CN104529939B - 3,7-二氨基-10h-吩噻嗪化合物盐及其用途 - Google Patents
3,7-二氨基-10h-吩噻嗪化合物盐及其用途 Download PDFInfo
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- CN104529939B CN104529939B CN201510002371.8A CN201510002371A CN104529939B CN 104529939 B CN104529939 B CN 104529939B CN 201510002371 A CN201510002371 A CN 201510002371A CN 104529939 B CN104529939 B CN 104529939B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/20—[b, e]-condensed with two six-membered rings with hydrogen atoms directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B21/00—Thiazine dyes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Psychology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- AIDS & HIV (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78669006P | 2006-03-29 | 2006-03-29 | |
| US60/786,690 | 2006-03-29 | ||
| CN200780020349.XA CN101460472B (zh) | 2006-03-29 | 2007-03-28 | 3,7-二氨基-10h-吩噻嗪盐及其用途 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200780020349.XA Division CN101460472B (zh) | 2006-03-29 | 2007-03-28 | 3,7-二氨基-10h-吩噻嗪盐及其用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104529939A CN104529939A (zh) | 2015-04-22 |
| CN104529939B true CN104529939B (zh) | 2019-05-07 |
Family
ID=38421429
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510002365.2A Active CN104606199B (zh) | 2006-03-29 | 2007-03-28 | 3,7-二氨基-10h-吩噻嗪化合物盐及其用途 |
| CN200780020349.XA Active CN101460472B (zh) | 2006-03-29 | 2007-03-28 | 3,7-二氨基-10h-吩噻嗪盐及其用途 |
| CN201811196758.1A Active CN109384741B (zh) | 2006-03-29 | 2007-03-28 | 3,7-二氨基-10h-吩噻嗪化合物盐及其用途 |
| CN201410269784.8A Active CN104119294B (zh) | 2006-03-29 | 2007-03-28 | 3,7-二氨基-10h-吩噻嗪化合物的制备方法 |
| CN201510002371.8A Active CN104529939B (zh) | 2006-03-29 | 2007-03-28 | 3,7-二氨基-10h-吩噻嗪化合物盐及其用途 |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510002365.2A Active CN104606199B (zh) | 2006-03-29 | 2007-03-28 | 3,7-二氨基-10h-吩噻嗪化合物盐及其用途 |
| CN200780020349.XA Active CN101460472B (zh) | 2006-03-29 | 2007-03-28 | 3,7-二氨基-10h-吩噻嗪盐及其用途 |
| CN201811196758.1A Active CN109384741B (zh) | 2006-03-29 | 2007-03-28 | 3,7-二氨基-10h-吩噻嗪化合物盐及其用途 |
| CN201410269784.8A Active CN104119294B (zh) | 2006-03-29 | 2007-03-28 | 3,7-二氨基-10h-吩噻嗪化合物的制备方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (5) | US7888350B2 (enExample) |
| EP (1) | EP2013191B3 (enExample) |
| JP (3) | JP5520043B2 (enExample) |
| KR (1) | KR100983301B1 (enExample) |
| CN (5) | CN104606199B (enExample) |
| AT (1) | ATE478058T3 (enExample) |
| AU (1) | AU2007231124B2 (enExample) |
| CA (1) | CA2646163C (enExample) |
| DE (1) | DE602007008550D1 (enExample) |
| DK (1) | DK2013191T6 (enExample) |
| EA (1) | EA014552B1 (enExample) |
| ES (1) | ES2349322T7 (enExample) |
| HR (1) | HRP20100614T4 (enExample) |
| IL (2) | IL194516A (enExample) |
| MY (1) | MY143757A (enExample) |
| PL (1) | PL2013191T6 (enExample) |
| PT (1) | PT2013191E (enExample) |
| WO (1) | WO2007110627A2 (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7790881B2 (en) | 2004-09-23 | 2010-09-07 | Wista Laboratories Ltd. | Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (MTC) |
| CA2645946C (en) | 2006-03-29 | 2014-04-01 | Wista Laboratories Ltd. | Inhibitors of protein aggregation |
| DK2013191T6 (en) * | 2006-03-29 | 2019-04-23 | Wista Lab Ltd | 3,7-Diamino-10H-phenothiazine salts and their use |
| PT3121169T (pt) | 2006-07-11 | 2022-05-13 | Wista Lab Ltd | Processos de síntese e/ou purificação de compostos diaminofenotiazínio |
| JP2010523591A (ja) * | 2007-04-03 | 2010-07-15 | プロセッタ バイオコンフォーマティクス インコーポレイテッド | 抗ウイルス処置 |
| AU2008265045B2 (en) * | 2007-06-19 | 2014-02-27 | Wista Laboratories Ltd. | Phenothiazine compounds for treating Mild Cognitive Impairment |
| FR2920775B1 (fr) * | 2007-09-07 | 2009-11-06 | Pharma Hydro Dev P H D Soc Par | Nouveaux composes diaminophenothiazine, leur procede de preparation et leurs utilisations. |
| PL2205245T3 (pl) * | 2007-10-03 | 2015-12-31 | Wista Lab Ltd | Zastosowanie terapeutyczne diaminofenotiazyn |
| MX367131B (es) * | 2008-12-10 | 2019-08-06 | Wista Lab Ltd | Sales de xantilio 3,6-disustituidas. |
| ES2659091T3 (es) * | 2009-09-24 | 2018-03-13 | Wista Laboratories Ltd. | Pentahidrato de cloruro de metiltioninio, preparación y uso farmacéutico del mismo |
| MX2012003083A (es) * | 2009-09-24 | 2012-04-30 | Wista Lab Ltd | Clorhidratos de metiltioninio (azul de metileno) cristalinos. |
| US8828986B2 (en) | 2011-04-20 | 2014-09-09 | Prosetta Antiviral Inc. | Antiviral compounds |
| CN102958525B (zh) | 2010-04-30 | 2017-05-24 | 普罗瑟塔抗病毒股份有限公司 | 抗病毒化合物 |
| CA2818068C (en) | 2010-11-30 | 2019-06-11 | Wista Laboratories Ltd. | Formulations comprising methylthioninium chloride |
| US8703137B2 (en) | 2011-01-31 | 2014-04-22 | Intellect Neurosciences Inc. | Treatment of tauopathies |
| CA2827027C (en) | 2011-02-11 | 2019-06-04 | Wista Laboratories Ltd. | Phenothiazine diaminium salts and their use |
| US20130315825A1 (en) * | 2012-05-03 | 2013-11-28 | Washington University | Tricyclic heteroaromatic compounds as alpha-synuclein ligands |
| GB201512678D0 (en) * | 2015-07-20 | 2015-08-26 | Wista Lab Ltd | Methods of chemical synthesis |
| CN105541756B (zh) * | 2015-12-17 | 2018-02-09 | 陕西方舟制药有限公司 | 一种制备1‑(3,7‑双二甲氨基‑吩噻嗪‑10‑基)乙酮的方法 |
| ITUA20163526A1 (it) | 2016-05-17 | 2017-11-17 | Icrom Spa | Procedimento per la preparazione di composti diamminofenotiazinici ad elevato grado di purezza |
| KR20230058533A (ko) | 2016-07-25 | 2023-05-03 | 위스타 레보레이토리스 리미티드 | 디아미노페노티아진 (diaminophenothiazines)의 투여 및 투여량 (dosage) |
| GB201614834D0 (en) * | 2016-09-01 | 2016-10-19 | Wista Lab Ltd | Treatment of dementia |
| GB201621817D0 (en) * | 2016-12-21 | 2017-02-01 | Wista Lab Ltd | Methods of chemical synthesis |
| CN107253936B (zh) * | 2017-06-23 | 2021-07-23 | 复旦大学 | 一类可用于次氯酸检测的荧光探针及其制备方法和应用 |
| CN108129418A (zh) * | 2017-12-22 | 2018-06-08 | 郑州大学 | 吩噻嗪-氨基二硫代甲酸酯衍生物及其制备方法和应用 |
| EP4364801B1 (en) | 2018-07-26 | 2025-11-12 | TauRx Therapeutics Management Ltd. | Optimised dosage of diaminophenothiazines in populations |
| SG11202102139YA (en) | 2018-09-05 | 2021-04-29 | Genting Taurx Diagnostic Centre Sdn Bhd | Network methods for neurodegenerative diseases |
| CN109223800A (zh) * | 2018-10-26 | 2019-01-18 | 辽宁大学 | 3,7-二对甲苯胺基-吩噻嗪-5-鎓碘化物与超声协同在抑制肿瘤细胞增殖中的应用 |
| WO2020201828A1 (en) | 2019-04-05 | 2020-10-08 | Tauc3 Biologics Limited | Anti-tauc3 antibodies and uses thereof |
| GB201909454D0 (en) | 2019-07-01 | 2019-08-14 | Wista Lab Ltd | Enhancers |
| GB201909493D0 (en) | 2019-07-01 | 2019-08-14 | Wista Lab Ltd | Therapeutic interactions |
| GB201909506D0 (en) | 2019-07-02 | 2019-08-14 | Wista Lab Ltd | Synaptopathies |
| JP2023524146A (ja) * | 2020-05-05 | 2023-06-08 | ウィスタ ラボラトリーズ リミテッド | 低酸素血症の治療に使用されるメチルチオニニウム化合物 |
| EP4146223A1 (en) | 2020-05-05 | 2023-03-15 | WisTa Laboratories Ltd. | Methylthioninium compounds for use in the treatment of covid-19 |
| GB202006659D0 (en) | 2020-05-05 | 2020-06-17 | Wista Lab Ltd | Therapeutic treatments |
| GB202010652D0 (en) | 2020-07-10 | 2020-08-26 | Wista Lab Ltd | Anti-tau antibodies |
| DE102020212508A1 (de) * | 2020-10-02 | 2022-04-07 | Continental Reifen Deutschland Gmbh | Verbindung, Kautschukmischung enthaltend die Verbindung, Fahrzeugreifen, der die Kautschukmischung in wenigstens einem Bauteil aufweist, Verfahren zur Herstellung der Verbindung sowie Verwendung der Verbindung als Alterungsschutzmittel und/oder Antioxidationsmittel und/oder Antiozonant und/oder Farbstoff |
| GB202204185D0 (en) | 2022-03-24 | 2022-05-11 | Wista Lab Ltd | Oral treatment |
| JP2025518248A (ja) | 2022-05-31 | 2025-06-12 | ウィスタ ラボラトリーズ リミテッド | メチルチオニニウム(mt)含有化合物を利用した神経変性障害の処置 |
| CN119947729A (zh) | 2022-09-21 | 2025-05-06 | 罗颍诗 | 二氨基吩噻嗪的口服制剂及其在治疗和/或预防疾病中的制备和使用方法 |
| US12410394B2 (en) | 2023-01-06 | 2025-09-09 | Athergen, Inc. | Composition comprising nicotinamide mononucleotide and leucomethylene blue |
| AU2024231880A1 (en) | 2023-03-03 | 2025-09-11 | Taurx Therapeutics Management Ltd. | Diaminophenothiazine for the treatment of microvascular brain disease disease |
| CN117447421A (zh) * | 2023-10-30 | 2024-01-26 | 上海沃凯生物技术有限公司 | 一种3,7-双-(二甲胺基)-吩噻嗪的合成方法 |
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| US5220009A (en) * | 1990-05-03 | 1993-06-15 | Yeda Research And Development Company Limited | Phenothiazinium salts and their use for disinfecting aqueous effluents |
| CN1179829A (zh) * | 1995-03-27 | 1998-04-22 | 霍夫曼-拉罗奇有限公司 | Tau-Tau结合的抑制 |
| CN1496404A (zh) * | 2001-01-15 | 2004-05-12 | ����˹���ѧ���»� | 与神经变性疾病中蛋白聚集相关的物质和方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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