CN1037932C - 能耐受胃液的口服片剂和丸剂剂型药剂的制备方法 - Google Patents

能耐受胃液的口服片剂和丸剂剂型药剂的制备方法 Download PDF

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Publication number
CN1037932C
CN1037932C CN92104690A CN92104690A CN1037932C CN 1037932 C CN1037932 C CN 1037932C CN 92104690 A CN92104690 A CN 92104690A CN 92104690 A CN92104690 A CN 92104690A CN 1037932 C CN1037932 C CN 1037932C
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core
tablet
compound
physiologically tolerable
covered
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Expired - Lifetime
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CN92104690A
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English (en)
Chinese (zh)
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CN1067809A (zh
Inventor
R·迪特里希
H·柰伊
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Takeda GmbH
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Byk Gulden Lomberg Chemische Fabrik GmbH
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
CN92104690A 1991-06-17 1992-06-17 能耐受胃液的口服片剂和丸剂剂型药剂的制备方法 Expired - Lifetime CN1037932C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1788/91 1991-06-17
CH178891 1991-06-17

Publications (2)

Publication Number Publication Date
CN1067809A CN1067809A (zh) 1993-01-13
CN1037932C true CN1037932C (zh) 1998-04-08

Family

ID=4218617

Family Applications (1)

Application Number Title Priority Date Filing Date
CN92104690A Expired - Lifetime CN1037932C (zh) 1991-06-17 1992-06-17 能耐受胃液的口服片剂和丸剂剂型药剂的制备方法

Country Status (33)

Country Link
US (1) US5997903A (enExample)
EP (2) EP0519365A1 (enExample)
JP (1) JP3338052B2 (enExample)
KR (1) KR100254021B1 (enExample)
CN (1) CN1037932C (enExample)
AT (1) ATE144416T1 (enExample)
AU (1) AU683411B2 (enExample)
BG (1) BG61796B1 (enExample)
CA (2) CA2524168A1 (enExample)
CZ (1) CZ281697B6 (enExample)
DE (2) DE4219390A1 (enExample)
DK (1) DK0589981T3 (enExample)
ES (1) ES2096080T3 (enExample)
FI (1) FI101598B1 (enExample)
GR (1) GR3022154T3 (enExample)
HR (1) HRP920162B1 (enExample)
IE (1) IE77640B1 (enExample)
IL (1) IL102096A (enExample)
LV (1) LV11982B (enExample)
MX (1) MX9202961A (enExample)
NO (1) NO303714B1 (enExample)
NZ (1) NZ243147A (enExample)
PL (1) PL169951B1 (enExample)
RO (1) RO117502B1 (enExample)
RU (1) RU2089180C1 (enExample)
SI (1) SI9200111A (enExample)
SK (1) SK278566B6 (enExample)
TW (1) TW224429B (enExample)
UA (1) UA32525C2 (enExample)
WO (1) WO1992022284A1 (enExample)
YU (1) YU48263B (enExample)
ZA (1) ZA924386B (enExample)
ZW (1) ZW9392A1 (enExample)

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US6489346B1 (en) * 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
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EP0244380A2 (en) * 1986-04-30 1987-11-04 Aktiebolaget Hässle Pharmaceutical formulations of acid labile substances for oral use
EP0342522A1 (en) * 1988-05-18 1989-11-23 Eisai Co., Ltd. Peroral preparation of an acid-unstable compound

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LV11982B (lv) 1998-09-20
ATE144416T1 (de) 1996-11-15
NO934648D0 (no) 1993-12-16
SK128793A3 (en) 1994-06-08
HK1005851A1 (en) 1999-01-29
YU57692A (sh) 1995-03-27
CA2109697C (en) 2005-11-22
ES2096080T3 (es) 1997-03-01
SK278566B6 (en) 1997-10-08
DE59207438D1 (de) 1996-11-28
FI935677L (fi) 1993-12-16
IL102096A (en) 1996-06-18
RO117502B1 (ro) 2002-04-30
JPH06508118A (ja) 1994-09-14
CA2524168A1 (en) 1992-12-23
TW224429B (enExample) 1994-06-01
DE4219390A1 (de) 1992-12-24
ZA924386B (en) 1993-02-24
GR3022154T3 (en) 1997-03-31
UA32525C2 (uk) 2001-02-15
PL169951B1 (pl) 1996-09-30
KR100254021B1 (ko) 2000-05-01
IL102096A0 (en) 1993-01-14
BG61796B1 (bg) 1998-06-30
FI101598B (fi) 1998-07-31
HRP920162A2 (en) 1996-08-31
IE77640B1 (en) 1997-12-31
AU683411B2 (en) 1997-11-13
JP3338052B2 (ja) 2002-10-28
LV11982A (lv) 1998-03-20
EP0519365A1 (de) 1992-12-23
YU48263B (sh) 1997-09-30
EP0589981B1 (de) 1996-10-23
RU2089180C1 (ru) 1997-09-10
DK0589981T3 (da) 1997-03-17
HRP920162B1 (en) 1998-08-31
KR940701256A (ko) 1994-05-28
AU1974692A (en) 1993-01-12
NO303714B1 (no) 1998-08-24
SI9200111A (en) 1992-12-31
CZ281697B6 (cs) 1996-12-11
IE921733A1 (en) 1992-11-18
FI935677A0 (fi) 1993-12-16
MX9202961A (es) 1993-02-01
CN1067809A (zh) 1993-01-13
FI101598B1 (fi) 1998-07-31
WO1992022284A1 (de) 1992-12-23
US5997903A (en) 1999-12-07
CZ276493A3 (en) 1994-07-13
EP0589981A1 (de) 1994-04-06
NZ243147A (en) 1995-12-21
NO934648L (no) 1993-12-16
ZW9392A1 (en) 1993-02-17
BG98286A (bg) 1994-08-30
CA2109697A1 (en) 1992-12-23

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