CN104395455B - 重组微生物及其使用方法 - Google Patents

重组微生物及其使用方法 Download PDF

Info

Publication number
CN104395455B
CN104395455B CN201380018640.9A CN201380018640A CN104395455B CN 104395455 B CN104395455 B CN 104395455B CN 201380018640 A CN201380018640 A CN 201380018640A CN 104395455 B CN104395455 B CN 104395455B
Authority
CN
China
Prior art keywords
seq
microorganism
acetolactate
clostridium
gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201380018640.9A
Other languages
English (en)
Chinese (zh)
Other versions
CN104395455A (zh
Inventor
M·科普克
S·那加拉祖
陈铱婷
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lanzatech NZ Inc
Original Assignee
Lanzatech New Zealand Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lanzatech New Zealand Ltd filed Critical Lanzatech New Zealand Ltd
Publication of CN104395455A publication Critical patent/CN104395455A/zh
Application granted granted Critical
Publication of CN104395455B publication Critical patent/CN104395455B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/02Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/06Ethanol, i.e. non-beverage
    • C12P7/065Ethanol, i.e. non-beverage with microorganisms other than yeasts
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0006Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1022Transferases (2.) transferring aldehyde or ketonic groups (2.2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88Lyases (4.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/04Alpha- or beta- amino acids
    • C12P13/06Alanine; Leucine; Isoleucine; Serine; Homoserine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/04Alpha- or beta- amino acids
    • C12P13/08Lysine; Diaminopimelic acid; Threonine; Valine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/02Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/06Ethanol, i.e. non-beverage
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42Hydroxy-carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44Polycarboxylic acids
    • C12P7/46Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44Polycarboxylic acids
    • C12P7/48Tricarboxylic acids, e.g. citric acid
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44Polycarboxylic acids
    • C12P7/50Polycarboxylic acids having keto groups, e.g. 2-ketoglutaric acid
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/56Lactic acid
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y101/00Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01004R,R-butanediol dehydrogenase (1.1.1.4)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y202/00Transferases transferring aldehyde or ketonic groups (2.2)
    • C12Y202/01Transketolases and transaldolases (2.2.1)
    • C12Y202/01006Acetolactate synthase (2.2.1.6)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y401/00Carbon-carbon lyases (4.1)
    • C12Y401/01Carboxy-lyases (4.1.1)
    • C12Y401/01005Acetolactate decarboxylase (4.1.1.5)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00Genetically modified cells
    • C12N2510/02Cells for production
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02EREDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00Technologies for the production of fuel of non-fossil origin
    • Y02E50/10Biofuels, e.g. bio-diesel

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
CN201380018640.9A 2012-01-31 2013-01-31 重组微生物及其使用方法 Active CN104395455B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261593269P 2012-01-31 2012-01-31
US61/593,269 2012-01-31
PCT/NZ2013/000012 WO2013115659A2 (en) 2012-01-31 2013-01-31 Recombinant microorganisms and methods of use thereof

Publications (2)

Publication Number Publication Date
CN104395455A CN104395455A (zh) 2015-03-04
CN104395455B true CN104395455B (zh) 2020-05-19

Family

ID=48905994

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380018640.9A Active CN104395455B (zh) 2012-01-31 2013-01-31 重组微生物及其使用方法

Country Status (13)

Country Link
US (2) US9057071B2 (enExample)
EP (1) EP2710117B1 (enExample)
JP (2) JP6512825B2 (enExample)
KR (1) KR101511639B1 (enExample)
CN (1) CN104395455B (enExample)
AU (1) AU2013215706B2 (enExample)
BR (1) BR112014018844B1 (enExample)
CA (1) CA2862790C (enExample)
EA (1) EA031093B1 (enExample)
ES (1) ES2583203T3 (enExample)
MY (1) MY165103A (enExample)
WO (1) WO2013115659A2 (enExample)
ZA (1) ZA201405858B (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA031093B1 (ru) * 2012-01-31 2018-11-30 Ланцатек Нью Зилэнд Лимитед Рекомбинантный карбоксидотрофный ацетогенный микроорганизм, способ его получения и способ получения продуктов с его использованием
EA033071B1 (ru) * 2013-09-22 2019-08-30 Ланцатек Нью Зилэнд Лимитед Способ увеличения выхода продуктов из ацетолактата
JP2016538869A (ja) * 2013-12-03 2016-12-15 ランザテク・ニュージーランド・リミテッド ケトンの生成のための微生物及び方法
CN106133132A (zh) 2014-01-30 2016-11-16 朗泽科技新西兰有限公司 重组微生物和其使用方法
MY178182A (en) * 2014-08-11 2020-10-06 Lanzatech New Zealand Ltd Genetically engineered bacterium with altered carbon monoxide dehydrogenase (codh) activity
PT3230459T (pt) * 2014-12-08 2020-12-18 Lanzatech New Zealand Ltd Microrganismos recombinantes que exibem fluxo aumentado através de uma via de fermentação
WO2017037897A1 (ja) * 2015-09-02 2017-03-09 積水化学工業株式会社 組換え細胞、組換え細胞の製造方法、並びに、1,4-ブタンジオールの生産方法
AU2016339989B2 (en) 2015-10-13 2022-11-17 Lanzatech Nz, Inc. Genetically engineered bacterium comprising energy-generating fermentation pathway
KR102089516B1 (ko) * 2016-01-06 2020-03-16 주식회사 씨원켐 Co 수화효소 및 이를 이용한 개미산의 제조방법
WO2019006257A1 (en) 2017-06-30 2019-01-03 Invista North America .S.A.R.L. METHODS, SYNTHETIC HOSTS AND REAGENTS FOR HYDROCARBON BIOSYNTHESIS
WO2019006255A1 (en) 2017-06-30 2019-01-03 Invista North America S.A.R.L. METHODS, MATERIALS, SYNTHETIC HOSTS AND REAGENTS FOR HYDROCARBON BIOSYNTHESIS AND DERIVATIVES
US11505809B2 (en) * 2017-09-28 2022-11-22 Inv Nylon Chemicals Americas Llc Organisms and biosynthetic processes for hydrocarbon synthesis
WO2019147743A1 (en) 2018-01-26 2019-08-01 Massachusetts Institute Of Technology Structure-guided chemical modification of guide rna and its applications
CN113490748A (zh) * 2019-02-25 2021-10-08 西北大学 来源于梭菌属提取物的无细胞蛋白质合成平台
CN111089914A (zh) * 2019-11-07 2020-05-01 河北首朗新能源科技有限公司 微生物发酵生产乙醇中代谢物的高效液相检测方法
CN111154683B (zh) * 2020-01-19 2022-05-13 南京工业大学 一种食甲基丁酸杆菌的优化培养方法及其应用
CN111220762A (zh) * 2020-03-24 2020-06-02 河北首朗新能源科技有限公司 一种乙醇梭菌蛋白中有机物的含量的检测方法及应用
MX2022013570A (es) * 2020-04-29 2022-11-30 Lanzatech Inc Produccion fermentativa de b-cetoadipato a partir de sustratos gaseosos.
MY207363A (en) * 2020-06-06 2025-02-22 Lanzatech Inc Microorganism with knock-in at acetolactate decarboxylase gene locus
TW202212566A (zh) * 2020-09-25 2022-04-01 美商朗澤科技有限公司 重組微生物及其用途
CN113234653B (zh) * 2021-04-22 2022-10-04 中国科学院青岛生物能源与过程研究所 一种提高合成气发酵产乙醇含量的突变株和利用突变株的应用
US20240117393A1 (en) 2022-09-30 2024-04-11 Ajinomoto Co., Inc. Method for producing l-amino acid
CN115960808A (zh) * 2022-11-24 2023-04-14 苏州聚维元创生物科技有限公司 一种敲除基因的重组大肠杆菌及其构建方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009064200A2 (en) * 2007-11-13 2009-05-22 Lanzatech New Zealand Limited Novel bacteria and methods of use thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8652817B2 (en) * 2005-07-01 2014-02-18 Univeristy Of Florida Research Foundation, Inc. Recombinant host cells and media for ethanol production
WO2008013996A2 (en) 2006-07-27 2008-01-31 Gevo Inc. Engineered microorganisms for increasing product yield in biotransformations, related methods and systems
DE102007048277A1 (de) 2007-10-08 2009-04-09 Agraferm Technologies Ag Verfahren und Vorrichtung zur mikrobiellen Herstellung eines bestimmten Produktes und Methan
KR101312107B1 (ko) 2008-03-12 2013-09-27 란자테크 뉴질랜드 리미티드 미생물 알콜 생산 방법
BRPI0915017B1 (pt) * 2008-06-09 2018-12-26 Lanzatech New Zealand Ltd método para produzir 2,3-butanodiol pela fermentação microbiana de um substrato gasoso compreendendo co
DE102009002583A1 (de) 2009-04-23 2010-10-28 Evonik Degussa Gmbh Zellen und Verfahren zur Herstellung von Aceton
US8143037B2 (en) * 2010-03-19 2012-03-27 Coskata, Inc. Ethanologenic Clostridium species, Clostridium coskatii
EA025778B1 (ru) * 2010-07-28 2017-01-30 Ланзатек Нью Зиленд Лимитед Новые бактерии и способы их применения
EA031093B1 (ru) * 2012-01-31 2018-11-30 Ланцатек Нью Зилэнд Лимитед Рекомбинантный карбоксидотрофный ацетогенный микроорганизм, способ его получения и способ получения продуктов с его использованием

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009064200A2 (en) * 2007-11-13 2009-05-22 Lanzatech New Zealand Limited Novel bacteria and methods of use thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
development of industrial-required elimination of the 2,3-butanediol fermentation pathway to maintain ethanol yield in an ethanologenic strain of klebsiellaoxytoca;brent e.wood et al.;《biotechnology progress》;20051031;第21卷(第5期);摘要 *

Also Published As

Publication number Publication date
CN104395455A (zh) 2015-03-04
ES2583203T3 (es) 2016-09-19
US20150299737A1 (en) 2015-10-22
AU2013215706B2 (en) 2014-03-27
CA2862790C (en) 2016-09-27
BR112014018844A2 (pt) 2020-08-18
EA031093B1 (ru) 2018-11-30
JP6898365B2 (ja) 2021-07-07
WO2013115659A3 (en) 2013-10-03
MY165103A (en) 2018-02-28
CA2862790A1 (en) 2013-08-08
WO2013115659A2 (en) 2013-08-08
EP2710117A2 (en) 2014-03-26
EA201491418A1 (ru) 2015-02-27
EP2710117A4 (en) 2014-04-16
JP2015505471A (ja) 2015-02-23
BR112014018844B1 (pt) 2022-09-27
JP6512825B2 (ja) 2019-05-15
US20140206901A1 (en) 2014-07-24
US9057071B2 (en) 2015-06-16
KR101511639B1 (ko) 2015-04-16
JP2019088292A (ja) 2019-06-13
AU2013215706A1 (en) 2013-10-10
US9297026B2 (en) 2016-03-29
KR20130138866A (ko) 2013-12-19
ZA201405858B (en) 2016-08-31
EP2710117B1 (en) 2016-04-27

Similar Documents

Publication Publication Date Title
CN104395455B (zh) 重组微生物及其使用方法
CN108486169B (zh) 重组微生物及其用途
JP6445970B2 (ja) 組換え微生物およびその使用
US11549103B2 (en) Recombinant microorganisms and methods of use thereof
CN104487580B (zh) 选择方法和重组微生物及其用途
CN113840909A (zh) 从气态底物发酵生产2-苯乙醇
EP3140412A1 (en) Genetically modified microorganism for improved production of fine chemicals on sucrose
EP3102675A1 (en) Improved microorganisms for succinic acid production

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C53 Correction of patent of invention or patent application
CB02 Change of applicant information

Address after: Parnell, Oakland, New Zealand

Applicant after: LANZATECH NEW ZEALAND LTD.

Address before: Parnell, Oakland, New Zealand

Applicant before: Lanzatech New Zealand Limited

COR Change of bibliographic data

Free format text: CORRECT: APPLICANT; FROM: LANZATECH NEW ZEALAND LTD. TO: LANZATECH NEW ZEALAND LTD.

GR01 Patent grant
GR01 Patent grant
CP02 Change in the address of a patent holder
CP02 Change in the address of a patent holder

Address after: Illinois, America

Patentee after: LANZATECH NEW ZEALAND Ltd.

Address before: Parnell, Oakland, New Zealand

Patentee before: LANZATECH NEW ZEALAND Ltd.