CN1042537C - 氮杂大环或无环氨基膦酸酯衍生物的制备方法 - Google Patents

氮杂大环或无环氨基膦酸酯衍生物的制备方法 Download PDF

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Publication number
CN1042537C
CN1042537C CN94192530A CN94192530A CN1042537C CN 1042537 C CN1042537 C CN 1042537C CN 94192530 A CN94192530 A CN 94192530A CN 94192530 A CN94192530 A CN 94192530A CN 1042537 C CN1042537 C CN 1042537C
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CN
China
Prior art keywords
paraformaldehyde
thf
formula
tetraazabicyclo
triene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN94192530A
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English (en)
Chinese (zh)
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CN1125949A (zh
Inventor
G·E·基弗
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Dow Chemical Co
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Dow Chemical Co
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Publication of CN1042537C publication Critical patent/CN1042537C/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN94192530A 1993-05-06 1994-05-04 氮杂大环或无环氨基膦酸酯衍生物的制备方法 Expired - Fee Related CN1042537C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/065,963 US5714604A (en) 1993-05-06 1993-05-06 Process for the preparation of azamacrocyclic or acyclic aminophosphonate ester derivatives
US065963 1993-05-06
US065,963 1993-05-06

Publications (2)

Publication Number Publication Date
CN1125949A CN1125949A (zh) 1996-07-03
CN1042537C true CN1042537C (zh) 1999-03-17

Family

ID=22066341

Family Applications (1)

Application Number Title Priority Date Filing Date
CN94192530A Expired - Fee Related CN1042537C (zh) 1993-05-06 1994-05-04 氮杂大环或无环氨基膦酸酯衍生物的制备方法

Country Status (34)

Country Link
US (1) US5714604A (https=)
EP (1) EP0698029B1 (https=)
JP (1) JP3556669B2 (https=)
KR (1) KR100311560B1 (https=)
CN (1) CN1042537C (https=)
AP (1) AP543A (https=)
AT (1) ATE172978T1 (https=)
AU (1) AU682190B2 (https=)
BG (1) BG62775B1 (https=)
CA (1) CA2162170C (https=)
CO (1) CO4230080A1 (https=)
CZ (1) CZ290993B6 (https=)
DE (1) DE69414382T2 (https=)
DK (1) DK0698029T3 (https=)
DZ (1) DZ1777A1 (https=)
EE (1) EE03159B1 (https=)
EG (1) EG20296A (https=)
ES (1) ES2123137T3 (https=)
FI (1) FI115632B (https=)
HU (1) HU223769B1 (https=)
IL (1) IL109561A (https=)
IS (1) IS1735B (https=)
LT (1) LT3713B (https=)
LV (1) LV10867B (https=)
MA (1) MA23186A1 (https=)
NO (1) NO304742B1 (https=)
PL (1) PL180756B1 (https=)
RO (1) RO115883B1 (https=)
RU (1) RU2135507C1 (https=)
TN (1) TNSN94040A1 (https=)
TW (1) TW273549B (https=)
UA (1) UA44704C2 (https=)
WO (1) WO1994026753A1 (https=)
ZA (1) ZA943158B (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207826B1 (en) 1995-03-27 2001-03-27 Isis Pharmaceuticals, Inc. Macrocyclic compounds having nitrogen-containing linkages
JPH10508036A (ja) 1995-03-27 1998-08-04 アイシス・ファーマシューティカルス・インコーポレーテッド 窒素含有大環状化合物
JP2003501488A (ja) * 1999-06-11 2003-01-14 ネオルックス コーポレイション 骨髄抑制のための高投与量放射性核種錯体
US7094885B2 (en) * 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
WO2001028567A2 (en) * 1999-10-18 2001-04-26 The Dow Chemical Company Aminoalkylenephosphonates for treatment of bone disorders
US6794371B1 (en) * 1999-10-18 2004-09-21 The Dow Chemical Company Aminoalkylenephosphonates for treatment of bone disorders
US6565828B2 (en) * 2000-04-07 2003-05-20 Bristol-Myers Squibb Company Macrocyclic chelants for metallopharmaceuticals
EP1390081A2 (en) 2001-01-08 2004-02-25 Neorx Corporation Therapeutic and diagnostic compounds, compositions, and methods
DE60212424T2 (de) * 2001-10-22 2006-10-12 Dow Global Technologies, Inc., Midland Radiopharmazeutisches mittel zur behandlung von krebs im frühstadium
DE60207288T2 (de) * 2001-10-22 2006-05-18 Dow Global Technologies, Inc., Midland Gewebespezifische fluoreszierende chelate
WO2003051403A1 (en) 2001-12-13 2003-06-26 Dow Global Technologies Inc. Treatment of osteomyelitis with radiopharmaceuticals
US20050112066A1 (en) * 2003-11-26 2005-05-26 Concat Lp, A California Limited Partnership Complexes of cyclic polyaza chelators with cations of alkaline earth metals for enhanced biological activity
US20060210479A1 (en) * 2004-08-10 2006-09-21 Dow Global Technologies Inc. Targeting chelants and chelates
CN112442069A (zh) * 2019-08-28 2021-03-05 广东广山新材料股份有限公司 一种带有胺基的含磷阻燃剂及其制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0382582A1 (en) * 1989-02-10 1990-08-16 Celltech Therapeutics Limited Tetra-aza macrocyles and processes for their preparation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5362476A (en) * 1984-10-18 1994-11-08 Board Of Regents, The University Of Texas System Alkyl phosphonate polyazamacrocyclic cheates for MRI
GB8817185D0 (en) * 1988-07-19 1988-08-24 Interox Chemicals Ltd Organic polyphosphonates
US5342936A (en) * 1989-02-10 1994-08-30 David Parker Tetra-aza macrocycles and processes for their preparation
US5236695A (en) * 1989-11-27 1993-08-17 Concat, Ltd. MRI image enhancement of bone and related tissue using complexes of paramagnetic cations and polyphosphonate ligands
ATE140869T1 (de) * 1989-11-27 1996-08-15 Concat Ltd Qualitätssteigerung von mr-bildern von knochen und ähnlichem gewebe mittels paramagnetischer kationenkomplexe und polyphosphonatliganden
US5385893A (en) * 1993-05-06 1995-01-31 The Dow Chemical Company Tricyclopolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents
US5606053A (en) * 1995-05-02 1997-02-25 Johnson Matthey Plc Process for preparing 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0382582A1 (en) * 1989-02-10 1990-08-16 Celltech Therapeutics Limited Tetra-aza macrocyles and processes for their preparation

Also Published As

Publication number Publication date
US5714604A (en) 1998-02-03
WO1994026753A1 (en) 1994-11-24
DE69414382T2 (de) 1999-03-25
HUT73142A (en) 1996-06-28
FI955281A0 (fi) 1995-11-03
ZA943158B (en) 1995-11-06
LT3713B (en) 1996-02-26
DK0698029T3 (da) 1999-07-19
IL109561A (en) 2002-07-25
KR100311560B1 (ko) 2001-12-28
FI955281L (fi) 1995-12-20
AU6908694A (en) 1994-12-12
JP3556669B2 (ja) 2004-08-18
CO4230080A1 (es) 1995-10-19
ATE172978T1 (de) 1998-11-15
BG62775B1 (bg) 2000-07-31
RU2135507C1 (ru) 1999-08-27
RO115883B1 (ro) 2000-07-28
TW273549B (https=) 1996-04-01
MA23186A1 (fr) 1994-12-31
CA2162170A1 (en) 1994-11-24
HK1014537A1 (en) 1999-09-30
EP0698029A1 (en) 1996-02-28
EE03159B1 (et) 1999-02-15
PL180756B1 (pl) 2001-04-30
ES2123137T3 (es) 1999-01-01
FI115632B (fi) 2005-06-15
NO954439D0 (no) 1995-11-06
IS4158A (is) 1994-11-07
CZ290993B6 (cs) 2002-11-13
AP9400639A0 (en) 1994-07-31
HU223769B1 (hu) 2005-01-28
JPH08510249A (ja) 1996-10-29
CZ289095A3 (en) 1996-03-13
NO954439L (no) 1996-01-05
CN1125949A (zh) 1996-07-03
DZ1777A1 (fr) 2002-02-17
UA44704C2 (uk) 2002-03-15
EG20296A (en) 1998-10-31
AP543A (en) 1996-10-09
IL109561A0 (en) 1994-08-26
NO304742B1 (no) 1999-02-08
TNSN94040A1 (fr) 1995-04-25
LTIP1925A (en) 1995-01-31
LV10867A (lv) 1995-10-20
IS1735B (is) 1999-12-14
EP0698029B1 (en) 1998-11-04
HU9503175D0 (en) 1995-12-28
LV10867B (en) 1996-08-20
DE69414382D1 (de) 1998-12-10
BG100193A (bg) 1996-12-31
AU682190B2 (en) 1997-09-25
CA2162170C (en) 2005-03-15
KR960702469A (ko) 1996-04-27
PL311651A1 (en) 1996-03-04

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