CN104262251A - 一种从千层塔中提取石杉碱甲的方法 - Google Patents
一种从千层塔中提取石杉碱甲的方法 Download PDFInfo
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- CN104262251A CN104262251A CN201410480238.9A CN201410480238A CN104262251A CN 104262251 A CN104262251 A CN 104262251A CN 201410480238 A CN201410480238 A CN 201410480238A CN 104262251 A CN104262251 A CN 104262251A
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- ZRJBHWIHUMBLCN-YQEJDHNASA-N huperzine A Chemical compound N1C(=O)C=CC2=C1C[C@H]1\C(=C/C)[C@]2(N)CC(C)=C1 ZRJBHWIHUMBLCN-YQEJDHNASA-N 0.000 title claims abstract description 75
- ZRJBHWIHUMBLCN-BMIGLBTASA-N rac-huperzine A Natural products N1C(=O)C=CC2=C1C[C@@H]1C(=CC)[C@@]2(N)CC(C)=C1 ZRJBHWIHUMBLCN-BMIGLBTASA-N 0.000 title claims abstract description 75
- 238000000034 method Methods 0.000 title claims abstract description 63
- ZRJBHWIHUMBLCN-SEQYCRGISA-N Huperzine A Natural products N1C(=O)C=CC2=C1C[C@H]1/C(=C/C)[C@]2(N)CC(C)=C1 ZRJBHWIHUMBLCN-SEQYCRGISA-N 0.000 title abstract description 7
- 241001504070 Huperzia Species 0.000 title abstract 5
- 102000011842 Serrate-Jagged Proteins Human genes 0.000 title abstract 5
- 108010036039 Serrate-Jagged Proteins Proteins 0.000 title abstract 5
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- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims abstract description 62
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- 239000000463 material Substances 0.000 claims description 37
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- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical group CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 17
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- 239000012535 impurity Substances 0.000 claims description 12
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- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 10
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 8
- 239000000706 filtrate Substances 0.000 claims description 6
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- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 4
- 239000003929 acidic solution Substances 0.000 claims description 4
- 229910021529 ammonia Inorganic materials 0.000 claims description 4
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- 241001090156 Huperzia serrata Species 0.000 description 2
- ZQPQGKQTIZYFEF-WCVJEAGWSA-N Huperzine Natural products C1([C@H]2[C@H](O)C(=O)N[C@H]2[C@@H](O)C=2C=CC=CC=2)=CC=CC=C1 ZQPQGKQTIZYFEF-WCVJEAGWSA-N 0.000 description 2
- 208000026139 Memory disease Diseases 0.000 description 2
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- ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 description 2
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- PIJVFDBKTWXHHD-UHFFFAOYSA-N Physostigmine Natural products C12=CC(OC(=O)NC)=CC=C2N(C)C2C1(C)CCN2C PIJVFDBKTWXHHD-UHFFFAOYSA-N 0.000 description 1
- 206010036631 Presenile dementia Diseases 0.000 description 1
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- PIJVFDBKTWXHHD-HIFRSBDPSA-N physostigmine Chemical compound C12=CC(OC(=O)NC)=CC=C2N(C)[C@@H]2[C@@]1(C)CCN2C PIJVFDBKTWXHHD-HIFRSBDPSA-N 0.000 description 1
- 229960001697 physostigmine Drugs 0.000 description 1
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- 102000004169 proteins and genes Human genes 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Description
提取方式 | 浸提时间(min) | 石杉碱甲浸提率(%) | 溶剂使用量(倍) |
传统提取 | 90~120 | 85~90 | 24~30 |
逆流提取 | 40~50 | 93~95 | 10~15 |
超声逆流提取 | 30~40 | 95~98 | 10~15 |
Claims (10)
Priority Applications (1)
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CN201410480238.9A CN104262251B (zh) | 2014-09-19 | 2014-09-19 | 一种从千层塔中提取石杉碱甲的方法 |
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CN201410480238.9A CN104262251B (zh) | 2014-09-19 | 2014-09-19 | 一种从千层塔中提取石杉碱甲的方法 |
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CN104262251A true CN104262251A (zh) | 2015-01-07 |
CN104262251B CN104262251B (zh) | 2016-08-17 |
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105061310A (zh) * | 2015-08-31 | 2015-11-18 | 桂林三宝生物科技有限公司 | 一种从千层塔中提取石杉碱甲的方法 |
CN105949123A (zh) * | 2016-06-06 | 2016-09-21 | 江西海富生物工程有限公司 | 一种适用工业生产的石杉碱甲的方法 |
CN106749021A (zh) * | 2016-12-20 | 2017-05-31 | 湖南铭沃生物科技有限公司 | 一种高纯石杉碱甲液相制备方法及系统 |
CN109053574A (zh) * | 2018-09-19 | 2018-12-21 | 湖南中茂生物科技有限公司 | 一种石杉碱甲的提取方法 |
CN110078667A (zh) * | 2019-04-28 | 2019-08-02 | 云南汉德生物技术有限公司 | 一种提取石杉碱甲的方法 |
CN111377866A (zh) * | 2018-12-29 | 2020-07-07 | 宁波杰顺生物科技有限公司 | 千层塔提取物石杉碱甲的制备工艺 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08301851A (ja) * | 1995-05-01 | 1996-11-19 | Sagami Chem Res Center | 光学活性5,9−メタノシクロオクタ[b]ピリジン誘導体の製造法 |
US20070270454A1 (en) * | 2006-05-17 | 2007-11-22 | Industrial Technology Research Institute | Huperzine a compound for treatment of Alzheimer's disease |
CN101880259A (zh) * | 2010-04-27 | 2010-11-10 | 南京泽朗农业发展有限公司 | 一种石杉碱甲的提纯方法 |
CN102702101A (zh) * | 2012-05-23 | 2012-10-03 | 长沙市惠瑞生物科技有限公司 | 一种从千层塔中提取石杉碱甲的方法 |
-
2014
- 2014-09-19 CN CN201410480238.9A patent/CN104262251B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08301851A (ja) * | 1995-05-01 | 1996-11-19 | Sagami Chem Res Center | 光学活性5,9−メタノシクロオクタ[b]ピリジン誘導体の製造法 |
US20070270454A1 (en) * | 2006-05-17 | 2007-11-22 | Industrial Technology Research Institute | Huperzine a compound for treatment of Alzheimer's disease |
CN101880259A (zh) * | 2010-04-27 | 2010-11-10 | 南京泽朗农业发展有限公司 | 一种石杉碱甲的提纯方法 |
CN102702101A (zh) * | 2012-05-23 | 2012-10-03 | 长沙市惠瑞生物科技有限公司 | 一种从千层塔中提取石杉碱甲的方法 |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105061310A (zh) * | 2015-08-31 | 2015-11-18 | 桂林三宝生物科技有限公司 | 一种从千层塔中提取石杉碱甲的方法 |
CN105949123A (zh) * | 2016-06-06 | 2016-09-21 | 江西海富生物工程有限公司 | 一种适用工业生产的石杉碱甲的方法 |
CN106749021A (zh) * | 2016-12-20 | 2017-05-31 | 湖南铭沃生物科技有限公司 | 一种高纯石杉碱甲液相制备方法及系统 |
CN109053574A (zh) * | 2018-09-19 | 2018-12-21 | 湖南中茂生物科技有限公司 | 一种石杉碱甲的提取方法 |
CN111377866A (zh) * | 2018-12-29 | 2020-07-07 | 宁波杰顺生物科技有限公司 | 千层塔提取物石杉碱甲的制备工艺 |
CN110078667A (zh) * | 2019-04-28 | 2019-08-02 | 云南汉德生物技术有限公司 | 一种提取石杉碱甲的方法 |
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