NO960777L - Use of N-alkylated 1,4-dihydropyridine dicarboxylic acid esters as medicaments - Google Patents

Use of N-alkylated 1,4-dihydropyridine dicarboxylic acid esters as medicaments

Info

Publication number
NO960777L
NO960777L NO960777A NO960777A NO960777L NO 960777 L NO960777 L NO 960777L NO 960777 A NO960777 A NO 960777A NO 960777 A NO960777 A NO 960777A NO 960777 L NO960777 L NO 960777L
Authority
NO
Norway
Prior art keywords
alkylated
dicarboxylic acid
acid esters
carbon atoms
medicaments
Prior art date
Application number
NO960777A
Other languages
Norwegian (no)
Other versions
NO960777D0 (en
Inventor
Siegfried Zaiss
Dieter Neuser
Johannes-Peter Stasch
Siegfried Goldmann
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of NO960777D0 publication Critical patent/NO960777D0/en
Publication of NO960777L publication Critical patent/NO960777L/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Oppfinnelsen angår anvendelse av delvis kjente N-alkylerte l,4-dlhydropyridin dikarboksylsyreestere med generell formel (I), hvori R1 blant annet står for hydrogen, nitro, cyano eller trlfluormetyl, R2 står for hydrogen, halogen, nitro eller hydroksy, R3 står for hydrogen eller cyano, og R2 og R3 kan sammen danne en tllkondensert benzoring, R4 og R5 er like eller forskjellige og kan bety alkyl med inntil 8 karbonatomer , og kan være substituert, R^ står for rettkjedet eller forgrenet alkyl med inntil 6 karbonatomer eller cykloalkyl med 3 til 7 karbonatomer. Forbindelsene kan anvendes som antiatherosklerotlske medikamenter, særlig for å forhindre restenose etter angioplasti og kirurgi l blodkar.The invention relates to the use of partially known N-alkylated 1,4-dihydropyridine dicarboxylic acid esters of general formula (I), wherein R1 represents, inter alia, hydrogen, nitro, cyano or trifluoromethyl, R2 represents hydrogen, halogen, nitro or hydroxy, R3 represents hydrogen or cyano, and R 2 and R 3 may together form a fully condensed benzoring, R 4 and R 5 are the same or different and may represent alkyl of up to 8 carbon atoms, and may be substituted, R 2 represents straight or branched alkyl of up to 6 carbon atoms or cycloalkyl with 3 to 7 carbon atoms. The compounds can be used as antiatherosclerotic drugs, especially to prevent restenosis after angioplasty and blood vessel surgery.

NO960777A 1993-08-27 1996-02-26 Use of N-alkylated 1,4-dihydropyridine dicarboxylic acid esters as medicaments NO960777L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4328884A DE4328884A1 (en) 1993-08-27 1993-08-27 Use of N-alkylated 1,4-dihydropyridinecarboxylic acid esters as medicaments
PCT/EP1994/002723 WO1995005823A1 (en) 1993-08-27 1994-08-16 Use of n-alkylated 1,4-dihydropyridine dicarboxylic acid esters as medicaments

Publications (2)

Publication Number Publication Date
NO960777D0 NO960777D0 (en) 1996-02-26
NO960777L true NO960777L (en) 1996-04-10

Family

ID=6496196

Family Applications (1)

Application Number Title Priority Date Filing Date
NO960777A NO960777L (en) 1993-08-27 1996-02-26 Use of N-alkylated 1,4-dihydropyridine dicarboxylic acid esters as medicaments

Country Status (13)

Country Link
EP (1) EP0714301A1 (en)
JP (1) JPH09501923A (en)
KR (1) KR960703594A (en)
CN (1) CN1129906A (en)
AU (1) AU7613594A (en)
BG (1) BG100367A (en)
CA (1) CA2170285A1 (en)
CZ (1) CZ43896A3 (en)
DE (1) DE4328884A1 (en)
HU (1) HUT75302A (en)
NO (1) NO960777L (en)
PL (1) PL313116A1 (en)
WO (1) WO1995005823A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19741694C2 (en) * 1997-09-18 2002-10-31 Schering Ag Use of complexes whose ligand is a bis-amine oxime derivative or an N¶2¶S¶2¶ derivative and whose central atom is a radionuclide
WO2003053930A1 (en) * 2001-12-20 2003-07-03 Bayer Healthcare Ag 1,4-dihydro-1,4-diphenylpyridine derivatives
CN110606822A (en) * 2011-11-24 2019-12-24 里克特吉迪翁公司 1,4-dihydropyridine derivatives having HSP modulating activity

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3222367A1 (en) * 1982-06-15 1983-12-15 Bayer Ag, 5090 Leverkusen Use of 1,4-dihydropyridines in antiarteriosclerotics and preparation thereof
EP0169009A3 (en) * 1984-07-17 1988-08-31 FISONS plc Novel dihydropyridine derivatives and their production, formulation and use as pharmaceuticals
DE4011695A1 (en) * 1990-04-11 1991-10-17 Bayer Ag USE OF N-ALKYLATED 1,4-DIHYDROPYRIDE INDICARBOXIC ACID ESTERS AS DRUGS, NEW COMPOUNDS AND METHOD FOR THEIR PREPARATION

Also Published As

Publication number Publication date
PL313116A1 (en) 1996-06-10
CA2170285A1 (en) 1995-03-02
KR960703594A (en) 1996-08-31
CZ43896A3 (en) 1996-05-15
WO1995005823A1 (en) 1995-03-02
HU9600472D0 (en) 1996-04-29
NO960777D0 (en) 1996-02-26
BG100367A (en) 1996-07-31
CN1129906A (en) 1996-08-28
DE4328884A1 (en) 1995-03-02
HUT75302A (en) 1997-05-28
EP0714301A1 (en) 1996-06-05
AU7613594A (en) 1995-03-21
JPH09501923A (en) 1997-02-25

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