CN1038126A - 双边条曲菌素：一种新型的双功能生长调节糖蛋白 - Google Patents

双边条曲菌素：一种新型的双功能生长调节糖蛋白 Download PDF

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Publication number
CN1038126A
CN1038126A CN89101545A CN89101545A CN1038126A CN 1038126 A CN1038126 A CN 1038126A CN 89101545 A CN89101545 A CN 89101545A CN 89101545 A CN89101545 A CN 89101545A CN 1038126 A CN1038126 A CN 1038126A
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cell
protein
sequence
growth
plasmid
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CN89101545A
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Chinese (zh)
Inventor
模罕默德·索雅
维基·L·麦唐纳德
詹姆斯·G·布雷德利
格雷格·普洛曼
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Oncogen LP
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Oncogen LP
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Priority claimed from US07/297,816 external-priority patent/US5115096A/en
Application filed by Oncogen LP filed Critical Oncogen LP
Publication of CN1038126A publication Critical patent/CN1038126A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/108—Plasmid DNA episomal vectors

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  • Life Sciences & Earth Sciences (AREA)
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  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN89101545A 1988-01-25 1989-01-25 双边条曲菌素：一种新型的双功能生长调节糖蛋白 Pending CN1038126A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US14832788A 1988-01-25 1988-01-25
US148,327 1988-01-25
US18188488A 1988-04-15 1988-04-15
US181,884 1988-04-15
US07/297,816 US5115096A (en) 1988-04-15 1989-01-17 Amphiregulin: a bifunctional growth modulating glycoprotein
US297,816 1989-01-17

Publications (1)

Publication Number Publication Date
CN1038126A true CN1038126A (zh) 1989-12-20

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ID=27386678

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CN89101545A Pending CN1038126A (zh) 1988-01-25 1989-01-25 双边条曲菌素：一种新型的双功能生长调节糖蛋白

Country Status (24)

Country Link
US (1) US5830995A (enExample)
JP (1) JPH02104596A (enExample)
CN (1) CN1038126A (enExample)
AT (1) AT399720B (enExample)
AU (1) AU623109B2 (enExample)
BE (1) BE1004201A5 (enExample)
CH (1) CH681080A5 (enExample)
DE (1) DE3902157A1 (enExample)
DK (1) DK29989A (enExample)
ES (1) ES2016432A6 (enExample)
FI (1) FI890312L (enExample)
FR (1) FR2628109B1 (enExample)
GB (1) GB2214185B (enExample)
GR (1) GR1000849B (enExample)
HU (1) HUT52545A (enExample)
IE (1) IE61146B1 (enExample)
IL (1) IL89033A (enExample)
IT (1) IT1229504B (enExample)
MY (1) MY104980A (enExample)
NL (1) NL8900178A (enExample)
NO (1) NO177788C (enExample)
NZ (1) NZ227729A (enExample)
SE (1) SE504554C2 (enExample)
YU (1) YU16989A (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104010882A (zh) * 2011-12-22 2014-08-27 宝马股份公司 用于机动行驶装置的内饰部件
CN110531023A (zh) * 2019-10-08 2019-12-03 安徽理工大学 一种薄层色谱分析仪

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US5262298A (en) * 1989-05-12 1993-11-16 The State Of Oregon Acting By And Through The State Board Of Education On Behalf Of The Oregon Health Sciences University Method to assess the ability of a substance to inhibit or stimulate keratinocyte autocrine factor production
CA2037440A1 (en) * 1990-03-02 1991-09-03 Gregory D. Plowman Her3: a novel egf receptor homolog
JPH06502538A (ja) * 1990-10-16 1994-03-24 ザ　チルドレンズメディカルセンターコーポレーション 上皮細胞成長因子（ｅｇｆ）との相同性をもつヘパリン結合性マイトジェン
US5302706A (en) * 1991-12-16 1994-04-12 Baylor College Of Medicine Senescent cell derived inhibitors of DNA synthesis
US6235884B1 (en) 1993-06-15 2001-05-22 Scios Nova, Inc. Heparin binding mitogen with homology to epidermal growth factor (EGF)
US5633147A (en) * 1994-03-08 1997-05-27 Human Genome Sciences, Inc. Transforming growth factor αH1
WO1997023507A2 (en) * 1995-12-22 1997-07-03 Innogenetics N.V. New form of amphiregulin, methods for producing and using the same and compositions comprising the same
US6852506B1 (en) 1996-04-10 2005-02-08 Human Genome Sciences, Inc. Extracellular/epidermal growth factor-like protein
US5948889A (en) * 1996-05-21 1999-09-07 Case Western Reserve University Compositions and methods for screening antimicrobials
AU752206B2 (en) * 1997-04-11 2002-09-12 Human Genome Sciences, Inc. Extracellular/epidermal growth factor like protein
US7541429B2 (en) * 2000-10-10 2009-06-02 The Board Of Regents Of The University Of Oklahoma Comparative ligand mapping from MHC positive cells
US20060276629A9 (en) * 1999-12-17 2006-12-07 Hildebrand William H Purification and characterization of soluble human HLA proteins
US20070099182A1 (en) * 2000-10-10 2007-05-03 Hildebrand William H Comparative ligand mapping from MHC class I positive cells
US20090062512A1 (en) * 2000-10-10 2009-03-05 Hildebrand William H Comparative ligand mapping from MHC class I positive cells
US20050003483A1 (en) * 2000-10-10 2005-01-06 Hildebrand William H. Comparative ligand mapping from MHC class 1 positive cells
US20070026433A1 (en) * 2001-03-09 2007-02-01 Hildebrand William H Epitope testing using soluble HLA
US20020122820A1 (en) * 2001-01-16 2002-09-05 Hildebrand William H. Soluble MHC artificial antigen presenting cells
WO2002059376A1 (en) * 2001-01-23 2002-08-01 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of human colon cancer
EP1417487B1 (en) * 2001-03-09 2007-10-17 The Board Of Regents Of The University Of Oklahoma Epitope testing using hla
US20040126829A1 (en) * 2001-12-18 2004-07-01 Hildebrand William H. Anti-HLA assay and methods
RU2224255C2 (ru) * 2002-04-15 2004-02-20 Государственное учреждение Нижегородский научно-исследовательский кожно-венерологический институт Способ прогнозирования течения псориаза
US8227411B2 (en) 2002-08-20 2012-07-24 BioSurface Engineering Technologies, Incle FGF growth factor analogs
US7598224B2 (en) * 2002-08-20 2009-10-06 Biosurface Engineering Technologies, Inc. Dual chain synthetic heparin-binding growth factor analogs
CA2496732A1 (en) * 2002-08-20 2004-03-04 Biosurface Engineering Technologies, Inc. Synthetic heparin-binding growth factor analogs
US7223393B2 (en) 2003-02-07 2007-05-29 Pdl Biopharma, Inc Amphiregulin antibodies and their use to treat cancer and psoriasis
EP1449538A1 (en) * 2003-02-21 2004-08-25 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Inhibition of TACE or amphiregulin for the modulation of EGF receptor signal transactivation
US20050130897A1 (en) * 2003-12-11 2005-06-16 Ma Jian-Xing Compounds useful in inhibiting vascular leakage, inflammation and fibrosis and methods of making and using same
US20080227696A1 (en) 2005-02-22 2008-09-18 Biosurface Engineering Technologies, Inc. Single branch heparin-binding growth factor analogs
DE602005023714D1 (de) 2004-02-20 2010-11-04 Biosurface Eng Tech Inc Positiver modulator des knochenmorphogenetisches protein-2 (bmp-2)
CA2568427A1 (en) * 2004-05-27 2006-01-12 Tanox, Inc. Method for preventing and treating mast cell mediated diseases
US7820172B1 (en) 2006-06-01 2010-10-26 Biosurface Engineering Technologies, Inc. Laminin-derived multi-domain peptides
CA2692240C (en) 2006-06-22 2018-03-13 Biosurface Engineering Technologies, Inc. Composition and method for delivery of bmp-2 amplifier/co-activator for enhancement of osteogenesis
GB0807018D0 (en) * 2008-04-17 2008-05-21 Fusion Antibodies Ltd Antibodies and treatment
WO2010137012A1 (en) 2009-05-25 2010-12-02 Ramot At Tel-Aviv University Ltd. Peptide therapy for amphiregulin mediated diseases
CA2936675C (en) * 2014-01-12 2023-06-27 Igf Oncology, Llc Fusion proteins containing insulin-like growth factor-1 and epidermal growth factor and variants thereof and uses thereof
WO2015148960A1 (en) 2014-03-28 2015-10-01 The Board Of Regents Of The University Of Oklahoma Compositions comprising soluble hla/m. tuberculosis-specific ligand complexes and methods of production and use thereof
WO2017083491A2 (en) * 2015-11-10 2017-05-18 Proteothera, Inc. Methods of producing and purifying matrix-binding fusion proteins by ion-exchange chromatography
CN110636867B (zh) 2017-05-21 2023-09-05 Igf肿瘤公司 胰岛素样生长因子——用于治疗骨髓增生异常综合症的化学治疗缀合物
CN112779209B (zh) * 2019-11-08 2023-01-24 合肥中科普瑞昇生物医药科技有限公司 原代乳腺上皮细胞培养基、培养方法及其应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5115096A (en) * 1988-04-15 1992-05-19 Oncogen Amphiregulin: a bifunctional growth modulating glycoprotein

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104010882A (zh) * 2011-12-22 2014-08-27 宝马股份公司 用于机动行驶装置的内饰部件
CN110531023A (zh) * 2019-10-08 2019-12-03 安徽理工大学 一种薄层色谱分析仪

Also Published As

Publication number Publication date
AT399720B (de) 1995-07-25
IE61146B1 (en) 1994-10-05
CH681080A5 (enExample) 1993-01-15
IT1229504B (it) 1991-09-03
FR2628109B1 (fr) 1993-04-09
IT8919186A0 (it) 1989-01-25
BE1004201A5 (fr) 1992-10-13
US5830995A (en) 1998-11-03
IL89033A (en) 1994-05-30
FI890312A0 (fi) 1989-01-20
AU2876989A (en) 1989-08-24
SE8900247L (sv) 1989-07-26
AU623109B2 (en) 1992-05-07
GR1000849B (el) 1993-02-17
NO890299L (no) 1989-07-26
FI890312A7 (fi) 1989-07-26
YU16989A (en) 1991-10-31
DK29989A (da) 1989-07-26
SE8900247D0 (sv) 1989-01-24
MY104980A (en) 1994-07-30
IL89033A0 (en) 1989-08-15
NO177788C (no) 1995-11-22
FI890312L (fi) 1989-07-26
ES2016432A6 (es) 1990-11-01
HUT52545A (en) 1990-07-28
NO890299D0 (no) 1989-01-24
FR2628109A1 (fr) 1989-09-08
GB8901469D0 (en) 1989-03-15
NZ227729A (en) 1992-02-25
SE504554C2 (sv) 1997-03-03
GR890100037A (en) 1990-01-31
NL8900178A (nl) 1989-08-16
IE890207L (en) 1989-07-25
ATA14789A (de) 1994-11-15
NO177788B (no) 1995-08-14
GB2214185B (en) 1992-06-17
JPH02104596A (ja) 1990-04-17
DK29989D0 (da) 1989-01-24
DE3902157A1 (de) 1989-07-27
GB2214185A (en) 1989-08-31

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