ES2116663T3 - Compuestos intermediarios para la preparacion de derivados triterpenos antagonistas del receptor de endotelina. - Google Patents

Compuestos intermediarios para la preparacion de derivados triterpenos antagonistas del receptor de endotelina.

Info

Publication number
ES2116663T3
ES2116663T3 ES95112524T ES95112524T ES2116663T3 ES 2116663 T3 ES2116663 T3 ES 2116663T3 ES 95112524 T ES95112524 T ES 95112524T ES 95112524 T ES95112524 T ES 95112524T ES 2116663 T3 ES2116663 T3 ES 2116663T3
Authority
ES
Spain
Prior art keywords
derivatives
triterpen
antagonist
preparation
endothelin receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95112524T
Other languages
English (en)
Inventor
Toshiro Konoike
Yoshitaka Araki
Tetsuyoshi Hayashi
Kensuke Sakurai
Takehiko Tozyo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Application granted granted Critical
Publication of ES2116663T3 publication Critical patent/ES2116663T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
    • C07C233/33—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Abstract

LOS COMPUESTOS INTERMEDIOS PARA LA PREPARACION DE COMPUESTOS DE TRITEPENO ANTAGONISTAS DE RECEPTOR DE ENDOTELINA TIENEN LA FORMULA (III) EN LA QUE R2 ES HIDROGENO O R3 ES SO3-, -CHO2COO-, -COCOO-, O -COR5COO- DONDE R5 ES ALKILENO C1-6 O HASTA ALKENILENO C6, R4 ES HIDROGENO, ALKILO C1-6 RECTO O RAMIFICADO Y R7 ES T-BUTOXICARBONILO O HIDROGENO, O UNA DE SUS SALES FARMACEUTICAMENTE ACEPTABLE.
ES95112524T 1993-06-11 1994-06-09 Compuestos intermediarios para la preparacion de derivados triterpenos antagonistas del receptor de endotelina. Expired - Lifetime ES2116663T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14041693 1993-06-11

Publications (1)

Publication Number Publication Date
ES2116663T3 true ES2116663T3 (es) 1998-07-16

Family

ID=15268217

Family Applications (2)

Application Number Title Priority Date Filing Date
ES94304165T Expired - Lifetime ES2094622T3 (es) 1993-06-11 1994-06-09 Derivados triterpenos y antagonistas del receptor de endotelina que los contiene.
ES95112524T Expired - Lifetime ES2116663T3 (es) 1993-06-11 1994-06-09 Compuestos intermediarios para la preparacion de derivados triterpenos antagonistas del receptor de endotelina.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES94304165T Expired - Lifetime ES2094622T3 (es) 1993-06-11 1994-06-09 Derivados triterpenos y antagonistas del receptor de endotelina que los contiene.

Country Status (11)

Country Link
US (2) US5463107A (es)
EP (2) EP0628569B1 (es)
JP (1) JP2724114B2 (es)
KR (1) KR100201015B1 (es)
CN (2) CN1041938C (es)
AT (2) ATE165811T1 (es)
DE (2) DE69410081T2 (es)
DK (1) DK0628569T3 (es)
ES (2) ES2094622T3 (es)
GR (1) GR3021952T3 (es)
TW (1) TW272974B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2094622T3 (es) 1993-06-11 1997-01-16 Shionogi & Co Derivados triterpenos y antagonistas del receptor de endotelina que los contiene.
DK0838223T3 (da) * 1995-06-02 2003-11-17 Shionogi & Co Hjerneødeminhibitor
WO1997027314A1 (fr) * 1996-01-23 1997-07-31 Shionogi & Co., Ltd. Processus de production d'analogues d'acide oleanolique par la culture de racine pileuse
TWI232102B (en) 2001-07-17 2005-05-11 Shionogi & Co A pharmaceutical formulation for injection
JP2007217438A (ja) * 2001-07-17 2007-08-30 Shionogi & Co Ltd 注射用医薬製剤
JP4437923B2 (ja) * 2002-03-22 2010-03-24 塩野義製薬株式会社 トリテルペン誘導体の製造方法
JPWO2004108163A1 (ja) * 2003-06-04 2006-07-20 塩野義製薬株式会社 低帯電性粉末の製造方法
TWI335335B (en) * 2004-03-24 2011-01-01 Shionogi & Co A novel crystal of a triterpene derivative
JP4827189B2 (ja) 2004-05-14 2011-11-30 塩野義製薬株式会社 過酸化水素およびタングステン触媒を用いたアルコールの酸化反応
WO2006077801A1 (ja) * 2005-01-18 2006-07-27 Shionogi & Co., Ltd. ミリセロン誘導体の製造方法
US20090030075A1 (en) * 2005-12-21 2009-01-29 Mitsuyoshi Ninomiya Remedy for and Method of Treating Ischemic Cerebral Stroke
WO2007103727A2 (en) * 2006-03-03 2007-09-13 Savipu Pharmaceuticals Triterpene derivatives for the treatment of cancer and inflammatory disease by inhibition of nf-kb
US20070207989A1 (en) * 2006-03-03 2007-09-06 Savipu Pharmaceuticals Diterpene derivatives for the treatment of cardiovascular, cancer and inflammatory diseases
US7323476B2 (en) * 2006-03-03 2008-01-29 Savipu Pharmaceuticals Myriceric acid derivatives for the treatment of cancer, cardiovascular and inflammatory diseases
US20070243273A1 (en) * 2006-04-12 2007-10-18 Savipu Pharmaceuticals Reduction of the Deleterious Effects of Tobacco Smoking
US20080017207A1 (en) * 2006-07-18 2008-01-24 Savipu Pharmaceuticals Reduction of the Deleterious Effects of Tobacco Smoking by the Induction of Phase 2 Enzymes by Nerf2
US20080187608A1 (en) * 2007-02-05 2008-08-07 Savipu Pharmaceuticals Enriched fractions from clary sage for the treatment of cancer, cardiovascular and inflammatory diseases
US20090022821A1 (en) * 2007-07-17 2009-01-22 Inderjit Kumar Dev Compositions from wax myrtle for the treatment of cancer, cardiovascular and inflammatory diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2115665T3 (es) 1991-01-29 1998-07-01 Shionogi & Co Derivado de triterpeno.
ES2094622T3 (es) 1993-06-11 1997-01-16 Shionogi & Co Derivados triterpenos y antagonistas del receptor de endotelina que los contiene.

Also Published As

Publication number Publication date
EP0682009A2 (en) 1995-11-15
GR3021952T3 (en) 1997-03-31
EP0628569A1 (en) 1994-12-14
TW272974B (es) 1996-03-21
DE69410081T2 (de) 1998-10-08
KR950000663A (ko) 1995-01-03
CN1070183C (zh) 2001-08-29
JP2724114B2 (ja) 1998-03-09
EP0682009A3 (en) 1997-02-05
DK0628569T3 (da) 1996-09-30
DE69410081D1 (de) 1998-06-10
ES2094622T3 (es) 1997-01-16
ATE165811T1 (de) 1998-05-15
KR100201015B1 (ko) 1999-06-15
CN1215725A (zh) 1999-05-05
DE69400506T2 (de) 1997-02-13
CN1041938C (zh) 1999-02-03
ATE142640T1 (de) 1996-09-15
JPH0753484A (ja) 1995-02-28
EP0628569B1 (en) 1996-09-11
CN1106368A (zh) 1995-08-09
US5463107A (en) 1995-10-31
DE69400506D1 (de) 1996-10-17
EP0682009B1 (en) 1998-05-06
US5587505A (en) 1996-12-24

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