CN104520293B - 抗病毒化合物的合成 - Google Patents

抗病毒化合物的合成 Download PDF

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Publication number
CN104520293B
CN104520293B CN201380029806.7A CN201380029806A CN104520293B CN 104520293 B CN104520293 B CN 104520293B CN 201380029806 A CN201380029806 A CN 201380029806A CN 104520293 B CN104520293 B CN 104520293B
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formula
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CN104520293A (zh
Inventor
罗伯特·威廉·斯科特
贾斯汀·菲利普·维塔莱
肯尼斯·斯坦利·马修斯
马丁·杰拉德·特里斯克
亚历山德拉·弗姆拉
杰瑞德·韦恩·埃文斯
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Gilead Sciences Inc
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Gilead Pharmasset LLC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201380029806.7A 2012-06-05 2013-06-04 抗病毒化合物的合成 Active CN104520293B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710524415.2A CN107266428A (zh) 2012-06-05 2013-06-04 抗病毒化合物的合成

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261655935P 2012-06-05 2012-06-05
US61/655,935 2012-06-05
US13/800,202 US9056860B2 (en) 2012-06-05 2013-03-13 Synthesis of antiviral compound
US13/800,202 2013-03-13
PCT/US2013/044148 WO2013184702A1 (en) 2012-06-05 2013-06-04 Synthesis of antiviral compound

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201710524415.2A Division CN107266428A (zh) 2012-06-05 2013-06-04 抗病毒化合物的合成

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CN104520293B true CN104520293B (zh) 2017-07-28

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CN201710524415.2A Pending CN107266428A (zh) 2012-06-05 2013-06-04 抗病毒化合物的合成

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EP (1) EP2855454B1 (enExample)
JP (3) JP6181169B2 (enExample)
KR (2) KR20200066376A (enExample)
CN (2) CN104520293B (enExample)
AU (1) AU2013271772B2 (enExample)
BR (1) BR112014030365A2 (enExample)
CA (1) CA2875508C (enExample)
ES (1) ES2587782T3 (enExample)
HK (2) HK1209124A1 (enExample)
IL (2) IL235941B (enExample)
IN (1) IN2014MN02496A (enExample)
MX (1) MX350892B (enExample)
PT (1) PT2855454T (enExample)
RU (1) RU2636943C2 (enExample)
SG (1) SG11201408011SA (enExample)
WO (1) WO2013184702A1 (enExample)

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US8969588B2 (en) * 2012-06-05 2015-03-03 Gilead Pharmasset Llc Solid forms of an antiviral compound
US9056860B2 (en) * 2012-06-05 2015-06-16 Gilead Pharmasset Llc Synthesis of antiviral compound
EA029081B9 (ru) 2013-01-31 2018-09-28 Джилид Фармассет Ллс Комбинированный состав двух противовирусных соединений
CN104211565A (zh) * 2013-05-31 2014-12-17 浙江九洲药业股份有限公司 一种抗丙型肝炎药物中间体的制备方法
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CN104961733B (zh) * 2015-07-06 2019-04-09 上海众强药业有限公司 雷迪帕韦晶型及其制备方法
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CN105237516B (zh) * 2015-10-13 2018-01-02 厦门市蔚嘉化学科技有限公司 一种雷迪帕韦的制备方法
CN105399657B (zh) * 2015-10-21 2017-10-10 海门慧聚药业有限公司 雷迪帕韦关键中间体的制备
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Publication number Publication date
SG11201408011SA (en) 2015-01-29
EP2855454A1 (en) 2015-04-08
PT2855454T (pt) 2016-08-26
US20130324740A1 (en) 2013-12-05
KR20150027158A (ko) 2015-03-11
KR102206434B1 (ko) 2021-01-22
JP6356876B2 (ja) 2018-07-11
MX2014014569A (es) 2015-05-11
ES2587782T3 (es) 2016-10-26
JP6594487B2 (ja) 2019-10-23
US20160340345A1 (en) 2016-11-24
RU2014150435A (ru) 2016-07-27
CA2875508C (en) 2021-05-04
BR112014030365A2 (pt) 2016-07-05
RU2636943C2 (ru) 2017-11-29
JP2015518892A (ja) 2015-07-06
JP6181169B2 (ja) 2017-08-16
MX350892B (es) 2017-09-22
CA2875508A1 (en) 2013-12-12
CN104520293A (zh) 2015-04-15
HK1245273A1 (zh) 2018-08-24
JP2018145200A (ja) 2018-09-20
WO2013184702A1 (en) 2013-12-12
US9056860B2 (en) 2015-06-16
US20150232453A1 (en) 2015-08-20
EP2855454B1 (en) 2016-05-25
IN2014MN02496A (enExample) 2015-07-17
IL258327A (en) 2018-05-31
AU2013271772A1 (en) 2015-01-15
CN107266428A (zh) 2017-10-20
AU2013271772B2 (en) 2017-11-02
US9718807B2 (en) 2017-08-01
KR20200066376A (ko) 2020-06-09
JP2017160262A (ja) 2017-09-14
IL235941A0 (en) 2015-02-01
HK1209124A1 (en) 2016-03-24
IL235941B (en) 2018-04-30
HK1208670A1 (zh) 2016-03-11

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