ES2079570T3 - Nuevas pirido(2,3-f)(1,4)tiazepinas y pirido(3,2-b)(1,5)benzotiazepinas. - Google Patents

Nuevas pirido(2,3-f)(1,4)tiazepinas y pirido(3,2-b)(1,5)benzotiazepinas.

Info

Publication number
ES2079570T3
ES2079570T3 ES91303970T ES91303970T ES2079570T3 ES 2079570 T3 ES2079570 T3 ES 2079570T3 ES 91303970 T ES91303970 T ES 91303970T ES 91303970 T ES91303970 T ES 91303970T ES 2079570 T3 ES2079570 T3 ES 2079570T3
Authority
ES
Spain
Prior art keywords
pirido
new
benzotiazepinas
thiazepines
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91303970T
Other languages
English (en)
Inventor
David J Wustrow
John H Dodd
Charles F Schwender
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Pharmaceutical Corp
Original Assignee
Ortho Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharmaceutical Corp filed Critical Ortho Pharmaceutical Corp
Application granted granted Critical
Publication of ES2079570T3 publication Critical patent/ES2079570T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Luminescent Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE DESCRIBEN NUEVAS PIRIDO [2,3-F] [1,4] TIACEPINAS Y NUEVAS PIRIDO [3,2-B] [1,5] BENZOTIACEPINAS. ESTOS COMPUESTOS SON UTILES COMO ANTAGONISTAS DEL CANAL DE CALCIO CON ACTIVIDAD CARDIOVASCULAR, ANTIASMATICA Y DE ANTIBRONCO CONSTRICCION. TAMBIEN SE DESCRIBEN METODOS PARA PRODUCIR LOS NUEVOS COMPUESTOS Y SUS INTERMEDIOS.
ES91303970T 1990-05-03 1991-05-02 Nuevas pirido(2,3-f)(1,4)tiazepinas y pirido(3,2-b)(1,5)benzotiazepinas. Expired - Lifetime ES2079570T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/518,351 US5075440A (en) 1990-05-03 1990-05-03 Novel pyrido[2,3-f](1,4)thiazepines and pyrido[3,2-b](1,5)benzothiazepines

Publications (1)

Publication Number Publication Date
ES2079570T3 true ES2079570T3 (es) 1996-01-16

Family

ID=24063558

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91303970T Expired - Lifetime ES2079570T3 (es) 1990-05-03 1991-05-02 Nuevas pirido(2,3-f)(1,4)tiazepinas y pirido(3,2-b)(1,5)benzotiazepinas.

Country Status (25)

Country Link
US (1) US5075440A (es)
EP (1) EP0462696B1 (es)
JP (1) JP3296499B2 (es)
KR (1) KR100195345B1 (es)
CN (2) CN1034077C (es)
AT (1) ATE126231T1 (es)
AU (1) AU651580B2 (es)
CA (1) CA2041594C (es)
DE (1) DE69111915T2 (es)
DK (1) DK0462696T3 (es)
ES (1) ES2079570T3 (es)
FI (1) FI95912C (es)
GR (1) GR3017305T3 (es)
HK (1) HK51496A (es)
HU (1) HU218909B (es)
IE (1) IE68524B1 (es)
IL (6) IL97999A (es)
MY (1) MY106552A (es)
NO (1) NO179411C (es)
NZ (1) NZ237988A (es)
PT (1) PT97547B (es)
TN (1) TNSN91030A1 (es)
TW (1) TW218878B (es)
ZA (1) ZA913319B (es)
ZW (1) ZW5291A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6593335B1 (en) * 1997-12-18 2003-07-15 Abbott Laboratories Potassium channel openers
IL135985A0 (en) * 1997-12-18 2001-05-20 Abbott Lab Potassium channel openers
US6265417B1 (en) 1997-12-18 2001-07-24 Abbott Laboratories Potassium channel openers
JPH11193289A (ja) 1997-12-26 1999-07-21 Suntory Ltd ピロールスルホンアミド誘導体
US6482854B1 (en) * 1999-03-25 2002-11-19 Massachusetts Eye And Ear Infirmary Glaucoma treatment
US7015212B1 (en) 1999-05-12 2006-03-21 The United States Of America As Represented By The Department Of Health And Human Services Thiazepine inhibitors of HIV-1 integrase
JP2003502335A (ja) 1999-06-14 2003-01-21 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド ジチエピノ［６，５−ｂ］ピリジンおよび関連組成物および方法
ATE302206T1 (de) * 1999-07-12 2005-09-15 Ortho Mcneil Pharm Inc Oxathiepino(6,5-b)dihydropyridine und verwandte verbindungen und verfahren
US6472530B1 (en) 1999-09-22 2002-10-29 Ortho-Mcneil Pharmaceutical, Inc. Benzo-fused dithiepino[6,5-b]pyridines, and related compositions and methods
JP2003519626A (ja) 2000-01-12 2003-06-24 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド カルシウムアンタゴニスト活性を有するベンゾスルホン類
EP1257554A1 (en) 2000-01-27 2002-11-20 Ortho-McNeil Pharmaceutical, Inc. Benzoxathiepino[3,4-b]pyridine derivatives, process for their preparation and their use as medicaments
DE60103261T2 (de) 2000-03-23 2005-06-02 Ortho-Mcneil Pharmaceutical, Inc. Thiepino[3,2-b]dihydropyridine und relatierte zusammensetzungen und verfahren
CN1680324A (zh) 2000-05-30 2005-10-12 奥索-麦克尼尔药品公司 二氢吡啶软药及相关组合物和方法
KR101233139B1 (ko) 2011-04-21 2013-02-21 주식회사 한서켐 라세믹 1,4-티아제핀 화합물의 분할 방법
EP3240547A4 (en) * 2014-12-30 2018-06-13 Myotherix Inc. Novel calcium modulators

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1587128A (en) * 1977-04-07 1981-04-01 Hexachimie Benzothiazepine derivatives
US4285955A (en) * 1978-10-31 1981-08-25 Bayer Aktiengesellschaft 1,4-Dihydropyridinecarboxylic acids
NZ201395A (en) * 1981-07-30 1987-02-20 Bayer Ag Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines
FR2511683A1 (fr) * 1981-08-20 1983-02-25 Hexachimie Nouveaux derives de la pyrido (2,3-b) benzothiazepine(1,5) substituee en 5 par une carboxypiperazine, leur procede de preparation, leur application en therapeutique
EP0225175A3 (en) * 1985-11-28 1988-12-28 FISONS plc Dihydropyridine derivatives, processes for their preparation and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
NO911723L (no) 1991-11-04
EP0462696B1 (en) 1995-08-09
ATE126231T1 (de) 1995-08-15
IL120446A (en) 2000-08-31
FI912124A (fi) 1991-11-04
HU218909B (hu) 2000-12-28
HK51496A (en) 1996-03-29
IL97999A (en) 1997-06-10
FI912124A0 (fi) 1991-05-02
IL120447A (en) 1999-12-22
KR910020019A (ko) 1991-12-19
JPH04225986A (ja) 1992-08-14
AU7635491A (en) 1991-11-07
IL97999A0 (en) 1992-06-21
JP3296499B2 (ja) 2002-07-02
HU911476D0 (en) 1991-11-28
DK0462696T3 (da) 1995-09-18
HUT60745A (en) 1992-10-28
CN1118783A (zh) 1996-03-20
GR3017305T3 (en) 1995-12-31
EP0462696A1 (en) 1991-12-27
AU651580B2 (en) 1994-07-28
CA2041594C (en) 2002-07-23
US5075440A (en) 1991-12-24
PT97547B (pt) 1998-08-31
CN1039416C (zh) 1998-08-05
NO179411C (no) 1996-10-02
NO911723D0 (no) 1991-05-02
CN1056880A (zh) 1991-12-11
IE911488A1 (en) 1991-11-06
IL127047A (en) 2000-10-31
ZA913319B (en) 1993-01-27
TW218878B (es) 1994-01-11
IL120446A0 (en) 1997-07-13
MY106552A (en) 1995-06-30
NZ237988A (en) 1992-09-25
DE69111915D1 (de) 1995-09-14
IL120447A0 (en) 1997-07-13
CA2041594A1 (en) 1991-11-04
ZW5291A1 (en) 1993-01-06
TNSN91030A1 (fr) 1992-10-25
IL127047A0 (en) 1999-09-22
CN1034077C (zh) 1997-02-19
FI95912C (fi) 1996-04-10
FI95912B (fi) 1995-12-29
DE69111915T2 (de) 1996-01-04
KR100195345B1 (ko) 1999-06-15
NO179411B (no) 1996-06-24
PT97547A (pt) 1992-01-31
IE68524B1 (en) 1996-06-26

Similar Documents

Publication Publication Date Title
ES2079570T3 (es) Nuevas pirido(2,3-f)(1,4)tiazepinas y pirido(3,2-b)(1,5)benzotiazepinas.
ES2188984T3 (es) Procedimiento de enriquecimiento en r de epimeros de derivados de 16,17-acetales de derivados de 21-aciloxi-pregnano-1,4-dieno-11-beta, 16alfa-triol-3,20-dionas.
ES507430A0 (es) Procedimiento para la produccion de nuevos compuestos de xantato con propiedades farmacologicas.
ATE13667T1 (de) 8-aza-16,16-difluor-prostanoide.
BR8003656A (pt) Unidade de lampada circular, fluorescente
ES539579A0 (es) Procedimiento de fundicion, por deslizamiento, para unidadeshuecas de hormigon, con la maquina necesaria para la practi-ca del mismo
DK305578A (da) Fremgangsmaade til fremstilling af bicycliske thia-diaza-forbindelser isaer 1,3-diaza-cyclopent-2-eno(2,1-b) (1-thia-3-aza-cycloalkaner).
DK330578A (da) Fremgangsmaade til fremstilling af dibenzo (b,f) thiepin-forbindelser
AR228041A1 (es) Procedimiento para producir compuestos de pirazolo(3,4-b)(1,5)benzodiazepina
MX9204279A (es) Tiazolidindionas hipoglicemicas e intermediarios.
IT8047961A0 (it) Procedimento per la produzione di copolimeri ad innesto
ES8704469A1 (es) Procedimiento para preparar naftoxacinas
ES2052856T3 (es) Procedimiento para el funcionamiento de instalaciones de conmutacion de telecomunicaciones controladas de forma centralizada.
ES8504776A1 (es) Un metodo para preparar compuestos de fenilpiperazina sustituidos
ES2104464T3 (es) Compuestos benzoheterociclicos; como antioxidantes.
ES2005056B3 (es) Cilindro de cierre con oclusion del canal de cierre.
ES294936Y (es) Aro mejorado para canal de piston
IT1161224B (it) Procedimento per produrre 2,3-diidro-2,2-dimetil-7-benzofuranolo
ES2146837T3 (es) Procedimiento para preparar derivados de la rodanina sustituidos con bencilo.
IT7825710A0 (it) Procedimento per la produzione di filamenti sintetici con sezione trasversale rotonda.
IE792503L (en) Antipsychotic levorotatory or dextrorotatory enantiomers of¹3-halocypropeptadines.
IT8320739A0 (it) Procedimento per la produzione di2,3-diidro-2,2-dimetil-7-benzofuranolo.
ECSP961901A (es) Compuestos de imidazolidin 2,4- diona sustituida
SU1037648A1 (ru) 3-Фенилвинил-5,6,7,8-тетрагидро-6,8-диметилпиримидо-[5,4-е] [1,2,4]-триазин-5, 7-дион, проявляющий противовоспалительную активность
IT8522409A0 (it) Procedimento per la produzione di2,3-diidro-2,2-dimetil-7-benzofuranolo.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 462696

Country of ref document: ES