CN104311610A - 一种快速制备粒状乳糖醇的方法 - Google Patents
一种快速制备粒状乳糖醇的方法 Download PDFInfo
- Publication number
- CN104311610A CN104311610A CN201410624495.5A CN201410624495A CN104311610A CN 104311610 A CN104311610 A CN 104311610A CN 201410624495 A CN201410624495 A CN 201410624495A CN 104311610 A CN104311610 A CN 104311610A
- Authority
- CN
- China
- Prior art keywords
- saccharum lactis
- granular
- saccharum
- lactis
- lactitol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 title claims abstract description 28
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 title claims abstract description 16
- 229960003451 lactitol Drugs 0.000 title claims abstract description 16
- 235000010448 lactitol Nutrition 0.000 title claims abstract description 16
- 239000000832 lactitol Substances 0.000 title claims abstract description 16
- 239000013078 crystal Substances 0.000 claims abstract description 47
- 239000006188 syrup Substances 0.000 claims abstract description 19
- 235000020357 syrup Nutrition 0.000 claims abstract description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 238000001816 cooling Methods 0.000 claims abstract description 5
- 238000005507 spraying Methods 0.000 claims abstract description 4
- GUBGYTABKSRVRQ-DCSYEGIMSA-N Beta-Lactose Chemical compound OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-DCSYEGIMSA-N 0.000 claims description 94
- 238000002360 preparation method Methods 0.000 claims description 20
- 238000012216 screening Methods 0.000 claims description 15
- 239000007921 spray Substances 0.000 claims description 15
- 239000002245 particle Substances 0.000 claims description 7
- 239000002028 Biomass Substances 0.000 claims description 5
- 238000000889 atomisation Methods 0.000 claims description 5
- 238000005520 cutting process Methods 0.000 claims description 5
- 238000002425 crystallisation Methods 0.000 abstract description 13
- 230000008025 crystallization Effects 0.000 abstract description 12
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 238000005516 engineering process Methods 0.000 abstract description 3
- 238000009826 distribution Methods 0.000 abstract description 2
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 150000004682 monohydrates Chemical class 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 7
- 239000008101 lactose Substances 0.000 description 7
- WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 208000001647 Renal Insufficiency Diseases 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 238000002050 diffraction method Methods 0.000 description 2
- 201000006370 kidney failure Diseases 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 208000037157 Azotemia Diseases 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 208000014644 Brain disease Diseases 0.000 description 1
- 208000032274 Encephalopathy Diseases 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 241000220324 Pyrus Species 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000015218 chewing gum Nutrition 0.000 description 1
- 229940112822 chewing gum Drugs 0.000 description 1
- 235000019219 chocolate Nutrition 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000007907 direct compression Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 235000015243 ice cream Nutrition 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- -1 lactose alcohol monohydrate Chemical class 0.000 description 1
- JCQLYHFGKNRPGE-FCVZTGTOSA-N lactulose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 JCQLYHFGKNRPGE-FCVZTGTOSA-N 0.000 description 1
- 229960000511 lactulose Drugs 0.000 description 1
- PFCRQPBOOFTZGQ-UHFFFAOYSA-N lactulose keto form Natural products OCC(=O)C(O)C(C(O)CO)OC1OC(CO)C(O)C(O)C1O PFCRQPBOOFTZGQ-UHFFFAOYSA-N 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 235000021017 pears Nutrition 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000006722 reduction reaction Methods 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 208000009852 uremia Diseases 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
Abstract
Description
Claims (10)
Priority Applications (1)
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CN201410624495.5A CN104311610B (zh) | 2014-11-06 | 2014-11-06 | 一种快速制备粒状乳糖醇的方法 |
Applications Claiming Priority (1)
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---|---|---|---|
CN201410624495.5A CN104311610B (zh) | 2014-11-06 | 2014-11-06 | 一种快速制备粒状乳糖醇的方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104311610A true CN104311610A (zh) | 2015-01-28 |
CN104311610B CN104311610B (zh) | 2017-03-08 |
Family
ID=52366946
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410624495.5A Active CN104311610B (zh) | 2014-11-06 | 2014-11-06 | 一种快速制备粒状乳糖醇的方法 |
Country Status (1)
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CN (1) | CN104311610B (zh) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105833280A (zh) * | 2016-04-28 | 2016-08-10 | 湖南尔康制药股份有限公司 | 一种可压性蔗糖的制备方法 |
WO2018217769A1 (en) * | 2017-05-23 | 2018-11-29 | Particle Dynamics International, Llc | Processes for producing lactitol granulates and granulates produced thereby |
CN112934108A (zh) * | 2021-03-05 | 2021-06-11 | 江苏道宁药业有限公司 | 一种一水乳糖细粉的细化造粒设备及细化造粒方法 |
CN114945278A (zh) * | 2019-12-05 | 2022-08-26 | 涡龙设备与工艺公司 | 含乳糖的粉末状产品及其生产方法 |
Citations (14)
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US3883365A (en) * | 1972-01-04 | 1975-05-13 | Suomen Sokeri Oy | PH adjustment in fructose crystallization for increased yield |
JPH11217395A (ja) * | 1998-01-27 | 1999-08-10 | Hayashibara Biochem Lab Inc | 無水結晶マルチトールの連続的製造方法及び製造装置 |
CN1309626A (zh) * | 1998-05-18 | 2001-08-22 | 齐洛芬有限公司 | 木糖醇的结晶、结晶木糖醇产物及其用途 |
CN1336799A (zh) * | 1999-01-07 | 2002-02-20 | 丹尼斯科卡尔特美国公司 | 食用巧克力组合物 |
EP1553100A1 (en) * | 2002-06-19 | 2005-07-13 | Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyusho | Process for producing crystalline maltitol |
CN101217941A (zh) * | 2005-07-08 | 2008-07-09 | 罗盖特公司 | 用于制备包含木糖醇结晶颗粒和其它多元醇的粉末的方法 |
CN101438781A (zh) * | 2007-10-30 | 2009-05-27 | 火箭兄弟公司 | 麦芽糖醇蒸发结晶的方法 |
EP2264042A1 (en) * | 2007-07-27 | 2010-12-22 | Cargill, Incorporated | Micronization of polyols |
CN102178145A (zh) * | 2011-04-20 | 2011-09-14 | 池州市大恒生化有限公司 | 一种食品添加剂碳酸钙的制备方法 |
CN102321126A (zh) * | 2011-09-08 | 2012-01-18 | 天津大学 | 一种制备麦芽糖醇晶体的方法 |
CN102924539A (zh) * | 2012-10-31 | 2013-02-13 | 南京工业大学 | 一种制备海藻糖晶体的方法 |
CN103130961A (zh) * | 2011-11-22 | 2013-06-05 | 凯姆勒吸水材料(天津)有限公司 | 一种卫生材料用吸水树脂 |
CN103271201A (zh) * | 2013-05-08 | 2013-09-04 | 南京年吉冷冻食品有限公司 | 一种低能量膳食纤维巧克力糖及其制备方法 |
CN103980329A (zh) * | 2014-05-29 | 2014-08-13 | 山东绿健生物技术有限公司 | 一种制备结晶乳糖醇的方法 |
-
2014
- 2014-11-06 CN CN201410624495.5A patent/CN104311610B/zh active Active
Patent Citations (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3883365A (en) * | 1972-01-04 | 1975-05-13 | Suomen Sokeri Oy | PH adjustment in fructose crystallization for increased yield |
JPH11217395A (ja) * | 1998-01-27 | 1999-08-10 | Hayashibara Biochem Lab Inc | 無水結晶マルチトールの連続的製造方法及び製造装置 |
CN1309626A (zh) * | 1998-05-18 | 2001-08-22 | 齐洛芬有限公司 | 木糖醇的结晶、结晶木糖醇产物及其用途 |
CN1336799A (zh) * | 1999-01-07 | 2002-02-20 | 丹尼斯科卡尔特美国公司 | 食用巧克力组合物 |
EP1553100A1 (en) * | 2002-06-19 | 2005-07-13 | Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyusho | Process for producing crystalline maltitol |
CN101217941A (zh) * | 2005-07-08 | 2008-07-09 | 罗盖特公司 | 用于制备包含木糖醇结晶颗粒和其它多元醇的粉末的方法 |
EP2264042A1 (en) * | 2007-07-27 | 2010-12-22 | Cargill, Incorporated | Micronization of polyols |
CN101438781A (zh) * | 2007-10-30 | 2009-05-27 | 火箭兄弟公司 | 麦芽糖醇蒸发结晶的方法 |
CN102178145A (zh) * | 2011-04-20 | 2011-09-14 | 池州市大恒生化有限公司 | 一种食品添加剂碳酸钙的制备方法 |
CN102321126A (zh) * | 2011-09-08 | 2012-01-18 | 天津大学 | 一种制备麦芽糖醇晶体的方法 |
CN103130961A (zh) * | 2011-11-22 | 2013-06-05 | 凯姆勒吸水材料(天津)有限公司 | 一种卫生材料用吸水树脂 |
CN102924539A (zh) * | 2012-10-31 | 2013-02-13 | 南京工业大学 | 一种制备海藻糖晶体的方法 |
CN103271201A (zh) * | 2013-05-08 | 2013-09-04 | 南京年吉冷冻食品有限公司 | 一种低能量膳食纤维巧克力糖及其制备方法 |
CN103980329A (zh) * | 2014-05-29 | 2014-08-13 | 山东绿健生物技术有限公司 | 一种制备结晶乳糖醇的方法 |
Non-Patent Citations (1)
Title |
---|
罗建勇,等: "结晶麦芽糖性质及其制备工艺", 《粮食与油脂》 * |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105833280A (zh) * | 2016-04-28 | 2016-08-10 | 湖南尔康制药股份有限公司 | 一种可压性蔗糖的制备方法 |
CN105833280B (zh) * | 2016-04-28 | 2018-03-06 | 湖南尔康制药股份有限公司 | 一种可压性蔗糖的制备方法 |
WO2018217769A1 (en) * | 2017-05-23 | 2018-11-29 | Particle Dynamics International, Llc | Processes for producing lactitol granulates and granulates produced thereby |
CN114945278A (zh) * | 2019-12-05 | 2022-08-26 | 涡龙设备与工艺公司 | 含乳糖的粉末状产品及其生产方法 |
CN112934108A (zh) * | 2021-03-05 | 2021-06-11 | 江苏道宁药业有限公司 | 一种一水乳糖细粉的细化造粒设备及细化造粒方法 |
Also Published As
Publication number | Publication date |
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CN104311610B (zh) | 2017-03-08 |
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PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Method for rapidly preparing granular lactitol Effective date of registration: 20180109 Granted publication date: 20170308 Pledgee: Yucheng Shandong rural commercial bank Limited by Share Ltd Pledgor: Shandong Lvjian Biological Technology Co., Ltd. Registration number: 2018370000010 |
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