ATE142640T1 - Triterpenderivate und diese enthaltende endothelinrezeptor antagonisten - Google Patents

Triterpenderivate und diese enthaltende endothelinrezeptor antagonisten

Info

Publication number
ATE142640T1
ATE142640T1 AT94304165T AT94304165T ATE142640T1 AT E142640 T1 ATE142640 T1 AT E142640T1 AT 94304165 T AT94304165 T AT 94304165T AT 94304165 T AT94304165 T AT 94304165T AT E142640 T1 ATE142640 T1 AT E142640T1
Authority
AT
Austria
Prior art keywords
derivatives
triterpender
receptor antagonists
containing same
endothelin receptor
Prior art date
Application number
AT94304165T
Other languages
English (en)
Inventor
Toshiro Konoike
Yoshitaka Araki
Tetsuyoshi Hayashi
Kensuke Sakurai
Takehiko Tozyo
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Application granted granted Critical
Publication of ATE142640T1 publication Critical patent/ATE142640T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
    • C07C233/33—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT94304165T 1993-06-11 1994-06-09 Triterpenderivate und diese enthaltende endothelinrezeptor antagonisten ATE142640T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14041693 1993-06-11

Publications (1)

Publication Number Publication Date
ATE142640T1 true ATE142640T1 (de) 1996-09-15

Family

ID=15268217

Family Applications (2)

Application Number Title Priority Date Filing Date
AT95112524T ATE165811T1 (de) 1993-06-11 1994-06-09 Zwischenprodukte für die herstellung von endothelinrezeptor-antagonist-triterpen-derivat n
AT94304165T ATE142640T1 (de) 1993-06-11 1994-06-09 Triterpenderivate und diese enthaltende endothelinrezeptor antagonisten

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT95112524T ATE165811T1 (de) 1993-06-11 1994-06-09 Zwischenprodukte für die herstellung von endothelinrezeptor-antagonist-triterpen-derivat n

Country Status (11)

Country Link
US (2) US5463107A (de)
EP (2) EP0628569B1 (de)
JP (1) JP2724114B2 (de)
KR (1) KR100201015B1 (de)
CN (2) CN1041938C (de)
AT (2) ATE165811T1 (de)
DE (2) DE69410081T2 (de)
DK (1) DK0628569T3 (de)
ES (2) ES2116663T3 (de)
GR (1) GR3021952T3 (de)
TW (1) TW272974B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW272974B (de) 1993-06-11 1996-03-21 Shionogi & Co
KR100399797B1 (ko) * 1995-06-02 2004-04-13 시오노기세이야쿠가부시키가이샤 뇌부종억제제
WO1997027314A1 (fr) * 1996-01-23 1997-07-31 Shionogi & Co., Ltd. Processus de production d'analogues d'acide oleanolique par la culture de racine pileuse
JP2007217438A (ja) * 2001-07-17 2007-08-30 Shionogi & Co Ltd 注射用医薬製剤
TWI232102B (en) * 2001-07-17 2005-05-11 Shionogi & Co A pharmaceutical formulation for injection
MXPA04008944A (es) 2002-03-22 2004-11-26 Shionogi & Co Procedimiento para derivados de triterpeno.
EP1629853A1 (de) * 2003-06-04 2006-03-01 SHIONOGI & CO., LTD. Verfahren zur herstellung eines pulvers mit geringer anfälligkeit für elektrifizierung
TWI335335B (en) * 2004-03-24 2011-01-01 Shionogi & Co A novel crystal of a triterpene derivative
WO2005110958A1 (ja) 2004-05-14 2005-11-24 Shionogi & Co., Ltd. 過酸化水素およびタングステン触媒を用いたアルコールの酸化反応
JPWO2006077801A1 (ja) * 2005-01-18 2008-06-19 塩野義製薬株式会社 ミリセロン誘導体の製造方法
JPWO2007072845A1 (ja) * 2005-12-21 2009-05-28 塩野義製薬株式会社 虚血性脳卒中治療薬または治療方法
US7323476B2 (en) * 2006-03-03 2008-01-29 Savipu Pharmaceuticals Myriceric acid derivatives for the treatment of cancer, cardiovascular and inflammatory diseases
US7795306B2 (en) * 2006-03-03 2010-09-14 Inderjit Kumar Dev Triterpene derivatives for the treatment of cancer and inflammatory disease by inhibition of NF-κB
US20070207989A1 (en) * 2006-03-03 2007-09-06 Savipu Pharmaceuticals Diterpene derivatives for the treatment of cardiovascular, cancer and inflammatory diseases
US20070243273A1 (en) * 2006-04-12 2007-10-18 Savipu Pharmaceuticals Reduction of the Deleterious Effects of Tobacco Smoking
US20080017207A1 (en) * 2006-07-18 2008-01-24 Savipu Pharmaceuticals Reduction of the Deleterious Effects of Tobacco Smoking by the Induction of Phase 2 Enzymes by Nerf2
US20080187608A1 (en) * 2007-02-05 2008-08-07 Savipu Pharmaceuticals Enriched fractions from clary sage for the treatment of cancer, cardiovascular and inflammatory diseases
US20090022821A1 (en) * 2007-07-17 2009-01-22 Inderjit Kumar Dev Compositions from wax myrtle for the treatment of cancer, cardiovascular and inflammatory diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69129193T2 (de) * 1991-01-29 1998-07-30 Shionogi Seiyaku K K Trading U Triterpenderivat
TW272974B (de) 1993-06-11 1996-03-21 Shionogi & Co

Also Published As

Publication number Publication date
ATE165811T1 (de) 1998-05-15
DE69400506D1 (de) 1996-10-17
JPH0753484A (ja) 1995-02-28
DE69410081D1 (de) 1998-06-10
KR950000663A (ko) 1995-01-03
KR100201015B1 (ko) 1999-06-15
GR3021952T3 (en) 1997-03-31
CN1106368A (zh) 1995-08-09
EP0682009B1 (de) 1998-05-06
ES2094622T3 (es) 1997-01-16
EP0628569B1 (de) 1996-09-11
DE69410081T2 (de) 1998-10-08
CN1041938C (zh) 1999-02-03
EP0682009A2 (de) 1995-11-15
EP0628569A1 (de) 1994-12-14
CN1215725A (zh) 1999-05-05
CN1070183C (zh) 2001-08-29
JP2724114B2 (ja) 1998-03-09
US5587505A (en) 1996-12-24
TW272974B (de) 1996-03-21
DE69400506T2 (de) 1997-02-13
US5463107A (en) 1995-10-31
DK0628569T3 (da) 1996-09-30
EP0682009A3 (de) 1997-02-05
ES2116663T3 (es) 1998-07-16

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee