CN103649047B - 用于制备前列腺素酰胺的方法 - Google Patents

用于制备前列腺素酰胺的方法 Download PDF

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Publication number
CN103649047B
CN103649047B CN201280027006.7A CN201280027006A CN103649047B CN 103649047 B CN103649047 B CN 103649047B CN 201280027006 A CN201280027006 A CN 201280027006A CN 103649047 B CN103649047 B CN 103649047B
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group
formula
process according
reaction
general formula
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CN201280027006.7A
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Chinese (zh)
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CN103649047A (zh
Inventor
G.哈瓦西
T.基斯
I.霍托巴吉
Z.卡多斯
I.拉兹洛菲
Z.比肖夫
A.伯蒂斯
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Chinoin Private Co Ltd
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Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
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Priority claimed from HU1100291A external-priority patent/HU230703B1/hu
Priority claimed from HU1100292A external-priority patent/HU231134B1/hu
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority to CN201610603047.6A priority Critical patent/CN106316910A/zh
Priority to CN201610630836.9A priority patent/CN106349138A/zh
Priority to CN201610657048.9A priority patent/CN106278982B/zh
Publication of CN103649047A publication Critical patent/CN103649047A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/50—Iso-indoles; Hydrogenated iso-indoles with oxygen and nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyrrole Compounds (AREA)
CN201280027006.7A 2011-06-02 2012-05-25 用于制备前列腺素酰胺的方法 Active CN103649047B (zh)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CN201610603047.6A CN106316910A (zh) 2011-06-02 2012-05-25 用于制备前列腺素酰胺的新的方法
CN201610630836.9A CN106349138A (zh) 2011-06-02 2012-05-25 用于制备前列腺素酰胺的新的方法
CN201610657048.9A CN106278982B (zh) 2011-06-02 2012-05-25 用于制备前列腺素酰胺的新的方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
HU1100291A HU230703B1 (hu) 2011-06-02 2011-06-02 Új eljárás prosztaglandin amidok előállítására
HU1100292A HU231134B1 (hu) 2011-06-02 2011-06-02 Eljárás a bimatoprost kémiailag stabil új kristályformájának előállítására
HUP1100292 2011-06-02
HUP1100291 2011-06-02
PCT/HU2012/000045 WO2012164324A1 (en) 2011-06-02 2012-05-25 Novel processes for the preparation of prostaglandin amides

Related Child Applications (3)

Application Number Title Priority Date Filing Date
CN201610603047.6A Division CN106316910A (zh) 2011-06-02 2012-05-25 用于制备前列腺素酰胺的新的方法
CN201610630836.9A Division CN106349138A (zh) 2011-06-02 2012-05-25 用于制备前列腺素酰胺的新的方法
CN201610657048.9A Division CN106278982B (zh) 2011-06-02 2012-05-25 用于制备前列腺素酰胺的新的方法

Publications (2)

Publication Number Publication Date
CN103649047A CN103649047A (zh) 2014-03-19
CN103649047B true CN103649047B (zh) 2017-01-11

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CN201610630836.9A Pending CN106349138A (zh) 2011-06-02 2012-05-25 用于制备前列腺素酰胺的新的方法
CN201610603047.6A Pending CN106316910A (zh) 2011-06-02 2012-05-25 用于制备前列腺素酰胺的新的方法
CN201280027006.7A Active CN103649047B (zh) 2011-06-02 2012-05-25 用于制备前列腺素酰胺的方法
CN201610657048.9A Active CN106278982B (zh) 2011-06-02 2012-05-25 用于制备前列腺素酰胺的新的方法

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CN201610630836.9A Pending CN106349138A (zh) 2011-06-02 2012-05-25 用于制备前列腺素酰胺的新的方法
CN201610603047.6A Pending CN106316910A (zh) 2011-06-02 2012-05-25 用于制备前列腺素酰胺的新的方法

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Country Status (17)

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US (3) US9238621B2 (OSRAM)
EP (1) EP2723714B1 (OSRAM)
JP (3) JP6212485B2 (OSRAM)
KR (3) KR102135550B1 (OSRAM)
CN (4) CN106349138A (OSRAM)
BR (3) BR112013030973B1 (OSRAM)
CA (3) CA3209613A1 (OSRAM)
ES (1) ES2636756T3 (OSRAM)
HU (1) HUE033642T2 (OSRAM)
IL (1) IL229647A (OSRAM)
MX (1) MX341839B (OSRAM)
PL (1) PL2723714T3 (OSRAM)
PT (1) PT2723714T (OSRAM)
RU (1) RU2618223C2 (OSRAM)
TW (3) TWI632131B (OSRAM)
WO (1) WO2012164324A1 (OSRAM)
ZA (1) ZA201309357B (OSRAM)

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HU231203B1 (hu) 2011-12-21 2021-10-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Új eljárás travoprost előállítására
WO2014066775A1 (en) 2012-10-26 2014-05-01 Forsight Vision5, Inc. Ophthalmic system for sustained release of drug to eye
US9120738B2 (en) 2012-12-28 2015-09-01 Allergan, Inc. Crystalline forms of bimatoprost acid, methods for preparation, and methods for use thereof
US9447014B2 (en) * 2012-12-28 2016-09-20 Allergan, Inc. Tromethamine salt of bimatoprost acid in crystalline form, methods for preparation, and methods for use thereof
HU231214B1 (hu) * 2014-03-13 2021-11-29 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Új eljárás nagytisztaságú prosztaglandinok előállítására
US10273206B2 (en) 2014-06-27 2019-04-30 Allergan, Inc. Tromethamine salt of bimatoprost acid in crystalline form 1, methods for preparation, and methods for use thereof
WO2015199729A1 (en) * 2014-06-27 2015-12-30 Allergan, Inc. Tromethamine salt of bimatoprost acid in crystalline form 1, methods for preparation, and methods for use thereof
WO2016168141A1 (en) 2015-04-13 2016-10-20 Forsight Vision5, Inc. Ocular insert composition of semi-crystalline or crystalline pharmaceutically active agent
HU231185B1 (hu) * 2017-07-11 2021-07-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Eljárás Misoprostol előállítására és tisztítására
CN113548993B (zh) * 2021-09-01 2022-05-27 河北化工医药职业技术学院 一种卡前列素的制备方法

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EP2723714B1 (en) 2017-06-21
BR112013030973A2 (pt) 2016-08-16
WO2012164324A9 (en) 2014-01-09
PT2723714T (pt) 2017-08-18
CN106349138A (zh) 2017-01-25
KR102038048B1 (ko) 2019-10-30
ZA201309357B (en) 2014-08-27
BR112013030973B1 (pt) 2021-08-10
TWI632131B (zh) 2018-08-11
WO2012164324A1 (en) 2012-12-06
CA3209613A1 (en) 2012-12-06
JP2017061555A (ja) 2017-03-30
KR20140053941A (ko) 2014-05-08
TW201708190A (zh) 2017-03-01
BR112013030973A8 (pt) 2021-03-30
CA2837261A1 (en) 2012-12-06
CA2837261C (en) 2020-12-15
PL2723714T3 (pl) 2018-02-28
US20160137602A1 (en) 2016-05-19
JP2017075165A (ja) 2017-04-20
US9573892B2 (en) 2017-02-21
HUE033642T2 (en) 2017-12-28
CA3094762C (en) 2023-09-26
ES2636756T3 (es) 2017-10-09
RU2013158952A (ru) 2015-07-20
IL229647A0 (en) 2014-01-30
CN106316910A (zh) 2017-01-11
IL229647A (en) 2017-09-28
JP6212485B2 (ja) 2017-10-11
CN106278982A (zh) 2017-01-04
KR20200087871A (ko) 2020-07-21
JP2014527026A (ja) 2014-10-09
US20140135503A1 (en) 2014-05-15
TW201708191A (zh) 2017-03-01
MX341839B (es) 2016-09-05
KR20190124804A (ko) 2019-11-05
CA3094762A1 (en) 2012-12-06
CN106278982B (zh) 2019-06-14
US9856213B2 (en) 2018-01-02
BR122021008918B1 (pt) 2021-08-10
US9238621B2 (en) 2016-01-19
US20160145207A1 (en) 2016-05-26
RU2618223C2 (ru) 2017-05-03
MX2013014034A (es) 2015-06-17
TWI653222B (zh) 2019-03-11
KR102135550B1 (ko) 2020-07-21
TWI653223B (zh) 2019-03-11
TW201311629A (zh) 2013-03-16
KR102277188B1 (ko) 2021-07-15
JP6487410B2 (ja) 2019-03-20
JP6693859B2 (ja) 2020-05-13
CN103649047A (zh) 2014-03-19
EP2723714A1 (en) 2014-04-30
BR122021008946B1 (pt) 2021-08-10

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