NO960777L - Use of N-alkylated 1,4-dihydropyridine dicarboxylic acid esters as medicaments - Google Patents
Use of N-alkylated 1,4-dihydropyridine dicarboxylic acid esters as medicamentsInfo
- Publication number
- NO960777L NO960777L NO960777A NO960777A NO960777L NO 960777 L NO960777 L NO 960777L NO 960777 A NO960777 A NO 960777A NO 960777 A NO960777 A NO 960777A NO 960777 L NO960777 L NO 960777L
- Authority
- NO
- Norway
- Prior art keywords
- alkylated
- dicarboxylic acid
- acid esters
- carbon atoms
- medicaments
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Oppfinnelsen angår anvendelse av delvis kjente N-alkylerte l,4-dlhydropyridin dikarboksylsyreestere med generell formel (I), hvori R1 blant annet står for hydrogen, nitro, cyano eller trlfluormetyl, R2 står for hydrogen, halogen, nitro eller hydroksy, R3 står for hydrogen eller cyano, og R2 og R3 kan sammen danne en tllkondensert benzoring, R4 og R5 er like eller forskjellige og kan bety alkyl med inntil 8 karbonatomer , og kan være substituert, R^ står for rettkjedet eller forgrenet alkyl med inntil 6 karbonatomer eller cykloalkyl med 3 til 7 karbonatomer. Forbindelsene kan anvendes som antiatherosklerotlske medikamenter, særlig for å forhindre restenose etter angioplasti og kirurgi l blodkar.The invention relates to the use of partially known N-alkylated 1,4-dihydropyridine dicarboxylic acid esters of general formula (I), wherein R1 represents, inter alia, hydrogen, nitro, cyano or trifluoromethyl, R2 represents hydrogen, halogen, nitro or hydroxy, R3 represents hydrogen or cyano, and R 2 and R 3 may together form a fully condensed benzoring, R 4 and R 5 are the same or different and may represent alkyl of up to 8 carbon atoms, and may be substituted, R 2 represents straight or branched alkyl of up to 6 carbon atoms or cycloalkyl with 3 to 7 carbon atoms. The compounds can be used as antiatherosclerotic drugs, especially to prevent restenosis after angioplasty and blood vessel surgery.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4328884A DE4328884A1 (en) | 1993-08-27 | 1993-08-27 | Use of N-alkylated 1,4-dihydropyridinecarboxylic acid esters as medicaments |
PCT/EP1994/002723 WO1995005823A1 (en) | 1993-08-27 | 1994-08-16 | Use of n-alkylated 1,4-dihydropyridine dicarboxylic acid esters as medicaments |
Publications (2)
Publication Number | Publication Date |
---|---|
NO960777D0 NO960777D0 (en) | 1996-02-26 |
NO960777L true NO960777L (en) | 1996-04-10 |
Family
ID=6496196
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO960777A NO960777L (en) | 1993-08-27 | 1996-02-26 | Use of N-alkylated 1,4-dihydropyridine dicarboxylic acid esters as medicaments |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP0714301A1 (en) |
JP (1) | JPH09501923A (en) |
KR (1) | KR960703594A (en) |
CN (1) | CN1129906A (en) |
AU (1) | AU7613594A (en) |
BG (1) | BG100367A (en) |
CA (1) | CA2170285A1 (en) |
CZ (1) | CZ43896A3 (en) |
DE (1) | DE4328884A1 (en) |
HU (1) | HUT75302A (en) |
NO (1) | NO960777L (en) |
PL (1) | PL313116A1 (en) |
WO (1) | WO1995005823A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19741694C2 (en) * | 1997-09-18 | 2002-10-31 | Schering Ag | Use of complexes whose ligand is a bis-amine oxime derivative or an N¶2¶S¶2¶ derivative and whose central atom is a radionuclide |
DE60214428T2 (en) * | 2001-12-20 | 2007-09-20 | Bayer Healthcare Ag | 1, 4-DIHYDRO-1, 4-DIPHENYLPYRIDINE DERIVATIVES |
US10258498B2 (en) * | 2011-11-24 | 2019-04-16 | Richter Gedeon Nyrt. | 1,4-dihydropyridine derivatives with Hsp modulating activity |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3222367A1 (en) * | 1982-06-15 | 1983-12-15 | Bayer Ag, 5090 Leverkusen | Use of 1,4-dihydropyridines in antiarteriosclerotics and preparation thereof |
EP0169009A3 (en) * | 1984-07-17 | 1988-08-31 | FISONS plc | Novel dihydropyridine derivatives and their production, formulation and use as pharmaceuticals |
DE4011695A1 (en) * | 1990-04-11 | 1991-10-17 | Bayer Ag | USE OF N-ALKYLATED 1,4-DIHYDROPYRIDE INDICARBOXIC ACID ESTERS AS DRUGS, NEW COMPOUNDS AND METHOD FOR THEIR PREPARATION |
-
1993
- 1993-08-27 DE DE4328884A patent/DE4328884A1/en not_active Withdrawn
-
1994
- 1994-08-16 CA CA002170285A patent/CA2170285A1/en not_active Abandoned
- 1994-08-16 WO PCT/EP1994/002723 patent/WO1995005823A1/en not_active Application Discontinuation
- 1994-08-16 KR KR1019960700944A patent/KR960703594A/en not_active Application Discontinuation
- 1994-08-16 AU AU76135/94A patent/AU7613594A/en not_active Abandoned
- 1994-08-16 CN CN94193170A patent/CN1129906A/en active Pending
- 1994-08-16 CZ CZ96438A patent/CZ43896A3/en unknown
- 1994-08-16 EP EP94926199A patent/EP0714301A1/en not_active Withdrawn
- 1994-08-16 PL PL94313116A patent/PL313116A1/en unknown
- 1994-08-16 JP JP7507325A patent/JPH09501923A/en not_active Ceased
- 1994-08-16 HU HU9600472A patent/HUT75302A/en unknown
-
1996
- 1996-02-19 BG BG100367A patent/BG100367A/en unknown
- 1996-02-26 NO NO960777A patent/NO960777L/en unknown
Also Published As
Publication number | Publication date |
---|---|
CZ43896A3 (en) | 1996-05-15 |
BG100367A (en) | 1996-07-31 |
WO1995005823A1 (en) | 1995-03-02 |
NO960777D0 (en) | 1996-02-26 |
JPH09501923A (en) | 1997-02-25 |
AU7613594A (en) | 1995-03-21 |
CN1129906A (en) | 1996-08-28 |
DE4328884A1 (en) | 1995-03-02 |
PL313116A1 (en) | 1996-06-10 |
EP0714301A1 (en) | 1996-06-05 |
HU9600472D0 (en) | 1996-04-29 |
KR960703594A (en) | 1996-08-31 |
CA2170285A1 (en) | 1995-03-02 |
HUT75302A (en) | 1997-05-28 |
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