CN104606199B - 3,7-二氨基-10h-吩噻嗪化合物盐及其用途 - Google Patents
3,7-二氨基-10h-吩噻嗪化合物盐及其用途 Download PDFInfo
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- CN104606199B CN104606199B CN201510002365.2A CN201510002365A CN104606199B CN 104606199 B CN104606199 B CN 104606199B CN 201510002365 A CN201510002365 A CN 201510002365A CN 104606199 B CN104606199 B CN 104606199B
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
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- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/20—[b, e]-condensed with two six-membered rings with hydrogen atoms directly attached to the ring nitrogen atom
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
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- C09B21/00—Thiazine dyes
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
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- Urology & Nephrology (AREA)
- Hematology (AREA)
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- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- AIDS & HIV (AREA)
- Endocrinology (AREA)
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- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Obesity (AREA)
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78669006P | 2006-03-29 | 2006-03-29 | |
| US60/786,690 | 2006-03-29 | ||
| PCT/GB2007/001103 WO2007110627A2 (en) | 2006-03-29 | 2007-03-28 | 3,7-diamino-10h-phenothiazine salts and their use |
| CN200780020349.XA CN101460472B (zh) | 2006-03-29 | 2007-03-28 | 3,7-二氨基-10h-吩噻嗪盐及其用途 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200780020349.XA Division CN101460472B (zh) | 2006-03-29 | 2007-03-28 | 3,7-二氨基-10h-吩噻嗪盐及其用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104606199A CN104606199A (zh) | 2015-05-13 |
| CN104606199B true CN104606199B (zh) | 2022-09-13 |
Family
ID=38421429
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811196758.1A Active CN109384741B (zh) | 2006-03-29 | 2007-03-28 | 3,7-二氨基-10h-吩噻嗪化合物盐及其用途 |
| CN201510002365.2A Active CN104606199B (zh) | 2006-03-29 | 2007-03-28 | 3,7-二氨基-10h-吩噻嗪化合物盐及其用途 |
| CN201410269784.8A Active CN104119294B (zh) | 2006-03-29 | 2007-03-28 | 3,7-二氨基-10h-吩噻嗪化合物的制备方法 |
| CN200780020349.XA Active CN101460472B (zh) | 2006-03-29 | 2007-03-28 | 3,7-二氨基-10h-吩噻嗪盐及其用途 |
| CN201510002371.8A Active CN104529939B (zh) | 2006-03-29 | 2007-03-28 | 3,7-二氨基-10h-吩噻嗪化合物盐及其用途 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN201811196758.1A Active CN109384741B (zh) | 2006-03-29 | 2007-03-28 | 3,7-二氨基-10h-吩噻嗪化合物盐及其用途 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410269784.8A Active CN104119294B (zh) | 2006-03-29 | 2007-03-28 | 3,7-二氨基-10h-吩噻嗪化合物的制备方法 |
| CN200780020349.XA Active CN101460472B (zh) | 2006-03-29 | 2007-03-28 | 3,7-二氨基-10h-吩噻嗪盐及其用途 |
| CN201510002371.8A Active CN104529939B (zh) | 2006-03-29 | 2007-03-28 | 3,7-二氨基-10h-吩噻嗪化合物盐及其用途 |
Country Status (18)
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|---|---|
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| JP (3) | JP5520043B2 (enExample) |
| KR (1) | KR100983301B1 (enExample) |
| CN (5) | CN109384741B (enExample) |
| AT (1) | ATE478058T3 (enExample) |
| AU (1) | AU2007231124B2 (enExample) |
| CA (1) | CA2646163C (enExample) |
| DE (1) | DE602007008550D1 (enExample) |
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| PL (1) | PL2013191T6 (enExample) |
| PT (1) | PT2013191E (enExample) |
| WO (1) | WO2007110627A2 (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5186212B2 (ja) | 2004-09-23 | 2013-04-17 | ウィスタ ラボラトリーズ リミテッド | メチルチオニニウム塩化物(mtc)などのジアミノフェノチアジニウム化合物を化学合成および精製する方法 |
| CN101460157B (zh) | 2006-03-29 | 2015-09-02 | 维斯塔实验室有限公司 | 蛋白聚集抑制剂 |
| MY143757A (en) | 2006-03-29 | 2011-07-15 | Wista Lab Ltd | 3,7-diamond-10h-phenothiazine salts and their use |
| AU2007274057B2 (en) | 2006-07-11 | 2012-12-13 | TauRx Therapeutics Management Ltd | Methods of synthesis and/or purification of diaminophenothiazinium compounds |
| EP2137172A1 (en) * | 2007-04-03 | 2009-12-30 | Prosetta Bioconformatics Inc. | Phenothiazin derivatives for antiviral treatments |
| CA2690746C (en) * | 2007-06-19 | 2018-01-02 | Wista Laboratories Ltd | Phenothizine compounds for treating mild cognitive impairment |
| FR2920775B1 (fr) * | 2007-09-07 | 2009-11-06 | Pharma Hydro Dev P H D Soc Par | Nouveaux composes diaminophenothiazine, leur procede de preparation et leurs utilisations. |
| SI2954932T1 (sl) * | 2007-10-03 | 2019-01-31 | Wista Laboratories Ltd. | Terapevtska uporaba diaminofenotiazinov |
| CA3039907C (en) | 2008-12-10 | 2022-12-13 | Wista Laboratories Ltd. | 3,6-disubstituted xanthylium salts |
| PT2480540T (pt) * | 2009-09-24 | 2018-02-16 | Wista Lab Ltd | Pentahidrato de cloreto de metiltionínio e respetivas preparação e utilização farmacêutica |
| KR20180094126A (ko) * | 2009-09-24 | 2018-08-22 | 위스타 레보레이토리스 리미티드 | 결정질 메틸티오니늄 클로라이드(메틸렌 블루) 수화물 |
| US8785434B2 (en) | 2010-04-30 | 2014-07-22 | Prosetta Antiviral Inc. | Antiviral compounds |
| US9192611B2 (en) | 2010-11-30 | 2015-11-24 | Wista Laboratories Ltd. | Formulations comprising methylthioninium chloride |
| CA2826286C (en) | 2011-01-31 | 2021-09-21 | Intellect Neurosciences Inc. | Treatment of tauopathies |
| SG192666A1 (en) * | 2011-02-11 | 2013-09-30 | Wista Lab Ltd | Phenothiazine diaminium salts and their use |
| EP2699241B1 (en) | 2011-04-20 | 2016-07-27 | Prosetta Antiviral Inc. | Antiviral compounds |
| US20130315825A1 (en) * | 2012-05-03 | 2013-11-28 | Washington University | Tricyclic heteroaromatic compounds as alpha-synuclein ligands |
| GB201512678D0 (en) | 2015-07-20 | 2015-08-26 | Wista Lab Ltd | Methods of chemical synthesis |
| CN105541756B (zh) * | 2015-12-17 | 2018-02-09 | 陕西方舟制药有限公司 | 一种制备1‑(3,7‑双二甲氨基‑吩噻嗪‑10‑基)乙酮的方法 |
| ITUA20163526A1 (it) * | 2016-05-17 | 2017-11-17 | Icrom Spa | Procedimento per la preparazione di composti diamminofenotiazinici ad elevato grado di purezza |
| EP3487505B1 (en) | 2016-07-25 | 2023-05-03 | WisTa Laboratories Ltd. | Administration and dosage of diaminophenothiazines |
| GB201614834D0 (en) * | 2016-09-01 | 2016-10-19 | Wista Lab Ltd | Treatment of dementia |
| GB201621817D0 (en) * | 2016-12-21 | 2017-02-01 | Wista Lab Ltd | Methods of chemical synthesis |
| CN107253936B (zh) * | 2017-06-23 | 2021-07-23 | 复旦大学 | 一类可用于次氯酸检测的荧光探针及其制备方法和应用 |
| CN108129418A (zh) * | 2017-12-22 | 2018-06-08 | 郑州大学 | 吩噻嗪-氨基二硫代甲酸酯衍生物及其制备方法和应用 |
| EP4364801B1 (en) | 2018-07-26 | 2025-11-12 | TauRx Therapeutics Management Ltd. | Optimised dosage of diaminophenothiazines in populations |
| US20210193322A1 (en) | 2018-09-05 | 2021-06-24 | Genting Taurx Diagnostic Centre Sdn Bhd | Network methods for neurodegenerative diseases |
| CN109223800A (zh) * | 2018-10-26 | 2019-01-18 | 辽宁大学 | 3,7-二对甲苯胺基-吩噻嗪-5-鎓碘化物与超声协同在抑制肿瘤细胞增殖中的应用 |
| WO2020201828A1 (en) | 2019-04-05 | 2020-10-08 | Tauc3 Biologics Limited | Anti-tauc3 antibodies and uses thereof |
| GB201909454D0 (en) | 2019-07-01 | 2019-08-14 | Wista Lab Ltd | Enhancers |
| GB201909493D0 (en) | 2019-07-01 | 2019-08-14 | Wista Lab Ltd | Therapeutic interactions |
| GB201909506D0 (en) | 2019-07-02 | 2019-08-14 | Wista Lab Ltd | Synaptopathies |
| GB202006659D0 (en) | 2020-05-05 | 2020-06-17 | Wista Lab Ltd | Therapeutic treatments |
| CN115916211A (zh) | 2020-05-05 | 2023-04-04 | 维斯塔实验室有限公司 | 用于治疗低氧血症的甲基硫堇鎓化合物 |
| US20230165875A1 (en) | 2020-05-05 | 2023-06-01 | Wista Laboratories Ltd. | Methylthioninium compounds for use in the treatment of covid-19 |
| GB202010652D0 (en) | 2020-07-10 | 2020-08-26 | Wista Lab Ltd | Anti-tau antibodies |
| DE102020212508A1 (de) | 2020-10-02 | 2022-04-07 | Continental Reifen Deutschland Gmbh | Verbindung, Kautschukmischung enthaltend die Verbindung, Fahrzeugreifen, der die Kautschukmischung in wenigstens einem Bauteil aufweist, Verfahren zur Herstellung der Verbindung sowie Verwendung der Verbindung als Alterungsschutzmittel und/oder Antioxidationsmittel und/oder Antiozonant und/oder Farbstoff |
| GB202204185D0 (en) | 2022-03-24 | 2022-05-11 | Wista Lab Ltd | Oral treatment |
| WO2023232764A1 (en) | 2022-05-31 | 2023-12-07 | Wista Laboratories Ltd. | Treatment of neurodegenerative disorders utilising methylthioninium (mt)-containing compounds |
| AU2023346900A1 (en) | 2022-09-21 | 2025-04-10 | TauRx Therapeutics Management Ltd | Novel formulations and vehicles |
| US12410394B2 (en) | 2023-01-06 | 2025-09-09 | Athergen, Inc. | Composition comprising nicotinamide mononucleotide and leucomethylene blue |
| WO2024184146A1 (en) | 2023-03-03 | 2024-09-12 | Wista Laboratories Ltd. | Diaminophenothiazine for the treatment of microvascular brain disease disease |
| CN117447421A (zh) * | 2023-10-30 | 2024-01-26 | 上海沃凯生物技术有限公司 | 一种3,7-双-(二甲胺基)-吩噻嗪的合成方法 |
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| BE569430A (enExample) | 1957-07-17 | |||
| US3641016A (en) * | 1968-02-16 | 1972-02-08 | Egyt Gyogyszervegyeszeti Gyar | Thionine derivatives |
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