SG11201909368TA - Compositions and systems for renal function determination - Google Patents
Compositions and systems for renal function determinationInfo
- Publication number
- SG11201909368TA SG11201909368TA SG11201909368TA SG11201909368TA SG 11201909368T A SG11201909368T A SG 11201909368TA SG 11201909368T A SG11201909368T A SG 11201909368TA SG 11201909368T A SG11201909368T A SG 11201909368TA
- Authority
- SG
- Singapore
- Prior art keywords
- louis
- international
- missouri
- suite
- square drive
- Prior art date
Links
- 230000003907 kidney function Effects 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 230000005670 electromagnetic radiation Effects 0.000 abstract 2
- 230000024924 glomerular filtration Effects 0.000 abstract 2
- 241000699729 Muridae Species 0.000 abstract 1
- 230000007423 decrease Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 239000000700 radioactive tracer Substances 0.000 abstract 1
- 102220240796 rs553605556 Human genes 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1495—Calibrating or testing of in-vivo probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/20—Measuring for diagnostic purposes; Identification of persons for measuring urological functions restricted to the evaluation of the urinary system
- A61B5/201—Assessing renal or kidney functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6813—Specially adapted to be attached to a specific body part
- A61B5/6814—Head
- A61B5/6815—Ear
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B57/00—Other synthetic dyes of known constitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6813—Specially adapted to be attached to a specific body part
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Medical Informatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Physiology (AREA)
- Signal Processing (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Psychiatry (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Artificial Intelligence (AREA)
- Otolaryngology (AREA)
- Optics & Photonics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
WO 19/08 4475 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 02 May 2019 (02.05.2019) WIPO I PCT 11111111111111011111111111111110111110101111111111111111111111111111111111111011110111111 (10) International Publication Number WO 2019/084475 Al (51) International Patent Classification: A 61K 49/00 (2006.01) CO7D 241/20 (2006.01) A61P 13/12 (2006.01) (21) International Application Number: PCT/US2018/057820 (22) International Filing Date: 26 October 2018 (26.10.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/577,962 27 October 2017 (27.10.2017) US (71) Applicant: MEDIBEACON INC. [US/US]; 1100 Como- rate Square Drive, Helix Center, Suite 175, St. Louis, Mis- souri 63132 (US). (72) Inventors: DEBRECZENY, Martin P.; 1100 Corporate Square Drive, Helix Center, Suite 175, St. Louis, Missouri 63132 (US). RAJAGOPALAN, Raghavan; 5097 Neptune Drive, Solon, Ohio 44139 (US). DORSHOW, Richard B.; 11077 Niehaus Lane, St. Louis, Missouri 63146 (US). NEUMANN, William L.; 1100 Corporate Square Drive, Helix Center, Suite 175, St. Louis, Missouri 63132 (US). ROGERS, Thomas E.; 1100 Corporate Square Drive, He- lix Center, Suite 175, St. Louis, Missouri 63132 (US). (74) Agent: FLOREK, Erin M. et al.; Armstrong Teas- dale LLP, 7700 Forsyth Boulevard, St. Louis, Missouri 63105-1847 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, 1E, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (54) Title: COMPOSITIONS AND SYSTEMS FOR RENAL FUNCTION DETERMINATION (57) : The present disclosure relates to systems and methods for de- termining the renal glomerular filtration rate or assessing the renal function in a patient in need thereof. The system includes a computing device, a pow- 10 er supply, one or more sensors, and at least one tracer agent that fluoresces _,\ when exposed to electromagnetic radiation. The electromagnetic radiation is detected using the sensors, and the rate in which the fluorescence decreases in the patient is used to calculate the renal glomerular filtration rate in the patient. 10 FIG. 2 [Continued on next page] 20 _\ ,12 WO 2019/084475 Al I 0111 111111110111111 0111 11111 111 1101 II III 11111 VIII VIII VIII VIII EH 1111111111111111 TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762577962P | 2017-10-27 | 2017-10-27 | |
| PCT/US2018/057820 WO2019084475A1 (en) | 2017-10-27 | 2018-10-26 | Compositions and systems for renal function determination |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201909368TA true SG11201909368TA (en) | 2019-11-28 |
Family
ID=66245914
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201909368T SG11201909368TA (en) | 2017-10-27 | 2018-10-26 | Compositions and systems for renal function determination |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US11602570B2 (en) |
| EP (1) | EP3700578A4 (en) |
| JP (3) | JP7202355B2 (en) |
| KR (3) | KR20200010191A (en) |
| CN (1) | CN110494167A (en) |
| AU (1) | AU2018355541B2 (en) |
| BR (1) | BR112019020605A2 (en) |
| CA (1) | CA3058772C (en) |
| IL (2) | IL269617B2 (en) |
| MX (2) | MX2019011977A (en) |
| MY (1) | MY197859A (en) |
| NZ (1) | NZ757917A (en) |
| PH (1) | PH12019502352A1 (en) |
| RU (2) | RU2760279C2 (en) |
| SG (1) | SG11201909368TA (en) |
| WO (1) | WO2019084475A1 (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019032746A1 (en) | 2017-08-08 | 2019-02-14 | Fresenius Medical Care Holdings, Inc. | Systems and methods for treating and estimating progression of chronic kidney disease |
| KR20210102371A (en) * | 2018-12-12 | 2021-08-19 | 메디비콘 아이엔씨. | Use of Percutaneous Glomerular Filtration Rate Measurement in Continuous Renal Replacement Therapy |
| JP2023540433A (en) * | 2020-07-24 | 2023-09-25 | メディビーコン，インク． | System and method for transcutaneous evaluation of gastrointestinal function at home |
| EP4313173A1 (en) * | 2021-03-31 | 2024-02-07 | MediBeacon Inc. | Purification of substituted diaminopyrazine dicarboxylic acids |
| TW202321203A (en) * | 2021-08-11 | 2023-06-01 | 中國大陸商杭州中美華東製藥有限公司 | Method for preparing pyrazine carboxylic acid derivative as fluorescent tracer |
| TW202319052A (en) * | 2021-08-27 | 2023-05-16 | 中國大陸商杭州中美華東製藥有限公司 | Crystal form of pyrazine derivative and preparation method therefor |
| WO2023046046A1 (en) * | 2021-09-24 | 2023-03-30 | 杭州中美华东制药有限公司 | Hydrogenation synthesis method for preparing pyrazinecarboxylic acid derivative as fluorescent tracer |
| WO2023078440A1 (en) * | 2021-11-08 | 2023-05-11 | 杭州中美华东制药有限公司 | Crystal form of salt of pyrazine derivative, and preparation method therefor |
Family Cites Families (24)
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|---|---|---|---|---|
| US5301673A (en) * | 1991-11-18 | 1994-04-12 | Massachusetts General Hospital | Ambulatory clearance function monitor |
| US6280703B1 (en) * | 1997-03-13 | 2001-08-28 | Mallinckrodt Inc. | Simultaneous multimodal measurement of physiological function |
| US6909912B2 (en) | 2002-06-20 | 2005-06-21 | University Of Florida | Non-invasive perfusion monitor and system, specially configured oximeter probes, methods of using same, and covers for probes |
| ATE539674T1 (en) | 2003-04-24 | 2012-01-15 | Univ Texas | NON-INVASIVE BLOOD ANALYSIS BY OPTICAL PROBING OF THE VEINS UNDER THE TONGUE |
| US20060095102A1 (en) | 2003-09-17 | 2006-05-04 | Thomas Perez | Method and apparatus for sublingual application of light to blood |
| US8664392B2 (en) | 2004-12-23 | 2014-03-04 | Medibeacon, LLC | Pyrazine derivatives for bioconjugation |
| ES2375395T3 (en) | 2004-12-23 | 2012-02-29 | Mallinckrodt Llc | FLUORESCENT PIRAZINE DERIVATIVES AND METHOD OF USE OF THE SAME IN THE EVALUATION OF RENAL FUNCTION. |
| US7710872B2 (en) | 2005-12-14 | 2010-05-04 | Cisco Technology, Inc. | Technique for enabling traffic engineering on CE-CE paths across a provider network |
| ES2390314T3 (en) | 2006-02-24 | 2012-11-08 | Medibeacon Development, Llc | Optical agents for use in surgery |
| CA2655857C (en) | 2006-06-22 | 2014-12-02 | Mallinckrodt Inc. | Pyrazine derivatives with extended conjugation and uses thereof |
| JP2009534396A (en) * | 2006-06-22 | 2009-09-24 | マリンクロッド・インコーポレイテッド | Pyrazine derivatives and their use in kidney monitoring |
| CN102065904A (en) * | 2008-04-18 | 2011-05-18 | 药物影像股份有限公司 | Renal function analysis method and apparatus |
| US8591865B2 (en) * | 2008-04-18 | 2013-11-26 | Pharmacophotonics, Inc. | Renal function analysis method and apparatus |
| CA2747402A1 (en) | 2008-12-17 | 2010-07-08 | Amruta Poreddy | Modified pyrazine derivatives and uses thereof |
| US9554739B2 (en) * | 2009-09-29 | 2017-01-31 | Covidien Lp | Smart cable for coupling a medical sensor to an electronic patient monitor |
| US20120172677A1 (en) | 2010-12-30 | 2012-07-05 | Logan Robert J | Systems and methods for monitoring and processing biometric data |
| US9795296B2 (en) | 2011-04-26 | 2017-10-24 | Incube Labs, Llc | Mouthpiece for measurement of biometric data of a diver and underwater communication |
| WO2013170219A1 (en) * | 2012-05-11 | 2013-11-14 | BioMetric Holdings, Inc. | Systems, methods, and apparatuses for monitoring end stage renal disease |
| HUE043467T2 (en) | 2013-10-22 | 2019-08-28 | Medibeacon Inc | Improved transcutaneous organ function measurement |
| US11077211B2 (en) * | 2013-11-11 | 2021-08-03 | Medibeacon Inc. | Compositions and methods for assessing gut function |
| JP2016112375A (en) * | 2014-12-16 | 2016-06-23 | イオム株式会社 | Dermofluorometer |
| WO2016183351A1 (en) | 2015-05-12 | 2016-11-17 | Medibeacon Inc. | Compositions and methods for assessing eye vasculature |
| CA3203465A1 (en) * | 2017-01-30 | 2018-08-02 | Medibeacon Inc. | Method for non-invasive monitoring of fluorescent tracer agent with diffuse reflection corrections |
| KR102438880B1 (en) * | 2017-10-27 | 2022-09-01 | 메디비콘 아이엔씨. | How to measure kidney function |
-
2018
- 2018-10-26 SG SG11201909368T patent/SG11201909368TA/en unknown
- 2018-10-26 CN CN201880009623.1A patent/CN110494167A/en active Pending
- 2018-10-26 CA CA3058772A patent/CA3058772C/en active Active
- 2018-10-26 IL IL269617A patent/IL269617B2/en unknown
- 2018-10-26 KR KR1020197030121A patent/KR20200010191A/en not_active IP Right Cessation
- 2018-10-26 KR KR1020237012662A patent/KR20230054506A/en active IP Right Grant
- 2018-10-26 IL IL312255A patent/IL312255A/en unknown
- 2018-10-26 RU RU2019132431A patent/RU2760279C2/en active
- 2018-10-26 WO PCT/US2018/057820 patent/WO2019084475A1/en active Search and Examination
- 2018-10-26 NZ NZ757917A patent/NZ757917A/en unknown
- 2018-10-26 EP EP18870574.3A patent/EP3700578A4/en active Pending
- 2018-10-26 KR KR1020217043268A patent/KR20220003659A/en not_active IP Right Cessation
- 2018-10-26 AU AU2018355541A patent/AU2018355541B2/en active Active
- 2018-10-26 MY MYPI2019006091A patent/MY197859A/en unknown
- 2018-10-26 MX MX2019011977A patent/MX2019011977A/en unknown
- 2018-10-26 RU RU2021133174A patent/RU2021133174A/en unknown
- 2018-10-26 US US16/171,689 patent/US11602570B2/en active Active
- 2018-10-26 BR BR112019020605A patent/BR112019020605A2/en unknown
- 2018-10-26 JP JP2020504300A patent/JP7202355B2/en active Active
-
2019
- 2019-10-04 MX MX2023011017A patent/MX2023011017A/en unknown
- 2019-10-16 PH PH12019502352A patent/PH12019502352A1/en unknown
-
2022
- 2022-09-28 JP JP2022155098A patent/JP7362869B2/en active Active
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2023
- 2023-01-31 US US18/162,163 patent/US20230173111A1/en active Pending
- 2023-10-04 JP JP2023172653A patent/JP2023175915A/en active Pending
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