ATE168372T1 - Hepoxilin analoga verwendbar als entzündungshemmende mittel - Google Patents
Hepoxilin analoga verwendbar als entzündungshemmende mittelInfo
- Publication number
- ATE168372T1 ATE168372T1 AT94912660T AT94912660T ATE168372T1 AT E168372 T1 ATE168372 T1 AT E168372T1 AT 94912660 T AT94912660 T AT 94912660T AT 94912660 T AT94912660 T AT 94912660T AT E168372 T1 ATE168372 T1 AT E168372T1
- Authority
- AT
- Austria
- Prior art keywords
- double
- alkyl
- triple bonds
- hepoxilin
- analogue
- Prior art date
Links
- 150000002377 hepoxilins Chemical class 0.000 title abstract 2
- 229940121363 anti-inflammatory agent Drugs 0.000 title 1
- 239000002260 anti-inflammatory agent Substances 0.000 title 1
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- SGTUOBURCVMACZ-LMIMMGIZSA-N (5e,9e)-8-hydroxy-10-[3-[(e)-oct-2-enyl]oxiran-2-yl]deca-5,9-dienoic acid Chemical compound CCCCC\C=C\CC1OC1\C=C\C(O)C\C=C\CCCC(O)=O SGTUOBURCVMACZ-LMIMMGIZSA-N 0.000 abstract 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 150000005840 aryl radicals Chemical class 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000002148 esters Chemical group 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- -1 substituted alkyl radicals Chemical class 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D331/00—Heterocyclic compounds containing rings of less than five members, having one sulfur atom as the only ring hetero atom
- C07D331/02—Three-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
- C07C45/292—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with chromium derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/38—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings
- C07C47/45—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings having unsaturation outside the rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D303/40—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by ester radicals
- C07D303/42—Acyclic compounds having a chain of seven or more carbon atoms, e.g. epoxidised fats
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Chemical And Physical Treatments For Wood And The Like (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3832493A | 1993-03-29 | 1993-03-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE168372T1 true ATE168372T1 (de) | 1998-08-15 |
Family
ID=21899300
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94912660T ATE168372T1 (de) | 1993-03-29 | 1994-03-28 | Hepoxilin analoga verwendbar als entzündungshemmende mittel |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5616607A (de) |
| EP (1) | EP0691963B1 (de) |
| AT (1) | ATE168372T1 (de) |
| AU (1) | AU6511794A (de) |
| CA (1) | CA2159584A1 (de) |
| DE (1) | DE69411716T2 (de) |
| WO (1) | WO1994022848A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69524639T2 (de) * | 1994-10-13 | 2002-08-08 | Peptech Ltd., North Ryde | Modifizierte mehrfach ungesättigte fettsäuren |
| WO1997038688A1 (en) * | 1996-04-12 | 1997-10-23 | Peptide Technology Pty. Limited | Methods of treating immunopathologies using polyunsaturated fattyacids |
| US6673785B1 (en) | 1999-08-04 | 2004-01-06 | Cecil R. Pace-Asciak | Use of hepoxilins or hepoxilin analogs as antidiabetics, antiinflammatory agents |
| WO2001010422A2 (en) * | 1999-08-04 | 2001-02-15 | Hsc Research And Development Limited Partnership | Use of hepoxilins or hepoxilin analogs as antidiabetics, antiinframmatory agents |
| CA2427774C (en) | 2000-11-09 | 2013-01-15 | The Hospital For Sick Children | Inhibitors of thromboxane formation and action |
| ATE443520T1 (de) * | 2002-05-28 | 2009-10-15 | Pace Asciak Cecil R | Zusammensetzungen, hepoxilinanaloga enthaltend, und deren verwendung in der krebsbehandlung |
| WO2004104022A2 (en) * | 2003-05-16 | 2004-12-02 | The General Hospital Corporation | Compositions comprising pathogen elicited epithelial chemoattractant (eicosanoid hepoxilin a3), inhibitors thereof and methods of use thereof |
| WO2006106438A2 (en) * | 2005-01-11 | 2006-10-12 | Evolva Sa | Modulators of ppar activity |
| US8710252B2 (en) | 2006-04-19 | 2014-04-29 | Cecil Pace-Asciak | Hepodxilin analog enantiomers |
| CA3064132C (en) | 2017-07-07 | 2024-06-04 | Gregory Keyes | Fatty acid derivatives and their use |
| US12103898B2 (en) * | 2020-07-30 | 2024-10-01 | Firmenich Sa | Process for preparing diene |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3775432A (en) * | 1971-02-01 | 1973-11-27 | Zoecon Corp | Epithio dienamides |
| DE3518271A1 (de) * | 1985-05-22 | 1986-11-27 | Bayer Ag, 5090 Leverkusen | 2-(3-hydroxy-1-alkenyl)-cyclopropan-carboxamido-alkancarbonsaeuren und 2-(3-hydroxy-1-alkenyl)-cyclopropan-alkencarbonsaeuren, verfahren zu deren herstellung sowie die verwendung von 2-(3-hydroxy-1-alkenyl)-cyclopropan-carboxamido-alkancarbonsaeuren und 2-(3-hydroxy-1-alkenyl)-cyclopropan-alkencarbonsaeuren als arzneimittel |
-
1994
- 1994-03-28 AT AT94912660T patent/ATE168372T1/de not_active IP Right Cessation
- 1994-03-28 CA CA002159584A patent/CA2159584A1/en not_active Abandoned
- 1994-03-28 DE DE69411716T patent/DE69411716T2/de not_active Expired - Fee Related
- 1994-03-28 WO PCT/IB1994/000085 patent/WO1994022848A1/en not_active Ceased
- 1994-03-28 EP EP94912660A patent/EP0691963B1/de not_active Expired - Lifetime
- 1994-03-28 AU AU65117/94A patent/AU6511794A/en not_active Abandoned
-
1995
- 1995-03-21 US US08/405,603 patent/US5616607A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU6511794A (en) | 1994-10-24 |
| US5616607A (en) | 1997-04-01 |
| EP0691963B1 (de) | 1998-07-15 |
| WO1994022848A1 (en) | 1994-10-13 |
| CA2159584A1 (en) | 1994-10-13 |
| DE69411716D1 (de) | 1998-08-20 |
| EP0691963A1 (de) | 1996-01-17 |
| DE69411716T2 (de) | 1999-03-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |