JP3296499B2 - 新規なピリド〔２，３−ｆ〕〔１，４〕チアゼピン類およびピリド〔３，２−ｂ〕〔１，５〕ベンゾチアゼピン類 - Google Patents

新規なピリド〔２，３−ｆ〕〔１，４〕チアゼピン類およびピリド〔３，２−ｂ〕〔１，５〕ベンゾチアゼピン類

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Publication number
JP3296499B2
JP3296499B2 JP13047291A JP13047291A JP3296499B2 JP 3296499 B2 JP3296499 B2 JP 3296499B2 JP 13047291 A JP13047291 A JP 13047291A JP 13047291 A JP13047291 A JP 13047291A JP 3296499 B2 JP3296499 B2 JP 3296499B2
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JP
Japan
Prior art keywords
substituted
formula
alkyl
compound
dioxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP13047291A
Other languages
English (en)
Japanese (ja)
Other versions
JPH04225986A (ja
Inventor
デビツド・ジエイ・ウストロウ
ジヨン・エイチ・ドツド
チヤールズ・エフ・シユウエンダー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Pharmaceutical Corp
Original Assignee
Ortho Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharmaceutical Corp filed Critical Ortho Pharmaceutical Corp
Publication of JPH04225986A publication Critical patent/JPH04225986A/ja
Application granted granted Critical
Publication of JP3296499B2 publication Critical patent/JP3296499B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Luminescent Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP13047291A 1990-05-03 1991-05-02 新規なピリド〔２，３−ｆ〕〔１，４〕チアゼピン類およびピリド〔３，２−ｂ〕〔１，５〕ベンゾチアゼピン類 Expired - Fee Related JP3296499B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/518,351 US5075440A (en) 1990-05-03 1990-05-03 Novel pyrido[2,3-f](1,4)thiazepines and pyrido[3,2-b](1,5)benzothiazepines
US518351 1990-05-03

Publications (2)

Publication Number Publication Date
JPH04225986A JPH04225986A (ja) 1992-08-14
JP3296499B2 true JP3296499B2 (ja) 2002-07-02

Family

ID=24063558

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13047291A Expired - Fee Related JP3296499B2 (ja) 1990-05-03 1991-05-02 新規なピリド〔２，３−ｆ〕〔１，４〕チアゼピン類およびピリド〔３，２−ｂ〕〔１，５〕ベンゾチアゼピン類

Country Status (25)

Country Link
US (1) US5075440A (https=)
EP (1) EP0462696B1 (https=)
JP (1) JP3296499B2 (https=)
KR (1) KR100195345B1 (https=)
CN (2) CN1034077C (https=)
AT (1) ATE126231T1 (https=)
AU (1) AU651580B2 (https=)
CA (1) CA2041594C (https=)
DE (1) DE69111915T2 (https=)
DK (1) DK0462696T3 (https=)
ES (1) ES2079570T3 (https=)
FI (1) FI95912C (https=)
GR (1) GR3017305T3 (https=)
HK (1) HK51496A (https=)
HU (1) HU218909B (https=)
IE (1) IE68524B1 (https=)
IL (6) IL127047A0 (https=)
MY (1) MY106552A (https=)
NO (1) NO179411C (https=)
NZ (1) NZ237988A (https=)
PT (1) PT97547B (https=)
TN (1) TNSN91030A1 (https=)
TW (1) TW218878B (https=)
ZA (1) ZA913319B (https=)
ZW (1) ZW5291A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6593335B1 (en) 1997-12-18 2003-07-15 Abbott Laboratories Potassium channel openers
US6265417B1 (en) 1997-12-18 2001-07-24 Abbott Laboratories Potassium channel openers
AU756505B2 (en) * 1997-12-18 2003-01-16 Abbott Laboratories Potassium channel openers
JPH11193289A (ja) * 1997-12-26 1999-07-21 Suntory Ltd ピロールスルホンアミド誘導体
US6482854B1 (en) * 1999-03-25 2002-11-19 Massachusetts Eye And Ear Infirmary Glaucoma treatment
US7015212B1 (en) 1999-05-12 2006-03-21 The United States Of America As Represented By The Department Of Health And Human Services Thiazepine inhibitors of HIV-1 integrase
HUP0201566A3 (en) * 1999-06-14 2004-03-01 Ortho Mcneil Pharm Inc Dithiepino[6,5-b]pyridines, their preparation pharmaceutical compositions containing thereof and an apparatus for their administering
ES2246248T3 (es) * 1999-07-12 2006-02-16 Ortho-Mcneil Pharmaceutical, Inc. Oxatiepino (6,5-b)dihidropiridinas, y composiciones y metodos relacionados.
US6472530B1 (en) 1999-09-22 2002-10-29 Ortho-Mcneil Pharmaceutical, Inc. Benzo-fused dithiepino[6,5-b]pyridines, and related compositions and methods
CA2396962A1 (en) 2000-01-12 2001-07-19 Ortho-Mcneil Pharmaceutical, Inc. Benzosulfones and related compositions and methods
AU783503B2 (en) * 2000-01-27 2005-11-03 Ortho-Mcneil Pharmaceutical, Inc. Benzoxathiepino(3,4-b)pyridine derivatives, process for their preparation and their use as medicaments
JP2003528104A (ja) 2000-03-23 2003-09-24 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド チエピノ［３，２−ｂ］ジヒドロピリジンおよび関連組成物ならびに方法
CN1444587A (zh) 2000-05-30 2003-09-24 奥索-麦克尼尔药品公司 二氢吡啶软药及相关组合物和方法
KR101233139B1 (ko) 2011-04-21 2013-02-21 주식회사 한서켐 라세믹 1,4-티아제핀 화합물의 분할 방법
US20160207893A1 (en) * 2014-12-30 2016-07-21 Myotherix, Inc. Novel calcium modulators

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1587128A (en) * 1977-04-07 1981-04-01 Hexachimie Benzothiazepine derivatives
US4285955A (en) * 1978-10-31 1981-08-25 Bayer Aktiengesellschaft 1,4-Dihydropyridinecarboxylic acids
NZ201395A (en) * 1981-07-30 1987-02-20 Bayer Ag Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines
FR2511683A1 (fr) * 1981-08-20 1983-02-25 Hexachimie Nouveaux derives de la pyrido (2,3-b) benzothiazepine(1,5) substituee en 5 par une carboxypiperazine, leur procede de preparation, leur application en therapeutique
EP0225175A3 (en) * 1985-11-28 1988-12-28 FISONS plc Dihydropyridine derivatives, processes for their preparation and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
CA2041594A1 (en) 1991-11-04
IE68524B1 (en) 1996-06-26
IL120446A0 (en) 1997-07-13
HU911476D0 (en) 1991-11-28
KR910020019A (ko) 1991-12-19
TNSN91030A1 (fr) 1992-10-25
KR100195345B1 (ko) 1999-06-15
JPH04225986A (ja) 1992-08-14
ATE126231T1 (de) 1995-08-15
IE911488A1 (en) 1991-11-06
HU218909B (hu) 2000-12-28
IL120446A (en) 2000-08-31
IL127047A0 (en) 1999-09-22
HK51496A (en) 1996-03-29
IL127047A (en) 2000-10-31
PT97547A (pt) 1992-01-31
AU651580B2 (en) 1994-07-28
CN1056880A (zh) 1991-12-11
MY106552A (en) 1995-06-30
FI912124A7 (fi) 1991-11-04
IL97999A0 (en) 1992-06-21
FI912124A0 (fi) 1991-05-02
CN1034077C (zh) 1997-02-19
EP0462696B1 (en) 1995-08-09
ZW5291A1 (en) 1993-01-06
NO179411B (no) 1996-06-24
CN1039416C (zh) 1998-08-05
CA2041594C (en) 2002-07-23
AU7635491A (en) 1991-11-07
GR3017305T3 (en) 1995-12-31
ES2079570T3 (es) 1996-01-16
HUT60745A (en) 1992-10-28
IL120447A (en) 1999-12-22
IL97999A (en) 1997-06-10
TW218878B (https=) 1994-01-11
NO179411C (no) 1996-10-02
EP0462696A1 (en) 1991-12-27
DE69111915T2 (de) 1996-01-04
CN1118783A (zh) 1996-03-20
FI95912C (fi) 1996-04-10
NO911723L (no) 1991-11-04
DK0462696T3 (da) 1995-09-18
PT97547B (pt) 1998-08-31
US5075440A (en) 1991-12-24
NZ237988A (en) 1992-09-25
ZA913319B (en) 1993-01-27
NO911723D0 (no) 1991-05-02
FI95912B (fi) 1995-12-29
DE69111915D1 (de) 1995-09-14
IL120447A0 (en) 1997-07-13

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