NO960777L - Anvendelse av N-alkylerte 1,4-dihydropyridin dikarboksylsyreestere som medikamenter - Google Patents

Anvendelse av N-alkylerte 1,4-dihydropyridin dikarboksylsyreestere som medikamenter

Info

Publication number
NO960777L
NO960777L NO960777A NO960777A NO960777L NO 960777 L NO960777 L NO 960777L NO 960777 A NO960777 A NO 960777A NO 960777 A NO960777 A NO 960777A NO 960777 L NO960777 L NO 960777L
Authority
NO
Norway
Prior art keywords
alkylated
dicarboxylic acid
acid esters
carbon atoms
medicaments
Prior art date
Application number
NO960777A
Other languages
English (en)
Other versions
NO960777D0 (no
Inventor
Siegfried Zaiss
Dieter Neuser
Johannes-Peter Stasch
Siegfried Goldmann
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of NO960777D0 publication Critical patent/NO960777D0/no
Publication of NO960777L publication Critical patent/NO960777L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Oppfinnelsen angår anvendelse av delvis kjente N-alkylerte l,4-dlhydropyridin dikarboksylsyreestere med generell formel (I), hvori R1 blant annet står for hydrogen, nitro, cyano eller trlfluormetyl, R2 står for hydrogen, halogen, nitro eller hydroksy, R3 står for hydrogen eller cyano, og R2 og R3 kan sammen danne en tllkondensert benzoring, R4 og R5 er like eller forskjellige og kan bety alkyl med inntil 8 karbonatomer , og kan være substituert, R^ står for rettkjedet eller forgrenet alkyl med inntil 6 karbonatomer eller cykloalkyl med 3 til 7 karbonatomer. Forbindelsene kan anvendes som antiatherosklerotlske medikamenter, særlig for å forhindre restenose etter angioplasti og kirurgi l blodkar.
NO960777A 1993-08-27 1996-02-26 Anvendelse av N-alkylerte 1,4-dihydropyridin dikarboksylsyreestere som medikamenter NO960777L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4328884A DE4328884A1 (de) 1993-08-27 1993-08-27 Verwendung von N-alkylierten 1,4-Dihydropyridincarbonsäureestern als Arzneimittel
PCT/EP1994/002723 WO1995005823A1 (de) 1993-08-27 1994-08-16 Verwendung von n-alkylierten 1,4-dihydropyridindicarbonsäureestern als arzneimittel

Publications (2)

Publication Number Publication Date
NO960777D0 NO960777D0 (no) 1996-02-26
NO960777L true NO960777L (no) 1996-04-10

Family

ID=6496196

Family Applications (1)

Application Number Title Priority Date Filing Date
NO960777A NO960777L (no) 1993-08-27 1996-02-26 Anvendelse av N-alkylerte 1,4-dihydropyridin dikarboksylsyreestere som medikamenter

Country Status (13)

Country Link
EP (1) EP0714301A1 (no)
JP (1) JPH09501923A (no)
KR (1) KR960703594A (no)
CN (1) CN1129906A (no)
AU (1) AU7613594A (no)
BG (1) BG100367A (no)
CA (1) CA2170285A1 (no)
CZ (1) CZ43896A3 (no)
DE (1) DE4328884A1 (no)
HU (1) HUT75302A (no)
NO (1) NO960777L (no)
PL (1) PL313116A1 (no)
WO (1) WO1995005823A1 (no)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19741694C2 (de) * 1997-09-18 2002-10-31 Schering Ag Verwendung von Komplexen, deren Ligand ein Bis-Amin-Oxim-Derivat oder ein N¶2¶S¶2¶-Derivat und deren Zentralatom ein Radionuklid ist
ES2271365T3 (es) 2001-12-20 2007-04-16 Bayer Healthcare Ag Derivados de 1,4-dihidro-1,4-difenilpiridina.
US10258498B2 (en) * 2011-11-24 2019-04-16 Richter Gedeon Nyrt. 1,4-dihydropyridine derivatives with Hsp modulating activity

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3222367A1 (de) * 1982-06-15 1983-12-15 Bayer Ag, 5090 Leverkusen Verwendung von 1,4-dihydropyridinen in antiarteriosklerotika und deren herstellung
EP0169009A3 (en) * 1984-07-17 1988-08-31 FISONS plc Novel dihydropyridine derivatives and their production, formulation and use as pharmaceuticals
DE4011695A1 (de) * 1990-04-11 1991-10-17 Bayer Ag Verwendung von n-alkylierten 1,4-dihydropyridindicarbonsaeureestern als arzneimittel, neue verbindungen und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
AU7613594A (en) 1995-03-21
JPH09501923A (ja) 1997-02-25
HUT75302A (en) 1997-05-28
WO1995005823A1 (de) 1995-03-02
HU9600472D0 (en) 1996-04-29
CA2170285A1 (en) 1995-03-02
NO960777D0 (no) 1996-02-26
CZ43896A3 (en) 1996-05-15
DE4328884A1 (de) 1995-03-02
BG100367A (en) 1996-07-31
CN1129906A (zh) 1996-08-28
EP0714301A1 (de) 1996-06-05
PL313116A1 (en) 1996-06-10
KR960703594A (ko) 1996-08-31

Similar Documents

Publication Publication Date Title
TW226375B (no)
EP0487745A4 (en) Pyridine derivative with angiotensin ii antagonism
ES2092316T3 (es) Agentes antianginosos de purinona.
NO20003179L (no) Farmasøytisk sammensetning for Õ antagonisere CCR5 som innbefatter anilid-derivat
TW369533B (en) Quinoline compounds, process for preparing them and pharmaceutical composition containing them
ATE128975T1 (de) Harnstoffderivate, verfahren zu ihrer herstellung und diese enthaltende medikamente.
DE60139639D1 (de) Substituierte thiazolderivate mit 3-pyridylgruppen, verfahren zu deren herstellung und deren verwendung
NO862621D0 (no) Fremgangsmaate ved fremstilling av pyridonkarboksylsyrederivater.
NO20022558L (no) 4-karboksyamino-2-etyl-1,2,3,4-tetrahydrokinolinkrystall som CETP inhibitor
EE03215B1 (et) 3-kinoloonkarboksüülhappe derivaatide ühereaktoriline saamismeetod
GR3030798T3 (en) 2-(Piperidin-4-yl, pyridin-4-yl and tetrahydropyridin-4-yl)benzofuran-7-ol and carbamate derivatives, their preparation and their use as acetylcholinesterase inhibitors.
DE69428142D1 (de) Quinolin- oder Quinazolinderivate, deren Herstellung und Verwendung
DE3876813D1 (de) 3(2h)pyridazinon, verfahren zu dessen herstellung und dieses enthaltendes mittel gegen srs-a.
AU8212591A (en) Diphenylmethylpiperazine derivative
AU5504694A (en) Substituted amic acid derivatives
DE69202120D1 (de) Harnstoffderivate, ihre Herstellung und ihre Verwendung bei der Therapie.
GR3021143T3 (en) Imidazole derivatives and pharmaceutical compositions containing the same.
NO960777L (no) Anvendelse av N-alkylerte 1,4-dihydropyridin dikarboksylsyreestere som medikamenter
AU622590B2 (en) Lowering of blood uric acid levels
ES2020012A6 (es) Procedimiento para la obtencion de un preparado farmaceutico antimicrobiano de uso topico.
HUP9904498A2 (hu) 17-Difluor-metilén-ösztra-triének alkalmazása lipoprotein(A) plazmaszintek csökkentésére
DE69511449D1 (de) Octahydro-2-Naphthalincarbonsäure-Derivate, ihre Herstellung und Verwendung
GR3022450T3 (en) Piperidine derivatives with antihistaminic and antileukohienic activity.
TH4773EX (th) อนุพันธ์ของควิโนลีน-3-คาร์บอกซิลิค แอซิตการเตรียมและการใช้สารเหล่านี้
TH19528B (th) อนุพันธ์กรดอะมิโนชนิดใหม่ด้วยสภาพแห่งความว่องไวต้านทานยาหลายขนานที่ปรับปรุงแล้ว