ES2130403T3 - Derivado del acido quinolin-3-acetico, procedimiento para su produccion, y uso del mismo. - Google Patents

Derivado del acido quinolin-3-acetico, procedimiento para su produccion, y uso del mismo.

Info

Publication number
ES2130403T3
ES2130403T3 ES94904000T ES94904000T ES2130403T3 ES 2130403 T3 ES2130403 T3 ES 2130403T3 ES 94904000 T ES94904000 T ES 94904000T ES 94904000 T ES94904000 T ES 94904000T ES 2130403 T3 ES2130403 T3 ES 2130403T3
Authority
ES
Spain
Prior art keywords
acetic acid
same
neurosis
cataract
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94904000T
Other languages
English (en)
Inventor
Tomoji Aotsuka
Toshiyuki Nishio
Hiroshi Hosono
Yoshiyuki Nakamura
Tetsuo Matsui
Hiromichi Ishikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Senju Pharmaceutical Co Ltd
Welfide Corp
Original Assignee
Senju Pharmaceutical Co Ltd
Welfide Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senju Pharmaceutical Co Ltd, Welfide Corp filed Critical Senju Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2130403T3 publication Critical patent/ES2130403T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

SE PRESENTA UN DERIVADO DEL ACIDO QUINOLINA-3-ACETICO REPRESENTADO POR LA FORMULA GENERAL (I) O UNA SAL MEDICINALMENTE ACEPTABLE DEL MISMO, EN DONDE R1, R2 Y R3 PUEDEN SER IGUALES O DIFERENTES ENTRE SI Y CADA UNA DE ELLAS REPRESENTA HIDROGENO O HALOGENO; R4 REPRESENTA HIDROGENO, HALOGENO O ALQUILO INFERIOR SUSTITUIDO O INSUSTITUIDO; R5 REPRESENTA CARBOXILO OPCIONALMENTE ESTERIFICADO; Y LA LINEA DISCONTINUA REPRESENTA UNA PRESENCIA OPCIONAL DE UN DOBLE ENLACE. EL COMPUESTO (I) Y LA SAL DEL MISMO TIENEN UNA ACTIVIDAD INHIBITORIA DE LA REDUCTASA DE ALDOSA EN LOS MAMIFEROS, INCLUYENDO LOS HUMANOS, Y SON EXCELENTES EN SU SEGURIDAD DE USO Y POR LO TANTO UTILES COMO DROGA EN EL TRATAMIENTO TERAPEUTICO DE LAS COMPLICACIONES DE LA DIABETES, TAL COMO LOS DAÑOS CORNEALES, CATARATAS, NEUROSIS, LA RETINOPATIA Y LA NEFROPATIA, EN PARTICULAR LAS CATARATAS Y LA NEUROSIS.
ES94904000T 1993-01-06 1994-01-06 Derivado del acido quinolin-3-acetico, procedimiento para su produccion, y uso del mismo. Expired - Lifetime ES2130403T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP01589993A JP3195455B2 (ja) 1993-01-06 1993-01-06 キノリン−３−酢酸誘導体、その製造法と用途

Publications (1)

Publication Number Publication Date
ES2130403T3 true ES2130403T3 (es) 1999-07-01

Family

ID=11901633

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94904000T Expired - Lifetime ES2130403T3 (es) 1993-01-06 1994-01-06 Derivado del acido quinolin-3-acetico, procedimiento para su produccion, y uso del mismo.

Country Status (12)

Country Link
US (1) US5543420A (es)
EP (1) EP0633261B1 (es)
JP (1) JP3195455B2 (es)
KR (1) KR950700289A (es)
CN (1) CN1102040A (es)
AT (1) ATE179172T1 (es)
AU (1) AU667426B2 (es)
CA (1) CA2131370A1 (es)
DE (1) DE69417957T2 (es)
ES (1) ES2130403T3 (es)
TW (1) TW287162B (es)
WO (1) WO1994015934A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5700819A (en) * 1994-11-29 1997-12-23 Grelan Pharmaceutical Co., Ltd. 2-substituted benzothiazole derivatives and prophylactic and therapeutic agents for the treatment of diabetic complications
TNSN99224A1 (fr) 1998-12-01 2005-11-10 Inst For Pharm Discovery Inc Methodes de reduction des niveaux de glucose et triglyceride en serum et pour suppression de l'antigenese utilisant les acides la indolealkanoique
CN101058558B (zh) * 2007-05-28 2013-04-10 沈阳药科大学 具有醛糖还原酶抑制活性的4-氧代-1(4h)-喹啉羧酸类化合物、组合物及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986007056A1 (en) * 1985-05-21 1986-12-04 Pfizer Inc. Hypoglycemic thiazolidinediones
JPS63270678A (ja) * 1987-04-30 1988-11-08 Mitsui Petrochem Ind Ltd 新規含窒素化合物
US5143930A (en) * 1990-02-07 1992-09-01 Sankyo Company, Limited Thiazolidine derivatives with anti-diabetic activity, their preparation and their use
TW202450B (es) * 1991-06-26 1993-03-21 Dainippon Pharmaceutical Co
US5262433A (en) * 1991-08-06 1993-11-16 Wakamoto Pharmaceutical Co., Ltd. Tetrazoleacetic acid derivatives and method of aldose reductase inhibition therewith

Also Published As

Publication number Publication date
KR950700289A (ko) 1995-01-16
TW287162B (es) 1996-10-01
CA2131370A1 (en) 1994-07-21
AU5823394A (en) 1994-08-15
WO1994015934A1 (en) 1994-07-21
DE69417957T2 (de) 1999-09-16
CN1102040A (zh) 1995-04-26
JPH06199851A (ja) 1994-07-19
EP0633261A4 (en) 1995-04-12
EP0633261A1 (en) 1995-01-11
US5543420A (en) 1996-08-06
ATE179172T1 (de) 1999-05-15
EP0633261B1 (en) 1999-04-21
AU667426B2 (en) 1996-03-21
JP3195455B2 (ja) 2001-08-06
DE69417957D1 (de) 1999-05-27

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