CN1034077C - 新的吡啶并[2，3-f][1，4]硫代吖庚因的制备方法 - Google Patents

新的吡啶并[2，3-f][1，4]硫代吖庚因的制备方法 Download PDF

Info

Publication number
CN1034077C
CN1034077C CN91103594A CN91103594A CN1034077C CN 1034077 C CN1034077 C CN 1034077C CN 91103594 A CN91103594 A CN 91103594A CN 91103594 A CN91103594 A CN 91103594A CN 1034077 C CN1034077 C CN 1034077C
Authority
CN
China
Prior art keywords
ethyl
dioxo
thioazepine
dichlorophenyl
carboxylate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN91103594A
Other languages
English (en)
Chinese (zh)
Other versions
CN1056880A (zh
Inventor
戴维·J·武斯特罗
约翰·H·多德
查尔斯·F·施文德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Pharmaceutical Corp
Original Assignee
Ortho Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharmaceutical Corp filed Critical Ortho Pharmaceutical Corp
Publication of CN1056880A publication Critical patent/CN1056880A/zh
Application granted granted Critical
Publication of CN1034077C publication Critical patent/CN1034077C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Luminescent Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN91103594A 1990-05-03 1991-05-03 新的吡啶并[2，3-f][1，4]硫代吖庚因的制备方法 Expired - Fee Related CN1034077C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/518,351 US5075440A (en) 1990-05-03 1990-05-03 Novel pyrido[2,3-f](1,4)thiazepines and pyrido[3,2-b](1,5)benzothiazepines
US518,351 1990-05-03

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN95109346A Division CN1039416C (zh) 1990-05-03 1995-07-29 新的吡啶并[3,2－b][1,5]苯并硫代吖庚因的制备方法

Publications (2)

Publication Number Publication Date
CN1056880A CN1056880A (zh) 1991-12-11
CN1034077C true CN1034077C (zh) 1997-02-19

Family

ID=24063558

Family Applications (2)

Application Number Title Priority Date Filing Date
CN91103594A Expired - Fee Related CN1034077C (zh) 1990-05-03 1991-05-03 新的吡啶并[2，3-f][1，4]硫代吖庚因的制备方法
CN95109346A Expired - Fee Related CN1039416C (zh) 1990-05-03 1995-07-29 新的吡啶并[3,2－b][1,5]苯并硫代吖庚因的制备方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN95109346A Expired - Fee Related CN1039416C (zh) 1990-05-03 1995-07-29 新的吡啶并[3,2－b][1,5]苯并硫代吖庚因的制备方法

Country Status (25)

Country Link
US (1) US5075440A (https=)
EP (1) EP0462696B1 (https=)
JP (1) JP3296499B2 (https=)
KR (1) KR100195345B1 (https=)
CN (2) CN1034077C (https=)
AT (1) ATE126231T1 (https=)
AU (1) AU651580B2 (https=)
CA (1) CA2041594C (https=)
DE (1) DE69111915T2 (https=)
DK (1) DK0462696T3 (https=)
ES (1) ES2079570T3 (https=)
FI (1) FI95912C (https=)
GR (1) GR3017305T3 (https=)
HK (1) HK51496A (https=)
HU (1) HU218909B (https=)
IE (1) IE68524B1 (https=)
IL (6) IL127047A0 (https=)
MY (1) MY106552A (https=)
NO (1) NO179411C (https=)
NZ (1) NZ237988A (https=)
PT (1) PT97547B (https=)
TN (1) TNSN91030A1 (https=)
TW (1) TW218878B (https=)
ZA (1) ZA913319B (https=)
ZW (1) ZW5291A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6593335B1 (en) 1997-12-18 2003-07-15 Abbott Laboratories Potassium channel openers
US6265417B1 (en) 1997-12-18 2001-07-24 Abbott Laboratories Potassium channel openers
AU756505B2 (en) * 1997-12-18 2003-01-16 Abbott Laboratories Potassium channel openers
JPH11193289A (ja) * 1997-12-26 1999-07-21 Suntory Ltd ピロールスルホンアミド誘導体
US6482854B1 (en) * 1999-03-25 2002-11-19 Massachusetts Eye And Ear Infirmary Glaucoma treatment
US7015212B1 (en) 1999-05-12 2006-03-21 The United States Of America As Represented By The Department Of Health And Human Services Thiazepine inhibitors of HIV-1 integrase
HUP0201566A3 (en) * 1999-06-14 2004-03-01 Ortho Mcneil Pharm Inc Dithiepino[6,5-b]pyridines, their preparation pharmaceutical compositions containing thereof and an apparatus for their administering
ES2246248T3 (es) * 1999-07-12 2006-02-16 Ortho-Mcneil Pharmaceutical, Inc. Oxatiepino (6,5-b)dihidropiridinas, y composiciones y metodos relacionados.
US6472530B1 (en) 1999-09-22 2002-10-29 Ortho-Mcneil Pharmaceutical, Inc. Benzo-fused dithiepino[6,5-b]pyridines, and related compositions and methods
CA2396962A1 (en) 2000-01-12 2001-07-19 Ortho-Mcneil Pharmaceutical, Inc. Benzosulfones and related compositions and methods
AU783503B2 (en) * 2000-01-27 2005-11-03 Ortho-Mcneil Pharmaceutical, Inc. Benzoxathiepino(3,4-b)pyridine derivatives, process for their preparation and their use as medicaments
JP2003528104A (ja) 2000-03-23 2003-09-24 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド チエピノ［３，２−ｂ］ジヒドロピリジンおよび関連組成物ならびに方法
CN1444587A (zh) 2000-05-30 2003-09-24 奥索-麦克尼尔药品公司 二氢吡啶软药及相关组合物和方法
KR101233139B1 (ko) 2011-04-21 2013-02-21 주식회사 한서켐 라세믹 1,4-티아제핀 화합물의 분할 방법
US20160207893A1 (en) * 2014-12-30 2016-07-21 Myotherix, Inc. Novel calcium modulators

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1587128A (en) * 1977-04-07 1981-04-01 Hexachimie Benzothiazepine derivatives
US4285955A (en) * 1978-10-31 1981-08-25 Bayer Aktiengesellschaft 1,4-Dihydropyridinecarboxylic acids
NZ201395A (en) * 1981-07-30 1987-02-20 Bayer Ag Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines
FR2511683A1 (fr) * 1981-08-20 1983-02-25 Hexachimie Nouveaux derives de la pyrido (2,3-b) benzothiazepine(1,5) substituee en 5 par une carboxypiperazine, leur procede de preparation, leur application en therapeutique
EP0225175A3 (en) * 1985-11-28 1988-12-28 FISONS plc Dihydropyridine derivatives, processes for their preparation and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
CA2041594A1 (en) 1991-11-04
IE68524B1 (en) 1996-06-26
IL120446A0 (en) 1997-07-13
HU911476D0 (en) 1991-11-28
KR910020019A (ko) 1991-12-19
TNSN91030A1 (fr) 1992-10-25
KR100195345B1 (ko) 1999-06-15
JPH04225986A (ja) 1992-08-14
ATE126231T1 (de) 1995-08-15
IE911488A1 (en) 1991-11-06
HU218909B (hu) 2000-12-28
IL120446A (en) 2000-08-31
IL127047A0 (en) 1999-09-22
HK51496A (en) 1996-03-29
IL127047A (en) 2000-10-31
PT97547A (pt) 1992-01-31
AU651580B2 (en) 1994-07-28
CN1056880A (zh) 1991-12-11
MY106552A (en) 1995-06-30
FI912124A7 (fi) 1991-11-04
IL97999A0 (en) 1992-06-21
FI912124A0 (fi) 1991-05-02
EP0462696B1 (en) 1995-08-09
ZW5291A1 (en) 1993-01-06
NO179411B (no) 1996-06-24
CN1039416C (zh) 1998-08-05
CA2041594C (en) 2002-07-23
AU7635491A (en) 1991-11-07
GR3017305T3 (en) 1995-12-31
ES2079570T3 (es) 1996-01-16
HUT60745A (en) 1992-10-28
IL120447A (en) 1999-12-22
IL97999A (en) 1997-06-10
TW218878B (https=) 1994-01-11
NO179411C (no) 1996-10-02
EP0462696A1 (en) 1991-12-27
DE69111915T2 (de) 1996-01-04
CN1118783A (zh) 1996-03-20
FI95912C (fi) 1996-04-10
NO911723L (no) 1991-11-04
DK0462696T3 (da) 1995-09-18
JP3296499B2 (ja) 2002-07-02
PT97547B (pt) 1998-08-31
US5075440A (en) 1991-12-24
NZ237988A (en) 1992-09-25
ZA913319B (en) 1993-01-27
NO911723D0 (no) 1991-05-02
FI95912B (fi) 1995-12-29
DE69111915D1 (de) 1995-09-14
IL120447A0 (en) 1997-07-13

Similar Documents

Publication Publication Date Title
CN1034077C (zh) 新的吡啶并[2，3-f][1，4]硫代吖庚因的制备方法
CN1478076A (zh) Mch拮抗剂及它们在治疗肥胖症方面的用途
CN1029960C (zh) 具有神经保护作用的苯并二氢吡喃醇衍生物的制备方法
CN1128026A (zh) 新型1，4-(二苯基烷基)哌嗪衍生物
CN1438220A (zh) 1－（1，2－双取代哌啶基〕－4－取代哌嗪衍生物
CN1015707B (zh) 酰胺衍生物的生产方法
CN1608050A (zh) 哌嗪衍生物
CN1177839C (zh) 奎替阿平及其中间体的制备方法
CN1771234A (zh) 吡咯并三嗪激酶抑制剂的制备方法
CN1134695A (zh) 具有血小板凝聚抑制作用的新颖化合物
CN1016420B (zh) 苯并二氢呋喃羧酰胺衍生物的制备方法
CN86102349A (zh) 制备n-[(4-哌啶基)烷基]取代的双环稠合的唑与噻唑胺之方法
CN1064964C (zh) 新型苯并二噁烷,它们的制备方法以及含这些化合物的药物组合物
CN1048014C (zh) 取代的吡咯类化合物及其制法、药物组合物和用途
CN1166629C (zh) 新型苯磺酰胺化合物、其制备方法和含有其的药物组合物
CN1610674A (zh) 2－氨基－二氢噻唑衍生物及其作为诱导型no－合酶抑制剂的用途
CN1042028C (zh) 吗啉衍生物及其含吗啉衍生物的药物组合物
CN1306510A (zh) 光学活性四氢苯并吲哚衍生物
CN1100098A (zh) 2-氨基-4-喹啉基-二氢吡啶类化合物及其制备和应用
TW201343642A (zh) 製備利伐沙班（ｒｉｖａｒｏｘａｂａｎ）之方法
CN87100686A (zh) 用作心血管剂的3-烷氧基-2-氨基丙胺类化合物
CN87107427A (zh) 取代的氨甲基-5，6，7，8-四氢萘氧代乙酸，新的中间体产物，它们的制备过程及其作为药物的应用
CN1606557A (zh) 经氘代的吡唑嘧啶酮以及包含该化合物的药物组合物
CN1158276C (zh) 具有抑制tnf活性的苯基-和吡啶基-四氢吡啶
CN1247593C (zh) 噻庚英并[3,2－b]二氢吡啶和相关组合物及方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C15 Extension of patent right duration from 15 to 20 years for appl. with date before 31.12.1992 and still valid on 11.12.2001 (patent law change 1993)
OR01 Other related matters
C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee