JP6400480B2 - ペプチドグリカン認識タンパク質１に結合する抗体 - Google Patents

ペプチドグリカン認識タンパク質１に結合する抗体 Download PDF

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Publication number
JP6400480B2
JP6400480B2 JP2014556935A JP2014556935A JP6400480B2 JP 6400480 B2 JP6400480 B2 JP 6400480B2 JP 2014556935 A JP2014556935 A JP 2014556935A JP 2014556935 A JP2014556935 A JP 2014556935A JP 6400480 B2 JP6400480 B2 JP 6400480B2
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Prior art keywords
seq
amino acid
pglyrp1
antibody
sequence
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JP2015508763A5 (enExample
JP2015508763A (ja
Inventor
ヴィーベケ・ヴェストフェール・ステンニッケ
クレスティーネ・ブレンデル・レアド
ジョー・クイパー
シャオティン・タン
マーク・ヘイペル
シヴ・アンネグレテ・ヨルト
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Novo Nordisk AS
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Novo Nordisk AS
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2014556935A 2012-02-15 2012-11-30 ペプチドグリカン認識タンパク質１に結合する抗体 Active JP6400480B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261598968P 2012-02-15 2012-02-15
US61/598,968 2012-02-15
EP12158974 2012-03-12
EP12158974.1 2012-03-12
US201261672799P 2012-07-18 2012-07-18
US61/672,799 2012-07-18
PCT/EP2012/074093 WO2013120554A1 (en) 2012-02-15 2012-11-30 Antibodies that bind peptidoglycan recognition protein 1

Publications (3)

Publication Number Publication Date
JP2015508763A JP2015508763A (ja) 2015-03-23
JP2015508763A5 JP2015508763A5 (enExample) 2016-01-21
JP6400480B2 true JP6400480B2 (ja) 2018-10-03

Family

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Family Applications (1)

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JP2014556935A Active JP6400480B2 (ja) 2012-02-15 2012-11-30 ペプチドグリカン認識タンパク質１に結合する抗体

Country Status (13)

Country Link
US (3) US9663568B2 (enExample)
EP (2) EP3456742A1 (enExample)
JP (1) JP6400480B2 (enExample)
CN (2) CN104203977A (enExample)
DK (1) DK2814842T3 (enExample)
ES (1) ES2690786T3 (enExample)
HR (1) HRP20181817T1 (enExample)
LT (1) LT2814842T (enExample)
PL (1) PL2814842T3 (enExample)
RS (1) RS57827B1 (enExample)
SI (1) SI2814842T1 (enExample)
SM (1) SMT201800620T1 (enExample)
WO (1) WO2013120554A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3456742A1 (en) 2012-02-15 2019-03-20 Novo Nordisk A/S Antibodies that bind peptidoglycan recognition protein 1
CN103484468B (zh) * 2013-09-11 2015-04-08 华南农业大学 一种小菜蛾肽聚糖识别蛋白及其制备方法与应用
CN107106672B (zh) * 2015-01-12 2021-06-22 新加坡科技研究局 用于预防和治疗免疫介导性疾病的针对胞壁酰肽的单克隆抗体
WO2017083682A1 (en) * 2015-11-12 2017-05-18 The Board Of Trustees Of Leland Stanford Junior University Labeled probe and methods of use
CN107417773B (zh) * 2016-05-30 2020-09-08 国盛生化股份有限公司 黏合细胞壁之胜肽
EP3664845A4 (en) * 2017-08-08 2021-03-10 Pionyr Immunotherapeutics, Inc. COMPOSITIONS AND METHODS FOR DEACTIVATING MEYLOID CELLS EXPRESSING TREM1
US10836828B2 (en) 2019-02-06 2020-11-17 Pionyr Immunotherapeutics, Inc. Anti-TREM1 antibodies and related methods
CN109879956A (zh) * 2019-03-04 2019-06-14 哈尔滨工业大学 一种肿瘤免疫生物标志物及其应用
CN115611982B (zh) * 2021-07-14 2024-05-10 浙江大学 一种抗人MICA/Bα3区的单克隆抗体及其应用
CN115873109B (zh) * 2022-05-16 2024-02-09 江苏省中国科学院植物研究所 单克隆抗体及其在制备用于预防/治疗神经系统退行性疾病的生物制品中的应用
WO2025007943A1 (zh) * 2023-07-06 2025-01-09 荣昌生物制药(烟台)股份有限公司 用taci-fc融合蛋白治疗anca相关性血管炎的方法
WO2025042607A1 (en) * 2023-08-18 2025-02-27 The Brigham And Women's Hospital, Inc. Modulation of pglyrp1 for treatment of cancer and autoimmunity
CN119286795B (zh) * 2024-12-12 2025-02-25 天津一瑞生物科技股份有限公司 鼠抗革兰阳性菌肽聚糖杂交瘤细胞株,单克隆抗体和应用
CN120718152B (zh) * 2025-09-01 2025-11-18 北京大学口腔医学院 一种特异性结合pglyrp1的单克隆抗体及其制备方法和应用
CN120737202B (zh) * 2025-09-01 2025-11-14 北京大学口腔医学院 一种抗pglyrp1抗体及其制备方法和应用
CN120737201B (zh) * 2025-09-01 2025-11-18 北京大学口腔医学院 一种靶向pglyrp1的单克隆抗体及其制备方法和应用

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