CN103651657A - Health-care flour composition and food - Google Patents
Health-care flour composition and food Download PDFInfo
- Publication number
- CN103651657A CN103651657A CN201310345691.4A CN201310345691A CN103651657A CN 103651657 A CN103651657 A CN 103651657A CN 201310345691 A CN201310345691 A CN 201310345691A CN 103651657 A CN103651657 A CN 103651657A
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- CN
- China
- Prior art keywords
- hericium erinaceus
- health
- biscuit
- food
- flour composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Abstract
The invention provides a health-care flour composition and food and a preparing method thereof. According to the preparing method, hericium erinaceus and flour are used as main raw materials, swelling agents, sweetening agents, oil, salt and the like are added and mixed with water, and then rolling, forming, baking, oil injection and cooling are carried out to obtain various foods made of flour or pastries such as cookies, cakes and noodles. The health-care flour composition and food are even in texture, capable of being stored for a long time easily, good in mouthfeel and rich in nutrient, and market vacancy is filled. The health-care flour composition and food have definite effects in repairing gastric mucosal damage caused by chronic gastritis, or gastric ulcers or duodenal ulcers, relieving abdominal pains caused by chronic gastritis, or gastric ulcers or duodenal ulcers, inhibiting helicobacter pylori, and assisting the treatment of chronic gastritis, gastric ulcers and duodenal ulcers.
Description
Technical field
The present invention relates to a kind of health-care flour composition and food.
Background technology
Along with the raising of people's living standard, people's health care consciousness is more and more stronger, also more and more higher to the requirement of leisure food.In daily life, pursue food delicious, convenient, that be of high nutritive value and become fashion.In numerous leisure food, for what most people was liked, surely belong to wheaten food or millet cake: as biscuit, bread, cake or instant noodles etc.This based food can not only supplement body energy, and each tool local flavor, all-ages.But, this series products of the prior art, though mouthfeel pretty good, there is full abdomen function, but nutritive value is limited.At present, on market, the rarely seen food with health care that can play raising immunity of organisms, prevention or adjuvant treatment of diseases, therefore, is difficult to meet modern's requirement.
Hericium erinaceus is a kind of high protein, low fat, is rich in the good food of minerals and vitamins, containing unrighted acid, can reduce cholesterolemia and content of triglyceride, regulates blood fat, is beneficial to blood circulation.The polysaccharide body that Hericium erinaceus contains, polypeptide class and fatty material, can prevent and treat the disease of digestive tracts such as gastric ulcer, duodenal ulcer, has the function that improves immunity of organisms, and delaying sanility.But Hericium erinaceus is edible usually used as the vegetables of rare kind in daily life, eating method is complicated, and inconvenience is often edible, and amount is not enough, and health-care effect is difficult to give full play to.
Hericium erinaceus (Hericium erinaceum) is widely used for treating the diseases such as chronic gastritis, gastroduodenal ulcer on clinical medicine, has accumulated a large amount of clinical experiences and data.But yet there are no on the market the daily edible food with health care that application Hericium erinaceus is made.
Chinese Patent Application No. 200510046418.7 discloses a kind of nutrition wheat flour and method for making containing fruit or vegetables, is by the fruit of vacuum freeze drying or vegetables are made dry powder and wheat flour is mixed.Shortcoming is that fruit or the vegetables of pulverizing have certain granules degree, is difficult to mix completely with wheat flour, affects the ferment effect of dough, and the outward appearance of product and mouthfeel exist defect.Chinese Patent Application No. 99113217.3 discloses a kind of production method of pesticide-eating fungus floor, is that to take wheat or mung bean be culture medium, and inoculated fungi bacterial classification, dries and pulverize to obtain domestic fungus flour.Shortcoming is flour preparation and processing conditions harshness, and flour should not be preserved, and preparation Flour product kind is limited.
Summary of the invention
The object of this invention is to provide a kind of apply to suitability for industrialized production, homogeneous, be easy to long-term preservation, be suitable for preparing polytype wheaten food or millet cake, comfortable taste, nutritious health-care flour composition and food, to solve the deficiencies in the prior art, make up the market vacancy.
The invention provides a kind of health-care flour composition, it is characterized in that Hericium erinaceus to add in flour, by the deep processing to flour, obtain a kind of health-care flour composition.Specifically, health-care flour composition of the present invention contains flour 100 weight portions, Hericium erinaceus 1～30 weight portion, wherein Hericium erinaceus can be not only new fresh Hericium erinaceus or dry product Hericium erinaceus or Hericium erinaceus powder (commercially available buying), also can be by Hericium erinaceus fresh goods or dry product raw material add extract that water and/or alcohol extracting obtain or by extract dry and Hericium erinaceus extract; Also can be Hericium erinaceus fresh goods or dry product raw material are added to water and/or alcohol extracting, and material after extracting is carried out to Hericium erinaceus extract inclusion compound or the microcapsules that inclusion obtains.Preferred Hericium erinaceus extract is to be concentrated into proportion 1.02～1.10, preferred specific gravity 1.04～1.07 after Hericium erinaceus fresh goods or dry product raw material add water and/or alcohol extracting.Preferred Hericium erinaceus extract is to be concentrated into proportion 1.02～1.10 after Hericium erinaceus fresh goods or dry product raw material add water and/or alcohol extracting, and preferred specific gravity 1.04～1.07 is dry and obtain.Preferred Hericium erinaceus extract inclusion compound or microcapsules are to be concentrated into proportion 1.02～1.10 after Hericium erinaceus fresh goods or dry product raw material add water and/or alcohol extracting, preferred specific gravity 1.04～1.07, one or more in concentrate and cyclodextrin, gelatin, converted starch, natural plant gum, alginic acid are water-soluble, add thermal agitation, be cooled to room temperature, dry and obtain.
Especially, the invention provides a kind of health-care flour composition for the preparation of wheaten food or cake that is easy to digest and assimilate, this health-care flour composition contains: flour 100 weight portions, Hericium erinaceus 1～30 weight portion, leavening agent 0.1～2.5 weight portion.Wherein Hericium erinaceus can be not only new fresh Hericium erinaceus or dry product Hericium erinaceus or Hericium erinaceus powder, also can be Hericium erinaceus extract or extract dry and Hericium erinaceus extract or Hericium erinaceus extract inclusion compound or microcapsules.Hericium erinaceus extract is to be concentrated into proportion 1.02～1.10, preferred specific gravity 1.04～1.07 after Hericium erinaceus fresh goods or dry product raw material add water and/or alcohol extracting.Hericium erinaceus extract is to be concentrated into proportion 1.02～1.10 after Hericium erinaceus fresh goods or dry product raw material add water and/or alcohol extracting, and preferred specific gravity 1.04～1.07 is dry and obtain.Hericium erinaceus extract inclusion compound or microcapsules are to be concentrated into proportion 1.02～1.10 after Hericium erinaceus fresh goods or dry product raw material add water and/or alcohol extracting, preferred specific gravity 1.04～1.07, one or more in concentrate and cyclodextrin, gelatin, converted starch, natural plant gum, alginic acid are water-soluble, add thermal agitation, be cooled to room temperature, dry and obtain.In health-care flour composition of the present invention, can also add the appropriate sweetener of food, preferably add sweetener 1～35 weight portion.
In a preferred embodiment of the invention, health-care flour composition of the present invention contains: flour 100 weight portions, Hericium erinaceus 5～20 weight portions, leavening agent 0.1～2.0 weight portion, sweetener 10～30 weight portions.In an especially preferred embodiment, health-care flour composition composition of the present invention is: flour 100 weight portions, Hericium erinaceus 5～20 weight portions, leavening agent 0.1～2.0 weight portion, sweetener 10～30 weight portions.In technical scheme of the present invention, Hericium erinaceus can be not only new fresh Hericium erinaceus or dry product Hericium erinaceus or Hericium erinaceus powder, also can be after Hericium erinaceus fresh goods or dry product raw material are added to water and/or alcohol extracting and be concentrated into proportion 1.02～1.10, the Hericium erinaceus extract of preferred specific gravity 1.04～1.07; Or be concentrated into proportion 1.02～1.10 after Hericium erinaceus fresh goods or dry product raw material are added to water and/or alcohol extracting, and preferred specific gravity 1.04～1.07, dry and obtain; Also can be fresh goods or dry product Hericium erinaceus raw material are added after water and/or alcohol extracting concentrated, and with cyclodextrin, gelatin, converted starch, natural plant gum, alginic acid in one or more are water-soluble, add thermal agitation, be cooled to room temperature, dry, carry out Hericium erinaceus extract inclusion compound or microcapsules that inclusion obtains.More preferably, health-care flour composition provided by the invention contains: flour 100 weight portions, Hericium erinaceus 5～20 weight portions, leavening agent 0.5～1.5 weight portion, sweetener 5～20 weight portions, wherein Hericium erinaceus can be not only new fresh Hericium erinaceus or dry product Hericium erinaceus or Hericium erinaceus powder, also can be Hericium erinaceus extract or extract dry and Hericium erinaceus extract or Hericium erinaceus extract inclusion compound or microcapsules.Hericium erinaceus extract is to be concentrated into proportion 1.02～1.10, preferred specific gravity 1.04～1.07 after Hericium erinaceus fresh goods or dry product raw material add water and/or alcohol extracting; Hericium erinaceus extract is to be concentrated into proportion 1.02～1.10 after Hericium erinaceus fresh goods or dry product raw material add water and/or alcohol extracting, and preferred specific gravity 1.04～1.07 is dry and obtain; Hericium erinaceus extract inclusion compound or microcapsules are that Hericium erinaceus fresh goods or dry product raw material add water and/or alcohol extracting, extract is concentrated into proportion 1.02～1.10, one or more in concentrate and cyclodextrin, gelatin, converted starch, natural plant gum, alginic acid are water-soluble, add thermal agitation, be cooled to room temperature, dry and obtain.In one embodiment of the invention, health-care flour composition provided by the invention contains: flour 100 weight portions, Hericium erinaceus 3～7 weight portions, leavening agent 0.5～1.5 weight portion, sweetener 15～30 weight portions, wherein Hericium erinaceus can be not only new fresh Hericium erinaceus or dry product Hericium erinaceus or Hericium erinaceus powder, also can be Hericium erinaceus extract or extract dry and Hericium erinaceus extract or Hericium erinaceus extract inclusion compound or microcapsules.Preferably, above-mentioned Hericium erinaceus extract is to be concentrated into proportion 1.02～1.10, preferred specific gravity 1.04～1.07 after Hericium erinaceus fresh goods or dry product raw material add water and/or alcohol extracting; Above-mentioned Hericium erinaceus extract is to be concentrated into proportion 1.02～1.10 after Hericium erinaceus raw material adds water and/or alcohol extracting, and preferred specific gravity 1.04～1.07 is dry and obtain; Above-mentioned Hericium erinaceus extract inclusion compound or microcapsules are to be concentrated into proportion 1.02～1.10 after Hericium erinaceus fresh goods or dry product raw material add water and/or alcohol extracting, preferred specific gravity 1.04～1.07, one or more in concentrate and cyclodextrin, gelatin, converted starch, natural plant gum, alginic acid are water-soluble, add thermal agitation, be cooled to room temperature, dry and obtain.
In an embodiment being more preferably, by new fresh Hericium erinaceus, clean, dry, with pulverizer, pulverized 40-80 mesh sieve, obtain crude product; Through ultracentrifugation beveller, under 12000r/min-16000r/min condition, pulverize 10-20 min again, obtain 350-500 order Ultramicro-powder.Preferably, Hericium erinaceus raw material is pulverized, added 10～20 times of decoctings of weight ratio and boil 1～3 time, each 1～2 hour, merge decoction liquor, after filtration, be concentrated into proportion 1.02～1.10, preferably, proportion 1.04～1.07, is dried to obtain Hericium erinaceus extract.Or, Hericium erinaceus raw material is pulverized, add 3～8 times of alcohol dipping of weight ratio 15～35 days; Or alcohol reflux extracts 1～3 time, each 2～4 hours, maceration extract or extract reclaimed ethanol, are concentrated into proportion 1.02～1.10, and preferably, proportion 1.04～1.07, is dried to obtain Hericium erinaceus extract.Or, Hericium erinaceus raw material is pulverized, add 3～8 times of alcohol dipping of weight ratio 15～35 days, or refluxing extraction 1～3 time, each 1～3 hour, maceration extract or extract reclaimed after ethanol, standby; Hericium erinaceus after alcohol extracting adds 15～20 times of decoctings of weight ratio boils 1～3 time, and each 1～2 hour, after decoction liquor is filtered, then merge with alcohol extract, be concentrated into proportion 1.02～1.10, preferably, proportion 1.04～1.07, is dried to obtain Hericium erinaceus extract.Also can replace ethanol to extract with propyl alcohol and/or butanols, or use ethanol and/or propyl alcohol and/or butanols.
The inclusion agents that in health-care flour composition material of the present invention, Hericium erinaceus extract inclusion compound is used is cyclodextrin, and wherein, cyclodextrin is selected from alpha-cyclodextrin, beta-schardinger dextrin-, gamma-cyclodextrin or their derivative, for example HP-β-CD.Preferably use beta-schardinger dextrin-.The method of preparing cyclodextrin inclusion compound includes but not limited to saturated water solution method, ultrasonic method, freeze-drying or spray drying process.The capsule material that in health-care flour composition material of the present invention, Hericium erinaceus extract microcapsules is used is selected from one or more in converted starch, gelatin, natural plant gum, alginic acid.The method of preparing microcapsules include but not limited to spray drying process, extrusion, spraying cooling/condensation method or minute attached bag connection.In one embodiment of the invention, Hericium erinaceus extract concentrate and cyclodextrin is water-soluble, add thermal agitation, be cooled to room temperature, spraying is dry, obtains Hericium erinaceus extract cyclodextrin inclusion compound.More preferably, Hericium erinaceus extract concentrate and cyclodextrin is water-soluble according to weight ratio 1:1～20, and the weight ratio of cyclodextrin and water is 1:1～20.Heating inclusion temperature is 30～45 ℃, and mixing time is more than 15 minutes.In another embodiment of the invention, Hericium erinaceus extract microcapsules is to take extract, adds suitable quantity of water, and heating for dissolving is made core solution.Take a certain amount of gelatin, add a certain amount of water, make its swelling, dispersion, 40 ℃ of heating water baths dissolve it, make wall material solution.According to certain wall material core, than (5:1～15:1, m/m) and certain wall material concentration level (1:50, m/V) requirement, core solution is joined in wall material solution, stir, mix, spraying is drying to obtain.More preferably, by the comparatively suitable drying process with atomizing condition of orthogonal design optimization, be that wall material core is than 10:1 (m/m), 170 ℃ of EATs, feed rate 3mL/min.With this understanding, having prepared average grain diameter is the microcapsules of 11.93 μ m.
Flour described in health-care flour raw material of the present invention is selected from but is not limited to one or more powder made for raw material grinding mill in wheat, rice, corn, millet, barley, jowar, the seed of Job's tears, glutinous rice, oat, buckwheat, naked oats, pumpkin, the root of kudzu vine, potato, cassava, soya bean, red bean, mung bean, kidney bean, broad bean, pea, cowpea, chick-pea, lotus root, water caltrop, lily, konjaku, bajiao banana taro.Preferably, described in health-care flour raw material of the present invention, flour is that wheat flour adds coarse cereal powder, and more preferably, described in health-care flour raw material of the present invention, flour is wheat flour.
In one embodiment of the invention, can also in health-care flour composition of the present invention, add food auxiliary material, for example, for 101-130 weight portion flour composition, can add food appropriate, preferred one or more in the vitamin, starch, salt, five-spice powder etc. of 0.2～10 weight portion.In another embodiment of the invention, can also in health-care flour composition of the present invention, add food additives, for example, for 101-130 weight portion flour composition, can add one or more in the monosodium glutamate, milk powder, essence, stearoyl lactate, disodium ethylene diamine tetraacetate etc. of 0.02～5 weight portion.Described essence includes but not limited to one or more in vanillic aldehyde, the turbid essence of milk etc.
Leavening agent of the present invention is selected from but is not limited to one or more in sodium bicarbonate, baking powder, ammonia bicarbonate (carbonic hydroammonium), alum, sodium pyrosulfite, Sodium Acid Pyrophosphate, yeast.Preferably, leavening agent of the present invention is one or more in sodium bicarbonate, ammonia bicarbonate, sodium pyrosulfite, Sodium Acid Pyrophosphate.Preferred, leavening agent of the present invention is sodium bicarbonate.
Sweetener in health-care flour composition raw materials of the present invention is selected from one or more in glucose, fructose, sucrose, maltose, starch sugar, lactose, stevioside, Aspartame, 3,4-Dihydro-6-methyl-1,2,3-oxathiazin-4-one 2,2-dioxide potassium salt, saccharin sodium, honey element, maltitol.
Health-care flour composition of the present invention is to make by processing method below: by proportioning each composition of weighing, be uniformly mixed; Or by proportioning each composition of weighing, ground and mixed; Or by proportioning each composition of weighing, the mixing of sieving; Or each composition of weighing by proportioning is placed in to container rotary mixing machine to be mixed; Or each composition of weighing by proportioning is placed in to container fixed mixer to be mixed; Or the flour of weighing by proportioning is placed in to fluid bed granulator, the mixture aqueous solution of the Hericium erinaceus of weighing by proportioning and other composition is mixed by dry.
On the other hand, the invention provides the dough of preparing with health-care flour composition of the present invention, described health-care flour composition is made to dough, standing.If needed, allow dough fermentation.Health-care flour composition fatten of the present invention, flavoring essence and water, can make shortbread type biscuit or soda cracker.Described grease, include but not limited in butter, butter, lard, shortening, edible vegetable oil these one or more.One or more in the preferred coconut oil of described edible vegetable oil, palm oil, olive oil, salad oil, peanut oil, tea-seed oil, soya-bean oil, sesame oil, long beggar's oil.Preferably, in 101-130 weight portion dough, add 10～30 weight portion greases.In dough of the present invention, can also add the conventional auxiliary material of one or more pastry product industry in egg, vegetables, shredded coconut meat, dry fruit, raisins, chocolate, cocoa power, dried meat floss etc.
In dough of the present invention, can add the appropriate food additives of food, include but not limited to one or more in acidity regulator, anticaking agent, defoamer, antioxidant, colouring agent, color stabilizer, enzyme preparation, flavoring agent, nutrition fortifier, anticorrisive agent, sweetener, thickener, spices.
On the one hand, the invention provides the food with health care of preparing with health-care flour composition of the present invention or dough again, include but not limited to biscuit, bread, instant noodles, steamed bun, noodles or cake etc.Health-care flour composition of the present invention is made to dough, if needed, ferment, pressing mold base, baking, if needed, low temperature drying, obtains health care flour-made food.
Preferably, biscuit prepared by health-care flour composition of the present invention or dough dough in preparation technology bakes by 3～4 stoving temperature districts successively, and 150～360 ℃ of stoving temperatures, always cure 4～8 minutes time.Biscuit prepared by health-care flour composition of the present invention or dough can be coated with chocolate cream, jam or other tartar sauce and make sandwich biscuits or decorate biscuit between biscuit monolithic.
In a preferred technical scheme of the present invention, the step of preparing shortbread type biscuit comprises:
(1) modulate dough: by described composition of raw materials, take each raw material: first sweetener and grease are mixed to get to material A; Leavening agent, salt, flavoring essence are mixed, and the material B that is dissolved in water to obtain; Material A, material B, Hericium erinaceus, other raw material and water are dropped in mixer successively, be stirred to evenly; Then flour and above-mentioned homogeneous material are mixed, add water and continue to be stirred to evenly, standby;
(2) compressing: the biscuit green compact that make various shapes through roll marks shaping mechanism;
(3) cure: biscuit green compact are sent into curer baking, and burner hearth is divided into Si Ge district: 1st district sets 220～235 ℃ of face temperature, 200～220 ℃ of end temperature; 2nd district set 230～250 ℃ of face temperature, 190～210 ℃ of end temperature; 3rd district set 230～240 ℃ of face temperature, 200～210 ℃ of end temperature; 4th district set 160～200 ℃ of face temperature, 170～210 ℃ of end temperature; Whole curing 4～10 minutes time;
(4) oil spout: the biscuit rear surface oil spout of coming out of the stove;
(5) pack: the biscuit after oil spout, through arranging, is packed to finished product.
In a preferred technical scheme of the present invention, the step of preparing soda cracker comprises:
(1) dough modulation and fermentation: first part flour, Hericium erinaceus are dropped into and adjusted in powder cylinder, slowly adding after adjusting powder machine to start is the even dirty solution that dry yeast and suitable quantity of water are modulated into, and is blended into dough; Then dough is poured in fermentation tank, controlling dough temperature is 28～32 ℃, ferments 6～10 hours; Complete dough modulation for the first time and fermentation; The dough having fermented for the first time is again dropped into and adjusted in powder cylinder, add all the other flour and the Hericium erinaceus of formula regulation, then add grease, sweetener, salt, flavoring essence and other raw material and water, start the powder machine of adjusting, mixed, dough has been modulated for the second time; Dough is poured in fermentation tank, and controlling dough temperature is 30～35 ℃, ferments 4～6 hours;
(2) dough sheet calendering and moulding: through stamped or rolling cut dough sheet, cut out the biscuit green compact of different appearance profiles;
(3) cure: biscuit green compact are sent into curer baking, and burner hearth is divided into San Ge district: 1st district sets 190～210 ℃ of face temperature, 320～360 ℃ of end temperature; 2nd district set 240～280 ℃ of face temperature, 230～250 ℃ of end temperature; 3rd district set 180～220 ℃ of face temperature, 180～220 ℃ of end temperature.Whole curing 5～8 minutes time;
(4) oil spout: the biscuit rear surface oil spout of coming out of the stove;
(5) pack: the biscuit after oil spout, through arranging, is packed to finished product.
In another preferred technical scheme of the present invention, the step of preparing soda cracker comprises:
(1) dough modulation and fermentation: first flour, Hericium erinaceus are dropped into and adjusted in powder cylinder, add again grease, sweetener, salt, sodium bicarbonate, flavoring essence and other raw material, after adjusting powder machine to start, slowly adding is the even dirty solution that dry yeast and suitable quantity of water are modulated into, and is blended into dough; Then dough is poured in fermentation tank, controlling dough temperature is 33～34 ℃, ferments 4 hours; Complete dough modulation and fermentation;
(2) dough sheet calendering and moulding: through stamped or rolling cut dough sheet, cut out the biscuit green compact of different appearance profiles;
(3) cure: biscuit green compact are sent into curer baking, and burner hearth is divided into San Ge district: 1st district sets 190～210 ℃ of face temperature, 320～360 ℃ of end temperature; 2nd district set 240～280 ℃ of face temperature, 230～250 ℃ of end temperature; 3rd district set 180～220 ℃ of face temperature, 180～220 ℃ of end temperature; Whole curing 7～10 minutes time;
(4) oil spout: the biscuit rear surface oil spout of coming out of the stove;
(5) pack: the biscuit after oil spout, through arranging, is packed to finished product.
The raw material of the biscuit that in a preferred embodiment of the invention, prepared by health-care flour composition of the present invention contains following weight proportion:
100 parts of wheat flours
1～30 part of Hericium erinaceus
0.1～2.5 part of leavening agent
1～35 part of sweetener
10～30 parts of greases
0.6～2 part of salt
0.02～5 part of flavoring essence
10～30 parts, water.
The raw material of above-mentioned biscuit prepared by health-care flour composition of the present invention can also further contain:
0.2～10 part of starch
0.02～5 part of milk powder
The food that inventor finder's day eats the Hericium erinaceus extract that contains 8～15 grams of Hericium erinaceus crude drug amounts can reach daily health caring effect.Therefore, on the one hand, the invention provides health-care flour composition of the present invention and there is the purposes in the food of repairing the gastric mucosa injure function that chronic gastritis, gastric ulcer or duodenal ulcer cause in preparation.Another aspect, the present invention also provides health-care flour composition of the present invention to have the purposes in the food of the abdominal pain function that relieve chronic gastritis, gastric ulcer or duodenal ulcer cause in preparation.On the other hand, the present invention also provides health-care flour composition of the present invention to have the purposes in the food of auxiliary curing chronic gastritis, gastric ulcer, duodenal ulcer function in preparation.Again on the one hand, the present invention also provides health-care flour composition of the present invention to have the purposes in the food that suppresses helicobacter pylori function in preparation.
Modern often due to work, rhythm of life is fast, have no time to have meal on time; Or after having missed meal time because excessive hunger is eaten and drunk immoderately, thereby cause stomach and intestine indigestion, gasteremphraxis, feel sick, the digestion class problem such as stomachache occurs again and again, health is usually in sub-health state.But most people is often taken exception to this type of healthy hidden danger, think that these symptoms are just owing to not taking food and causing, thereby often ignored the health care to stomach and intestine in daily life.Except the stomach trouble crowd that doctor makes a definite diagnosis, general upset,gastro-intestinal crowd can initiatively not take the medicine for the treatment of stomach trouble.
The raw material Hericium erinaceus of health-care flour composition of the present invention is recorded according to < < Compendium of Materia Medica > >: property is flat, and taste is sweet, has the function of " sharp the five internal organs, aid digestion ".Modern study also shows that Hericium erinaceus has invigorating spleen and reinforcing stomach, norcholesterol, and nourishing, anticancer, the effect such as protect the liver.The leisure food such as biscuit, bread, instant noodles, steamed bun, noodles or cake that health-care flour composition of the present invention is prepared into, having solved the edible Hericium erinaceus of people in daily life need cook not only consuming time but also be limited to the inconvenience in place, make this Precious Edible Fungi that has nutritive value and health-care efficacy of Hericium erinaceus from luxurious bamboo mat spread on the floor for people to sit in ancient China is feted, enter in common people's daily life.Food prepared by health-care flour composition of the present invention was both convenient for carrying, and was easy to again store.For the crowd who is busy with one's work and cannot has meal on time, this based food can be their makeup energy in time.In addition, because having, this based food repairs the gastric mucosa injure function that chronic gastritis, gastric ulcer or duodenal ulcer cause; There is the abdominal pain function that relieve chronic gastritis, gastric ulcer or duodenal ulcer cause; Also can suppress helicobacter pylori, auxiliary curing chronic gastritis, gastric ulcer, duodenal ulcer, people eat this based food, when alleviating hunger, can play a role in health care again, be to kill two birds with one stone.
The Hericium erinaceus of adding in health-care flour composition of the present invention, except can be new fresh Hericium erinaceus or dry product Hericium erinaceus or Hericium erinaceus powder, also Hericium erinaceus fresh goods or dry product raw material are added concentrated gained Hericium erinaceus extract after water and/or alcohol extracting or extract dry and Hericium erinaceus extract; Also fresh goods or dry product Hericium erinaceus raw material are added to water and/or alcohol extracting, and material after extracting is carried out to Hericium erinaceus extract inclusion compound or the microcapsules that inclusion obtains.Hericium erinaceus food of the prior art, need first decoct Hericium erinaceus fresh goods or dry product during preparation to add or Hericium erinaceus Strains is obtained to zymotic fluid through fermentation after making beating and add.Health-care flour composition of the present invention by comparison, can not only fully retain the abundant nutrition composition in Hericium erinaceus raw material directly as raw-food material, and is easier to obtain, and is conducive to storage and deep processing, adapts to industrialized production.Health-care flour composition of the present invention is in the Hericium erinaceus extract situation that contains higher deal, its mouthfeel has a little bitterness, consider that consumer often extremely focuses on the mouthfeel of food, the present invention does not have employing to add sugar to wait the mode of flavouring to cover pained taste, but explore by repetition test, determine the inclusion technique parameter of Hericium erinaceus extract, by inclusion, solved the problem of its mouthfeel shortcoming.When having guaranteed food mouthfeel, also reduced adding of sweetener as much as possible, what the crowd that need control sugar part intake for diabetes patient or other provided edible this based food may.In addition, because Hericium erinaceus extract draws moist byer force, make to take its health-care flour composition of preparing as raw material in storage process, easily the moisture absorption is rotten, thereby affects the stability of product.Adopt inclusion technique can prevent the Hericium erinaceus extract moisture absorption, thereby improve the stability of made health-care flour composition.In addition, inventor also finds to adopt inclusion technique to process the solubility that resulting Hericium erinaceus extract inclusion compound or microcapsules can obviously increase the effective health-care components of Hericium erinaceus extract, improves its bioavilability, improves its stability simultaneously, reduces excitant.
The amount that contains Hericium erinaceus in health-care flour composition of the present invention is determined through repetition test, not only the mouthfeel of the food made from this health-care flour composition had no adverse effect, and the gastric mucosa injure causing in reparation chronic gastritis, gastric ulcer or duodenal ulcer; The abdominal pain that relieve chronic gastritis, gastric ulcer or duodenal ulcer cause; Suppress helicobacter pylori, there is precise effects auxiliary curing chronic gastritis, gastric ulcer, duodenal ulcer aspect.We have carried out effect contrast to the biscuit of preparing with health-care flour composition of the present invention and commercially available common digestion class biscuit, and concrete test is as follows:
1, clinical data
Selection confirms to suffer from disease of stomach patient 50 examples, 18～55 years old age, male or female through gastrocopy.Selected within first 1 week, once took PPI or bisfentidine person forecloses.Patient is divided into observation group and each 25 examples of control group, superficial gastritis 10 examples in treatment group, erosive gastritis 5 examples, atrophic gastritis 5 examples, gastric ulcer 3 examples, duodenal ulcer 2 examples at random; Superficial gastritis 9 examples in control group, erosive gastritis 7 examples, atrophic gastritis 5 examples, gastric ulcer 2 examples, duodenal ulcer 2 examples.Two groups of ordinary circumstances have comparativity.
2, Dietotherapy method
The biscuit (take biscuit amount 60g every day, wherein contain 10g Hericium erinaceus crude drug) of making by embodiment 28 methods in observation group's edible " specific embodiment ", edible 4 weeks.Control group eats commercially available digestive biscuit, and edible time and amount Jun Yu observation group are identical.
3, curative effect determinate standard
Effective: symptom disappears substantially, gastrocopy still has mild inflammation to change; Effective: symptom is improved, gastrocopy gastritis scope is dwindled to some extent, is alleviated; Invalid: symptom is not improved, gastrocopy gastritis situation is not improved.
4, result
[0032]as seen from the experiment, the Hericium erinaceus biscuit that health-care flour composition of the present invention is made has repairs the gastric mucosa injure that chronic gastritis, gastric ulcer or duodenal ulcer cause, relieve chronic gastritis, gastric ulcer cause abdominal pain, suppress helicobacter pylori, the effect of auxiliary curing chronic gastritis, gastric ulcer or duodenal ulcer disease.
Health-care flour composition of the present invention has carried out deep processing to long patent flour, in effect, has compared this qualitative leap with long patent flour.And inventor's discovery, when adding 1～30 weight portion Hericium erinaceus in 100 weight portion flour, prepared food mouthfeel is good.Concrete test is as follows:
1, experiment purpose: the quality of 5 kinds of shortbread type biscuit finished products that employing different ratios of raw materials is made is evaluated.
2, laboratory sample:
The raw material of 2.1 samples 1 and preparation method:
Raw material: 4 kilograms, flour, 0.2 kilogram of Hericium erinaceus, 47 grams of leavening agents, 0.7 kilogram of grease, sweetener 0.5kg, in right amount other auxiliary material.
Preparation method:
1) modulation dough: take each raw material by described composition of raw materials: first sweetener and grease are mixed to get to material 1; Leavening agent, salt, flavoring essence are mixed, and the material 2 that is dissolved in water to obtain; Material 1, material 2, Hericium erinaceus extract and water are dropped in mixer successively, be stirred to evenly; Then flour and above-mentioned homogeneous material are mixed, add water and continue to be stirred to evenly, standby.
2) compressing: the biscuit green compact that make various shapes through roll marks shaping mechanism;
3) cure: biscuit green compact are sent into curer baking, and burner hearth is divided into Si Ge district: 1st district sets 235 ℃ of face temperature, 210 ℃ of end temperature; 2nd district set 230 ℃ of face temperature, 200 ℃ of end temperature; 3rd district set 230 ℃ of face temperature, 200 ℃ of end temperature; 4th district set 190 ℃ of face temperature, 200 ℃ of end temperature.Whole curing 4 minutes time.
4) oil spout: the biscuit rear surface oil spout of coming out of the stove.
5) packing: the biscuit after oil spout, through arranging, is packed to finished product.
The raw material of 2.2 samples 2 and preparation method:
Raw material: 4 kilograms, flour, 0.6 kilogram of Hericium erinaceus, 52 grams of leavening agents, 0.8 kilogram of grease, 0.6 kilogram of sweetener, in right amount other auxiliary material.
Preparation method is with sample 1.
The raw material of 2.3 samples 3 and preparation method:
Raw material: 4 kilograms, flour, 1.2 kilograms of Hericium erinaceus, 58 grams of leavening agents, 0.9 kilogram of grease, 0.7 kilogram of sweetener, in right amount other auxiliary material.
Preparation method is with sample 1.
The raw material of 2.4 samples 4 and preparation method:
Raw material: 4 kilograms, flour, 2 kilograms of Hericium erinaceus, 68 grams of leavening agents, 1 kilogram of grease, 0.8 kilogram of sweetener, in right amount other auxiliary material.
Preparation method is with sample 1.
The raw material of 2.5 samples 5 and preparation method:
Raw material: 4 kilograms, flour, 2.8 kilograms of Hericium erinaceus, 0.12 kilogram of leavening agent, 1.3 kilograms of greases, 1.4 kilograms of sweeteners, in right amount other auxiliary material.
Preparation method is with sample 1.
3, experimental procedure:
Biscuit complete and cooling after, select 50 of experienced personnel (25 male sex and 25 women, 20～50 years old age), by shortbread type biscuit organoleptic indicator standards of grading (in Table 1), mark, finally average, total points is 100 minutes, the results are shown in Table 2.
Above experimental result shows, when adding 1～30 weight portion Hericium erinaceus in 100 weight portion flour, prepared food mouthfeel is good.
the specific embodiment
the preparation of embodiment 1 Hericium erinaceus water extract of the present invention
Take 10 kilograms of Hericium erinaceus dried food and nuts, pulverize, add 100 premium on currency, decoct 2 hours, filter, collect filtrate.In residue, add 80 premium on currency again, decoct 2 hours, filter, collect filtrate, twice gained filtrate is merged, being concentrated into proportion is 1.06, spraying dry 3 kilograms of Hericium erinaceus extracts.
the preparation of embodiment 2 Hericium erinaceus alcohol extract of the present invention
Take 15 kilograms of Hericium erinaceus dried food and nuts, pulverize, add 125 liter of 50% ethanol, flood 20 days, maceration extract reclaims after distillation ethanol, is concentrated into proportion 1.06, and spraying is dried to obtain 1.5 kilograms of Hericium erinaceus extracts.
the preparation of embodiment 3 Hericium erinaceus alcohol extract of the present invention
Take 18 kilograms of Hericium erinaceus dried food and nuts, pulverize, add 250 liter of 60% ethanol, keep being heated under fluidized state refluxing extraction 2 hours, filter, extract reclaims ethanol, is concentrated into proportion 1.05, spraying dry 1.3 kilograms of Hericium erinaceus extracts.
the preparation that embodiment 4 Hericium erinaceus Ultramicro-powder of the present invention minces
Take 20 kilograms of new fresh Hericium erinaceus, clean, dry, with pulverizer, pulverized 60 mesh sieves, obtain crude product; Through ultracentrifugation beveller, under 16000r/min condition, pulverize 15 min again, obtain 350-500 order Ultramicro-powder.
the preparation of embodiment 5 Hericium erinaceus alcohol and water of the present invention extract
Take 20 kilograms of Hericium erinaceus dried food and nuts, pulverize, add 188 liter of 70% ethanol, keep being heated under fluidized state refluxing extraction 2 times, each 1.5 hours, extract reclaimed after ethanol, standby.Hericium erinaceus after alcohol extracting is added to 115 premium on currency, decoct 2 times, each 2 hours, decoction liquor merged with reflux extracting liquid after filtering, and being concentrated into proportion is 1.08, and spraying is dried to obtain 6 liters of Hericium erinaceus extracts.
the preparation of embodiment 6 Hericium erinaceus extract microcapsules of the present invention
By 8 kilograms of Hericium erinaceus extracts that obtain by embodiment 1 method, add 1L water, heating for dissolving is made core solution.Take 16 kilograms of gelatin, add 800 premium on currency, at 40 ℃, heating water bath dissolves it, makes wall material solution.Core solution is joined in wall material solution, stir, mix, spraying is dry, obtains Hericium erinaceus extract microcapsules.
the preparation of embodiment 7 Hericium erinaceus alcohol extract of the present invention inclusion compound
5 kilograms of Hericium erinaceus extracts that obtain by embodiment 3 methods are joined in 375 premium on currency solution of 75 kilograms of HP-β-CDs, with ultrasonic disruption instrument, process 20 minutes, by the sedimentation and filtration of separating out, washing, dry, obtain Hericium erinaceus extract inclusion compound.
the preparation of embodiment 8 Hericium erinaceus extract of the present invention inclusion compound
6 kilograms of Hericium erinaceus extracts that obtain by embodiment 5 methods and 120 kg beta-schardinger dextrin-are dissolved in 1800 premium on currency, stir 20 minutes at 38 ℃, cooling, spraying is dry, obtains Hericium erinaceus extract inclusion compound.
the preparation of embodiment 9 Hericium erinaceus extract microcapsules of the present invention
By 5 kilograms of Hericium erinaceus extracts that obtain by embodiment 5 methods, add 15 premium on currency, heating for dissolving is made core solution.Take 10 kilograms of gelatin and add 500 premium on currency, at 38 ℃, heating water bath dissolves it, makes wall material solution.Core solution is joined in wall material solution, stir, mix, spraying is dry, obtains Hericium erinaceus extract microcapsules.
the preparation of embodiment 10 health-care flour composition of the present invention
Take 10 kilograms of wheat flours, 1.2 kilograms of Hericium erinaceus extracts that obtain by embodiment 1 method, are uniformly mixed, and obtain health-care flour composition of the present invention.
the preparation of embodiment 11 health-care flour composition of the present invention
2.3 kilograms of Hericium erinaceus extracts that obtain by embodiment 2 methods are dissolved with 0.3 premium on currency; Take 15 kilograms of wheat flours and be placed in fluid bed granulator, both combination dryings of spraying, obtain health-care flour composition of the present invention.
the preparation of embodiment 12 health-care flour composition of the present invention
Take 12 kilograms of wheat flours, 2.9 kilograms of Hericium erinaceus extracts that obtain by embodiment 3 methods, 0.3 kilogram of sodium bicarbonate, ground and mixed is even, obtains health-care flour composition.
the preparation of embodiment 13 health-care flour composition of the present invention
1.8 kilograms of Hericium erinaceus extracts that obtain by embodiment 4 methods, 0.2 kilogram of sodium bicarbonate, 1.5 kilograms of white sugar are dissolved with 0.3 premium on currency; Take 10 kilograms of wheat flours and be placed in fluid bed granulator, both combination dryings of spraying, obtain health-care flour composition of the present invention.
the preparation of embodiment 14 health-care flour composition of the present invention
1.8 kilograms of Hericium erinaceus extracts that obtain by embodiment 5 methods, 0.15 kilogram of sodium bicarbonate, 1.2 kilograms of steviosides are dissolved with 0.25 premium on currency; Take 9 kilograms of wheat flours and be placed in fluid bed granulator, both combination dryings of spraying, obtain health-care flour composition of the present invention.
the preparation of embodiment 15 health-care flour composition of the present invention
0.3 kilogram of Hericium erinaceus extract obtaining by embodiment 5 methods, 0.2 kilogram of sodium bicarbonate, 0.6 kilogram of white sugar are dissolved with 0.1 premium on currency; Take 16 kilograms of wheat flours, 0.3 kilogram of glutinous rice flour is placed in fluid bed granulator, both combination dryings of spraying, obtain health-care flour composition of the present invention.
the preparation of embodiment 16 health-care flour composition of the present invention
1.3 kilograms of Hericium erinaceus extracts that obtain by embodiment 3 methods, 0.35 kilogram of sodium bicarbonate are dissolved with 0.3 premium on currency; Take 18 kilograms of wheat flours, 3 kilograms of glutinous rice, 2 kilograms of buckwheats and be placed in fluid bed granulator, both combination dryings of spraying, obtain health-care flour composition of the present invention.
the preparation of embodiment 17 health-care flour composition of the present invention
1 kilogram of Hericium erinaceus extract obtaining by EXAMPLE Example 1 method is dissolved with 0.2 premium on currency; Take 10 kilograms of wheat flours and be placed in fluid bed granulator, both combination dryings of spraying, obtain health-care flour composition of the present invention.
the preparation of embodiment 18 health-care flour composition of the present invention
3.5 kilograms of Hericium erinaceus extracts that obtain by embodiment 1 method, 0.2 kilogram of sodium bicarbonate are dissolved with 0.4 premium on currency; Take 13 kilograms of wheat flours, 4 kilograms of glutinous rice, 2 kilograms of buckwheats and be placed in fluid bed granulator, both combination dryings of spraying, obtain health-care flour composition of the present invention.
the preparation of embodiment 19 health-care flour composition of the present invention
Take 15 kilograms of wheat flours, 4.5 kilograms of Hericium erinaceus extracts that obtain by embodiment 5 methods, 0.35 kilogram of sodium bicarbonate, ground and mixed is even, obtains health-care flour composition of the present invention.
the preparation of embodiment 20 health-care flour composition of the present invention
Take 8 kilograms of wheat flours, 1.2 kilograms of Hericium erinaceus extract microcapsules that obtain by embodiment 6 methods, are placed in container rotary mixing machine and mix, and obtain health-care flour composition of the present invention.
the preparation of embodiment 21 health-care flour composition of the present invention
3 kilograms of Hericium erinaceus extract inclusion compounds that obtain by embodiment 7 methods are dissolved with 0.4 premium on currency; Take 12 kilograms of wheat flours and be placed in fluid bed granulator, both combination dryings of spraying, obtain health-care flour composition of the present invention.
the preparation of embodiment 22 health-care flour composition of the present invention
Take 17 kilograms of wheat flours, 2.8 kilograms of Hericium erinaceus extract inclusion compounds that obtain by embodiment 8 methods, 0.4 kilogram of sodium bicarbonate, sieves and mixes, and obtains health-care flour composition of the present invention.
the preparation of embodiment 23 health-care flour composition of the present invention
0.5 kilogram of Hericium erinaceus extract microcapsules obtaining by embodiment 6 methods, 0.1 kilogram of sodium bicarbonate, 1.5 kilograms of white sugar are dissolved with 0.2 premium on currency; Take 10 kilograms of wheat flours and be placed in fluid bed granulator, both combination dryings of spraying, obtain health-care flour composition of the present invention.
the preparation of embodiment 24 health-care flour composition of the present invention
1.3 kilograms of Hericium erinaceus extract inclusion compounds that obtain by embodiment 7 methods, 0.12 kilogram of sodium bicarbonate, 1.5 kilograms of white sugar are dissolved with 0.3 premium on currency; Take 10 kilograms of wheat flours and be placed in fluid bed granulator, both combination dryings of spraying, obtain health-care flour composition of the present invention.
the preparation of embodiment 25 health-care flour composition of the present invention
4.8 kilograms of Hericium erinaceus extract microcapsules that obtain by embodiment 9 methods, 0.2 kilogram of sodium bicarbonate, 2 kilograms of white sugar are dissolved with 0.6 premium on currency; Take 17 kilograms of wheat flours, 1000 grams of glutinous rice flours are placed in fluid bed granulator, both combination dryings of spraying, obtain health-care flour composition of the present invention.
the preparation of embodiment 26 health-care flour composition of the present invention
1.1 kilograms of Hericium erinaceus extract inclusion compounds that obtain by embodiment 7,0.15 kilogram of sodium bicarbonate are dissolved with 0.15 premium on currency; Take 13 kilograms of wheat flours, 3 kilograms of glutinous rice, 3 kilograms of buckwheats and be placed in fluid bed granulator, both combination dryings of spraying, obtain health-care flour composition of the present invention.
the preparation of embodiment 27 health-care flour composition of the present invention
2.5 kilograms of Hericium erinaceus powder, 0.2 kilogram of sodium bicarbonate are dissolved with 0.4 premium on currency; Take 15 kilograms of wheat flours, 5 kilograms of glutinous rice, 2 kilograms of buckwheats and be placed in fluid bed granulator, both combination dryings of spraying, obtain health-care flour composition of the present invention.
the preparation of embodiment 28 Hericium erinaceus shortbread type biscuit of the present invention
Take 20 kilograms of the health-care flour compositions of the present invention that obtain according to the method for embodiment 10,0.4 kilogram of maltose, 0.6 kilogram of milk powder, 130 grams of salt, 0.6 kilogram of starch, 50 grams of baking powders, 1.5 kilograms of lards, 1.5 kilograms of palm oils.Each material except health-care flour composition of the present invention, starch is dropped in mixer successively, add water and stir, mixing time 6min; Health-care flour composition of the present invention, starch and water are added in above-mentioned homogeneous material, be stirred to evenly, mixing time 5min, standby.Whole process adds 3.5 kilograms, water altogether.By the above-mentioned fabric stirring by the moulding of mould roll marks, cure, obtain semi-finished product biscuit A; Or by the above-mentioned fabric stirring by the moulding of mould roll marks, cure, oil spout, obtain semi-finished product biscuit B.Moulding dough sheet, successively by Si Ge baking temperature district, is one minute half left and right the time of staying in each district, bakes altogether 6 min.Cure parameter: 1st district: 230 ℃ of setting face temperature, set 200 ℃ of end temperature.2nd district: 240 ℃ of setting face temperature, set 210 ℃ of end temperature.3rd district: 230 ℃ of setting face temperature, set 210 ℃ of end temperature.4th district: 190 ℃ of setting face temperature, set 200 ℃ of end temperature.Described temperature is the temperature of biscuit one side upward on conveyer belt; Temperature of the described end is the temperature of biscuit one side down on conveyer belt.Stove guipure rotating speed: 650cm/min.To baking the oil spout of rear surface of semi-finished sesame oil.Fuel injection parameter: set 65 ℃ of oil temperatures, conveyer belt rotating speed 700cm/min.Each semi-finished product biscuit is crossed after wafer separator burst, packed, obtain finished product biscuit A and B.
the preparation of embodiment 29 Hericium erinaceus soda cracker of the present invention
Take 10 kilograms of the health-care flour compositions of the present invention that obtain according to the method for embodiment 11,0.18 kilogram is dry yeast, 1.2 kilograms of palm oils, 0.2 kilogram of maltose, 0.1 kilogram of salt.First 6 kilograms of flour are dropped into and adjusted in powder cylinders, after adjusting powder machine to start, slowly adding is the even dirty solution that dry yeast and suitable quantity of water are modulated into, mixed 5 min, dough.Then dough is poured in fermentation tank, controlling dough temperature is 30 ℃, ferments 8 hours, completes dough modulation for the first time and fermentation.The dough having fermented for the first time is again dropped into and adjusted in powder cylinder, add all the other 4 kilograms health-care flour compositions of the present invention of formula regulation, add grease, maltose and water, start the powder machine of adjusting, mixed 6min, after dough forms, be sprinkled into salt again, then modulate 2min, dough has been modulated for the second time.Dough is poured in fermentation tank, and controlling dough temperature is 32 ℃, ferments 4 hours.With 2 kilograms of health-care flour compositions of the present invention that obtain by embodiment 13 methods and 0.8 kilogram of palm oil and 0.1 kilogram of salt, drop into and adjust in powder cylinder, be uniformly mixed 15min left and right, be mixed evenly to material, short, be sub-packed in short dish stand-by.Roll extrusion and lamination folder are crisp.Dough sheet calendering and moulding.Moulding dough sheet by San Ge baking temperature district, is one minute half the time of staying in each district successively, bakes altogether 6 min.Cure parameter: 1st district: 200 ℃ of setting face temperature, set 360 ℃ of end temperature.2nd district: 280 ℃ of setting face temperature, set 250 ℃ of end temperature.3rd district: 190 ℃ of setting face temperature, set 210 ℃ of end temperature.Described temperature is the temperature of biscuit one side upward on conveyer belt; Temperature of the described end is the temperature of biscuit one side down on conveyer belt.To baking the coconut oil oil spout of rear surface of semi-finished.Fuel injection parameter: set 50 ℃ of oil temperatures, 14% of the weight that is finished product by oil mass.Cooling, obtain Hericium erinaceus soda cracker of the present invention, packing.
the preparation of embodiment 30 Hericium erinaceus soda cracker of the present invention
Take 10 kilograms of the health-care flour compositions of the present invention that obtain according to the method for embodiment 14,0.15 kilogram of yeast, 1.5 kilograms of sesame oil, 0.5 kilogram of coconut oil, 0.3 kilogram of maltose, 0.2 kilogram of salt.First 5 kilograms of health-care flour compositions of the present invention are dropped into and adjusted in powder cylinders, after adjusting powder machine to start, slowly adding is the even dirty solution that dry yeast and suitable quantity of water are modulated into, mixed 6 min, dough.Then dough is poured in fermentation tank, controlling dough temperature is 32 ℃, ferments 6 hours.Complete dough modulation for the first time and fermentation.The dough having fermented for the first time is again dropped into and adjusted in powder cylinder, add all the other 5 kilograms health-care flour compositions of the present invention of formula regulation, add grease, maltose and water, start the powder machine of adjusting, mixed 6min, after dough forms, be sprinkled into salt again, then modulate 3min, dough has been modulated for the second time.Dough is poured in fermentation tank, and controlling dough temperature is 30 ℃, ferments 4 hours.With 3 kilograms of health-care flour compositions of the present invention that obtain by embodiment 14 methods and 300 grams of palm oils and 18 grams of salt, drop into and adjust in powder cylinders, be uniformly mixed 20min left and right, be mixed evenly to material, short, be sub-packed in short dish stand-by.Roll extrusion and lamination folder are crisp.Dough sheet calendering and moulding.Moulding dough sheet by San Ge baking temperature district, is one minute half the time of staying in each district successively, bakes altogether 5 min.Cure parameter: 1st district: 200 ℃ of setting face temperature, set 320 ℃ of end temperature.2nd district: 250 ℃ of setting face temperature, set 280 ℃ of end temperature.3rd district: 180 ℃ of setting face temperature, set 220 ℃ of end temperature.Described temperature is the temperature of biscuit one side upward on conveyer belt; Temperature of the described end is the temperature of biscuit one side down on conveyer belt.To baking refining coconut oil oil spout for rear surface of semi-finished.Fuel injection parameter: set 60 ℃ of oil temperatures, 16% of the weight that is finished product by oil mass.Cooling, obtain Hericium erinaceus soda cracker of the present invention, packing.
the preparation of embodiment 31 Hericium erinaceus wafer of the present invention
Take 10 kilograms of the health-care flour compositions of the present invention that obtain according to the method for embodiment 18,0.6 kilogram of maltose, 0.4 kilogram of milk powder, 0.1 kilogram of salt, 0.3 kilogram of starch, 80 grams, carbonic hydroammonium, 5 grams of vanillic aldehydes, 40 grams of Sodium Acid Pyrophosphates, 3 grams of sodium pyrosulfites, 20 grams, the turbid essence of milk, 1.2 kilograms of lards, 1 kilogram of palm oil.Sodium Acid Pyrophosphate and sodium pyrosulfite water are dissolved, standby; All the other each materials except health-care flour composition of the present invention, starch drop in mixer successively, add water and stir, mixing time 5min; Health-care flour composition of the present invention, starch, the Sodium Acid Pyrophosphate having dissolved in advance and sodium pyrosulfite are added in above-mentioned homogeneous material, be stirred to evenly, mixing time 6min, standby.Whole process shares 4 kilograms, water.By the above-mentioned fabric stirring by the moulding of mould roll marks, cure oil spout.Moulding dough sheet, successively by San Ge baking temperature district, is one minute half left and right the time of staying in each district, bakes altogether 5 min.Cure parameter: 1st district: 230 ℃ of setting face temperature, set 220 ℃ of end temperature.2nd district: 230 ℃ of setting face temperature, set 200 ℃ of end temperature.3rd district: 220 ℃ of setting face temperature, set 190 ℃ of end temperature.Described temperature is the temperature of biscuit one side upward on conveyer belt; Temperature of the described end is the temperature of biscuit one side down on conveyer belt.Stove guipure rotating speed: 600cm/min.To baking the oil spout of rear surface of semi-finished sesame oil.Fuel injection parameter: set 60 ℃ of oil temperatures, conveyer belt rotating speed 600cm/min.
the preparation of embodiment 32 Hericium erinaceus soda cracker of the present invention
Take 5 kilograms of the health-care flour compositions of the present invention that obtain according to the method for embodiment 20,0.1 kilogram of yeast, 0.8 kilogram of palm oil, 80 grams of salt.First health-care flour composition of the present invention and other raw material are dropped into and are adjusted in powder cylinder, the even dirty solution that slowly adds yeast and suitable quantity of water to be modulated into after adjusting powder machine to start, mixed 8 min, dough.Then dough is poured in fermentation tank, controlling dough temperature is 33 ℃, ferments 4 hours.Dough sheet calendering and moulding.Moulding dough sheet by San Ge baking temperature district, is one minute half the time of staying in each district successively, bakes altogether 5 min.Cure parameter: 1st district: 200 ℃ of setting face temperature, set 360 ℃ of end temperature.2nd district: 250 ℃ of setting face temperature, set 280 ℃ of end temperature.3rd district: 180 ℃ of setting face temperature, set 220 ℃ of end temperature.Described temperature is the temperature of biscuit one side upward on conveyer belt; Temperature of the described end is the temperature of biscuit one side down on conveyer belt.To baking refining coconut oil oil spout for rear surface of semi-finished.Fuel injection parameter: set 55 ℃ of oil temperatures, 10% of the weight that is finished product by oil mass.Cooling, obtain Hericium erinaceus soda cracker of the present invention, packing.
the preparation of embodiment 33 Hericium erinaceus soda cracker of the present invention
Take 15 kilograms of the health-care flour compositions of the present invention that obtain according to the method for embodiment 27,0.27 kilogram is dry yeast, 2 kilograms of ready-mixed oils, 1 kilogram of coconut oil, 0.2 kilogram of salt, 2 kilograms of onions.Onion chopping, dry for standby; First 10 kilograms of health-care flour compositions of the present invention are dropped into and adjusted in powder cylinders, after adjusting powder machine to start, slowly adding is the even dirty solution that dry yeast and suitable quantity of water are modulated into, mixed 5 min, dough.Then dough is poured in fermentation tank, controlling dough temperature is 31 ℃, ferments 4 hours.Complete dough modulation for the first time and fermentation.The dough having fermented for the first time is again dropped into and adjusted in powder cylinder, all the other 5 kilograms health-care flour compositions of the present invention that add formula regulation, add grease, onion chip and water, start the powder machine of adjusting, mixed 6min, after dough forms, then is sprinkled into salt, modulate 3min, dough has been modulated for the second time again.Dough is poured in fermentation tank, and controlling dough temperature is 30 ℃, ferments 4 hours.Dough sheet calendering and moulding.Moulding dough sheet by San Ge baking temperature district, is about one minute the time of staying in each district successively, bakes altogether 5 min.Cure parameter: 1st district: 200 ℃ of setting face temperature, set 330 ℃ of end temperature.2nd district: 250 ℃ of setting face temperature, set 280 ℃ of end temperature.3rd district: 180 ℃ of setting face temperature, set 220 ℃ of end temperature.Described temperature is the temperature of biscuit one side upward on conveyer belt; Temperature of the described end is the temperature of biscuit one side down on conveyer belt.To baking the coconut oil oil spout of rear surface of semi-finished.Fuel injection parameter: set 60 ℃ of oil temperatures, 16% of the weight that is finished product by oil mass.Cooling, obtain Hericium erinaceus soda cracker of the present invention, packing.
the preparation of embodiment 34 Hericium erinaceus wafer of the present invention
Take 20 kilograms of the health-care flour compositions of the present invention that obtain according to the method for embodiment 16,1 kilogram of maltose, 0.7 kilogram of milk powder, 0.25 kilogram of salt, 0.6 kilogram of starch, 0.1 kilogram, carbonic hydroammonium, 15 grams of vanillic aldehydes, 60 grams of Sodium Acid Pyrophosphates, 5 grams of sodium pyrosulfites, 40 grams, the turbid essence of milk, 2 kilograms of lards, 0.5 kilogram, sesame oil, 5 kilograms, egg, 0.3 kilogram of cocoa power.Sodium Acid Pyrophosphate and sodium pyrosulfite water are dissolved, standby; All the other each materials except health-care flour composition of the present invention, starch drop in mixer successively, add 3.5 premium on currency to stir, mixing time 5min; Health-care flour composition of the present invention, starch, the Sodium Acid Pyrophosphate having dissolved in advance and sodium pyrosulfite are added in above-mentioned homogeneous material, be stirred to evenly, mixing time 6min, standby.By the above-mentioned fabric stirring by the moulding of mould roll marks, cure oil spout.Moulding dough sheet, successively by San Ge baking temperature district, is one minute half left and right the time of staying in each district, bakes altogether 5 min.Cure parameter: 1st district: 230 ℃ of setting face temperature, set 220 ℃ of end temperature.2nd district: 230 ℃ of setting face temperature, set 200 ℃ of end temperature.3rd district: 220 ℃ of setting face temperature, set 190 ℃ of end temperature.Described temperature is the temperature of biscuit one side upward on conveyer belt; Temperature of the described end is the temperature of biscuit one side down on conveyer belt.Stove guipure rotating speed: 600cm/min.To baking the oil spout of rear surface of semi-finished sesame oil.Fuel injection parameter: set 60 ℃ of oil temperatures, conveyer belt rotating speed 600cm/min.
the preparation of embodiment 35 Hericium erinaceus shortbread type biscuit of the present invention
Take 20 kilograms of the health-care flour compositions of the present invention that obtain according to the method for embodiment 19,0.6 kilogram of milk powder, 0.2 kilogram of salt, 0.12 kilogram, carbonic hydroammonium, 10 grams of vanillic aldehydes, 60 grams of Sodium Acid Pyrophosphates, 8 grams of sodium pyrosulfites, 3 kilograms, olive oil, 4 kilograms of celeries.Celery is rolled to juice; Sodium Acid Pyrophosphate and sodium pyrosulfite water are dissolved, standby; All the other each materials except health-care flour composition of the present invention drop in mixer successively, add 2.5 premium on currency to stir, mixing time 5min; Health-care flour composition of the present invention, the Sodium Acid Pyrophosphate having dissolved are in advance added in above-mentioned homogeneous material with sodium pyrosulfite and Celery Juice, be stirred to evenly, mixing time 6min, standby.By the above-mentioned fabric stirring by the moulding of mould roll marks, cure oil spout.Moulding dough sheet, successively by Si Ge baking temperature district, is one minute half left and right the time of staying in each district, bakes altogether 6 min.Cure parameter: 1st district: 235 ℃ of setting face temperature, set 210 ℃ of end temperature.2nd district: 240 ℃ of setting face temperature, set 200 ℃ of end temperature.3rd district: 235 ℃ of setting face temperature, set 200 ℃ of end temperature.4th district: 210 ℃ of setting face temperature, set 200 ℃ of end temperature.Described temperature is the temperature of biscuit one side upward on conveyer belt; Temperature of the described end is the temperature of biscuit one side down on conveyer belt.Stove guipure rotating speed: 600cm/min.To baking the oil spout of rear surface of semi-finished sesame oil.Fuel injection parameter: set 60 ℃ of oil temperatures, conveyer belt rotating speed 600cm/min.
the preparation of embodiment 36 Hericium erinaceus shortbread type biscuit of the present invention
Take 16 kilograms of the health-care flour compositions of the present invention that obtain according to the method for embodiment 12,0.6 kilogram of maltose, 0.3 kilogram of milk powder, 0.2 kilogram of salt, 0.5 kilogram of starch, 0.1 kilogram, carbonic hydroammonium, 10 grams of vanillic aldehydes, 50 grams of Sodium Acid Pyrophosphates, 6 grams of sodium pyrosulfites, 30 grams, the turbid essence of milk, 2.5 kilograms, butter, 1 kilogram of palm oil.Sodium Acid Pyrophosphate and sodium pyrosulfite water are dissolved, standby; All the other each materials except health-care flour composition of the present invention, starch drop in mixer successively, add water and stir, mixing time 6min; Health-care flour composition of the present invention, starch, the Sodium Acid Pyrophosphate having dissolved are in advance added in above-mentioned homogeneous material with sodium pyrosulfite and water, be stirred to evenly, mixing time 4min, standby.Whole process adds 3 kilograms, water altogether.By the above-mentioned fabric stirring by the moulding of mould roll marks, cure, obtain semi-finished product biscuit A; Or by the above-mentioned fabric stirring by the moulding of mould roll marks, cure, oil spout, obtain semi-finished product biscuit B.Moulding dough sheet by Si Ge baking temperature district, is one minute or one minute half the time of staying in each district successively, bakes altogether 5 min.Cure parameter: 1st district: 235 ℃ of setting face temperature, set 210 ℃ of end temperature.2nd district: 240 ℃ of setting face temperature, set 200 ℃ of end temperature.3rd district: 235 ℃ of setting face temperature, set 200 ℃ of end temperature.4th district: 190 ℃ of setting face temperature, set 200 ℃ of end temperature.Described temperature is the temperature of biscuit one side upward on conveyer belt; Temperature of the described end is the temperature of biscuit one side down on conveyer belt.Stove guipure rotating speed: 700cm/min.To baking the oil spout of rear surface of semi-finished sesame oil.Fuel injection parameter: set 70 ℃ of oil temperatures, conveyer belt rotating speed 560cm/min.Each semi-finished product biscuit is crossed after wafer separator burst, packed, obtain finished product biscuit A and B.
the preparation of embodiment 37 Hericium erinaceus bread of the present invention
Take 15 kilograms of the health-care flour compositions of the present invention that obtain according to the method for embodiment 10,0.6 kilogram of dry ferment.First health-care flour composition of the present invention is thrown to people and adjust in powder cylinder, after adjusting powder machine to start, slowly adding is the even dirty solution that dry yeast and suitable quantity of water are modulated into, mixed 5 min, dough.Then dough is poured in fermentation tank, controlling dough temperature is 28 ℃, ferments 4 hours.Make little dough, put into bread baking oven and toast 20 minutes, make hericium erinaceus health-care bread of the present invention.
the preparation of embodiment 38 hericium erinaceus health-care noodles of the present invention
Take 10 kilograms of the health-care flour compositions of the present invention that obtain according to the method for embodiment 13, each 5 kilograms of corn flour, millet powder, 0.1 kilogram of salt.Raw material is entered to tank and add suitable quantity of water, uniform stirring, discharging, is fed in flour stranding machine hopper, by flour stranding machine nip drum, is shaped, and chain is carried vermicelli.Then carry out drying and processing, after drying, press 24cm length and cut and pack.
the preparation of embodiment 39 hericium erinaceus health-care instant noodles of the present invention
Take 15 kilograms of the health-care flour compositions of the present invention that obtain according to the method for embodiment 17,0.15 kilogram of salt.By raw material premix 1 minute, Quick uniform added water stir about 12 minutes, then low rate mixing 3-4 minute, forms the dough with processing characteristics.The dough of becoming reconciled is put into a slaking dish, under the condition of 6 revs/min of 25 ℃, rotating speed, stir slaking 11 minutes.Dough after slaking, again by compound continuous calendering, chopping, forms instant noodles distinctive wavy.Dough after moulding is sent into steam box gelatinization, and wherein noodle feeder temperature arranges 65 ℃, and outlet temperature arranges 95 ℃.Again the dough after gelatinization is cut into face piece carry out fried, cooling, packing.
the preparation of embodiment 40 hericium erinaceus health-care steamed bun of the present invention
Take 10 kilograms, the hericium erinaceus health-care flour of the present invention that obtains according to the method for embodiment 24,0.5 kilogram is dry yeast.First hericium erinaceus health-care flour of the present invention is thrown to people and adjust in powder cylinder, after adjusting powder machine to start, slowly adding is the even dirty solution that dry yeast and suitable quantity of water are modulated into, mixed 5 min, dough.Then dough is poured in fermentation tank, controlling dough temperature is 32 ℃, ferments 6 hours.Make little dough, put into steamer 30 minutes, make hericium erinaceus health-care steamed bun of the present invention.
the preparation of embodiment 41 Hericium erinaceus bread of the present invention
Take 20 kilograms of the health-care flour compositions of the present invention that obtain according to the method for embodiment 11,0.8 kilogram of dry ferment.First health-care flour composition of the present invention is thrown to people and adjust in powder cylinder, after adjusting powder machine to start, slowly adding is the even dirty solution that dry yeast and suitable quantity of water are modulated into, mixed 7 min, dough.Then dough is poured in fermentation tank, controlling dough temperature is 30 ℃, ferments 4 hours.Make little dough, put into bread baking oven and toast 20 minutes, make hericium erinaceus health-care bread of the present invention.
the preparation of embodiment 42 Hericium erinaceus cake of the present invention
Take 10 kilograms of the health-care flour compositions of the present invention that obtain according to the method for embodiment 25,0.2 kilogram is dry yeast, 1.2 kilograms of palm oils, 1 kilogram of salad oil, 0.5 kilogram of maltose, 0.1 kilogram of baking powder, 0.2 kilogram of salt.15 eggs are cleaned and shelled, smash, add 1 kilogram of white sugar, stir 1-2 minute evenly, then high-speed stirring mixes foam-like.Flour of the present invention is thrown to people and adjust in powder cylinder, after adjusting powder machine to start, slowly adding is the even dirty solution that dry yeast and suitable quantity of water are modulated into, and mixed 5 min, pour dough in fermentation tank into, and controlling dough temperature is 32 ℃, ferments 4 hours.To fermented dough, add grease, baking powder, maltose, salt, egg and water, start the powder machine of adjusting, mixed 6min, forms batter.In grilled mold, be coated with one deck ready-mixed oil, the batter modulating is injected to grilled mold, baking, end temperature, face temperature control are made as 180 degree, surface brush one deck palm oil.The demoulding obtains Hericium erinaceus cake of the present invention.
embodiment 43 protective effects of Hericium erinaceus biscuit to stomach lining
1. materials and methods
1.1 sample sources:the biscuit that embodiment 28,33,36 obtains, clinical people's consumption is: take biscuit amount every day and be equivalent to 10g crude drug amount.
animal used as test:sD rat, male and female half and half, body weight 180～220g, is provided by Jiangxi College of Traditional Chinese Medicine Experimental Animal Center, SCXK (Jiangxi) 2006-0001.
main agents:indomethacin tablet: south China, Guangzhou medicine company Group Co.,Ltd, lot number: 20080614; Formaldehyde: Tianjin Chemical Co., Ltd.'s all generations, lot number: 091025; Glacial acetic acid: Guangzhou Chemical Reagent Factory is produced, lot number: 20081006, ethanol: Tianjin Chemical Co., Ltd.'s all generations, lot number: 090225.
key instrument:table-type high-speed refrigerated centrifuge (Thermo, the U.S.); Electronic balance (1/10,1/100,1/10000, Mei Tele company); Gilson pipettor (Gilson, France).
experimental technique
2. 1 pair of ethanol causes the protective effect that gastric mucosa damagesrat is divided into model control group at random, Hericium erinaceus biscuit group (be 28,33,36 groups of embodiment, dosage is 1.0g crude drug/kg), every group of 10 animals.Every day, gastric infusion was 1 time, and administration capacity is 10ml/kg, continuous 7 d, and model control group gives equivalent distilled water.First fasting 48 h of rat before experiment, freely drink water, every rat oral gavage absolute ethyl alcohol 1 mL of 1 h after last administration/only, put to death animal after the de-cervical vertebra of 1 h, folder closes orifice of the stomach, from pylorus, inject 1% formaldehyde 5 mL, then folder close pylorus, put into 1% formalin and fix 10 min, along greater curvature, cut off coat of the stomach, measure damaged length, using damaged length (width is greater than 1 mm and doubles) summation as gastric mucosal damage index, and calculate inhibiting rate.Inhibiting rate (%)=(control group UI-administration group UI) ÷ control group UI * 100%
2. 2 pairs of indocins cause the protective effect that gastric mucosa damagesgrouping and administration same 2.1.Rat fasting 24 h before experiment, freely drink water, every rat skin lower injection indocin 30mg/kg of 1 h after last administration, after 7 h, de-cervical vertebra is put to death animal, folder closes orifice of the stomach, from pylorus, inject 1% formaldehyde 5 mL, then folder close pylorus, put into 1% formalin and fix 10 min, along greater curvature, cut off coat of the stomach, measure damaged length, using damaged length (width is greater than 1 mm and doubles) summation as gastric mucosal damage index, and calculate inhibiting rate.
glacial acetic acid is caused to the protective effect of gastric mucosa damagegrouping and administration same 2.1.Animal fasting 24 h before experiment, freely drink water.With 10% chloraldurate 3. 5 mL/kg anesthetized animal, after belly sterilization, under xiphoid-process, open abdomen, gently pull out stomach, 30% glacial acetic acid 50 μ L are injected under glandular stomach portion antetheca hole body intersection serous coat, abdominal incision is sewed up in layering.Postoperative animal is conventional to be raised, postoperative next day, start to tested material, 1 time/d, continuous 14 d, control group gives isometric(al) distilled water, and after last administration, 24 h (fasting) put to death animal, measure and calculate ulcer index, equal value representation UI with the major diameter of ulcer and minor axis, carries out statistical procedures, relatively group difference.Ulcer healing rate (%)=(control group diameter average summation-administration group ulcer diameter average summation) ÷ control group diameter average summation * 100%
2.4 statistical method: experimental data with
represent, adopt one-way analysis of variance, the difference between each group relatively, P<0.05 is judged as difference and has conspicuousness, and P<0.01 is judged as difference and has utmost point conspicuousness.
result
3.1 pairs of ethanol cause the protective effect of gastric mucosa damageresult is as shown in table 1, and with model control group comparison, each group of Hericium erinaceus biscuit all can reduce ethanol and cause gastric mucosa damage index.
indocin is caused to the protective effect of gastric mucosa damageresult is as shown in table 2, and with model control group comparison, each group of Hericium erinaceus biscuit all can reduce indocin and cause gastric mucosa damage index.
3.3 pairs of glacial acetic acid cause the protective effect of gastric mucosa damageresult is as shown in table 3, and with model control group comparison, each group of Hericium erinaceus biscuit all can reduce glacial acetic acid and cause gastric mucosa damage index.
conclusion:
Animal experiment study shows: Hericium erinaceus biscuit has good protective effect to the acute and chronic gastritis mucosa injury due to ethanol, indocin, glacial acetic acid.
the auxiliary therapeutic action of embodiment 44 Hericium erinaceus biscuits to chronic gastritis
1. materials and methods
1.1 sample sources:with embodiment 43.
animal used as test:sD rat, male and female half and half, body weight 180～220g, is provided by Jiangxi College of Traditional Chinese Medicine Experimental Animal Center, SCXK (Jiangxi) 2006-0001.
main agents:sanjiu weitai capsules electuary is brown granular, and counter proprietaries, is dissolved in water before use.NaTDC, Beijing extensive and profound in meaning star biotechnology responsibility Co., Ltd produces, lot number: 20080206; Formaldehyde: Tianjin Chemical Co., Ltd.'s all generations, lot number: 091025; Ethanol: Tianjin Chemical Co., Ltd.'s all generations, lot number: 090225.
key instrument:table-type high-speed refrigerated centrifuge (Thermo, the U.S.); Electronic balance (1/10,1/100,1/10000, Mei Tele company); Gilson P type pipettor (Gilson, France).
experimental technique
2. 1 grouping, modeling and administrationrat is divided into 6 groups, i.e. blank group, model control group, sanjiu weitai capsules (0.6g/kg)+Hericium erinaceus biscuit group (being 28,33,36 groups of embodiment, 1.0g crude drug/kg), sanjiu weitai capsules group (0.6g/kg), 10 every group, male and female half and half.Buy after 1 week, except Normal group, every 5 days at 1st month 2ml/ gavage 60% ethanol of all the other each treated animals 1 time, replace running water freely to drink with 20mmol/ L deoxycholic aicd sodium water solution every day; Once, replace running water to animal freely to drink with 20mmol/ L deoxycholic aicd sodium water solution every day to 2nd month every 7 days 2ml/ gavage 60% ethanol; Within three month, with 30% ethanol water and 20mmol/ L deoxycholic aicd sodium water solution, every 3 days, replace in turn running water freely to drink to animal.From experiment beginning day pattern drawing control group and blank group, gavage distilled water every day, administration group is distinguished relative medicine of gavage every day totally 90 days.
detect indexafter last administration, fasting is 16 hours, the descending pyloric ligation of rat etherization, and after 6 hours, etherization is lethal.Open abdominal cavity, with haemostatic clamp, clamp orifice of the stomach (preventing that gastric juice from flowing out), take out full stomach.First with distilled water, wash surperficial crimson blood off, with filter paper, blot water, then along greater curvature, cut off body of stomach and take out gastric juice, with graduated cylinder amount gastric juice volume; With pH instrumentation, determine Gastric pH value; Get gastric juice supernatant and measure pepsin and total acidity gastric juice; Gastric tissue is fixedly made pathologic finding with 10% formaldehyde.Centrifugal 8 minutes of gastric juice 3000rpm, gets supernatant 011ml, adds 0.5% bSA 1ml (with 0.01N HCl preparation), and 37 ℃ of water bath heat preservations add 2ml 10% TCA after 20 minutes, and centrifugal 15 minutes of 3000rpm, gets supernatant 0.1ml and add 10%Na
2cO
30.9ml, 1N phenol reagent 0.5ml, room temperature is placed 20 minutes, and wavelength 660nm colorimetric is surveyed pepsin content (take tyrosine as standard).Get supernatant 1ml with 1 of phenolphthalein indicator, with 0.01N NaOH titration, record consumes NaOH ml quantity, calculates total acidity gastric juice value.
impact on the pathological change of chronic gastritis ratalong lesser curvature from glandular stomach to pylorus clip 3 * 10mm
24 of holostrome coat of the stomach, with 10% formalin, fix, paraffin inclusion, section, HE dyeing, with the pathological change of om observation glandular stomach and gland division and hole portion, scores by the grading of pathology, according to the visual field number of observing in section, averages and compares.Degree of inflammation divides 4 grades (0 ~ 4): (0) NIP; (+) has at body of gland or bottom the inflammatory cell being dispersed in individually; (++) all has more inflammatory cell at body of gland each several part; (+++) has gathering cell infiltration kitchen range in heaps.It is sign that tissue content be take the thickness of muscular layer of mucosa, by muscular layer of mucosa and on it thickness proportion of gastric mucosa analyze relatively.
statistical method: experimental data with
represent, adopt one-way analysis of variance, the difference between each group relatively, P<0.05 is judged as difference and has conspicuousness, and P<0.01 is judged as difference and has utmost point conspicuousness.
result
the variation of 3.1 gastric juice volumes and pH valueresult is as shown in table 1, and with model control group comparison, 28 groups of sanjiu weitai capsules+embodiment, 33 groups of sanjiu weitai capsules+embodiment, 36 groups of gastric secretions of sanjiu weitai capsules+embodiment increase, and pH value declines; Hericium erinaceus biscuit all can obviously increase the facilitation of sanjiu weitai capsules to gastric acid secretion.
the variation of gastric acidity and peptic activity of stomachresult is as shown in table 2, and with model control group comparison, sanjiu weitai capsules group, 28 groups of sanjiu weitai capsules+embodiment, 33 groups of sanjiu weitai capsules+embodiment, 36 groups of gastric acidities of sanjiu weitai capsules+embodiment increase, and peptic activity of stomach raises; Hericium erinaceus biscuit all can obviously promote the effect of sanjiu weitai capsules to gastric acidity increase and peptic activity of stomach rising.
impact on the pathological change of chronic gastritis ratthe results are shown in Table 3,4.The gastric mucosa surface of normal rats is smooth smooth, and pink is glossy, and histotomy shows that the surface epithelial cell of glandular stomach has thick mucus, under mucous membrane and the lymphocyte being dispersed on a small quantity as seen once in a while in flesh layer.The body of stomach degree of inflammation of the rat experiment gastritis of bringing out with deoxysodium cholate and alcohol obviously increases the weight of, and has volume lymphocyte and polymorphonuclear leukocyte in the lamina propria between gastric gland; There is the cell infiltration kitchen range that many places are larger in most animals stomach hole, the gastric gland at some position shortens or gland spacing broadens.The body of stomach of sanjiu weitai capsules+Hericium erinaceus biscuit group (being 28,33,36 groups of embodiment) and the degree of inflammation of stomach hole portion all alleviate than model control group is obvious.
conclusion:
Animal experiment study shows: Hericium erinaceus biscuit can increase sanjiu weitai capsules and chronic gastritis rat stomach liquid acidity be increased and peptic activity of stomach rising, promote that sanjiu weitai capsules increases chronic gastritis rat stomach liquid acidity and peptic activity of stomach raises, improve chronic gastritis rat pathological change, therefore there is the effect of auxiliary curing gastritis.
.
the auxiliary therapeutic action of embodiment 45 Hericium erinaceus biscuits to Experimental Gastric Ulcer in Rats
1. materials and methods
1.1 sample sources:with embodiment 43
1.2 animals used as test:sD rat, male and female half and half, body weight 180～220g, is provided by Jiangxi College of Traditional Chinese Medicine Experimental Animal Center, SCXK (Jiangxi) 2006-0001.
main agents:formaldehyde: Tianjin Chemical Co., Ltd.'s all generations, lot number: 091025; Ethanol: Tianjin Chemical Co., Ltd.'s all generations, lot number: 090225.Ranitidine hydrochloride capsules, Desheng, Fujian pharmaceutcal corporation, Ltd, lot number: 080505; Glacial acetic acid, reagent one factory in Shanghai produces, lot number: 20316.
key instrument:xT S-110 bitubular disecting microscopes, optical instrument factory, Chongqing; Table-type high-speed refrigerated centrifuge (Thermo, the U.S.); Electronic balance (1/10,1/100,1/10000, Mei Tele company); Gilson P type pipettor (Gilson, France).
experimental technique
2. 1 impact on stress in rats gastric ulcerchoose 50 of rats, be divided at random 5 groups, be i.e. model control group, ranitidine (0.15g/kg)+Hericium erinaceus biscuit group (being 28,33,36 groups of embodiment, 1.0g crude drug/kg), ranitidine group (0.15g/kg), 10 every group, male and female half and half.Ig administration respectively, administration every day 1 time, after totally 7 last administrations, 0. 5 h are fixed on the binding of rat four limbs on wire netting, head is upwards dipped vertically in (23 ± 1) ℃ water, water logging is to mouse xiphoid-process position, soak after 8 h, rat is put to death, open abdomen, ligation pylorus and orifice of the stomach, in stomach, inject 1% formalin 1mL, and stomach is dipped in to 10min in 1% formalin solution, and along greater curvature, cut off stomach, wash away gastric content, stomach lining is faced up and flattened on glass plate, under disecting microscope, count UI and ulcer inhibition rate that glandular stomach portion occurs.Stress gastric ulcer index calculation method: ulcer point or the following person of face 1 mm count 1 minute; 1 ~ 2 mm person, counts 2 minutes; 2 ~ 3 mm persons count 3 minutes; 3 ~ 4 mm persons count 4 minutes; Be greater than 4 mm persons and count 5 minutes, score is added to the UI that is this animal.Ulcer inhibition rate (%)=(control group UI-administration group UI) ÷ control group UI * 100%.
rat acetic acid is burnt to the impact of gastric ulcerrat under etherization opens abdomen, exposes stomach, and before glandular stomach portion, on hole body intersection serosal surface, the diameter that sticks glacial acetic acid is round filter paper 30 s of 5 mm, and reduction stomach is sewed up coat of the stomach.Postoperative 24 h are divided into 5 groups at random by animal, and grouping and medication are with 2.1, and every day, gavage was 1 time, successive administration 10 d.After last administration, 24 h, by sacrifice of animal, cut open stomach, under anatomical lens, measure ulcer area.
impact on pylorus ligation rat hydrochloric acid in gastric juice amountrat is divided into model control group at random, Hericium erinaceus biscuit group (being 28,33,36 groups of embodiment, 1.0g crude drug/kg), every group of 10 animals.Every day, gastric infusion was 1 time, and administration capacity is 10ml/kg, continuous 7 d, and model control group gives equivalent distilled water.Animal fasting 48 h before experiment, freely drink water.During experiment, with ether, animal is slightly anaesthetized, under ensiform process of sternum, along ventrimeson, cuts off stomach wall 2～3 cm, by stomach gently hook go out, at stomach pylorus underpass and by pylorus ligation, and in duodenal administration 1 time, control group gives equivalent distilled water.Sew up incision of abdominal wall.The single cage of postoperative rat is raised fasting and is prohibited water, and after operation, animal is put to death in 5 h cervical vertebra dislocations, opens abdominal cavity ligation orifice of the stomach, win full stomach, with filter paper, clean bloodstain, along greater curvature, cut off coat of the stomach, incline and content, be collected in graduated centrifuge tube, record gastric juice amount, then with centrifugal 10 min of 1 500 r/min speed, get supernatant 1 mL, with acid-base value analyzer, measure gastric acidity, and measure gastric juice peptic activity of stomach.
the impact that gastric acid secretion due to histamine is increasedgrouping and administration same 2.3.Rat fasting 24 h before experiment, freely drink water, urethane 1.25g/k g anesthesia, and back of the body position is fixing, trachea cannula.Open abdomen and by stomach pylorus, in stomach, insert internal diameter 3 m m vinyl tubes by duodenum, after ligation, from oral cavity, through orifice of the stomach, in stomach, insert the same plastic tube being connected with perfusion device again.After hydrochloric acid Saline perfusion liquid gastric lavage with pH 4 (till flowing out without gastric content), adjusting perfusion rate is that 5 m l/ min carry out constant speed perfusion.Administration group is given 1 time from duodenum, and control group gives respectively capacity physiological saline.After administration during 20 min, each mouse respectively subcutaneous excitants histamine 10 m g/k g that gives is accessed and is given the perfusate in 60min after excitants by pylorus intubate, measures gastric acidity, and measure gastric juice peptic activity of stomach with acid-base value analyzer.
statistical method: experimental data is with `
represent, adopt one-way analysis of variance, the difference between each group relatively, P<0.05 is judged as difference and has conspicuousness, and P<0.01 is judged as difference and has utmost point conspicuousness.
result
3.1 impacts on stress in rats gastric ulceras shown in table 1, with model control group comparison, ranitidine group, ranitidine+Hericium erinaceus biscuit group (being 28,33,36 groups of embodiment) UI obviously reduce; Hericium erinaceus biscuit all can obviously increase the reducing effect of ranitidine to ulcer index.
rat acetic acid is burnt to the impact of gastric ulceras shown in table 2, with model control group comparison, ranitidine group, ranitidine+Hericium erinaceus biscuit group (being 28,33,36 groups of embodiment) ulcer area obviously reduce; Hericium erinaceus biscuit all can obviously increase the inhibitory action of ranitidine to gastric ulcer area.
on pylorus ligation rat hydrochloric acid in gastric juice and pepsic impactresult is as shown in table 3, and with model control group comparison, Hericium erinaceus biscuit group (being 28,333,36 groups of embodiment) all can suppress the secretion of pylorus ligation rat hydrochloric acid in gastric juice, reduces its pepsin activity.
the impact that gastric acid secretion due to histamine is increasedresult is as shown in table 4, and with model control group comparison, to histamine, caused gastric acid secretion increase has obvious inhibitory action to Hericium erinaceus biscuit group (being 28,33,336 groups of embodiment).
conclusion:
Animal experiment study shows: Hericium erinaceus biscuit can increase the effect that ranitidine stress gastric ulcer rat and acetic acid burn gastric ulcer rat ulcer exponential sum ulcer area, Hericium erinaceus biscuit has inhibitory action to the gastric acid secretion of pylorus ligation rat, also can suppress the caused gastric acid secretion of histamine increases simultaneously, therefore there is the effect of auxiliary curing gastric ulcer.
the inhibitory action of embodiment 46 Hericium erinaceus biscuits to helicobacter pylori
1. materials and methods
1.1 sample sources:with embodiment 43.
animal used as test:60 of healthy adult Balb/c mouse, 6 week age, body weight 16g ~ 18g, male and female half and half, purchased from Institute of Experimental Animals, Chinese Academy of Medical Sciences, credit number is: scxk capital 2004-0001.
main agents:sydney reference culture that the Hpy lori bacterial strain adopting is international uniform, through identifying this bacterial strain CagA (+) and VacA (+).
key instrument:table-type high-speed refrigerated centrifuge (Thermo, the U.S.); Electronic balance (1/10,1/100,1/10000, Mei Tele company); Gilson pipettor (Gilson, France).
experimental technique
2. inhibitory action in the 1 pair of Hpylori body
2. 1. 1 animal modelsbefore mouse experiment, give and in drinking-water, add fresh preparation antibiotic mixed liquor, Dose standard is gentamicin 15mg/kg, and ampicillin 100 mg/kg drinks continuously 5d and carries out antibiotic pretreatment, after drug withdrawal 5d, start modeling, modeling method: after fasting 24h, give 2% NaHCO
3a solution 0. 2m l/gavage, after 1h, give the fresh suspendible bacterium of Hpylo ri liquid (
) a 0. 2m l/ gavage, after 1h, recover normal diet, the next day 1 time, totally 5 times.
modeling is successfully evaluatedafter giving for the last time the fresh suspendible bacterium of Hpylo ri liquid gavage, 24h extracts 10 sacrifice of animal immediately, sterile working is cut open the belly and is got stomach, along greater curvature, cut off, get gastric antrum pylorus portion tissue and do urease test (RUT), positive rate is 100% demonstration modeling success.
animal grouping and administrationafter modeling success, animal is divided into model control group, Hericium erinaceus biscuit group (being 28,33,36 groups of embodiment, 2.0g crude drug/kg), totally 4 groups, 10 every group at random.Give respectively relative medicine, every day 1 time, model group gives same volume physiological saline, continuous 7 days.
index detectsafter last gavage, 24h puts to death animal, and sterile working is cut open the belly and got stomach, along greater curvature, cuts off, and gets gastric antrum pylorus portion tissue and does gastric mucosa gram stain smear microscopy and look for Hpylori and RUT to test.
to Hpylori In-vitro Inhibitory Effect
2. 1 tested liquor strength preparationsbe dissolved in sterile distilled water embodiment 5 is extract obtained, carry out two-fold dilution and get its concentration, be respectively 1,0. 5,0. 25,0. 125,0. 0025,0. 0313,0. 0156,0. 0078,0. 0039g crude drug/m l.
drug paper disk preparationfilter paper is broken into diameter 6mm size with card punch, and autoclave sterilization, adds respectively in above-mentioned variable concentrations liquid and soaks after 2h, drying for standby.
antibacterial observation(concentration is with sterile cotton test paper, to dip Hpylori bacterium liquid
cFU/m l) be coated with whole media surface, guarantee that coating evenly.With aseptic tweezer, hold under the arm respectively and get the filter paper that contains above variable concentrations medicine, be attached to the surface of the agar plate of inoculated with Hp ylori, physiological saline filter paper compares, and between each dull and stereotyped upper each scraps of paper, the scraps of paper and plate edge are all evenly distributed.Under 37 ℃ of micro-aerobic environments, cultivate after 72h, observe having or not of inhibition zone, by its diameter of vernier caliper measurement.Take bacteriostatic diameter > 10mm as extremely sensitive, 7mm
< bacteriostatic diameter < 10mm is medium sensitivity, and 2mm< bacteriostatic diameter <7mm is low responsive, bacteriostatic diameter < 2mm be insensitive be criterion.
statistical method: experimental data is with `
represent, adopt one-way analysis of variance, the difference between each group relatively, P<0.05 is judged as difference and has conspicuousness, and P<0.01 is judged as difference and has utmost point conspicuousness.Enumeration data relatively adopts X between any two
2check.
result
the therapeutic action of 3.1 pairs of Hpylori infecting mousesresult is as shown in table 1, and with model control group comparison, Hericium erinaceus biscuit group can significantly reduce Hpylori infecting mouse Hpylori smear-positive number and RUT number positive.
to Hpylori In-vitro Inhibitory Effectresult is as shown in table 2, and with model control group comparison, Hericium erinaceus 0.0625～1.0g crude drug/ml has the bacteriostasis of moderate and height to Hpylori, and Hericium erinaceus 0.0156～0.0313g crude drug/ml has low bacteriostasis to Hpylori.
conclusion:
Research shows: Hericium erinaceus biscuit has in good body and the effect of external inhibition helicobacter pylori.
embodiment 47 Hericium erinaceus biscuits are alleviated the research of abdominal pain
1. materials and methods
1.1 sample sources:with embodiment 43.
animal used as test:kunming mouse, male and female half and half, body weight 18～22g, is provided by Jiangxi College of Traditional Chinese Medicine Experimental Animal Center, SCXK (Jiangxi) 2005-0001.
main agents:rotundine sheet, Sichuan Kang Fu comes medicine company Group Co.,Ltd, lot number: 20080322; Glacial acetic acid: Guangzhou Chemical Reagent Factory is produced, lot number: 20081006; Metoclopramide sheet, Jinan gold is safe, and pharmaceutical factory produces, lot number: 070906.
key instrument:table-type high-speed refrigerated centrifuge (Thermo, the U.S.); Electronic balance (1/10,1/100,1/10000, Mei Tele company); Gilson pipettor (Gilson, France); 722 grating spectrophotometers,
Shanghai San analytical instrument factory.
experimental technique
2. 1?
dichlorodiphenyl Acetate causes the impact of mouse writhing reaction50 of mouse, male and female half and half, are divided into 5 groups at random, every group 10, be blank group, Rotundine group (60 mg/kg), Hericium erinaceus biscuit group (being 28,33,36 groups of embodiment, 2.0g crude drug/kg), every group 10, ig administration respectively, continuous 7 days, 1 h after administration, each mouse is ip 0.6% glacial acetic acid 0.2 mL respectively, each mouse writhing response number of times in 15 min after record injection algogen.
the impact emptying on Mouse Stomachmouse is divided into blank group, Hericium erinaceus biscuit group (being 28,33,36 groups of embodiment, 2.0g crude drug/kg), metoclopramide group (0. 01 g/kg) at random.Gavage liquid every day 1 time, 7d, follows fasting and can't help water 18 h continuously, 1 h after administration on the 7th, each organizes equal gavage pastel (10 g carboxymethyl celluloses, 16 g milk powder, 8 g sugar, 8 g starch, be dissolved in distilled water, be made into the pastel of 1mL approximately 1 g), every mouse 1mL, the de-cervical vertebra of 40 m in is put to death mouse afterwards, cut open the belly, and ligation stomach orifice of the stomach and pylorus, take out stomach and wipe away the dry rear full weight that claims with filter paper, then along greater curvature, cut off body of stomach, wash out and wipe away after gastric content dryly, claim stomach net weight.The stomach full weight of take subtracts difference residue weight in stomach of stomach net weight, and this percentage heavy and give paste heavy (being 1 g by 1mL) is residual rate in stomach.
statistical method: experimental data is with `
represent, adopt one-way analysis of variance, the difference between each group relatively, P<0.05 is judged as difference and has conspicuousness, and P<0.01 is judged as difference and has utmost point conspicuousness.
result
3.1 Dichlorodiphenyl Acetates cause the impact of mouse writhing reactionresult is as shown in table 1, and with the comparison of blank group, Hericium erinaceus biscuit group all can reduce mouse writhing reaction times.
the impact emptying on Mouse Stomachresult is as shown in table 2, and with the comparison of blank group, Hericium erinaceus biscuit group all can reduce gastric content residual rate.
conclusion:
Animal experiment study shows: Hericium erinaceus biscuit can reduce acetic acid induced mice writhing number of times, reduces gastric content residual rate, and prompting Hericium erinaceus biscuit has relieving spasm and pain effect, can be used for alleviating the abdominal pain due to gastritis and ulcer.
Claims (24)
1. a health-care flour composition, is characterized in that containing flour, Hericium erinaceus.
2. the health-care flour composition of claim 1, is characterized in that containing: flour 100 weight portions, and Hericium erinaceus 1～30 weight portion, wherein Hericium erinaceus can be Hericium erinaceus dry product or new fresh Hericium erinaceus, also can be Hericium erinaceus powder; Hericium erinaceus dry product or new fresh Hericium erinaceus are processed one of in the following manner:
(1) directly pulverize;
(2) add water and/or alcohol extracting obtains extract;
(3) add water and/or alcohol extracting by the dry Hericium erinaceus extract that obtains;
(4) add water and/or alcohol extracting, and extraction gained material is carried out to inclusion obtain Hericium erinaceus extract inclusion compound or microcapsules, wherein inclusion agents is selected from cyclodextrin, and microcapsules capsule material is selected from one or more in gelatin, converted starch, natural plant gum, alginic acid.
3. claim 1 or 2 health-care flour composition, the flour in wherein said raw material is selected from but is not limited to one or more powder made for raw material grinding mill in wheat, corn, rice, millet, barley, jowar, the seed of Job's tears, oat, buckwheat, naked oats, pumpkin, the root of kudzu vine, potato, cassava, soya bean, red bean, mung bean, kidney bean, broad bean, pea, cowpea, chick-pea, lotus root, water caltrop, lily, konjaku, bajiao banana taro.
4. the health-care flour composition of claim 3, the flour in wherein said raw material is wheat flour.
5. claim 1 or 2 health-care flour composition, is characterized in that, described raw material further contains leavening agent 0.1～2.5 weight portion.
6. the health-care flour composition of claim 5, is characterized in that, described raw material further contains sweetener 1～35 weight portion.
7. the health-care flour composition of claim 6, is characterized in that containing: flour 100 weight portions, Hericium erinaceus 5～20 weight portions, leavening agent 0.5～1.5 weight portion, sweetener 5～20 weight portions.
8. the health-care flour composition of claim 6, wherein said raw material further contains one or more in vitamin, starch, salt, five-spice powder, monosodium glutamate, milk powder, stearoyl lactate, disodium ethylene diamine tetraacetate.
9. the health-care flour composition of claim 7, wherein said leavening agent is selected from one or more in sodium bicarbonate, baking powder, ammonia bicarbonate, alum, sodium pyrosulfite, Sodium Acid Pyrophosphate, yeast; Described sweetener is selected from one or more in glucose, fructose, sucrose, maltose, starch sugar, lactose, stevioside, Aspartame, 3,4-Dihydro-6-methyl-1,2,3-oxathiazin-4-one 2,2-dioxide potassium salt, saccharin sodium, honey element, maltitol.
10. a dough made from the health-care flour composition of claim 1～9 any one, is characterized in that described health-care flour composition to make dough, standing, or allows dough fermentation.
11. 1 kinds of food made from the health-care flour composition of claim 1～9 any one.
12. 1 kinds of food made from the dough of claim 10.
The food of 13. claims 11, it is biscuit, bread, instant noodles, steamed bun, noodles or cake.
The food of 14. claims 12, it is biscuit, bread, instant noodles, steamed bun, noodles or cake.
Food described in 15. claims 13 or 14, wherein said biscuit contains health-care flour composition, grease, flavoring essence and the water described in claim 1～9 any one, can make shortbread type biscuit or soda cracker; Wherein said grease is selected from one or more in shortening, edible vegetable oil, lard, butter, butter.
The food of 16. claims 15, the raw material of wherein said biscuit contains: flour 100 weight portions, Hericium erinaceus 1～30 weight portion, leavening agent 0.1～2.5 weight portion, sweetener 1～35 weight portion, grease 10～30 weight portions, salt 0.6～2 weight portion, flavoring essence 0.02～5 weight portion, water 10～30 weight portions.
Food described in 17. claims 16, the raw material of wherein said biscuit also further contains: starch 0.2～10 weight portion, milk powder 0.02～5 weight portion.
The food of 18. claim 16～17 any one, also contains one or more in egg, vegetables, dry fruit, raisins, shredded coconut meat, chocolate, cocoa power, dried meat floss in wherein said raw material.
Food described in 19. claims 18, the step of wherein preparing shortbread type biscuit comprises:
(1) modulate dough: by described composition of raw materials, take each raw material: first sweetener and grease are mixed to get to material A; Leavening agent, salt, flavoring essence are mixed, and the material B that is dissolved in water to obtain; Material A, material B, Hericium erinaceus, other raw material and water are dropped in mixer successively, be stirred to evenly; Then flour and above-mentioned homogeneous material are mixed, add water and continue to be stirred to evenly, standby;
(2) compressing: the biscuit green compact that make various shapes through shaping mechanism;
(3) cure: biscuit green compact are sent into curer baking, and burner hearth is divided into Si Ge district: 1st district sets 220～235 ℃ of face temperature, 200～220 ℃ of end temperature; 2nd district set 230～250 ℃ of face temperature, 190～210 ℃ of end temperature; 3rd district set 230～240 ℃ of face temperature, 200～210 ℃ of end temperature; 4th district set 160～200 ℃ of face temperature, 170～210 ℃ of end temperature; Whole curing 4～8 minutes time;
(4) oil spout: the biscuit rear surface oil spout of coming out of the stove;
(5) pack: the biscuit after oil spout, through arranging, is packed to finished product.
Food described in 20. claims 18, the step of wherein preparing soda cracker comprises:
(1) dough modulation and fermentation: first flour, Hericium erinaceus are dropped into and adjusted in powder cylinder, then add grease, sweetener, salt, sodium bicarbonate, flavoring essence and other raw material; After adjusting powder machine to start, slowly adding is the even dirty solution that dry yeast and suitable quantity of water are modulated into, and is blended into dough, then dough is poured in fermentation tank and is fermented;
(2) dough sheet calendering and moulding: through stamped or rolling cut dough sheet, cut out the biscuit green compact of different appearance profiles;
(3) cure: biscuit green compact are sent into curer baking, and burner hearth is divided into San Ge district: 1st district sets 190～210 ℃ of face temperature, 320～360 ℃ of end temperature; 2nd district set 240～280 ℃ of face temperature, 230～250 ℃ of end temperature; 3rd district set 180～220 ℃ of face temperature, 180～220 ℃ of end temperature; Whole curing 5～10 minutes time;
(4) oil spout: the biscuit rear surface oil spout of coming out of the stove;
(5) pack: the biscuit after oil spout, through arranging, is packed to finished product.
Health-care flour composition described in 21. claim 1～9 any one has the purposes in the food of repairing the gastric mucosa injure function that chronic gastritis, gastric ulcer or duodenal ulcer cause in preparation.
Health-care flour composition described in 22. claim 1～9 any one has the purposes in the food of the abdominal pain function that relieve chronic gastritis, gastric ulcer or duodenal ulcer cause in preparation.
Health-care flour composition described in 23. claim 1～9 any one has the purposes in the food that suppresses helicobacter pylori function in preparation.
Health-care flour composition described in 24. claim 1～9 any one has the purposes in the food of auxiliary curing chronic gastritis, gastric ulcer or duodenal ulcer function in preparation.
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Application publication date: 20140326 Assignee: JIANGXI JIANGZHONG DIETOTHERAPY TECHNOLOGY Co.,Ltd. Assignor: JIANGXI JIANGZHONG PHARMACEUTICAL (Group) Co.,Ltd. Contract record no.: 2016360000005 Denomination of invention: Health-care flour composition and food Granted publication date: 20150304 License type: Common License Record date: 20160607 |
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