CN103402994B - 作为α7 NACHR调节剂的杂芳基衍生物 - Google Patents
作为α7 NACHR调节剂的杂芳基衍生物 Download PDFInfo
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- CN103402994B CN103402994B CN201280010409.0A CN201280010409A CN103402994B CN 103402994 B CN103402994 B CN 103402994B CN 201280010409 A CN201280010409 A CN 201280010409A CN 103402994 B CN103402994 B CN 103402994B
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- Prior art keywords
- methyl
- benzenesulfonamide
- compound
- chlorophenyl
- propionylthiophen
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- 0 CC(*)C(C)(/C=C/C(C)(/C=C1)S(N)(N(*)*)=*)/C=C1\c1c(C(*)=O)[s]c(*)c1*=C Chemical compound CC(*)C(C)(/C=C/C(C)(/C=C1)S(N)(N(*)*)=*)/C=C1\c1c(C(*)=O)[s]c(*)c1*=C 0.000 description 7
- XZMAQJLPXKDKPS-UHFFFAOYSA-N CCC(c([s]c(-c1ccc(C)cc1)c1C)c1-c(cc1)ccc1S(N1CCCCC1)(=O)=O)=O Chemical compound CCC(c([s]c(-c1ccc(C)cc1)c1C)c1-c(cc1)ccc1S(N1CCCCC1)(=O)=O)=O XZMAQJLPXKDKPS-UHFFFAOYSA-N 0.000 description 1
- UHLAWZXNLOKAAV-UHFFFAOYSA-N CCC(c([s]c(C1C=CC(C)=CC1C)c1C)c1-c(cc1)ccc1S(N)(=O)=O)=O Chemical compound CCC(c([s]c(C1C=CC(C)=CC1C)c1C)c1-c(cc1)ccc1S(N)(=O)=O)=O UHLAWZXNLOKAAV-UHFFFAOYSA-N 0.000 description 1
- QHQQBPZGHOZXMK-UHFFFAOYSA-N CCOC(c([o]cc1)c1-c(cc1)ccc1S(N)(=O)=O)=O Chemical compound CCOC(c([o]cc1)c1-c(cc1)ccc1S(N)(=O)=O)=O QHQQBPZGHOZXMK-UHFFFAOYSA-N 0.000 description 1
- LUHASJKAYHQBHT-UHFFFAOYSA-N CCOC(c([s]c(-c(cc1)ccc1Cl)c1)c1Br)=O Chemical compound CCOC(c([s]c(-c(cc1)ccc1Cl)c1)c1Br)=O LUHASJKAYHQBHT-UHFFFAOYSA-N 0.000 description 1
- XUEGDHSBJFGHAG-UHFFFAOYSA-N Cc1c(C2CC2)[s]c(C(OC)=O)c1-c(c1c2CCCC1)ccc2S(N)(=O)=O Chemical compound Cc1c(C2CC2)[s]c(C(OC)=O)c1-c(c1c2CCCC1)ccc2S(N)(=O)=O XUEGDHSBJFGHAG-UHFFFAOYSA-N 0.000 description 1
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN242KO2011 | 2011-02-23 | ||
| IN242/KOL/2011 | 2011-02-23 | ||
| IN1184KO2011 | 2011-09-09 | ||
| IN1184/KOL/2011 | 2011-09-09 | ||
| PCT/IB2012/050806 WO2012114285A1 (en) | 2011-02-23 | 2012-02-22 | Heteroaryl derivatives as alpha7 nachr modulators |
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| CA2913987A1 (en) | 2013-06-17 | 2014-12-24 | Lupin Limited | Pyrrole derivatives as alpha 7 nachr modulators |
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| CA3102777A1 (en) * | 2018-06-07 | 2019-12-12 | The Regents Of The University Of Michigan | Prc1 inhibitors and methods of treatment therewith |
| US20230159486A1 (en) | 2018-07-05 | 2023-05-25 | Bayer Aktiengesellschaft | Substituted thiophenecarboxamides and analogues as antibacterials agents |
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