ES2132394T3 - Compuesto de benzotiazol, procedimiento para su produccion, y su utilizacion. - Google Patents

Compuesto de benzotiazol, procedimiento para su produccion, y su utilizacion.

Info

Publication number
ES2132394T3
ES2132394T3 ES94910543T ES94910543T ES2132394T3 ES 2132394 T3 ES2132394 T3 ES 2132394T3 ES 94910543 T ES94910543 T ES 94910543T ES 94910543 T ES94910543 T ES 94910543T ES 2132394 T3 ES2132394 T3 ES 2132394T3
Authority
ES
Spain
Prior art keywords
halogen
neurosis
cataract
lower alkyl
benzotiazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94910543T
Other languages
English (en)
Inventor
Takema Hase
Takahiro Kumonaka
Chikako Shimizu
Hiroshi Hosono
Tomoji Aotsuka
Yoshiyuki Nakamura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Senju Pharmaceutical Co Ltd
Welfide Corp
Original Assignee
Senju Pharmaceutical Co Ltd
Welfide Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senju Pharmaceutical Co Ltd, Welfide Corp filed Critical Senju Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2132394T3 publication Critical patent/ES2132394T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/25—Aminoacetonitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE PRESENTA UN COMPUESTO DE BENZOTIAZOL REPRESENTADO POR LA FORMULA GENERAL (I) Y UNA SAL FARMACOLOGICAMENTE ACEPTABLE DEL MISMO, EN DONDE R1 REPRESENTA HALOGENO; R2 Y R3 REPRESENTAN CADA UNA INDEPENDIENTEMENTE HIDROGENO O HALOGENO; R4 REPRESENTA HIDROGENO, HALOGENO, ALQUILO INFERIOR, ALCOXIDO O ALQUILMERCAPTO; Y R5 REPRESENTA HIDROGENO O ALQUILO INFERIOR. EL COMPUESTO (I) Y LA SAL DEL MISMO TIENEN UNA ACTIVIDAD INHIBIDORA DE LA REDUCTASA DE ALDOSA EN LOS MAMIFEROS, INCLUYENDO LOS HUMANOS, Y PRESENTA UNA SEGURIDAD EXCELENTE. ADEMAS SON UTILES COMO PRODUCTOS INTERMEDIOS PARA COMPLICACIONES EN EL TRATAMIENTO DE LA DIABETES, TALES COMO LA UNION DEFECTUOSA DE LA CORNEA LESIONADA, LAS CATARATAS, LA NEUROSIS, LA RETINOPATIA Y LA NEFROPATIA, EN PARTICULAR, CATARATAS Y NEUROSIS.
ES94910543T 1993-03-26 1994-03-25 Compuesto de benzotiazol, procedimiento para su produccion, y su utilizacion. Expired - Lifetime ES2132394T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP05090550A JP3126541B2 (ja) 1993-03-26 1993-03-26 ベンゾチアゾール誘導体、その製法及びその用途

Publications (1)

Publication Number Publication Date
ES2132394T3 true ES2132394T3 (es) 1999-08-16

Family

ID=14001528

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94910543T Expired - Lifetime ES2132394T3 (es) 1993-03-26 1994-03-25 Compuesto de benzotiazol, procedimiento para su produccion, y su utilizacion.

Country Status (12)

Country Link
US (1) US5532257A (es)
EP (1) EP0647636B1 (es)
JP (1) JP3126541B2 (es)
KR (1) KR100299558B1 (es)
CN (1) CN1108456A (es)
AT (1) ATE181067T1 (es)
AU (1) AU676894B2 (es)
CA (1) CA2136743A1 (es)
DE (1) DE69418961T2 (es)
ES (1) ES2132394T3 (es)
TW (1) TW245717B (es)
WO (1) WO1994022845A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05337783A (ja) * 1992-06-08 1993-12-21 Ona Electro Erosion Sa 荷積み荷下ろしパレットのドアの自動開放装置
JPH0782259A (ja) * 1993-09-14 1995-03-28 Senju Pharmaceut Co Ltd スクシンアミド酸誘導体及びそれを含有する糖尿病合併症治療剤
US5700819A (en) * 1994-11-29 1997-12-23 Grelan Pharmaceutical Co., Ltd. 2-substituted benzothiazole derivatives and prophylactic and therapeutic agents for the treatment of diabetic complications
US6121300A (en) * 1998-11-10 2000-09-19 Wagle; Dilip R. Reversing advanced glycosylation cross-links using heterocyclic-substituted thiazolium salts
UA100527C2 (en) * 2007-10-10 2013-01-10 Астразенека Аб Benzothiazoles as ghrelin receptor modulators
US20210347748A1 (en) * 2018-09-25 2021-11-11 Antabio Sas Indane derivatives for use in the treatment of bacterial infection
WO2024003408A1 (en) * 2022-07-01 2024-01-04 Universität Zürich Small-molecule inhibitors of the frs2-fgfr interaction

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3794485A (en) * 1972-06-09 1974-02-26 Polaroid Corp Color diffusion transfer film with incorporated dye and desensitizing agent precursor
JPS5740478A (en) * 1980-08-22 1982-03-06 Ono Pharmaceut Co Ltd Rhodanine derivative, its preparation and aldose reductase inhibitor containing rhodanine derivative
AU602641B2 (en) * 1986-04-17 1990-10-18 Senju Pharmaceutical Co., Ltd. Thiolactam-N-acetic acid derivatives, their production and use
JPH03107970A (ja) * 1989-09-22 1991-05-08 Ricoh Co Ltd 湿式現像の画像形成装置

Also Published As

Publication number Publication date
US5532257A (en) 1996-07-02
EP0647636A4 (es) 1995-04-19
DE69418961D1 (de) 1999-07-15
JP3126541B2 (ja) 2001-01-22
WO1994022845A1 (en) 1994-10-13
EP0647636A1 (en) 1995-04-12
ATE181067T1 (de) 1999-06-15
AU6291494A (en) 1994-10-24
CN1108456A (zh) 1995-09-13
EP0647636B1 (en) 1999-06-09
DE69418961T2 (de) 1999-12-23
KR950701627A (ko) 1995-04-28
KR100299558B1 (ko) 2001-11-22
AU676894B2 (en) 1997-03-27
CA2136743A1 (en) 1994-10-13
JPH06279423A (ja) 1994-10-04
TW245717B (es) 1995-04-21

Similar Documents

Publication Publication Date Title
DE69418243D1 (de) N-Heteroaryl-N'-Phenylharnstoffderivate, ihre Herstellung und Verwendung
ES2094308T3 (es) Derivados de aminoalcohol aromatico con propiedades antidiabeticas y antiobesidad, su preparacion y utilizacion terapeutica.
NO970892L (no) Isoksazolderivater
ES2082805T3 (es) Derivados de tiazol, procedimientos para su produccion y composiciones farmaceuticas que comprenden los mismos.
ATE205206T1 (de) Benzylidenthiazolidinderivate, ihre herstellung und ihre anwendung als lipidperoxid-inhibitoren
ES2036562T3 (es) Un procedimiento para produccion de un derivado de pirrolidinamida.
ES2132394T3 (es) Compuesto de benzotiazol, procedimiento para su produccion, y su utilizacion.
BR9907715A (pt) Composição oftálmica/método para tratamento de lesão córnea e/ou de estesia córnea deteriordada, sìndrome de olho seco, hipolarcrimação e uso de um inibidor de redutase de aldose
ES2145142T3 (es) Compuesto de acido succinamico, procedimiento para su produccion y su uso.
ATE100439T1 (de) 2-(2-hydroxy-3-phenoxypropylamino)-ethoxybenzol derivate.
ES2130403T3 (es) Derivado del acido quinolin-3-acetico, procedimiento para su produccion, y uso del mismo.
FI20041236A (fi) Silmänpainetta alentava aine
EP0644194A4 (en) COMPOUND BASED ON PYRIDOTHIAZINEACETIC ACID, PROCESS FOR PRODUCTION AND USE.
ES2168119T3 (es) Derivados de quinoxalina para el tratamiento de tinnitus.
ES2116528T3 (es) Nuevo compuesto, la leustroducsina h, su preparacion y su utilizacion terapeutica.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 647636

Country of ref document: ES