CL2013002449A1 - Compuestos derivados de heteroaril-bencenosulfonamida, moduladores de nachr alfa 7; composicion farmaceutica; y su uso en la enfermedad de alzheimer, trastorno cognitivo leve, demencia senil, demencia vascular, entre otras. - Google Patents
Compuestos derivados de heteroaril-bencenosulfonamida, moduladores de nachr alfa 7; composicion farmaceutica; y su uso en la enfermedad de alzheimer, trastorno cognitivo leve, demencia senil, demencia vascular, entre otras.Info
- Publication number
- CL2013002449A1 CL2013002449A1 CL2013002449A CL2013002449A CL2013002449A1 CL 2013002449 A1 CL2013002449 A1 CL 2013002449A1 CL 2013002449 A CL2013002449 A CL 2013002449A CL 2013002449 A CL2013002449 A CL 2013002449A CL 2013002449 A1 CL2013002449 A1 CL 2013002449A1
- Authority
- CL
- Chile
- Prior art keywords
- dementia
- alzheimer
- disease
- benzenesulfonamide
- modulators
- Prior art date
Links
- 208000024827 Alzheimer disease Diseases 0.000 title abstract 4
- 201000004810 Vascular dementia Diseases 0.000 title abstract 3
- 208000010877 cognitive disease Diseases 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 206010039966 Senile dementia Diseases 0.000 title abstract 2
- -1 heteroaryl benzenesulfonamide Chemical compound 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 206010012289 Dementia Diseases 0.000 abstract 1
- 208000030886 Traumatic Brain injury Diseases 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 239000003693 atypical antipsychotic agent Substances 0.000 abstract 1
- 229940127236 atypical antipsychotics Drugs 0.000 abstract 1
- 239000000544 cholinesterase inhibitor Substances 0.000 abstract 1
- 230000006735 deficit Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 239000003136 dopamine receptor stimulating agent Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 208000013403 hyperactivity Diseases 0.000 abstract 1
- 210000004558 lewy body Anatomy 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 230000009529 traumatic brain injury Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN242KO2011 | 2011-02-23 | ||
| IN1184KO2011 | 2011-09-09 |
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| Publication Number | Publication Date |
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| CL2013002449A1 true CL2013002449A1 (es) | 2014-04-11 |
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| CL2013002449A CL2013002449A1 (es) | 2011-02-23 | 2013-08-23 | Compuestos derivados de heteroaril-bencenosulfonamida, moduladores de nachr alfa 7; composicion farmaceutica; y su uso en la enfermedad de alzheimer, trastorno cognitivo leve, demencia senil, demencia vascular, entre otras. |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA34957B1 (fr) | 2011-02-23 | 2014-03-01 | Lupin Ltd | Derives heteroaryle a titre modulateurs des nachr alpha 7 |
| EP2822946A1 (en) | 2012-03-06 | 2015-01-14 | Lupin Limited | Thiazole derivatives as alpha 7 nachr modulators |
| HUE044048T2 (hu) * | 2012-09-28 | 2019-09-30 | Takeda Pharmaceuticals Co | Eljárás tienopirimidin származék elõállítására |
| EP2945936A1 (en) | 2012-11-12 | 2015-11-25 | Lupin Limited | Thiazole derivatives as alpha 7 nachr modulators |
| EP2945941B1 (en) | 2013-01-16 | 2016-12-07 | Lupin Limited | Pyrrole derivatives as alpha 7 nachr modulators |
| JP2016512225A (ja) * | 2013-03-13 | 2016-04-25 | ルピン・リミテッドLupin Limited | アルファー7nachrモジュレータとしてのピロール誘導体 |
| TW201446243A (zh) * | 2013-06-03 | 2014-12-16 | Lupin Ltd | 4-(5-(4-氯苯基)-2-(2-環丙基乙醯基)-1,4-二甲基-1氫-吡咯-3-基)苯磺醯胺作為α7尼古丁乙醯膽鹼受體調節劑 |
| AU2014282886A1 (en) * | 2013-06-17 | 2015-12-17 | Lupin Limited | Pyrrole derivatives as alpha 7 nAChR modulators |
| WO2016100184A1 (en) | 2014-12-16 | 2016-06-23 | Forum Pharmaceuticals, Inc. | Geminal substituted quinuclidine amide compounds as agonists of alpha-7 nicotinic acetylcholine receptors |
| JP2018516973A (ja) | 2015-06-10 | 2018-06-28 | フォーラム・ファーマシューティカルズ・インコーポレイテッドForum Pharmaceuticals Inc. | α7−ニコチン性アセチルコリン受容体のアゴニストとしてのアミノベンゾイソオキサゾール化合物 |
| EP3334740A4 (en) | 2015-08-12 | 2019-02-06 | Axovant Sciences GmbH | GEMINAL SUBSTITUTED AMINOBENZISOXAZOLE COMPOUNDS AS AGONISTS OF ALPHA 7-NICOTINIC ACETYLCHOLINE RECEPTORS |
| LT3433234T (lt) | 2016-03-22 | 2021-12-10 | Merck Sharp & Dohme Corp. | Nikotino acetilcholino receptorių alosteriniai moduliatoriai |
| CN112533581B (zh) * | 2018-06-07 | 2024-08-30 | 密歇根大学董事会 | Prc1抑制剂及用其进行治疗的方法 |
| CA3105411A1 (en) | 2018-07-05 | 2020-01-09 | Bayer Aktiengesellschaft | Substituted thiophenecarboxamides and analogues as antibacterials agents |
| ES2989675T3 (es) | 2019-07-03 | 2024-11-27 | Bayer Ag | Carboxamidas de tiofeno sustituidas y derivados de estas como microbicidas |
| EP4285723A3 (en) | 2019-12-20 | 2024-03-27 | Bayer Aktiengesellschaft | Substituted thiophene carboxamides, thiophene carboxylic acids and derivatives thereof |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3953596A (en) | 1973-06-14 | 1976-04-27 | Ici United States Inc. | 8-Oxa-3-azabicyclo(3.2.1)octane analgesic compositions and method of alleviating pain in animals |
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US5019369A (en) | 1984-10-22 | 1991-05-28 | Vestar, Inc. | Method of targeting tumors in humans |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5608082A (en) | 1994-07-28 | 1997-03-04 | Agouron Pharmaceuticals, Inc. | Compounds useful as antiproliferative agents and GARFT inhibitors |
| ATE273279T1 (de) | 1997-09-12 | 2004-08-15 | Merck Frosst Canada Inc | 2,3,5-trisubstituierte pyridine als inhibitoren von cyclooxygenase-2 |
| JP2004506734A (ja) * | 2000-08-21 | 2004-03-04 | ファルマシア・アンド・アップジョン・カンパニー | 疾患治療用のキヌクリド置換ヘテロアリール部分 |
| CA2473591C (en) | 2002-02-01 | 2011-11-01 | Dainippon Pharmaceutical Co., Ltd. | 2-furancarboxylic acid hydrazides and pharmaceutical compositions containing the same |
| FR2840303B1 (fr) | 2002-05-31 | 2005-07-15 | Rhodia Chimie Sa | Procede d'arylation ou de vinylation ou d'alcylynation d'un compose nucleophile |
| SE0201938D0 (sv) | 2002-06-20 | 2002-06-20 | Astrazeneca Ab | New process |
| DE10244810A1 (de) | 2002-09-26 | 2004-04-08 | Bayer Ag | Neue Morpholin-überbrückte Indazolderivate |
| US7129235B2 (en) | 2003-07-11 | 2006-10-31 | Abbott Laboratories | Amides useful for treating pain |
| US7442805B2 (en) | 2003-09-25 | 2008-10-28 | Wyeth | Substituted sulfonamide-indoles |
| GB0403038D0 (en) | 2004-02-11 | 2004-03-17 | Novartis Ag | Organic compounds |
| CA2561639A1 (en) | 2004-03-29 | 2005-10-06 | Neurosearch A/S | Novel urea derivatives and their medical use |
| ITTO20040264A1 (it) | 2004-04-28 | 2004-07-28 | Rotta Res Lab Spa | Nuovi derivati pirrolici ad attivita' angiotensina-ii antagonista |
| CN101676270A (zh) | 2004-09-09 | 2010-03-24 | 中外制药株式会社 | 新型四氢咪唑衍生物及其用途 |
| US20060142349A1 (en) | 2004-12-23 | 2006-06-29 | Pfizer Inc | Methods of modulating the activities of alpha-7 nicotinic acetylcholine receptor |
| EP1866314B1 (en) | 2005-02-16 | 2010-09-15 | NeuroSearch A/S | Novel diazabicyclic aryl derivatives and their medical use |
| FR2885616B1 (fr) | 2005-05-12 | 2007-06-22 | Servier Lab | Nouveaux derives de phenylpyridinylpiperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| EP1910328A1 (en) * | 2005-06-29 | 2008-04-16 | AstraZeneca AB | Thiophene-2-carboxamide derivatives as alpha 7 nicotinic receptor modulators |
| CA2617788A1 (en) | 2005-08-04 | 2007-02-15 | Apogee Biotechnology Corporation | Sphingosine kinase inhibitors and methods of their use |
| JP5341516B2 (ja) | 2005-09-13 | 2013-11-13 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 2−アニリン−4−アリール置換チアゾール誘導体 |
| CN101374834B (zh) | 2006-02-03 | 2011-12-14 | 伊莱利利公司 | 用于调节fxr的化合物和方法 |
| US20100227869A1 (en) | 2006-02-16 | 2010-09-09 | Dan Peters | Enantiopure quinuclidinyloxy pyridazines and their use as nicotinic acetylcholine receptor ligands |
| JO3019B1 (ar) | 2006-04-19 | 2016-09-05 | Janssen Pharmaceutica Nv | ثلاثي مستبدل 4،2،1-ثلاثي زولات |
| TW200813000A (en) | 2006-06-27 | 2008-03-16 | Abbott Lab | Thiazoline and oxazoline derivatives and their methods of use |
| CN101479241A (zh) * | 2006-06-27 | 2009-07-08 | 艾博特公司 | 吡咯衍生物及其使用方法 |
| JP2010509216A (ja) | 2006-11-02 | 2010-03-25 | メルク エンド カムパニー インコーポレーテッド | ヘテロシクリル置換抗高コレステロール血症化合物 |
| US20080287479A1 (en) | 2006-12-20 | 2008-11-20 | Pfizer Inc | Inhibitors of serine palmitoyltransferase |
| CA2695812A1 (en) | 2007-08-08 | 2009-02-12 | Neurosearch A/S | Novel 1,2,3-triazole derivatives useful as modulators of nicotinic acetylcholine receptors |
| GB0718735D0 (en) | 2007-09-25 | 2007-11-07 | Prolysis Ltd | Antibacterial agents |
| WO2009043784A1 (en) | 2007-10-04 | 2009-04-09 | F. Hoffmann-La Roche Ag | Cyclopropyl aryl amide derivatives and uses thereof |
| EP2205573B1 (en) | 2007-10-04 | 2013-10-23 | F. Hoffmann-La Roche AG | Tetrazole-substituted aryl amide derivatives and uses thereof |
| JO2784B1 (en) | 2007-10-18 | 2014-03-15 | شركة جانسين فارماسوتيكا ان. في | 5,3,1 - Triazole substitute derivative |
| NZ587669A (en) | 2008-03-19 | 2011-07-29 | Janssen Pharmaceutica Nv | Trisubstituted 1, 2, 4 -triazoles as nicotinic acetylcholine receptor modulators |
| US7786171B2 (en) | 2008-04-04 | 2010-08-31 | Abbott Laboratories | Amide derivatives as positive allosteric modulators and methods of use thereof |
| AU2009237650B2 (en) | 2008-04-17 | 2012-05-31 | Proximagen Limited | Indoles as modulators of nicoticic acetylcholine receptor subtype alpha-7 |
| EP2280945B1 (en) | 2008-05-09 | 2014-09-03 | Janssen Pharmaceutica, N.V. | Trisubstituted pyrazoles as acetylcholine receptor modulators |
| EP2387575B1 (en) | 2009-01-15 | 2013-09-04 | Anvyl, LLC | Alpha7 nicotinic acetylcholine receptor allosteric modulators, their derivatives and uses thereof |
| WO2010120854A1 (en) | 2009-04-15 | 2010-10-21 | Glaxosmithkline Llc | Chemical compounds |
| WO2010130768A1 (en) | 2009-05-14 | 2010-11-18 | Neurosearch A/S | Novel 1,4-diaza-bicyclo[3.2.1]octane derivatives useful as nicotinic acetylcholine receptor modulators |
| JO3250B1 (ar) | 2009-09-22 | 2018-09-16 | Novartis Ag | إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7 |
| JO3078B1 (ar) | 2009-11-27 | 2017-03-15 | Janssen Pharmaceutica Nv | مورفولينوثيازولات بصفتها منظمات الوستيرية نوع الفا 7 موجبة |
| US20130310419A1 (en) | 2011-02-03 | 2013-11-21 | Lupin Limited | Pyrrole derivatives used as modulators of alpha7 nachr |
| MA34957B1 (fr) | 2011-02-23 | 2014-03-01 | Lupin Ltd | Derives heteroaryle a titre modulateurs des nachr alpha 7 |
| EP2691368A1 (en) | 2011-03-31 | 2014-02-05 | Lupin Limited | Pyrrole derivatives as nicotinic acetylcholine receptor modulators for use in the treatment of neurodegenerative disorders such as alzheimer's and parkinson's disease |
| US8946432B2 (en) | 2011-07-05 | 2015-02-03 | Lupin Limited | Biaryl derivatives as nAChR modulators |
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