SG11201909442VA - Tangential flow filtration device for perfusion applications - Google Patents

Tangential flow filtration device for perfusion applications

Info

Publication number
SG11201909442VA
SG11201909442VA SG11201909442VA SG11201909442VA SG 11201909442V A SG11201909442V A SG 11201909442VA SG 11201909442V A SG11201909442V A SG 11201909442VA SG 11201909442V A SG11201909442V A SG 11201909442VA
Authority
SG
Singapore
Prior art keywords
international
filter element
pct
perfusion
rule
Prior art date
Application number
Inventor
Alison Dupont
Original Assignee
Emd Millipore Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emd Millipore Corp filed Critical Emd Millipore Corp
Publication of SG11201909442VA publication Critical patent/SG11201909442VA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/10—Separation or concentration of fermentation products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/08—Flat membrane modules
    • B01D63/082—Flat membrane modules comprising a stack of flat membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/08—Flat membrane modules
    • B01D63/082—Flat membrane modules comprising a stack of flat membranes
    • B01D63/0822—Plate-and-frame devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/10—Spiral-wound membrane modules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/10—Spiral-wound membrane modules
    • B01D63/103—Details relating to membrane envelopes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/14—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus with filters, sieves or membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/04—Specific process operations in the feed stream; Feed pretreatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/06—Specific process operations in the permeate stream
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/25—Recirculation, recycling or bypass, e.g. recirculation of concentrate into the feed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/14—Specific spacers
    • B01D2313/143—Specific spacers on the feed side
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/24—Specific pressurizing or depressurizing means
    • B01D2313/243—Pumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/10—Cross-flow filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2325/00—Details relating to properties of membranes
    • B01D2325/02—Details relating to pores or porosity of the membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/18—Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D65/00—Accessories or auxiliary operations, in general, for separation processes or apparatus using semi-permeable membranes
    • B01D65/02—Membrane cleaning or sterilisation ; Membrane regeneration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D65/00—Accessories or auxiliary operations, in general, for separation processes or apparatus using semi-permeable membranes
    • B01D65/08—Prevention of membrane fouling or of concentration polarisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis

Abstract

RESIDUEFLOW O N N N O 1-1 N C (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 06 December 2018 (06.12.2018) WIP0 I PCT ~~~~~ 11111111011101010VIIIOH olo om om Em ioo lio Elio ow (10) International Publication Number WO 2018/222550 Al (51) International Patent Classification: C12M 1/00 (2006.01) CO7K 1/34 (2006.01) BOLD 63/10 (2006.01) Cl 2M 1/26 (2006.01) (21) International Application Number: PCT/US2018/034709 (22) International Filing Date: 25 May 2018 (25.05.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/513,793 01 June 2017 (01.06.2017) US (71) Applicant: EMD MILLIPORE CORPORATION [US/US]; 400 Summit Drive, Burlington, MA 01803 (US). (72) Inventor: DUPONT, Alison; 161 Old Temple Road, Lyn- deborough, NH 03082 (US). (74) Agent: BALICKY, Eric, M. et al.; Hamilton, Brook, Smith & Reynolds, P.C., 530 Virginia Rd, P.O. Box 9133, Con- cord, MA 01742-9133 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (54) Title: TANGENTIAL FLOW FILTRATION DEVICE FOR PERFUSION APPLICATIONS FIG. 1 (57) : Filter elements (20, 100) for perfusion systems and methods are provided. A filter element sheet includes a microporous membrane (63, 112) having a mean pore size of at least about 0.651,1m and a feed spacer (25, 120) comprising woven fibers and having an open area of at least about 35%. The filter element sheet can be arranged within a filter element, for example, in a spiral-wound format or in a cassette format. A perfusion system includes at least one filter element and a pump configured to control flow of a liquid feed through the at least one filter element. [Continued on next page] WO 2018/222550 Al MIDEDIM011010EIRDERI0010110111111111101101111111111111111111 MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: of inventorship (Rule 4.17(iv)) Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))
SG11201909442V 2017-06-01 2018-05-25 Tangential flow filtration device for perfusion applications SG11201909442VA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762513793P 2017-06-01 2017-06-01
PCT/US2018/034709 WO2018222550A1 (en) 2017-06-01 2018-05-25 Tangential flow filtration device for perfusion applications

Publications (1)

Publication Number Publication Date
SG11201909442VA true SG11201909442VA (en) 2019-11-28

Family

ID=62599757

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201909442V SG11201909442VA (en) 2017-06-01 2018-05-25 Tangential flow filtration device for perfusion applications

Country Status (9)

Country Link
US (2) US20200139303A1 (en)
EP (1) EP3630937A1 (en)
JP (3) JP7303752B2 (en)
KR (2) KR102462294B1 (en)
CN (1) CN110997893B (en)
CA (1) CA3060705C (en)
SG (1) SG11201909442VA (en)
TW (1) TWI675696B (en)
WO (1) WO2018222550A1 (en)

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TW202003832A (en) * 2018-05-04 2020-01-16 美商健臻公司 Perfusion bioreactor with filtration systems
DE102018006286B3 (en) * 2018-08-08 2019-10-10 Sartorius Stedim Biotech Gmbh Bioreactor with filter unit and method for treating a cell broth
AU2020214316B2 (en) * 2019-01-30 2023-01-12 Repligen Corporation Method of using track etched membranes for the filtration of biological fluids
CN110317731A (en) * 2019-08-07 2019-10-11 上海交通大学医学院附属第九人民医院 Filling type bioreactor
CN114761109A (en) 2020-01-21 2022-07-15 Emd密理博公司 In situ filtration for biocontainers
CN113713621B (en) * 2021-08-26 2022-08-02 杭州纽创生物检测有限公司 SPTFF device applied to viruses, perfusion system and virus liquid filtering method
CN113694585B (en) * 2021-08-26 2023-01-03 杭州科百特过滤器材有限公司 Tangential flow filter assembly, tangential flow filter device and perfusion system
EP4268943A1 (en) * 2022-04-27 2023-11-01 Levitronix GmbH A device for tangential flow filtration of a fluid

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Also Published As

Publication number Publication date
TW201902555A (en) 2019-01-16
TWI675696B (en) 2019-11-01
US20220203303A1 (en) 2022-06-30
KR102316862B1 (en) 2021-10-25
EP3630937A1 (en) 2020-04-08
WO2018222550A1 (en) 2018-12-06
CA3060705A1 (en) 2018-12-06
KR102462294B1 (en) 2022-11-03
JP2022036980A (en) 2022-03-08
KR20200003054A (en) 2020-01-08
CN110997893A (en) 2020-04-10
CN110997893B (en) 2024-01-09
KR20210131427A (en) 2021-11-02
JP7303752B2 (en) 2023-07-05
CA3060705C (en) 2023-09-26
US20200139303A1 (en) 2020-05-07
JP2020522253A (en) 2020-07-30
JP2024023275A (en) 2024-02-21

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