SG11201811220UA - Methods, systems and devices for concentration of particles - Google Patents

Methods, systems and devices for concentration of particles

Info

Publication number
SG11201811220UA
SG11201811220UA SG11201811220UA SG11201811220UA SG11201811220UA SG 11201811220U A SG11201811220U A SG 11201811220UA SG 11201811220U A SG11201811220U A SG 11201811220UA SG 11201811220U A SG11201811220U A SG 11201811220UA SG 11201811220U A SG11201811220U A SG 11201811220UA
Authority
SG
Singapore
Prior art keywords
particles
international
carlsbad
california
life technologies
Prior art date
Application number
SG11201811220UA
Inventor
Michael Ward
Saul Selberg
Jason Malkin
Ken Lefton
Original Assignee
Life Technologies Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Life Technologies Corp filed Critical Life Technologies Corp
Publication of SG11201811220UA publication Critical patent/SG11201811220UA/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/28—Magnetic plugs and dipsticks
    • B03C1/288—Magnetic plugs and dipsticks disposed at the outer circumference of a recipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/025—High gradient magnetic separators
    • B03C1/031—Component parts; Auxiliary operations
    • B03C1/033—Component parts; Auxiliary operations characterised by the magnetic circuit
    • B03C1/0332—Component parts; Auxiliary operations characterised by the magnetic circuit using permanent magnets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/025—High gradient magnetic separators
    • B03C1/031—Component parts; Auxiliary operations
    • B03C1/033—Component parts; Auxiliary operations characterised by the magnetic circuit
    • B03C1/0335—Component parts; Auxiliary operations characterised by the magnetic circuit using coils
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1404—Fluid conditioning in flow cytometers, e.g. flow cells; Supply; Control of flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B01L2300/047—Additional chamber, reservoir
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/18—Magnetic separation whereby the particles are suspended in a liquid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1404—Fluid conditioning in flow cytometers, e.g. flow cells; Supply; Control of flow
    • G01N2015/142—Acoustic or ultrasonic focussing

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 January 2018 (04.01.2018) W I PO I 0111111010 VIII olon mommolm (10) International Publication Number WO 2018/005984 Al PCT (51) International Patent Classification: GO1N 15/14 (2006.01) GO1N 15/10 (2006.01) (21) International Application Number: PCT/US2017/040322 (22) International Filing Date: 30 June 2017 (30.06.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/357,440 01 July 2016 (01.07.2016) US (71) Applicant: LIFE TECHNOLOGIES CORPORATION [US/US]; 5823 Newton Drive, Legal Department, Intellec- tual Property, Carlsbad, California 92008 (US). (72) Inventors: WARD, Michael; Life Technologies Corpo- ration, 5823 Newton Drive, Carlsbad, California 92008 (US). SELBERG, Saul; Life Technologies Corporation, 5823 Newton Drive, Carlsbad, California 92008 (US). MALKIN, Jason; 11323 Sandy Creek Drive, Sandy, Utah 84094 (US). LEFTON, Ken; Life Technologies Corpora- tion, 5823 Newton Drive, Carlsbad, California 92008 (US). (74) Agent: YEE, Steven; Life Technologies Corporation, 5823 Newton Drive, Carlsbad, California 92008 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (54) Title: METHODS, SYSTEMS AND DEVICES FOR CONCENTRATION OF PARTICLES 410 12 4' D ,••+ 71' GC O O 00 O N O 25 25 18 • . S FIG. 4A 2 (57) : The present disclosure provides devices, systems and methods for concentrating particles after application of a field and flipping the direction of the particles. The field applied to the particles can be an acoustic field. The particles can be flipped from a first flow stream at a higher speed into a second flow stream at a lower speed to aid in concentrating the particles, including concentration within an analysis region. [Continued on next page] WO 2018/005984 Al MIDEDIMOMOIDEIREEMOOVIIMIHMOHMEHOIMIE MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: of inventorship (Rule 4.17(iv)) Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))
SG11201811220UA 2016-07-01 2017-06-30 Methods, systems and devices for concentration of particles SG11201811220UA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662357440P 2016-07-01 2016-07-01
PCT/US2017/040322 WO2018005984A1 (en) 2016-07-01 2017-06-30 Methods, systems and devices for concentration of particles

Publications (1)

Publication Number Publication Date
SG11201811220UA true SG11201811220UA (en) 2019-01-30

Family

ID=59521630

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201811220UA SG11201811220UA (en) 2016-07-01 2017-06-30 Methods, systems and devices for concentration of particles

Country Status (6)

Country Link
US (1) US11020745B2 (en)
EP (1) EP3479097B1 (en)
JP (1) JP7026063B2 (en)
CN (1) CN109416314A (en)
SG (1) SG11201811220UA (en)
WO (1) WO2018005984A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110023758B (en) 2016-11-24 2022-08-30 西门子医疗系统荷兰有限公司 Devices, systems, methods, and kits for separating analytes from bodily fluid samples
EP3704468A4 (en) * 2018-01-29 2020-11-25 Hewlett-Packard Development Company, L.P. Particle categorization
EP3647767A1 (en) 2018-10-30 2020-05-06 Siemens Healthcare GmbH Isovolumetric balling of red blood cells

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7340957B2 (en) * 2004-07-29 2008-03-11 Los Alamos National Security, Llc Ultrasonic analyte concentration and application in flow cytometry
WO2006079007A2 (en) * 2005-01-21 2006-07-27 President And Fellows Of Harvard College Microconcentrator/microfilter
US9220831B2 (en) * 2005-10-06 2015-12-29 Children's Medical Center Corporation Device and method for combined microfluidic-micromagnetic separation of material in continuous flow
US20100193407A1 (en) 2006-01-19 2010-08-05 Yeda Research And Development Co., Ltd. Device and Method For Particle Manipulation in Fluid
WO2008122051A1 (en) 2007-04-02 2008-10-09 Acoustic Cytometry Systems, Inc. Methods and devices for enhanced analysis of field focused cells and particles
US7837040B2 (en) * 2007-04-09 2010-11-23 Los Alamos National Security, Llc Acoustic concentration of particles in fluid flow
EP2142279A2 (en) * 2007-04-16 2010-01-13 The General Hospital Corporation d/b/a Massachusetts General Hospital Systems and methods for particle focusing in microchannels
EP2145687B1 (en) * 2007-05-15 2014-12-03 Panasonic Corporation Component separation device
US8266951B2 (en) * 2007-12-19 2012-09-18 Los Alamos National Security, Llc Particle analysis in an acoustic cytometer
CN102762990B (en) * 2009-12-04 2014-10-29 生命技术公司 Apparatuses, systems, methods, and computer readable media for acoustic flow cytometry
WO2012135663A2 (en) * 2011-03-31 2012-10-04 University Of South Florida Two-stage microfluidic device for acoustic particle manipulation and methods of separation
CN104870077A (en) * 2012-01-31 2015-08-26 宾夕法尼亚州立大学研究基金会 Microfluidic manipulation and sorting of particles using tunable standing surface acoustic wave
WO2013172810A1 (en) 2012-05-14 2013-11-21 Empire Technology Development Llc Acoustically driven nanoparticle concentrator
CN105073262B (en) * 2013-03-14 2017-08-25 英格朗公司 The apparatus and method sorted for high throughput sperm
US9645080B2 (en) 2013-04-16 2017-05-09 University Of Washington Systems, devices, and methods for separating, concentrating, and/or differentiating between cells from a cell sample
SG11201701581YA (en) 2014-08-28 2017-04-27 Sysmex Corp Particle imaging apparatus and particle imaging method

Also Published As

Publication number Publication date
JP2019530850A (en) 2019-10-24
EP3479097A1 (en) 2019-05-08
WO2018005984A1 (en) 2018-01-04
CN109416314A (en) 2019-03-01
JP7026063B2 (en) 2022-02-25
US20190126276A1 (en) 2019-05-02
US11020745B2 (en) 2021-06-01
EP3479097B1 (en) 2023-07-12

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