CN1041938C - 三萜衍生物及含有它们的内皮素－受体拮抗剂 - Google Patents

三萜衍生物及含有它们的内皮素－受体拮抗剂 Download PDF

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Publication number
CN1041938C
CN1041938C CN94102805A CN94102805A CN1041938C CN 1041938 C CN1041938 C CN 1041938C CN 94102805 A CN94102805 A CN 94102805A CN 94102805 A CN94102805 A CN 94102805A CN 1041938 C CN1041938 C CN 1041938C
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CN
China
Prior art keywords
compound
ethyl acetate
endothelin
mmole
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN94102805A
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English (en)
Chinese (zh)
Other versions
CN1106368A (zh
Inventor
鸿池敏郎
荒木美贵
林哲良
樱井谦介
东条武彦
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
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Shionogi and Co Ltd
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Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of CN1106368A publication Critical patent/CN1106368A/zh
Application granted granted Critical
Publication of CN1041938C publication Critical patent/CN1041938C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
    • C07C233/33—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN94102805A 1993-06-11 1994-06-10 三萜衍生物及含有它们的内皮素－受体拮抗剂 Expired - Fee Related CN1041938C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP14041693 1993-06-11
JP140416/93 1993-06-11

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN98109227A Division CN1070183C (zh) 1993-06-11 1998-05-20 用于制备三萜衍生物的中间体

Publications (2)

Publication Number Publication Date
CN1106368A CN1106368A (zh) 1995-08-09
CN1041938C true CN1041938C (zh) 1999-02-03

Family

ID=15268217

Family Applications (2)

Application Number Title Priority Date Filing Date
CN94102805A Expired - Fee Related CN1041938C (zh) 1993-06-11 1994-06-10 三萜衍生物及含有它们的内皮素－受体拮抗剂
CN98109227A Expired - Fee Related CN1070183C (zh) 1993-06-11 1998-05-20 用于制备三萜衍生物的中间体

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN98109227A Expired - Fee Related CN1070183C (zh) 1993-06-11 1998-05-20 用于制备三萜衍生物的中间体

Country Status (11)

Country Link
US (2) US5463107A (enExample)
EP (2) EP0628569B1 (enExample)
JP (1) JP2724114B2 (enExample)
KR (1) KR100201015B1 (enExample)
CN (2) CN1041938C (enExample)
AT (2) ATE142640T1 (enExample)
DE (2) DE69400506T2 (enExample)
DK (1) DK0628569T3 (enExample)
ES (2) ES2094622T3 (enExample)
GR (1) GR3021952T3 (enExample)
TW (1) TW272974B (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0628569B1 (en) 1993-06-11 1996-09-11 Shionogi & Co., Ltd. Triterpene derivatives and endothelin-receptor antagonists containing the same
BR9608413A (pt) * 1995-06-02 1998-12-29 Shionogi & Co Inibidor de edema cerebral
WO1997027314A1 (fr) * 1996-01-23 1997-07-31 Shionogi & Co., Ltd. Processus de production d'analogues d'acide oleanolique par la culture de racine pileuse
JP2007217438A (ja) * 2001-07-17 2007-08-30 Shionogi & Co Ltd 注射用医薬製剤
TWI232102B (en) * 2001-07-17 2005-05-11 Shionogi & Co A pharmaceutical formulation for injection
US7223882B2 (en) 2002-03-22 2007-05-29 Shionogi & Co., Ltd. Process for producing triterpene derivative
EP1629853A1 (en) * 2003-06-04 2006-03-01 SHIONOGI & CO., LTD. Method for preparing powder exhibiting low susceptibility to electrification
TWI335335B (en) * 2004-03-24 2011-01-01 Shionogi & Co A novel crystal of a triterpene derivative
EP1757573A4 (en) 2004-05-14 2008-05-07 Shionogi & Co Oxidation reaction of alcohol with hydrogen peroxide and tungsten catalyst
JPWO2006077801A1 (ja) * 2005-01-18 2008-06-19 塩野義製薬株式会社 ミリセロン誘導体の製造方法
TW200731966A (en) * 2005-12-21 2007-09-01 Shionogi & Co A pharmaceutical composition or a method for treating ischemic stroke
US7323476B2 (en) * 2006-03-03 2008-01-29 Savipu Pharmaceuticals Myriceric acid derivatives for the treatment of cancer, cardiovascular and inflammatory diseases
US20070207989A1 (en) * 2006-03-03 2007-09-06 Savipu Pharmaceuticals Diterpene derivatives for the treatment of cardiovascular, cancer and inflammatory diseases
WO2007103727A2 (en) * 2006-03-03 2007-09-13 Savipu Pharmaceuticals Triterpene derivatives for the treatment of cancer and inflammatory disease by inhibition of nf-kb
US20070243273A1 (en) * 2006-04-12 2007-10-18 Savipu Pharmaceuticals Reduction of the Deleterious Effects of Tobacco Smoking
US20080017207A1 (en) * 2006-07-18 2008-01-24 Savipu Pharmaceuticals Reduction of the Deleterious Effects of Tobacco Smoking by the Induction of Phase 2 Enzymes by Nerf2
US20080187608A1 (en) * 2007-02-05 2008-08-07 Savipu Pharmaceuticals Enriched fractions from clary sage for the treatment of cancer, cardiovascular and inflammatory diseases
US20090022821A1 (en) * 2007-07-17 2009-01-22 Inderjit Kumar Dev Compositions from wax myrtle for the treatment of cancer, cardiovascular and inflammatory diseases

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0526642A1 (en) * 1991-01-29 1993-02-10 Shionogi Seiyaku Kabushiki Kaisha Triterpene derivative

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0628569B1 (en) 1993-06-11 1996-09-11 Shionogi & Co., Ltd. Triterpene derivatives and endothelin-receptor antagonists containing the same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0526642A1 (en) * 1991-01-29 1993-02-10 Shionogi Seiyaku Kabushiki Kaisha Triterpene derivative

Also Published As

Publication number Publication date
EP0682009A3 (en) 1997-02-05
DE69400506D1 (de) 1996-10-17
CN1070183C (zh) 2001-08-29
ES2094622T3 (es) 1997-01-16
TW272974B (enExample) 1996-03-21
DE69410081D1 (de) 1998-06-10
CN1215725A (zh) 1999-05-05
ATE142640T1 (de) 1996-09-15
DE69400506T2 (de) 1997-02-13
JPH0753484A (ja) 1995-02-28
US5587505A (en) 1996-12-24
ATE165811T1 (de) 1998-05-15
DK0628569T3 (da) 1996-09-30
KR100201015B1 (ko) 1999-06-15
KR950000663A (ko) 1995-01-03
CN1106368A (zh) 1995-08-09
EP0628569B1 (en) 1996-09-11
JP2724114B2 (ja) 1998-03-09
US5463107A (en) 1995-10-31
DE69410081T2 (de) 1998-10-08
EP0682009A2 (en) 1995-11-15
ES2116663T3 (es) 1998-07-16
GR3021952T3 (en) 1997-03-31
EP0628569A1 (en) 1994-12-14
EP0682009B1 (en) 1998-05-06

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 19990203

Termination date: 20110610