CN103561576B - 脂质合成的杂环调节剂 - Google Patents
脂质合成的杂环调节剂 Download PDFInfo
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- CN103561576B CN103561576B CN201280020832.9A CN201280020832A CN103561576B CN 103561576 B CN103561576 B CN 103561576B CN 201280020832 A CN201280020832 A CN 201280020832A CN 103561576 B CN103561576 B CN 103561576B
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- QUUFZOBHTTTWMQ-UHFFFAOYSA-N Cc(nc(c(C(OC)=O)c1)Cl)c1[N+]([O-])=O Chemical compound Cc(nc(c(C(OC)=O)c1)Cl)c1[N+]([O-])=O QUUFZOBHTTTWMQ-UHFFFAOYSA-N 0.000 description 1
- CYEXEOXALMJXDI-UHFFFAOYSA-N Cc1cc(Br)ccc1C(OC)=O Chemical compound Cc1cc(Br)ccc1C(OC)=O CYEXEOXALMJXDI-UHFFFAOYSA-N 0.000 description 1
- BWZVCCNYKMEVEX-UHFFFAOYSA-N Cc1cc(C)nc(C)c1 Chemical compound Cc1cc(C)nc(C)c1 BWZVCCNYKMEVEX-UHFFFAOYSA-N 0.000 description 1
- BVDGNJPWEKZUJU-UHFFFAOYSA-N Cc1cc(C=C)ccc1C(OC)=O Chemical compound Cc1cc(C=C)ccc1C(OC)=O BVDGNJPWEKZUJU-UHFFFAOYSA-N 0.000 description 1
- DHFCAAHDNSOIAE-UHFFFAOYSA-N Cc1ccc(C#N)nc1Br Chemical compound Cc1ccc(C#N)nc1Br DHFCAAHDNSOIAE-UHFFFAOYSA-N 0.000 description 1
- WPSWBRXGXVKZFM-UHFFFAOYSA-N Cc1ccc(C(CC2)CCN2C(c2c(C3CCC3)cc(C)c(-c3nnc(COC)[nH]3)c2)=O)cc1 Chemical compound Cc1ccc(C(CC2)CCN2C(c2c(C3CCC3)cc(C)c(-c3nnc(COC)[nH]3)c2)=O)cc1 WPSWBRXGXVKZFM-UHFFFAOYSA-N 0.000 description 1
- ZRKHYBGHXAPVLS-UHFFFAOYSA-N Cc1ccc(C(CC2)CCN2C(c2cc(-c3nc4cc(N5CCN(C)CC5)ncc4[nH]3)c(C)cc2C)=O)cc1 Chemical compound Cc1ccc(C(CC2)CCN2C(c2cc(-c3nc4cc(N5CCN(C)CC5)ncc4[nH]3)c(C)cc2C)=O)cc1 ZRKHYBGHXAPVLS-UHFFFAOYSA-N 0.000 description 1
- PCZAFRLRWKOVOC-UHFFFAOYSA-N Cc1nnc(-c2c(C3CCC3)ccc(C(N(CC3)CCC3(c(cc3)ccc3C#N)F)=O)c2)[nH]1 Chemical compound Cc1nnc(-c2c(C3CCC3)ccc(C(N(CC3)CCC3(c(cc3)ccc3C#N)F)=O)c2)[nH]1 PCZAFRLRWKOVOC-UHFFFAOYSA-N 0.000 description 1
- QMKJWIRZIPCAKP-UHFFFAOYSA-N N#CC1C=CC(C2CCNCC2)=CC1 Chemical compound N#CC1C=CC(C2CCNCC2)=CC1 QMKJWIRZIPCAKP-UHFFFAOYSA-N 0.000 description 1
- VAVUGGHRBARCMG-UHFFFAOYSA-N N[IH]c1ccc(C2(CCNCC2)F)cc1 Chemical compound N[IH]c1ccc(C2(CCNCC2)F)cc1 VAVUGGHRBARCMG-UHFFFAOYSA-N 0.000 description 1
- NAGGYODWMPFKJQ-UHFFFAOYSA-N OC(c(c(Br)c1)ccc1Br)=O Chemical compound OC(c(c(Br)c1)ccc1Br)=O NAGGYODWMPFKJQ-UHFFFAOYSA-N 0.000 description 1
- NHQDETIJWKXCTC-UHFFFAOYSA-N OOC(c1cccc(Cl)c1)=O Chemical compound OOC(c1cccc(Cl)c1)=O NHQDETIJWKXCTC-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
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| US20170119786A1 (en) | 2011-03-08 | 2017-05-04 | 3-V Biosciences, Inc. | Heterocyclic modulators of lipid synthesis |
| US9624173B2 (en) | 2011-03-08 | 2017-04-18 | 3-V Biosciences, Inc. | Heterocyclic modulators of lipid synthesis |
| KR102071095B1 (ko) | 2012-07-03 | 2020-01-29 | 3-브이 바이오사이언시스, 인코포레이티드 | 지질 합성의 헤테로사이클릭 조절인자 |
| AR092211A1 (es) * | 2012-09-24 | 2015-04-08 | Merck Patent Ges Mit Beschränkter Haftung | Derivados de hidropirrolopirrol |
| HK1217649A1 (zh) | 2012-12-27 | 2017-01-20 | 德雷克塞尔大学 | 針對hbv感染的新型抗病毒劑 |
| CA2900309A1 (fr) * | 2013-02-14 | 2014-08-21 | Galderma Research & Development | Procede de synthese de 4-piperidin-4-yl-benzene-1,3-diol et de ses sels et nouveau compose 4-(2,4-dihydroxy-phenyl)-4-hydroxy-piperidine-1-carboxylate de tert-butyle |
| JP6163214B2 (ja) * | 2013-03-06 | 2017-07-12 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 抗ウイルス化合物 |
| MX364895B (es) * | 2013-03-13 | 2019-05-10 | Forma Therapeutics Inc | Nuevos compuestos y composiciones para la inhibicion de fasn. |
| CA2934251C (en) * | 2013-12-20 | 2024-01-02 | 3-V Biosciences, Inc. | A combination of heterocyclic modulators of lipid synthesis and chemotherapeutic drugs in treatment of cancer |
| JP6522007B2 (ja) * | 2014-01-07 | 2019-05-29 | 3−ブイ・バイオサイエンシーズ・インコーポレイテッド3−V Biosciences,Inc. | 癌及びウイルス感染症に対する使用のための脂質合成の複素環式モジュレータ |
| CN104774204A (zh) * | 2014-01-15 | 2015-07-15 | 鲁南贝特制药有限公司 | 一种制备奈韦拉平及其中间体的方法 |
| WO2015199206A1 (ja) * | 2014-06-27 | 2015-12-30 | 塩野義製薬株式会社 | Trpv4阻害活性を有する6員環誘導体 |
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| JP6758314B2 (ja) * | 2015-03-19 | 2020-09-23 | サギメット バイオサイエンシーズ インコーポレイテッド | 脂質合成の複素環式調節因子 |
| CN105175277B (zh) * | 2015-05-18 | 2018-04-03 | 中山大学肿瘤防治中心 | 一种3‑磷酸甘油醛脱氢酶的抑制剂及其制备方法和应用 |
| PE20180572A1 (es) | 2015-06-18 | 2018-04-04 | Cephalon Inc | Derivados de piperidina 1,4-sustituidos |
| EP3310773B1 (en) | 2015-06-18 | 2020-12-02 | 89Bio Ltd. | Substituted 4-benzyl and 4-benzoyl piperidine derivatives |
| AU2016314621B2 (en) * | 2015-09-04 | 2021-05-13 | Poli Md S.R.L. | Composition and medical device comprising acetylsalicylic acid for the treatment of human papilloma virus skin infections |
| KR102644934B1 (ko) * | 2016-11-11 | 2024-03-08 | 새지메트 바이오사이언시스, 인코포레이티드 | 지질 합성의 헤테로사이클릭 조절인자 |
| CN107043347B (zh) * | 2016-11-18 | 2019-07-02 | 泰州禾益新材料科技有限公司 | 一种阿加曲班中间体(2r,4r)-4-甲基哌啶-2-甲酸乙酯的合成方法 |
| CN109212056B (zh) * | 2018-08-19 | 2021-05-07 | 丁立平 | 一种测定水源水中三种痕量单卤代甲基苯甲酸的气相色谱-质谱联用法 |
| TWI767148B (zh) | 2018-10-10 | 2022-06-11 | 美商弗瑪治療公司 | 抑制脂肪酸合成酶(fasn) |
| CN113382633A (zh) | 2018-10-29 | 2021-09-10 | 福马治疗股份有限公司 | (4-(2-氟-4-(1-甲基-1H-苯并[d]咪唑-5-基)苯甲酰基)哌嗪-1-基)(1-羟基环丙基)甲酮的固体形式 |
| WO2021229533A1 (en) * | 2020-05-14 | 2021-11-18 | Palani Llc | A fatty acid based composition for treatment and/or prevention of enveloped-virus related infections |
| CN114469945A (zh) * | 2020-10-28 | 2022-05-13 | 歌礼生物科技(杭州)有限公司 | 脂肪酸合酶抑制剂的用途和药物组合物 |
| CN113584044A (zh) * | 2021-08-28 | 2021-11-02 | 青岛农业大学 | 一种牙鲆socs3基因及其真核表达载体、表达系统和异源表达方法 |
| IL319179A (en) * | 2022-10-01 | 2025-04-01 | Assia Chem Ind Ltd | Solid forms of Dinipenstat |
| WO2024240108A1 (zh) * | 2023-05-19 | 2024-11-28 | 上海海和药物研究开发股份有限公司 | 一种芳基脲类parp1抑制剂、其制备方法及用途 |
| CN119080742A (zh) * | 2023-06-05 | 2024-12-06 | 甘莱制药有限公司 | 脂质合成的杂环调节剂的工业化制备 |
| KR20260056149A (ko) * | 2023-07-21 | 2026-04-24 | 새지메트 바이오사이언시스, 인코포레이티드 | 헤테로고리 화합물을 함유하는 약제학적 조성물 |
| WO2025086054A1 (zh) * | 2023-10-23 | 2025-05-01 | 歌礼生物科技(杭州)有限公司 | 一种包含苯甲腈衍生物的药物组合物 |
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| US20080103208A1 (en) * | 2006-09-05 | 2008-05-01 | Bipar Sciences, Inc. | Inhibition of fatty acid synthesis by parp inhibitors and methods of treatment thereof |
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