래피 기반 미세입자 분리 장치 및 방법
US9752181B2 (en) 2013-01-26 2017-09-05 Denovo Sciences, Inc. System and method for capturing and analyzing cells
WO2014133451A1 (en) * 2013-02-28 2014-09-04 Acousort Ab System and method to analyze non-spherical cells
US9707562B2 (en) 2013-03-13 2017-07-18 Denovo Sciences, Inc. System for capturing and analyzing cells
ES2711364T3 (es) 2013-03-15 2019-05-03 Iris Int Inc Sistemas y métodos de célula de flujo para el análisis de partículas en muestras de sangre
CN105378471A (zh) * 2013-04-04 2016-03-02 洛斯阿拉莫斯国家安全股份有限公司 用于测量多相油-水-气混合物的属性的方法
US10391490B2 (en) 2013-05-31 2019-08-27 Celsee Diagnostics, Inc. System and method for isolating and analyzing cells
WO2014210046A1 (en) 2013-06-24 2014-12-31 Flodesign Sonics, Inc. Fluid dynamic sonic separator
US9745569B2 (en) 2013-09-13 2017-08-29 Flodesign Sonics, Inc. System for generating high concentration factors for low cell density suspensions
US9766168B2 (en) * 2013-10-23 2017-09-19 Applied Research Associates, Inc. Acoustic particulate concentration methods and system
US9360164B2 (en) * 2013-12-12 2016-06-07 Owl biomedical, Inc. Particle manipulation system with stay-wet algorithm
US20150177111A1 (en) * 2013-12-23 2015-06-25 Becton, Dickinson And Company Devices and methods for processing a biological sample
CA2935960C (en) 2014-01-08 2023-01-10 Bart Lipkens Acoustophoresis device with dual acoustophoretic chamber
EP3108219B1 (en) * 2014-02-20 2020-04-01 Malvern Panalytical Limited Heterogeneous fluid sample characterization
WO2015157978A1 (zh) * 2014-04-17 2015-10-22 深圳迈瑞生物医疗电子股份有限公司 粒子分析仪及其分析操作结果回退方法和装置
CN106536059B (zh) 2014-06-09 2019-01-11 阿森特生物纳米科技股份有限公司 用于颗粒的控制和分拣系统
US10357052B2 (en) 2014-06-16 2019-07-23 Sweet Green Fields USA LLC Rebaudioside A and stevioside with improved solubilities
US9744483B2 (en) 2014-07-02 2017-08-29 Flodesign Sonics, Inc. Large scale acoustic separation device
SG11201610712XA (en) 2014-07-02 2017-01-27 Flodesign Sonics Inc Acoustophoretic device with uniform fluid flow
EP3187854B1 (en) * 2014-08-28 2020-08-19 Sysmex Corporation Particle image-capturing device and particle image-capturing method
KR20170063882A (ko) 2014-09-30 2017-06-08 프로디자인 소닉스, 인크. 비-유동성 유체 내의 입자의 음향 영동 정화
WO2016053181A1 (en) * 2014-10-01 2016-04-07 Water Optics Technology Pte. Ltd A sensor for particle detection in a fluid
US11965812B2 (en) * 2014-10-09 2024-04-23 Kinetic River Corp. Apparatus and methods for particle analysis and autofluorescence discrimination
RU2689582C2 (ru) 2014-10-24 2019-05-28 Лайф Текнолоджиз Корпорейшн Система жидкостно-жидкостной очистки образца с акустическим осаждением
US9620006B2 (en) 2014-11-21 2017-04-11 At&T Intellectual Property I, L.P. Systems, methods, and computer readable storage devices for controlling an appearance of a surface using sound waves
CN105987870A (zh) * 2015-02-10 2016-10-05 博奥生物集团有限公司 一种流式细胞分选系统及其聚焦检测方法及其流体芯片
DE102015202574A1 (de) 2015-02-12 2016-08-18 Albert-Ludwigs-Universität Freiburg Vorrichtung und Verfahren zum Dispensieren von unter Verwendung eines akustischen Felds ausgerichteten Partikeln in frei fliegenden Tropfen
US10106770B2 (en) 2015-03-24 2018-10-23 Flodesign Sonics, Inc. Methods and apparatus for particle aggregation using acoustic standing waves
US9855382B2 (en) * 2015-03-31 2018-01-02 Biomet Biologics, Llc Cell washing device using standing acoustic waves and a phantom material
US20180071981A1 (en) 2015-03-31 2018-03-15 The Regents Of The University Of California System and method for tunable patterning and assembly of particles via acoustophoresis
US10737012B2 (en) 2015-03-31 2020-08-11 Biomet Biologics, Inc. Cell washing using acoustic waves
US11021699B2 (en) 2015-04-29 2021-06-01 FioDesign Sonics, Inc. Separation using angled acoustic waves
WO2016176663A1 (en) 2015-04-29 2016-11-03 Flodesign Sonics, Inc. Acoustophoretic device for angled wave particle deflection
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
CN107530676A (zh) * 2015-05-13 2018-01-02 株式会社爱瑞思 微粒控制方法
US9550134B2 (en) 2015-05-20 2017-01-24 Flodesign Sonics, Inc. Acoustic manipulation of particles in standing wave fields
US10161926B2 (en) 2015-06-11 2018-12-25 Flodesign Sonics, Inc. Acoustic methods for separation of cells and pathogens
US9663756B1 (en) 2016-02-25 2017-05-30 Flodesign Sonics, Inc. Acoustic separation of cellular supporting materials from cultured cells
ES2879238T3 (es) 2015-07-09 2021-11-22 Flodesign Sonics Inc Reflectores y cristales piezoeléctricos no planos y no simétricos
US11474085B2 (en) 2015-07-28 2022-10-18 Flodesign Sonics, Inc. Expanded bed affinity selection
US11459540B2 (en) 2015-07-28 2022-10-04 Flodesign Sonics, Inc. Expanded bed affinity selection
US10710012B2 (en) * 2015-09-23 2020-07-14 Aenitis Technologies Multi-use acoustic levitation trap
US10245821B2 (en) 2015-12-04 2019-04-02 At&T Intellectual Property I, L.P. Reusable networked 3-D printing
EP3362777B1 (de) * 2015-12-23 2023-02-22 Siemens Healthcare GmbH Fliesszelle zur analyse von partikeln in einer zu untersuchenden flüssigkeit, verfahren und verwendung
US10648900B2 (en) * 2015-12-23 2020-05-12 Becton, Dickinson And Company Multi-color flow cytometric analysis of samples with low cell numbers
JP6134402B1 (ja) * 2016-01-29 2017-05-24 シスメックス株式会社 生体試料撮像装置及び生体試料撮像方法
US10710006B2 (en) 2016-04-25 2020-07-14 Flodesign Sonics, Inc. Piezoelectric transducer for generation of an acoustic standing wave
US11085035B2 (en) 2016-05-03 2021-08-10 Flodesign Sonics, Inc. Therapeutic cell washing, concentration, and separation utilizing acoustophoresis
EP3481361A1 (en) 2016-05-03 2019-05-15 Flodesign Sonics, Inc. Therapeutic cell washing, concentration, and separation utilizing acoustophoresis
US11214789B2 (en) 2016-05-03 2022-01-04 Flodesign Sonics, Inc. Concentration and washing of particles with acoustics
SG11201811220UA (en) * 2016-07-01 2019-01-30 Life Technologies Corp Methods, systems and devices for concentration of particles
CA3032340A1 (en) * 2016-08-02 2018-02-08 Imec Vzw Method and arrangement for focusing objects in a flow
CN110494543A (zh) 2016-10-19 2019-11-22 弗洛设计声能学公司 通过声学的亲和细胞提取
CN106872339A (zh) * 2017-01-10 2017-06-20 中国科学院苏州生物医学工程技术研究所 一种粒子排序方法及其装置和用途
CN110506201B (zh) * 2017-02-10 2022-11-29 东曹株式会社 粒子检测装置和粒子检测方法
EP3595817A4 (en) * 2017-03-13 2021-06-23 New Mexico Technical Research Foundation SEPARATION OF NANOPARTICLE VIA ACOUSTOFLUIDIC FLOW RELOCATION
EP3602003B1 (en) 2017-03-31 2026-04-22 Life Technologies Corporation Apparatuses, systems and methods for imaging flow cytometry
ES2979247T3 (es) * 2017-04-07 2024-09-25 Univ Western Australia Un método para ensayar la sensibilidad a los antimicrobianos
CA3082582A1 (en) * 2017-06-13 2018-12-20 Flodesign Sonics, Inc. Driver and control for variable impedance load
EP3421975A1 (en) 2017-06-30 2019-01-02 Centre National De La Recherche Scientifique Methods and device for manipulating objects
WO2019046307A1 (en) 2017-08-29 2019-03-07 Celsee Diagnostics, Inc. SYSTEM AND METHOD FOR ISOLATING AND ANALYZING CELLS
JP2019086340A (ja) * 2017-11-02 2019-06-06 シスメックス株式会社 細胞検出方法および細胞検出システム
SG11202003907WA (en) 2017-12-14 2020-05-28 Flodesign Sonics Inc Acoustic transducer drive and controller
CN109946217B (zh) * 2017-12-21 2021-08-24 深圳先进技术研究院 一种声驱动的流式细胞检测装置
US10633693B1 (en) 2019-04-16 2020-04-28 Celsee Diagnostics, Inc. System and method for leakage control in a particle capture system
US11578322B2 (en) 2019-05-07 2023-02-14 Bio-Rad Laboratories, Inc. System and method for automated single cell processing
US11273439B2 (en) 2019-05-07 2022-03-15 Bio-Rad Laboratories, Inc. System and method for target material retrieval from microwells
US11504719B2 (en) 2020-03-12 2022-11-22 Bio-Rad Laboratories, Inc. System and method for receiving and delivering a fluid for sample processing
US20220187614A1 (en) 2020-12-14 2022-06-16 Life Technologies Corporation Reduced Speckle Illumination Systems And Methods
WO2022173345A1 (en) * 2021-02-09 2022-08-18 Amniotics Ab An amniotic cell separating apparatus
US20260049911A1 (en) * 2022-05-30 2026-02-19 Shinshu University Particle two-dimensional acoustic focusing device, and acoustic concentration device using the same
US12584902B2 (en) 2023-12-10 2026-03-24 Instrumentation Laboratory Company Acoustic separation of a test sample

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101060898A (zh) * 2004-09-24 2007-10-24 斯派克特罗尼克股份公司 用于分离粒子的方法和装置

Family Cites Families (221)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US452382A (en) * 1891-05-19 Charles ii
GB500271A (en) 1936-05-04 1939-02-06 Metallgesellschaft Ag Process of and apparatus for clarifying liquids
US2900536A (en) 1954-11-18 1959-08-18 Astatic Corp Design of electro-mechanical transducer elements
US3669542A (en) 1969-10-09 1972-06-13 Coulter Electronics Liquid borne particle sensor
US3882732A (en) * 1973-08-31 1975-05-13 Nasa Material suspension within an acoustically excited resonant chamber
US4055491A (en) 1976-06-02 1977-10-25 Porath Furedi Asher Apparatus and method for removing fine particles from a liquid medium by ultrasonic waves
CA1142466A (en) 1979-01-09 1983-03-08 National Research Development Corporation Cell lines
US4265124A (en) 1979-06-04 1981-05-05 Rockwell International Corporation Remote acoustic wave sensors
US4285810A (en) 1980-02-29 1981-08-25 E. I. Du Pont De Nemours And Company Method and apparatus for field flow fractionation
DE3027433A1 (de) 1980-07-19 1982-02-18 Messerschmitt-Bölkow-Blohm GmbH, 8000 München Verfahren zur trennung von gemischen
US4523982A (en) 1981-03-05 1985-06-18 The Dow Chemical Company Electron rich aromatics as cure promoters for radiation curable compositions
US4434230A (en) 1981-08-12 1984-02-28 Research Corporation Human nonsecretory plasmacytoid cell line
US4523682A (en) 1982-05-19 1985-06-18 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Acoustic particle separation
JPS5919230A (ja) * 1982-07-21 1984-01-31 Fuji Photo Film Co Ltd 磁気記録媒体
US4492752A (en) * 1982-09-03 1985-01-08 Ortho Diagnostics Systems Inc. Method for discriminating between unstained and absorbing dye stained cells
US4503385A (en) 1983-07-11 1985-03-05 Becton, Dickinson And Company Apparatus and method for regulating sheath fluid flow in a hydrodynamically focused fluid flow system
US4596464A (en) 1983-10-14 1986-06-24 Ortho Diagnostic Systems, Inc. Screening method for red cell abnormality
WO1985001892A1 (en) 1983-10-31 1985-05-09 Unilever Nv Manipulation of particles
GB8417240D0 (en) * 1984-07-06 1984-08-08 Unilever Plc Particle separation
US4604542A (en) * 1984-07-25 1986-08-05 Gould Inc. Broadband radial vibrator transducer with multiple resonant frequencies
IT1176731B (it) * 1984-09-20 1987-08-18 Anic Spa Promotori di adesione per substrati metallici
US5800861A (en) 1985-08-15 1998-09-01 The Sherwin-Williams Company High solid infrared absorbing compositions
JPH0747259Y2 (ja) 1985-08-20 1995-11-01 三菱自動車工業株式会社 動力操向装置の操舵力制御装置
US4983189A (en) 1986-02-21 1991-01-08 Technical Research Associates, Inc. Methods and apparatus for moving and separating materials exhibiting different physical properties
US4759775A (en) 1986-02-21 1988-07-26 Utah Bioresearch, Inc. Methods and apparatus for moving and separating materials exhibiting different physical properties
US4790653A (en) 1986-05-22 1988-12-13 Becton Dickinson And Company Housing for a flow cytometry apparatus with particle unclogging feature
GB8612759D0 (en) 1986-05-27 1986-07-02 Unilever Plc Manipulating particulate matter
JPS63139231A (ja) 1986-07-18 1988-06-11 Akira Mizuno 液体中の微粒子測定方法
US5346670A (en) 1986-12-24 1994-09-13 British Technology Group U.S.A. Inc. Phthalocyanine and tetrabenztriazaporphyrin reagents
AT389235B (de) 1987-05-19 1989-11-10 Stuckart Wolfgang Verfahren zur reinigung von fluessigkeiten mittels ultraschall und vorrichtungen zur durchfuehrung dieses verfahrens
US4913883A (en) * 1987-07-20 1990-04-03 Hitachi, Ltd. Particle agglutination immunoassay apparatus
JPH01112161A (ja) 1987-07-20 1989-04-28 Hitachi Ltd 免疫凝集定量装置
US5245318A (en) 1987-07-24 1993-09-14 Canon Kabushiki Kaisha Particle analyzing apparatus having pressure control system
US4777823A (en) 1987-08-20 1988-10-18 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Controlled sample orientation and rotation in an acoustic levitator
GB8724067D0 (en) * 1987-10-14 1987-11-18 Unilever Plc Manipulating particles
US4845025A (en) 1987-11-10 1989-07-04 Coulter Corporation Biological sample mixing apparatus and method
JPH01135515A (ja) 1987-11-19 1989-05-29 Agency Of Ind Science & Technol 流体中における比重差のない物質の分離法
US5040890A (en) 1987-11-25 1991-08-20 Becton, Dickinson And Company Sheathed particle flow controlled by differential pressure
US4987086A (en) * 1987-11-30 1991-01-22 Becton, Dickinson And Company Method for analysis of subpopulations of cells
US4867559A (en) 1988-01-06 1989-09-19 Amoco Corporation Liquid/liquid fiber-optic fluorescence detector and absorbance analyzer
JPH01112161U (OSRAM) 1988-01-25 1989-07-27
JPH0718785B2 (ja) 1988-09-19 1995-03-06 株式会社日立製作所 フローセル装置
ATE168724T1 (de) 1988-09-29 1998-08-15 Chiron Corp Nachweis eines polynukleotids durch ersätzung einer kette an einer fangsonde
AT390739B (de) 1988-11-03 1990-06-25 Ewald Dipl Ing Dr Benes Verfahren und einrichtung zur separation von teilchen, welche in einem dispersionsmittel dispergiert sind
US4964303A (en) 1988-11-15 1990-10-23 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Acoustic positioning and orientation prediction
US5032381A (en) 1988-12-20 1991-07-16 Tropix, Inc. Chemiluminescence-based static and flow cytometry
US4991923A (en) 1989-01-17 1991-02-12 Board Of Trustees Of The Leland Stanford Junior University Acousto-optic modulator for optical fibers using Hertzian contact with a grooved transducer substrate
CA1324894C (en) 1989-03-31 1993-12-07 Maritime Scientific Services Ltd. Method and apparatus for the identification of particles
US4979824A (en) 1989-05-26 1990-12-25 Board Of Trustees Of The Leland Stanford Junior University High sensitivity fluorescent single particle and single molecule detection apparatus and method
US5030002A (en) * 1989-08-11 1991-07-09 Becton, Dickinson And Company Method and apparatus for sorting particles with a moving catcher tube
US5396588A (en) * 1990-07-03 1995-03-07 Froessl; Horst Data processing using digitized images
US5085783A (en) 1990-08-16 1992-02-04 Case Western Reserve University Acoustically driven particle separation method and apparatus
WO1992007245A1 (en) * 1990-10-10 1992-04-30 The University Of Maryland Method and apparatus for performing phase fluorescence lifetime measurements in flow cytometry
US5376551A (en) 1991-03-12 1994-12-27 University Of Utah Research Foundation Apparatus for using fluorescently labeled ligands in studying interaction of a native ligand and its receptor
US5999256A (en) 1992-02-12 1999-12-07 Cambridge Consultants Limited Particle measurement system
US5264906A (en) 1992-07-08 1993-11-23 The United States Of America As Represented By The Secretary Of The Navy Bioluminescence bathyphotometer
US5674698A (en) 1992-09-14 1997-10-07 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
JP3488732B2 (ja) * 1992-12-02 2004-01-19 株式会社日立製作所 超音波処理装置
US6216538B1 (en) 1992-12-02 2001-04-17 Hitachi, Ltd. Particle handling apparatus for handling particles in fluid by acoustic radiation pressure
US5395588A (en) 1992-12-14 1995-03-07 Becton Dickinson And Company Control of flow cytometer having vacuum fluidics
JP2763468B2 (ja) 1992-12-25 1998-06-11 株式会社日立製作所 光散乱を用いた液体内の粒子分類装置
US5430541A (en) * 1993-01-12 1995-07-04 Applied Biosystems Inc. High efficiency fluorescence flow cell for capillary liquid chromatography or capillary electrophoresis
JP3052665B2 (ja) 1993-01-26 2000-06-19 株式会社日立製作所 フローセル装置
JP3205413B2 (ja) * 1993-02-15 2001-09-04 株式会社日立製作所 微粒子計測装置及び微粒子計測方法
US5547849A (en) * 1993-02-17 1996-08-20 Biometric Imaging, Inc. Apparatus and method for volumetric capillary cytometry
BR9406396A (pt) * 1993-05-11 1996-02-27 Sonosep Biotech Inc Ressonador piezoelétrico em múltiplas camadas para a separaçao de partículas em suspensao
AT398707B (de) * 1993-05-11 1995-01-25 Trampler Felix Mehrschichtiger piezoelektrischer resonator für die separation von suspendierten teilchen
NO932088L (no) 1993-06-08 1995-01-05 Oddbjoern Gjelsnes Anordning for anvendelse ved væskeströmscytometri
US5626767A (en) 1993-07-02 1997-05-06 Sonosep Biotech Inc. Acoustic filter for separating and recycling suspended particles
US5491344A (en) 1993-12-01 1996-02-13 Tufts University Method and system for examining the composition of a fluid or solid sample using fluorescence and/or absorption spectroscopy
US5640051A (en) 1993-12-13 1997-06-17 Matsushita Electric Industrial Co., Ltd. Chip package, a chip carrier, a terminal electrode for a circuit substrate and a chip package-mounted complex
JPH07286953A (ja) 1994-04-19 1995-10-31 Toa Medical Electronics Co Ltd イメージングフローサイトメータ
JP3260550B2 (ja) 1994-05-27 2002-02-25 株式会社日立製作所 微粒子分析装置
JPH08266891A (ja) 1995-04-03 1996-10-15 Hitachi Ltd 微粒子取扱装置
US5528045A (en) 1995-04-06 1996-06-18 Becton Dickinson And Company Particle analyzer with spatially split wavelength filter
AU6542196A (en) 1995-06-30 1997-02-05 Biometric Imaging, Inc. Volumetric cell quantification method and system
US5798222A (en) 1995-07-17 1998-08-25 Guava Technologies, Inc. Apparatus for monitoring substances in organisms
US5981180A (en) 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
JP3487699B2 (ja) * 1995-11-08 2004-01-19 株式会社日立製作所 超音波処理方法および装置
JP2700058B2 (ja) 1996-01-23 1998-01-19 工業技術院長 超音波を用いた非接触マイクロマニピュレーション方法
US5688406A (en) * 1996-02-28 1997-11-18 The United States Of America As Represented By The Secretary Of The Navy Method and apparatus for separating particulate from a flowing fluid
US5747349A (en) 1996-03-20 1998-05-05 University Of Washington Fluorescent reporter beads for fluid analysis
JPH09288052A (ja) 1996-04-24 1997-11-04 Hitachi Ltd 分画装置
US6221258B1 (en) 1996-06-14 2001-04-24 Case Western Reserve University Method and apparatus for acoustically driven media filtration
JP2002503334A (ja) 1996-09-04 2002-01-29 テクニカル ユニバーシティ オブ デンマーク 粒子の分離と分析用のマイクロフローシステム
JPH1082723A (ja) 1996-09-06 1998-03-31 Hitachi Ltd 微粒子処理装置
US6055859A (en) 1996-10-01 2000-05-02 Agency Of Industrial Science And Technology Non-contact micromanipulation method and apparatus
CN1181501A (zh) 1996-10-30 1998-05-13 杨祺 测定各种痕量样品中生物活性物质的荧光定量分析方法
JP3467995B2 (ja) 1996-11-28 2003-11-17 株式会社日立製作所 キャピラリー電気泳動装置
US5915925A (en) 1997-01-07 1999-06-29 North, Jr.; Howard L. Pulseless liquid supply system for flow cytometry
GB9708984D0 (en) 1997-05-03 1997-06-25 Univ Cardiff Particle manipulation
US5994089A (en) 1997-05-16 1999-11-30 Coulter International Corp. Simultaneous analyses of white blood cell subsets using multi-color, multi-intensity fluorescent markers in flow cytometry
US6710871B1 (en) 1997-06-09 2004-03-23 Guava Technologies, Inc. Method and apparatus for detecting microparticles in fluid samples
ZA984976B (en) * 1997-06-11 1999-04-19 Nalco Chemical Co Solid-state fluorometer and methods of use therefore
JPH1114533A (ja) * 1997-06-19 1999-01-22 Hitachi Ltd 微粒子形状測定装置
US6074879A (en) * 1997-06-23 2000-06-13 Bayer Corporation Synthetic polymer particles for use as standards and calibrators in flow cytometry
US6003388A (en) 1997-09-17 1999-12-21 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration System for manipulating drops and bubbles using acoustic radiation pressure
US6049380A (en) 1997-11-12 2000-04-11 Regents Of The University Of California Single molecule identification using selected fluorescence characteristics
JPH11197406A (ja) 1998-01-17 1999-07-27 Horiba Ltd 超音波脱泡槽
JP3375610B2 (ja) 1998-02-20 2003-02-10 エックスワイ，インコーポレイテッド 選別フローサイトメーター用振動システム
US6248590B1 (en) 1998-02-27 2001-06-19 Cytomation, Inc. Method and apparatus for flow cytometry
CA2640578A1 (en) 1998-05-14 1999-11-18 Luminex Corporation Multi-analyte diagnostic system and computer implemented process for same
WO1999060397A1 (en) 1998-05-18 1999-11-25 University Of Washington Liquid analysis cartridge
JPH11326155A (ja) 1998-05-20 1999-11-26 Hitachi Ltd 細胞分画装置
JPH11352048A (ja) 1998-06-04 1999-12-24 Toray Eng Co Ltd 液中微粒子測定装置
AU5221099A (en) 1998-07-21 2000-02-14 University Technology Corporation Method and apparatus for determining the state of fouling/cleaning of membrane modules
GB2339703B (en) 1998-07-22 2002-05-01 Univ Cardiff Particle manipulation device
US6090295A (en) 1998-08-11 2000-07-18 University Technology Corporation Method and apparatus for acoustically demixing aqueous solutions
US6197593B1 (en) * 1998-10-20 2001-03-06 Coulter International Corp. Method for enumerating blood cells
US20010006416A1 (en) 1999-01-11 2001-07-05 Johnson Paul E. Ribbon flow cytometry apparatus and methods
WO2000041794A1 (en) 1999-01-15 2000-07-20 University College Cardiff Consultants Ltd. Particle manipulation
US6565727B1 (en) 1999-01-25 2003-05-20 Nanolytics, Inc. Actuators for microfluidics without moving parts
US6975400B2 (en) 1999-01-25 2005-12-13 Amnis Corporation Imaging and analyzing parameters of small moving objects such as cells
US6228652B1 (en) 1999-02-16 2001-05-08 Coulter International Corp. Method and apparatus for analyzing cells in a whole blood sample
US6337465B1 (en) 1999-03-09 2002-01-08 Mide Technology Corp. Laser machining of electroactive ceramics
CN1181337C (zh) * 2000-08-08 2004-12-22 清华大学 微流体系统中实体分子的操纵方法及相关试剂盒
JP2000298092A (ja) 1999-04-13 2000-10-24 Horiba Ltd 液中微粒子測定装置
US6592821B1 (en) * 1999-05-17 2003-07-15 Caliper Technologies Corp. Focusing of microparticles in microfluidic systems
US6309886B1 (en) 1999-06-04 2001-10-30 The Regents Of The University Of California High throughput analysis of samples in flowing liquid
WO2000074814A1 (fr) 1999-06-07 2000-12-14 Hitachi, Ltd. Dispositif de traitement d'un echantillon contenant des particules
JP3306029B2 (ja) 1999-07-27 2002-07-24 サーパス工業株式会社 超音波流量計及びその製造方法
DE60040603D1 (de) 1999-08-17 2008-12-04 Luminex Corp Verfahren zur analyse einer mehrzahl von proben verschiedenen ursprungs auf einen analyten
US6348687B1 (en) * 1999-09-10 2002-02-19 Sandia Corporation Aerodynamic beam generator for large particles
US6449563B1 (en) 1999-10-12 2002-09-10 Dispersion Technology, Inc Method and device for determining particle size distribution and zeta potential in concentrated dispersions
US6813017B1 (en) 1999-10-20 2004-11-02 Becton, Dickinson And Company Apparatus and method employing incoherent light emitting semiconductor devices as particle detection light sources in a flow cytometer
US6263745B1 (en) * 1999-12-03 2001-07-24 Xy, Inc. Flow cytometer nozzle and flow cytometer sample handling methods
US6373567B1 (en) * 1999-12-17 2002-04-16 Micron Optical Systems Dispersive near-IR Raman spectrometer
US6784981B1 (en) 2000-06-02 2004-08-31 Idexx Laboratories, Inc. Flow cytometry-based hematology system
US7978329B2 (en) 2000-08-02 2011-07-12 Honeywell International Inc. Portable scattering and fluorescence cytometer
US6549275B1 (en) * 2000-08-02 2003-04-15 Honeywell International Inc. Optical detection system for flow cytometry
US7262838B2 (en) 2001-06-29 2007-08-28 Honeywell International Inc. Optical detection system for flow cytometry
JP2002022531A (ja) 2000-07-11 2002-01-23 Sasakura Engineering Co Ltd 共鳴管系の音圧測定装置及び制御装置
WO2002017219A1 (en) 2000-08-25 2002-02-28 Amnis Corporation Measuring the velocity of small moving objects such as cells
CN1221309C (zh) * 2000-09-30 2005-10-05 清华大学 利用声场力和其它作用力对微粒进行场流分离的装置和方法
CN100495030C (zh) * 2000-09-30 2009-06-03 清华大学 多力操纵装置及其应用
DE10054382A1 (de) 2000-10-27 2002-05-08 Attomol Gmbh Molekulare Diagno Verfahren und Testkit zum Nachweis von Analyten in einer Probe
US6736904B2 (en) 2001-03-02 2004-05-18 Paper Quality Management Associates Method and apparatus for the generation of ultrasonic energy fields within circular structures containing a liquid
SE0100820D0 (sv) 2001-03-09 2001-03-09 Erysave Ab Ideon Particle separation using an acoustic filter
DE10111392A1 (de) 2001-03-09 2002-09-12 Chromeon Gmbh Bioanalytisches Messverfahren unter Verwendung von Oxidasen
SE522801C2 (sv) * 2001-03-09 2004-03-09 Erysave Ab Anordning för att separera suspenderade partiklar från en fluid med ultraljud samt metod för sådan separering
SE0103013D0 (sv) 2001-03-09 2001-09-12 Erysave Ab Ideon System and method for treatment of whole blood
JP2004525758A (ja) * 2001-03-13 2004-08-26 パムジーン・ベー・ベー 基板を通しての流体の流通を制御するためのシステム
US6467350B1 (en) 2001-03-15 2002-10-22 The Regents Of The University Of California Cylindrical acoustic levitator/concentrator
DE60218074T2 (de) 2001-03-29 2008-02-07 Sysmex Corp. Durchflusszytometer
US7190832B2 (en) 2001-07-17 2007-03-13 Amnis Corporation Computational methods for the segmentation of images of objects from background in a flow imaging instrument
US7479630B2 (en) 2004-03-25 2009-01-20 Bandura Dmitry R Method and apparatus for flow cytometry linked with elemental analysis
US6683314B2 (en) 2001-08-28 2004-01-27 Becton, Dickinson And Company Fluorescence detection instrument with reflective transfer legs for color decimation
US6982165B2 (en) 2001-09-24 2006-01-03 Intel Corporation Nucleic acid sequencing by raman monitoring of molecular deconstruction
US7431892B2 (en) 2001-09-25 2008-10-07 Piezo Top Ltd. Apparatus for sterilizing a liquid with focused acoustic standing waves
WO2003027678A1 (en) 2001-09-26 2003-04-03 Psychiatric Genomics, Inc. Fluorescence proximity assay
CA2462914A1 (en) 2001-10-11 2003-04-17 Aviva Biosciences Corporation Methods, compositions, and automated systems for separating rare cells from fluid samples
US7166443B2 (en) 2001-10-11 2007-01-23 Aviva Biosciences Corporation Methods, compositions, and automated systems for separating rare cells from fluid samples
US6773556B1 (en) 2001-10-18 2004-08-10 Seagate Technology Llc Method for energy barrier equalization of magnetic recording media and media obtained thereby
US6831279B2 (en) 2001-11-27 2004-12-14 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of National Defence Laser diode-excited biological particle detection system
US7018819B2 (en) * 2001-11-30 2006-03-28 Cellectricon Ab Method and apparatus for manipulation of cells and cell-like structures focused electric fields in microfludic systems and use thereof
US7452725B2 (en) * 2002-01-10 2008-11-18 Board Of Regents, The University Of Texas System Flow sorting system and methods regarding same
JP4113361B2 (ja) 2002-02-05 2008-07-09 日立ソフトウエアエンジニアリング株式会社 複層半導体ナノ粒子の製造方法
JP4526004B2 (ja) 2002-03-05 2010-08-18 大日本印刷株式会社 希土類元素含有微粒子およびそれを用いた蛍光プローブ
CN1209615C (zh) 2002-03-10 2005-07-06 徐永源 测定生物活性物质的目视荧光免疫分析法
US6881324B2 (en) * 2002-03-16 2005-04-19 Catalytic Distillation Technologies Process for the simultaneous hydrotreating and fractionation of light naphtha hydrocarbon streams
SE0200860D0 (sv) 2002-03-20 2002-03-20 Monica Almqvist Microfluidic cell and method for sample handling
JP2003326202A (ja) 2002-05-10 2003-11-18 Olympus Optical Co Ltd 液体噴霧ヘッド、およびそれを用いる液体噴霧装置
CA2490961A1 (en) 2002-07-01 2004-01-08 Guava Technologies, Inc. Fluorescent dyes, energy transfer couples and methods
US6794671B2 (en) 2002-07-17 2004-09-21 Particle Sizing Systems, Inc. Sensors and methods for high-sensitivity optical particle counting and sizing
GB0221391D0 (en) * 2002-09-16 2002-10-23 Secr Defence Apparatus for directing particles in a fluid
US7329545B2 (en) 2002-09-24 2008-02-12 Duke University Methods for sampling a liquid flow
US7108137B2 (en) 2002-10-02 2006-09-19 Wisconsin Alumni Research Foundation Method and apparatus for separating particles by size
GB0223562D0 (en) 2002-10-10 2002-11-20 Secr Defence Apparatus for moving particles
KR20040039091A (ko) 2002-10-31 2004-05-10 히데오 나까조 제빙기
US7161665B2 (en) 2002-12-18 2007-01-09 University Of Wyoming High resolution imaging fountain flow cytometry
US7047809B2 (en) 2003-01-21 2006-05-23 Applied Sonics, Incorporated Ultrasonic monitor of material composition and particle size
US20050072677A1 (en) * 2003-02-18 2005-04-07 Board Of Regents, The University Of Texas System Dielectric particle focusing
CN1246448C (zh) 2003-02-25 2006-03-22 清华大学 一种超声裂解细胞或剪切大分子装置及其使用方法
US7025864B2 (en) * 2003-03-10 2006-04-11 Elchrom Scientific A.G. Method and apparatus for recovering target molecules from a gel containing said target molecules
DK2959774T3 (da) 2003-03-28 2019-05-13 Inguran Llc Fremgangsmåde til kryokonservering af sædceller
WO2004091255A1 (ja) 2003-04-01 2004-10-21 Olympus Corporation 超音波振動子及びその製造方法
US7008540B1 (en) 2003-04-07 2006-03-07 The Ohio State University Ultrasonically cleaned membrane filtration system
JP2005164571A (ja) 2003-11-11 2005-06-23 Kaijo Sonic Corp 超音波流量計及び超音波センサ
CN1910440A (zh) * 2004-01-14 2007-02-07 卢米尼克斯股份有限公司 用于动态范围扩展的方法和系统
KR101147147B1 (ko) 2004-04-01 2012-05-25 머크 샤프 앤드 돔 코포레이션 Ｒｎａ 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드
US7477363B2 (en) * 2004-04-08 2009-01-13 Nihon Kohden Corporation Flow cytometer
US7340957B2 (en) 2004-07-29 2008-03-11 Los Alamos National Security, Llc Ultrasonic analyte concentration and application in flow cytometry
US20060034733A1 (en) * 2004-08-16 2006-02-16 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Separation of particles from a fluid by wave action
WO2006032048A2 (en) * 2004-09-15 2006-03-23 The Board Of Trustees Of The Leland Stanford Junior University Separation of particle types using a non-uniform acoustic field
US8486371B2 (en) 2004-09-17 2013-07-16 The Regents Of The University Of Michigan Quantitative two-photon flow cytometry
US7392908B2 (en) 2005-01-12 2008-07-01 Beckman Coulter, Inc. Methods and apparatus for sorting particles hydraulically
JP4690743B2 (ja) 2005-02-28 2011-06-01 三菱重工業株式会社 スクロール圧縮機及び空気調和装置
US7113266B1 (en) 2005-03-30 2006-09-26 Beckman Coulter, Inc. Flow cytometer for differentiating small particles in suspension
JP4770251B2 (ja) * 2005-04-25 2011-09-14 パナソニック株式会社 成分分離デバイスおよびこれを用いた成分の分離方法
US7403125B2 (en) * 2005-05-06 2008-07-22 Accuri Cytometers, Inc. Flow cytometry system with bubble detection
WO2006119806A1 (en) 2005-05-13 2006-11-16 Agilent Technologies, Inc. Fluid cell with sheath flow
DE602005016736D1 (de) 2005-07-07 2009-10-29 Fraunhofer Ges Forschung Tion von partikeln, zellen und viren
JP4756948B2 (ja) 2005-08-08 2011-08-24 ベイバイオサイエンス株式会社 フローサイトメータおよびフローサイトメトリ方法
US8173413B2 (en) * 2005-08-11 2012-05-08 University Of Washington Separation and concentration of biological cells and biological particles using a one-dimensional channel
CN1731187A (zh) 2005-08-12 2006-02-08 浙江大学 铕标记巨细胞病毒感染早期诊断试剂盒
US7804595B2 (en) 2005-09-14 2010-09-28 University Of Washington Using optical scattering to measure properties of ultrasound contrast agent shells
US8264683B2 (en) 2005-09-14 2012-09-11 University Of Washington Dynamic characterization of particles with flow cytometry
US20070071683A1 (en) * 2005-09-27 2007-03-29 The Regents Of The University Of California Ultrasonic concentration of carrier particles
DE102005050167B4 (de) 2005-10-19 2009-02-19 Advalytix Ag Konzentrationsverfahren, Konzentrationsvorrichtung und Reaktionsverfahren
US7484414B2 (en) * 2005-11-30 2009-02-03 Nanoalert Ltd. Method and apparatus for determination of the concentration of particles in multi-component fluid systems
US8798338B2 (en) 2006-01-09 2014-08-05 University Of Wyoming Method and system for counting particles in a laminar flow with an imaging device
WO2007083295A2 (en) * 2006-01-19 2007-07-26 Yeda Research And Development Co. Ltd. Device and method for particle manipulation in fluid
AU2006335689A1 (en) 2006-01-20 2007-07-26 Agency For Science, Technology And Research Biosensor
JP4896534B2 (ja) 2006-01-31 2012-03-14 シスメックス株式会社 粒子分析装置用シース液
WO2007121179A2 (en) 2006-04-11 2007-10-25 Guava Technologies, Inc. Asymmetric capillary for capillary-flow cytometers
JP4848823B2 (ja) 2006-04-18 2011-12-28 パナソニック株式会社 成分分離デバイスと、この成分分離デバイスを用いた化学分析デバイス
WO2007128795A2 (en) * 2006-05-05 2007-11-15 Erysave Ab Method for separation
US7570676B2 (en) 2006-05-09 2009-08-04 Spectralus Corporation Compact efficient and robust ultraviolet solid-state laser sources based on nonlinear frequency conversion in periodically poled materials
US8075786B2 (en) 2006-09-05 2011-12-13 The Board Of Regents Of The University Of Oklahoma Acoustic/pressure wave-driven separation device
US7835000B2 (en) 2006-11-03 2010-11-16 Los Alamos National Security, Llc System and method for measuring particles in a sample stream of a flow cytometer or the like
EP2479552B1 (en) 2007-04-02 2015-09-02 Acoustic Cytometry Systems, Inc. Methods for enhanced analysis of acoustic field focused cells and particles
US8083068B2 (en) 2007-04-09 2011-12-27 Los Alamos National Security, Llc Apparatus for separating particles utilizing engineered acoustic contrast capture particles
US7837040B2 (en) 2007-04-09 2010-11-23 Los Alamos National Security, Llc Acoustic concentration of particles in fluid flow
US20090038932A1 (en) 2007-08-08 2009-02-12 Battelle Memorial Institute Device and method for noninvasive ultrasonic treatment of fluids and materials in conduits and cylindrical containers
US8528406B2 (en) * 2007-10-24 2013-09-10 Los Alamos National Security, LLP Method for non-contact particle manipulation and control of particle spacing along an axis
US8263407B2 (en) 2007-10-24 2012-09-11 Los Alamos National Security, Llc Method for non-contact particle manipulation and control of particle spacing along an axis
JP5163067B2 (ja) 2007-11-16 2013-03-13 富士ゼロックス株式会社 画像形成装置
US8266951B2 (en) 2007-12-19 2012-09-18 Los Alamos National Security, Llc Particle analysis in an acoustic cytometer
US8714014B2 (en) * 2008-01-16 2014-05-06 Life Technologies Corporation System and method for acoustic focusing hardware and implementations
US20100009333A1 (en) 2008-07-08 2010-01-14 Beckman Coulter, Inc. Methods for Acoustic Particle Focusing in Biological Sample Analyzers
EP2507639B1 (en) 2009-12-04 2020-04-01 Life Technologies Corporation Apparatuses, systems, methods, and computer readable media for acoustic flow cytometry

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101060898A (zh) * 2004-09-24 2007-10-24 斯派克特罗尼克股份公司 用于分离粒子的方法和装置

Also Published As

Publication number Publication date
KR20100120122A (ko) 2010-11-12
US20150260689A1 (en) 2015-09-17
KR101721265B1 (ko) 2017-03-29
US20200072794A1 (en) 2020-03-05
US20090162887A1 (en) 2009-06-25
EA201070765A1 (ru) 2010-12-30
CN102089635B (zh) 2015-04-08
CN104614302A (zh) 2015-05-13
US8266951B2 (en) 2012-09-18
AU2008343033A1 (en) 2009-07-09
EP2232212B1 (en) 2019-09-04
JP2011508220A (ja) 2011-03-10
ZA201004306B (en) 2012-01-25
AU2008343033B2 (en) 2014-12-04
WO2009086043A3 (en) 2009-10-22
JP2015172602A (ja) 2015-10-01
EA022506B1 (ru) 2016-01-29
US20120304749A1 (en) 2012-12-06
EP2232212A2 (en) 2010-09-29
JP2017134083A (ja) 2017-08-03
BRPI0821646A2 (pt) 2015-06-16
IL206331A (en) 2015-06-30
CN102089635A (zh) 2011-06-08
US20090158823A1 (en) 2009-06-25
US9038467B2 (en) 2015-05-26
JP6423315B2 (ja) 2018-11-14
BRPI0821646A8 (pt) 2018-12-18
US11287362B2 (en) 2022-03-29
US11287363B2 (en) 2022-03-29
US20120298564A1 (en) 2012-11-29
US8266950B2 (en) 2012-09-18
CA2709765A1 (en) 2009-07-09
EP2232212A4 (en) 2016-02-24
JP2013101153A (ja) 2013-05-23
WO2009086043A2 (en) 2009-07-09
US20160370326A9 (en) 2016-12-22
US9488621B2 (en) 2016-11-08
JP2014029344A (ja) 2014-02-13
US20200072795A1 (en) 2020-03-05
JP6163320B2 (ja) 2017-07-12
KR101817410B1 (ko) 2018-01-11
WO2009086043A9 (en) 2009-11-26
KR20150136619A (ko) 2015-12-07
IL206331A0 (en) 2010-12-30
CA2709765C (en) 2022-07-26

Similar Documents

Publication Publication Date Title
CN104614302A (zh) 在声细胞计中的颗粒分析
JP6336496B2 (ja) アコースティックフローサイトメトリーのための装置、システム、方法、およびコンピュータ読み取り可能な媒体
JP2013513109A5 (OSRAM)
CN106796169A (zh) 探测流体中颗粒的传感器
WO2020054317A1 (ja) 制御装置、該制御装置を用いた微小粒子分取装置及び微小粒子分取システム、並びに制御方法、及び制御プログラム
AU2013205061B9 (en) Particle analysis in an acoustic cytometer

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant