CN104203977A - 结合肽聚糖识别蛋白1的抗体 - Google Patents

结合肽聚糖识别蛋白1的抗体 Download PDF

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Publication number
CN104203977A
CN104203977A CN201280069905.3A CN201280069905A CN104203977A CN 104203977 A CN104203977 A CN 104203977A CN 201280069905 A CN201280069905 A CN 201280069905A CN 104203977 A CN104203977 A CN 104203977A
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China
Prior art keywords
amino
pglyrp1
antibody
trem
seq
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Pending
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CN201280069905.3A
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English (en)
Chinese (zh)
Inventor
V.W.斯坦尼科
C.B.里德
J.奎珀
X.唐
M.海佩
S.A.乔斯
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Novo Nordisk AS
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Novo Nordisk AS
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Priority to CN201810257792.9A priority Critical patent/CN108530535B/zh
Publication of CN104203977A publication Critical patent/CN104203977A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201280069905.3A 2012-02-15 2012-11-30 结合肽聚糖识别蛋白1的抗体 Pending CN104203977A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810257792.9A CN108530535B (zh) 2012-02-15 2012-11-30 结合肽聚糖识别蛋白1的抗体

Applications Claiming Priority (7)

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US201261598968P 2012-02-15 2012-02-15
US61/598968 2012-02-15
EP12158974.1 2012-03-12
EP12158974 2012-03-12
US201261672799P 2012-07-18 2012-07-18
US61/672799 2012-07-18
PCT/EP2012/074093 WO2013120554A1 (en) 2012-02-15 2012-11-30 Antibodies that bind peptidoglycan recognition protein 1

Related Child Applications (1)

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CN201810257792.9A Division CN108530535B (zh) 2012-02-15 2012-11-30 结合肽聚糖识别蛋白1的抗体

Publications (1)

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CN104203977A true CN104203977A (zh) 2014-12-10

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CN201810257792.9A Active CN108530535B (zh) 2012-02-15 2012-11-30 结合肽聚糖识别蛋白1的抗体

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Country Status (13)

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US (3) US9663568B2 (enExample)
EP (2) EP3456742A1 (enExample)
JP (1) JP6400480B2 (enExample)
CN (2) CN104203977A (enExample)
DK (1) DK2814842T3 (enExample)
ES (1) ES2690786T3 (enExample)
HR (1) HRP20181817T1 (enExample)
LT (1) LT2814842T (enExample)
PL (1) PL2814842T3 (enExample)
RS (1) RS57827B1 (enExample)
SI (1) SI2814842T1 (enExample)
SM (1) SMT201800620T1 (enExample)
WO (1) WO2013120554A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107106672A (zh) * 2015-01-12 2017-08-29 新加坡科技研究局 用于预防和治疗免疫介导性疾病的针对胞壁酰肽的单克隆抗体
CN107417773A (zh) * 2016-05-30 2017-12-01 国盛生化股份有限公司 新颖黏合细胞壁之胜肽序列
WO2025007943A1 (zh) * 2023-07-06 2025-01-09 荣昌生物制药(烟台)股份有限公司 用taci-fc融合蛋白治疗anca相关性血管炎的方法

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6400480B2 (ja) 2012-02-15 2018-10-03 ノヴォ ノルディスク アー／エス ペプチドグリカン認識タンパク質１に結合する抗体
CN103484468B (zh) * 2013-09-11 2015-04-08 华南农业大学 一种小菜蛾肽聚糖识别蛋白及其制备方法与应用
US11213598B2 (en) * 2015-11-12 2022-01-04 The Board Of Trustees Of The Leland Stanford Junior University Labeled probe and methods of use
WO2019032624A1 (en) * 2017-08-08 2019-02-14 Pionyr Immunotherapeutics, Inc. COMPOSITIONS AND METHODS FOR DEACTIVATING TREM1-EXPRESSING MESHLOID CELLS
US10836828B2 (en) 2019-02-06 2020-11-17 Pionyr Immunotherapeutics, Inc. Anti-TREM1 antibodies and related methods
CN109879956A (zh) * 2019-03-04 2019-06-14 哈尔滨工业大学 一种肿瘤免疫生物标志物及其应用
CN115611982B (zh) * 2021-07-14 2024-05-10 浙江大学 一种抗人MICA/Bα3区的单克隆抗体及其应用
CN115873109B (zh) * 2022-05-16 2024-02-09 江苏省中国科学院植物研究所 单克隆抗体及其在制备用于预防/治疗神经系统退行性疾病的生物制品中的应用
WO2025042607A1 (en) * 2023-08-18 2025-02-27 The Brigham And Women's Hospital, Inc. Modulation of pglyrp1 for treatment of cancer and autoimmunity
CN119286795B (zh) * 2024-12-12 2025-02-25 天津一瑞生物科技股份有限公司 鼠抗革兰阳性菌肽聚糖杂交瘤细胞株,单克隆抗体和应用
CN120718152B (zh) * 2025-09-01 2025-11-18 北京大学口腔医学院 一种特异性结合pglyrp1的单克隆抗体及其制备方法和应用
CN120737201B (zh) * 2025-09-01 2025-11-18 北京大学口腔医学院 一种靶向pglyrp1的单克隆抗体及其制备方法和应用
CN120737202B (zh) * 2025-09-01 2025-11-14 北京大学口腔医学院 一种抗pglyrp1抗体及其制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101139599A (zh) * 2007-08-07 2008-03-12 西南大学 家蚕肽聚糖识别蛋白基因
CN101619102A (zh) * 2008-12-16 2010-01-06 中国科学院海洋研究所 一种具杀菌活性的栉孔扇贝肽聚糖识别蛋白的制备及应用

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