ATE165811T1 - Zwischenprodukte für die herstellung von endothelinrezeptor-antagonist-triterpen-derivat n - Google Patents

Zwischenprodukte für die herstellung von endothelinrezeptor-antagonist-triterpen-derivat n

Info

Publication number
ATE165811T1
ATE165811T1 AT95112524T AT95112524T ATE165811T1 AT E165811 T1 ATE165811 T1 AT E165811T1 AT 95112524 T AT95112524 T AT 95112524T AT 95112524 T AT95112524 T AT 95112524T AT E165811 T1 ATE165811 T1 AT E165811T1
Authority
AT
Austria
Prior art keywords
production
receptor antagonist
intermediate products
endothelin receptor
hydrogen
Prior art date
Application number
AT95112524T
Other languages
English (en)
Inventor
Toshiro Konoike
Yoshitaka Araki
Tetsuyoshi Hayashi
Kensuke Sakurai
Takehiko Tozyo
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Application granted granted Critical
Publication of ATE165811T1 publication Critical patent/ATE165811T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J63/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/01Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/30Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
    • C07C233/33Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/18Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J63/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT95112524T 1993-06-11 1994-06-09 Zwischenprodukte für die herstellung von endothelinrezeptor-antagonist-triterpen-derivat n ATE165811T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14041693 1993-06-11

Publications (1)

Publication Number Publication Date
ATE165811T1 true ATE165811T1 (de) 1998-05-15

Family

ID=15268217

Family Applications (2)

Application Number Title Priority Date Filing Date
AT95112524T ATE165811T1 (de) 1993-06-11 1994-06-09 Zwischenprodukte für die herstellung von endothelinrezeptor-antagonist-triterpen-derivat n
AT94304165T ATE142640T1 (de) 1993-06-11 1994-06-09 Triterpenderivate und diese enthaltende endothelinrezeptor antagonisten

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT94304165T ATE142640T1 (de) 1993-06-11 1994-06-09 Triterpenderivate und diese enthaltende endothelinrezeptor antagonisten

Country Status (11)

Country Link
US (2) US5463107A (de)
EP (2) EP0628569B1 (de)
JP (1) JP2724114B2 (de)
KR (1) KR100201015B1 (de)
CN (2) CN1041938C (de)
AT (2) ATE165811T1 (de)
DE (2) DE69400506T2 (de)
DK (1) DK0628569T3 (de)
ES (2) ES2116663T3 (de)
GR (1) GR3021952T3 (de)
TW (1) TW272974B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2116663T3 (es) 1993-06-11 1998-07-16 Shionogi & Co Compuestos intermediarios para la preparacion de derivados triterpenos antagonistas del receptor de endotelina.
KR100399797B1 (ko) * 1995-06-02 2004-04-13 시오노기세이야쿠가부시키가이샤 뇌부종억제제
WO1997027314A1 (fr) * 1996-01-23 1997-07-31 Shionogi & Co., Ltd. Processus de production d'analogues d'acide oleanolique par la culture de racine pileuse
TWI232102B (en) * 2001-07-17 2005-05-11 Shionogi & Co A pharmaceutical formulation for injection
JP2007217438A (ja) * 2001-07-17 2007-08-30 Shionogi & Co Ltd 注射用医薬製剤
JP4437923B2 (ja) 2002-03-22 2010-03-24 塩野義製薬株式会社 トリテルペン誘導体の製造方法
EP1629853A1 (de) * 2003-06-04 2006-03-01 SHIONOGI & CO., LTD. Verfahren zur herstellung eines pulvers mit geringer anfälligkeit für elektrifizierung
TWI335335B (en) * 2004-03-24 2011-01-01 Shionogi & Co A novel crystal of a triterpene derivative
JP4827189B2 (ja) 2004-05-14 2011-11-30 塩野義製薬株式会社 過酸化水素およびタングステン触媒を用いたアルコールの酸化反応
JPWO2006077801A1 (ja) * 2005-01-18 2008-06-19 塩野義製薬株式会社 ミリセロン誘導体の製造方法
EP1964556A4 (de) * 2005-12-21 2010-03-24 Shionogi & Co Therapeutisches mittel oder therapeutisches verfahren gegen ischämischen schlaganfall
WO2007103727A2 (en) * 2006-03-03 2007-09-13 Savipu Pharmaceuticals Triterpene derivatives for the treatment of cancer and inflammatory disease by inhibition of nf-kb
US7323476B2 (en) * 2006-03-03 2008-01-29 Savipu Pharmaceuticals Myriceric acid derivatives for the treatment of cancer, cardiovascular and inflammatory diseases
US20070207989A1 (en) * 2006-03-03 2007-09-06 Savipu Pharmaceuticals Diterpene derivatives for the treatment of cardiovascular, cancer and inflammatory diseases
US20070243273A1 (en) * 2006-04-12 2007-10-18 Savipu Pharmaceuticals Reduction of the Deleterious Effects of Tobacco Smoking
US20080017207A1 (en) * 2006-07-18 2008-01-24 Savipu Pharmaceuticals Reduction of the Deleterious Effects of Tobacco Smoking by the Induction of Phase 2 Enzymes by Nerf2
US20080187608A1 (en) * 2007-02-05 2008-08-07 Savipu Pharmaceuticals Enriched fractions from clary sage for the treatment of cancer, cardiovascular and inflammatory diseases
US20090022821A1 (en) * 2007-07-17 2009-01-22 Inderjit Kumar Dev Compositions from wax myrtle for the treatment of cancer, cardiovascular and inflammatory diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2115665T3 (es) 1991-01-29 1998-07-01 Shionogi & Co Derivado de triterpeno.
ES2116663T3 (es) 1993-06-11 1998-07-16 Shionogi & Co Compuestos intermediarios para la preparacion de derivados triterpenos antagonistas del receptor de endotelina.

Also Published As

Publication number Publication date
TW272974B (de) 1996-03-21
CN1106368A (zh) 1995-08-09
KR100201015B1 (ko) 1999-06-15
ES2116663T3 (es) 1998-07-16
KR950000663A (ko) 1995-01-03
DE69400506D1 (de) 1996-10-17
EP0682009A3 (de) 1997-02-05
EP0682009B1 (de) 1998-05-06
EP0682009A2 (de) 1995-11-15
US5463107A (en) 1995-10-31
ATE142640T1 (de) 1996-09-15
EP0628569A1 (de) 1994-12-14
GR3021952T3 (en) 1997-03-31
EP0628569B1 (de) 1996-09-11
DE69410081T2 (de) 1998-10-08
DE69400506T2 (de) 1997-02-13
CN1215725A (zh) 1999-05-05
DK0628569T3 (da) 1996-09-30
CN1070183C (zh) 2001-08-29
CN1041938C (zh) 1999-02-03
DE69410081D1 (de) 1998-06-10
JPH0753484A (ja) 1995-02-28
JP2724114B2 (ja) 1998-03-09
ES2094622T3 (es) 1997-01-16
US5587505A (en) 1996-12-24

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee