ZA913319B - Novel pyrido(2,3-f)(1,4)thiazepines and pyrido(3,2-b)(1,5)benzothiazepines - Google Patents

Novel pyrido(2,3-f)(1,4)thiazepines and pyrido(3,2-b)(1,5)benzothiazepines

Info

Publication number
ZA913319B
ZA913319B ZA913319A ZA913319A ZA913319B ZA 913319 B ZA913319 B ZA 913319B ZA 913319 A ZA913319 A ZA 913319A ZA 913319 A ZA913319 A ZA 913319A ZA 913319 B ZA913319 B ZA 913319B
Authority
ZA
South Africa
Prior art keywords
pyrido
novel
thiazepines
benzothiazepines
compounds
Prior art date
Application number
ZA913319A
Other languages
English (en)
Inventor
David J Wustrow
J Wustrow David
John H Dodd
H Dodd John
Charles F Schwender
F Schwender Charles
Original Assignee
Ortho Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharma Corp filed Critical Ortho Pharma Corp
Publication of ZA913319B publication Critical patent/ZA913319B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Luminescent Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA913319A 1990-05-03 1991-05-02 Novel pyrido(2,3-f)(1,4)thiazepines and pyrido(3,2-b)(1,5)benzothiazepines ZA913319B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/518,351 US5075440A (en) 1990-05-03 1990-05-03 Novel pyrido[2,3-f](1,4)thiazepines and pyrido[3,2-b](1,5)benzothiazepines

Publications (1)

Publication Number Publication Date
ZA913319B true ZA913319B (en) 1993-01-27

Family

ID=24063558

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA913319A ZA913319B (en) 1990-05-03 1991-05-02 Novel pyrido(2,3-f)(1,4)thiazepines and pyrido(3,2-b)(1,5)benzothiazepines

Country Status (25)

Country Link
US (1) US5075440A (https=)
EP (1) EP0462696B1 (https=)
JP (1) JP3296499B2 (https=)
KR (1) KR100195345B1 (https=)
CN (2) CN1034077C (https=)
AT (1) ATE126231T1 (https=)
AU (1) AU651580B2 (https=)
CA (1) CA2041594C (https=)
DE (1) DE69111915T2 (https=)
DK (1) DK0462696T3 (https=)
ES (1) ES2079570T3 (https=)
FI (1) FI95912C (https=)
GR (1) GR3017305T3 (https=)
HK (1) HK51496A (https=)
HU (1) HU218909B (https=)
IE (1) IE68524B1 (https=)
IL (6) IL127047A0 (https=)
MY (1) MY106552A (https=)
NO (1) NO179411C (https=)
NZ (1) NZ237988A (https=)
PT (1) PT97547B (https=)
TN (1) TNSN91030A1 (https=)
TW (1) TW218878B (https=)
ZA (1) ZA913319B (https=)
ZW (1) ZW5291A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6593335B1 (en) 1997-12-18 2003-07-15 Abbott Laboratories Potassium channel openers
US6265417B1 (en) 1997-12-18 2001-07-24 Abbott Laboratories Potassium channel openers
AU756505B2 (en) * 1997-12-18 2003-01-16 Abbott Laboratories Potassium channel openers
JPH11193289A (ja) * 1997-12-26 1999-07-21 Suntory Ltd ピロールスルホンアミド誘導体
US6482854B1 (en) * 1999-03-25 2002-11-19 Massachusetts Eye And Ear Infirmary Glaucoma treatment
US7015212B1 (en) 1999-05-12 2006-03-21 The United States Of America As Represented By The Department Of Health And Human Services Thiazepine inhibitors of HIV-1 integrase
HUP0201566A3 (en) * 1999-06-14 2004-03-01 Ortho Mcneil Pharm Inc Dithiepino[6,5-b]pyridines, their preparation pharmaceutical compositions containing thereof and an apparatus for their administering
ES2246248T3 (es) * 1999-07-12 2006-02-16 Ortho-Mcneil Pharmaceutical, Inc. Oxatiepino (6,5-b)dihidropiridinas, y composiciones y metodos relacionados.
US6472530B1 (en) 1999-09-22 2002-10-29 Ortho-Mcneil Pharmaceutical, Inc. Benzo-fused dithiepino[6,5-b]pyridines, and related compositions and methods
CA2396962A1 (en) 2000-01-12 2001-07-19 Ortho-Mcneil Pharmaceutical, Inc. Benzosulfones and related compositions and methods
AU783503B2 (en) * 2000-01-27 2005-11-03 Ortho-Mcneil Pharmaceutical, Inc. Benzoxathiepino(3,4-b)pyridine derivatives, process for their preparation and their use as medicaments
JP2003528104A (ja) 2000-03-23 2003-09-24 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド チエピノ［３，２−ｂ］ジヒドロピリジンおよび関連組成物ならびに方法
CN1444587A (zh) 2000-05-30 2003-09-24 奥索-麦克尼尔药品公司 二氢吡啶软药及相关组合物和方法
KR101233139B1 (ko) 2011-04-21 2013-02-21 주식회사 한서켐 라세믹 1,4-티아제핀 화합물의 분할 방법
US20160207893A1 (en) * 2014-12-30 2016-07-21 Myotherix, Inc. Novel calcium modulators

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1587128A (en) * 1977-04-07 1981-04-01 Hexachimie Benzothiazepine derivatives
US4285955A (en) * 1978-10-31 1981-08-25 Bayer Aktiengesellschaft 1,4-Dihydropyridinecarboxylic acids
NZ201395A (en) * 1981-07-30 1987-02-20 Bayer Ag Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines
FR2511683A1 (fr) * 1981-08-20 1983-02-25 Hexachimie Nouveaux derives de la pyrido (2,3-b) benzothiazepine(1,5) substituee en 5 par une carboxypiperazine, leur procede de preparation, leur application en therapeutique
EP0225175A3 (en) * 1985-11-28 1988-12-28 FISONS plc Dihydropyridine derivatives, processes for their preparation and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
CA2041594A1 (en) 1991-11-04
IE68524B1 (en) 1996-06-26
IL120446A0 (en) 1997-07-13
HU911476D0 (en) 1991-11-28
KR910020019A (ko) 1991-12-19
TNSN91030A1 (fr) 1992-10-25
KR100195345B1 (ko) 1999-06-15
JPH04225986A (ja) 1992-08-14
ATE126231T1 (de) 1995-08-15
IE911488A1 (en) 1991-11-06
HU218909B (hu) 2000-12-28
IL120446A (en) 2000-08-31
IL127047A0 (en) 1999-09-22
HK51496A (en) 1996-03-29
IL127047A (en) 2000-10-31
PT97547A (pt) 1992-01-31
AU651580B2 (en) 1994-07-28
CN1056880A (zh) 1991-12-11
MY106552A (en) 1995-06-30
FI912124A7 (fi) 1991-11-04
IL97999A0 (en) 1992-06-21
FI912124A0 (fi) 1991-05-02
CN1034077C (zh) 1997-02-19
EP0462696B1 (en) 1995-08-09
ZW5291A1 (en) 1993-01-06
NO179411B (no) 1996-06-24
CN1039416C (zh) 1998-08-05
CA2041594C (en) 2002-07-23
AU7635491A (en) 1991-11-07
GR3017305T3 (en) 1995-12-31
ES2079570T3 (es) 1996-01-16
HUT60745A (en) 1992-10-28
IL120447A (en) 1999-12-22
IL97999A (en) 1997-06-10
TW218878B (https=) 1994-01-11
NO179411C (no) 1996-10-02
EP0462696A1 (en) 1991-12-27
DE69111915T2 (de) 1996-01-04
CN1118783A (zh) 1996-03-20
FI95912C (fi) 1996-04-10
NO911723L (no) 1991-11-04
DK0462696T3 (da) 1995-09-18
JP3296499B2 (ja) 2002-07-02
PT97547B (pt) 1998-08-31
US5075440A (en) 1991-12-24
NZ237988A (en) 1992-09-25
NO911723D0 (no) 1991-05-02
FI95912B (fi) 1995-12-29
DE69111915D1 (de) 1995-09-14
IL120447A0 (en) 1997-07-13

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