CN103384676B - 酮内酯化合物 - Google Patents

酮内酯化合物 Download PDF

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Publication number
CN103384676B
CN103384676B CN201180066627.1A CN201180066627A CN103384676B CN 103384676 B CN103384676 B CN 103384676B CN 201180066627 A CN201180066627 A CN 201180066627A CN 103384676 B CN103384676 B CN 103384676B
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China
Prior art keywords
compound
formula
pyridine
thiadiazol
give
Prior art date
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CN201180066627.1A
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English (en)
Chinese (zh)
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CN103384676A (zh
Inventor
B·特瑞范迪
P·德斯潘德
R·塔迪帕蒂
S·古普塔
S·迪瓦卡
S·帕瓦
V·帕蒂尔
D·德克哈内
M·帕特尔
S·巴夫萨
A·米希拉
M·索兰基
M·贾弗瑞
S·布哈格瓦特
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Wockhardt Ltd
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Wockhardt Ltd
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Publication of CN103384676A publication Critical patent/CN103384676A/zh
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Publication of CN103384676B publication Critical patent/CN103384676B/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201180066627.1A 2010-12-09 2011-02-03 酮内酯化合物 Active CN103384676B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN3352/MUM/2010 2010-12-09
IN3352MU2010 2010-12-09
PCT/IB2011/050464 WO2012076989A1 (en) 2010-12-09 2011-02-03 Ketolide compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201610004950.0A Division CN105669803A (zh) 2010-12-09 2011-02-03 酮内酯化合物

Publications (2)

Publication Number Publication Date
CN103384676A CN103384676A (zh) 2013-11-06
CN103384676B true CN103384676B (zh) 2016-02-03

Family

ID=54259620

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201180066627.1A Active CN103384676B (zh) 2010-12-09 2011-02-03 酮内酯化合物
CN201610004950.0A Pending CN105669803A (zh) 2010-12-09 2011-02-03 酮内酯化合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201610004950.0A Pending CN105669803A (zh) 2010-12-09 2011-02-03 酮内酯化合物

Country Status (18)

Country Link
US (2) US9175031B2 (cg-RX-API-DMAC10.html)
EP (2) EP3216798A3 (cg-RX-API-DMAC10.html)
JP (2) JP5851516B2 (cg-RX-API-DMAC10.html)
KR (1) KR101657751B1 (cg-RX-API-DMAC10.html)
CN (2) CN103384676B (cg-RX-API-DMAC10.html)
AU (1) AU2011340204B2 (cg-RX-API-DMAC10.html)
BR (1) BR112013014392B1 (cg-RX-API-DMAC10.html)
CA (2) CA2820451C (cg-RX-API-DMAC10.html)
DK (1) DK2673285T3 (cg-RX-API-DMAC10.html)
ES (1) ES2642287T3 (cg-RX-API-DMAC10.html)
HU (1) HUE036658T2 (cg-RX-API-DMAC10.html)
MX (1) MX348084B (cg-RX-API-DMAC10.html)
NZ (1) NZ623574A (cg-RX-API-DMAC10.html)
PL (1) PL2673285T3 (cg-RX-API-DMAC10.html)
PT (1) PT2673285T (cg-RX-API-DMAC10.html)
RU (1) RU2601550C2 (cg-RX-API-DMAC10.html)
WO (1) WO2012076989A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA201304150B (cg-RX-API-DMAC10.html)

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NZ587490A (en) * 2010-08-20 2013-03-28 Greentide Ltd Anti-Microbial Compounds containing compounds with a sugar substituent
EP2688900B1 (en) * 2011-03-22 2016-09-28 Wockhardt Limited Process for preparation of ketolide compounds
US9346828B2 (en) 2013-06-07 2016-05-24 Wisconsin Alumni Research Foundation Forazolines, compositions thereof and uses thereof
NZ739211A (en) * 2015-07-27 2019-05-31 Chong Kun Dang Pharmaceutical Corp 1,3,4-oxadiazole amide derivative compound as histone deacetylase 6 inhibitor, and pharmaceutical composition containing same
BR112017027798B1 (pt) 2015-07-27 2023-12-19 Chong Kun Dang Pharmaceutical Corp Compostos de derivado de 1,3,4-oxadiazol sulfamida como inibidor de histona desacetilase 6 e a composição farmacêutica que compreende os mesmos
HRP20230052T1 (hr) 2015-07-27 2023-03-03 Chong Kun Dang Pharmaceutical Corp. Spojevi derivata 1,3,4-oksadiazol sulfonamida kao inhibitori histonske deacetilaze 6, i farmaceutski pripravak koji ih sadrži
HRP20220003T1 (hr) 2015-08-04 2022-04-01 Chong Kun Dang Pharmaceutical Corp. Spojevi derivata 1,3,4-oksadiazola kao inhibitori histonske deacetilaze 6, i farmaceutski pripravak koji ih sadrži
FI3362445T3 (fi) 2015-10-12 2023-03-21 Chong Kun Dang Pharmaceutical Corp Oksadiatsoliamiinijohdannaisyhdisteitä histonideasetylaasi 6:n inhibiittoreina ja niitä käsittävä farmaseuttinen koostumus
KR20180101509A (ko) * 2016-01-12 2018-09-12 욱크하르트 리미티드 약학 조성물
AU2017206671A1 (en) * 2016-01-12 2018-08-23 Wockhardt Limited Pharmaceutical compositions for the treatment of bacterial infections
WO2017122127A1 (en) * 2016-01-12 2017-07-20 Wockhardt Limited Pharmaceutical compositions
KR20190129863A (ko) * 2017-03-16 2019-11-20 욱크하르트 리미티드 케톨라이드 화합물의 제조 방법
KR102316234B1 (ko) 2018-07-26 2021-10-22 주식회사 종근당 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이를 포함하는 약제학적 조성물
CN113874369B (zh) 2019-05-31 2024-08-27 株式会社钟根堂 作为组蛋白脱乙酰酶6抑制剂的1,3,4-噁二唑高邻苯二甲酰亚胺衍生化合物及包含其的药物组合物
US20230029266A1 (en) 2019-11-05 2023-01-26 Dermira, Inc. MrgprX2 Antagonists for the Treatment of Inflammatory Disorders
AU2020380926B2 (en) * 2019-11-05 2026-07-16 Dermira, Inc. MrgprX2 antagonists and uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1235162A (zh) * 1998-04-08 1999-11-17 赫斯特·马里恩·鲁索公司 新的红霉素的衍生物
CN101541331A (zh) * 2006-08-24 2009-09-23 沃克哈特研究中心 具有抗微生物活性的新颖大环内酯和酮内酯
CN101855219A (zh) * 2007-09-17 2010-10-06 英安塔制药有限公司 6，11-桥联的联芳大环内酯类
WO2010136971A1 (en) * 2009-05-27 2010-12-02 Wockhardt Research Centre Ketolide compounds having antimicrobial activity

Family Cites Families (16)

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FR2473525A1 (fr) 1980-01-11 1981-07-17 Roussel Uclaf Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments
US4331803A (en) 1980-06-04 1982-05-25 Taisho Pharmaceutical Co., Ltd. Novel erythromycin compounds
YU43006B (en) 1981-03-06 1989-02-28 Pliva Pharm & Chem Works Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof
FR2719587B1 (fr) 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
DE69733439T2 (de) 1996-09-04 2006-05-04 Abbott Laboratories, Abbott Park 6-o-Substituierte Ketoliden mit antibakteriellen Wirkung
JP2004514643A (ja) * 1997-10-29 2004-05-20 大正製薬株式会社 エリスロマイシンａ誘導体
HRP980189B1 (en) * 1998-04-06 2004-04-30 Pliva Pharm & Chem Works Novel 15-membered lactams ketolides
MXPA03001607A (es) 2000-08-22 2003-06-04 Basilea Pharmaceutica Ag Nuevos macrolidos con actividad antibacteriana.
GB0031312D0 (en) 2000-12-21 2001-02-07 Glaxo Group Ltd Macrolides
JP2004531471A (ja) * 2000-12-21 2004-10-14 グラクソ　グループ　リミテッド マクロライド抗生物質
GB0127349D0 (en) 2001-11-14 2002-01-02 Glaxo Group Ltd Macrolides
US6995143B2 (en) * 2002-02-28 2006-02-07 Basilea Pharmaceutica Ag Macrolides with antibacterial activity
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WO2004108744A2 (en) * 2003-05-19 2004-12-16 Prasad K Deshpande Azalides and azaketolides having antimicrobial activity
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Patent Citations (4)

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CN1235162A (zh) * 1998-04-08 1999-11-17 赫斯特·马里恩·鲁索公司 新的红霉素的衍生物
CN101541331A (zh) * 2006-08-24 2009-09-23 沃克哈特研究中心 具有抗微生物活性的新颖大环内酯和酮内酯
CN101855219A (zh) * 2007-09-17 2010-10-06 英安塔制药有限公司 6，11-桥联的联芳大环内酯类
WO2010136971A1 (en) * 2009-05-27 2010-12-02 Wockhardt Research Centre Ketolide compounds having antimicrobial activity

Non-Patent Citations (1)

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Title
新一代大环内酯类抗生素——酮内酯类简介;顾觉奋,等;《抗感染药学》;20060625;第3卷(第2期);第50页右栏-第51页左栏 *

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Publication number Publication date
EP3216798A3 (en) 2017-10-25
JP5851516B2 (ja) 2016-02-03
PT2673285T (pt) 2017-10-19
MX348084B (es) 2017-05-26
CA2820451C (en) 2017-12-12
EP3216798A2 (en) 2017-09-13
KR20130112911A (ko) 2013-10-14
BR112013014392A2 (pt) 2016-07-19
RU2601550C2 (ru) 2016-11-10
EP2673285A1 (en) 2013-12-18
MX2013006461A (es) 2013-10-01
JP2015172085A (ja) 2015-10-01
JP2013544877A (ja) 2013-12-19
ES2642287T3 (es) 2017-11-16
AU2011340204B2 (en) 2016-04-14
US20140005133A1 (en) 2014-01-02
HUE036658T2 (hu) 2018-07-30
NZ623574A (en) 2015-07-31
PL2673285T3 (pl) 2017-12-29
US9175031B2 (en) 2015-11-03
CN105669803A (zh) 2016-06-15
CN103384676A (zh) 2013-11-06
ZA201304150B (en) 2014-11-26
RU2013131234A (ru) 2015-01-20
DK2673285T3 (en) 2017-10-16
WO2012076989A1 (en) 2012-06-14
JP6102991B2 (ja) 2017-03-29
CA2820451A1 (en) 2012-06-14
US20160083412A1 (en) 2016-03-24
EP2673285B1 (en) 2017-07-19
BR112013014392B1 (pt) 2021-09-21
AU2011340204A1 (en) 2013-07-04
CA2964104A1 (en) 2012-06-14
KR101657751B1 (ko) 2016-09-19

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