CN1041281C - 聚合物键合的紫杉醇衍生物 - Google Patents
聚合物键合的紫杉醇衍生物 Download PDFInfo
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- CN1041281C CN1041281C CN93107196A CN93107196A CN1041281C CN 1041281 C CN1041281 C CN 1041281C CN 93107196 A CN93107196 A CN 93107196A CN 93107196 A CN93107196 A CN 93107196A CN 1041281 C CN1041281 C CN 1041281C
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- Prior art keywords
- phe
- gly
- leu
- βala
- paclitaxel
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- 210000004185 liver Anatomy 0.000 description 1
- 210000001699 lower leg Anatomy 0.000 description 1
- 210000004688 microtubule Anatomy 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
- 201000000050 myeloid neoplasm Diseases 0.000 description 1
- WHQSYGRFZMUQGQ-UHFFFAOYSA-N n,n-dimethylformamide;hydrate Chemical compound O.CN(C)C=O WHQSYGRFZMUQGQ-UHFFFAOYSA-N 0.000 description 1
- VZKBEZDJWDUUFH-UHFFFAOYSA-N n-[2-(2-hydroxypropylamino)-2-oxoethyl]-2-methylprop-2-enamide Chemical compound CC(O)CNC(=O)CNC(=O)C(C)=C VZKBEZDJWDUUFH-UHFFFAOYSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- 239000003495 polar organic solvent Substances 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 description 1
- 229930189271 taxine Natural products 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Epoxy Compounds (AREA)
- Peptides Or Proteins (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9213077.2 | 1992-06-19 | ||
| GB929213077A GB9213077D0 (en) | 1992-06-19 | 1992-06-19 | Polymerbound taxol derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1079971A CN1079971A (zh) | 1993-12-29 |
| CN1041281C true CN1041281C (zh) | 1998-12-23 |
Family
ID=10717411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN93107196A Expired - Fee Related CN1041281C (zh) | 1992-06-19 | 1993-06-17 | 聚合物键合的紫杉醇衍生物 |
Country Status (25)
| Country | Link |
|---|---|
| US (4) | US5362831A (https=) |
| EP (1) | EP0600062B1 (https=) |
| JP (1) | JP3693340B2 (https=) |
| KR (1) | KR100281606B1 (https=) |
| CN (1) | CN1041281C (https=) |
| AT (1) | ATE205725T1 (https=) |
| AU (2) | AU659750B2 (https=) |
| CA (1) | CA2112482A1 (https=) |
| CZ (1) | CZ62094A3 (https=) |
| DE (1) | DE69330776T2 (https=) |
| ES (1) | ES2164663T3 (https=) |
| FI (1) | FI940733A0 (https=) |
| GB (1) | GB9213077D0 (https=) |
| HU (2) | HUT67914A (https=) |
| IL (1) | IL106023A (https=) |
| MX (1) | MX9303598A (https=) |
| MY (1) | MY109213A (https=) |
| NZ (1) | NZ253116A (https=) |
| PL (1) | PL173898B1 (https=) |
| RU (1) | RU2130462C1 (https=) |
| SG (1) | SG49248A1 (https=) |
| TW (1) | TW266201B (https=) |
| UA (1) | UA39926C2 (https=) |
| WO (1) | WO1994000156A1 (https=) |
| ZA (1) | ZA934388B (https=) |
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| US5037883A (en) * | 1985-01-04 | 1991-08-06 | Ceskoslovenska Akademie Ved | Synthetic polymeric drugs |
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