KR101657751B1 - 케토라이드 화합물 - Google Patents

케토라이드 화합물 Download PDF

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Publication number
KR101657751B1
KR101657751B1 KR1020137016527A KR20137016527A KR101657751B1 KR 101657751 B1 KR101657751 B1 KR 101657751B1 KR 1020137016527 A KR1020137016527 A KR 1020137016527A KR 20137016527 A KR20137016527 A KR 20137016527A KR 101657751 B1 KR101657751 B1 KR 101657751B1
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KR
South Korea
Prior art keywords
formula
compound
thiadiazol
pyridin
compounds
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Expired - Fee Related
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KR1020137016527A
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English (en)
Korean (ko)
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KR20130112911A (ko
Inventor
브하라트 트리베디
프라사드 데쉬판더
라비쿠마르 타디파르티
수닐 굽타
산토쉬 디와카르
쉬바이 파와르
비야이 파틸
디파크 데크하네
마헤쉬 파텔
사티쉬 브하브사르
아미트 미쉬라
마니쉬 솔란키
모하마드 야프리
사친 브하그와트
Original Assignee
욱크하르트 리미티드
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Publication of KR20130112911A publication Critical patent/KR20130112911A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020137016527A 2010-12-09 2011-02-03 케토라이드 화합물 Expired - Fee Related KR101657751B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN3352/MUM/2010 2010-12-09
IN3352MU2010 2010-12-09
PCT/IB2011/050464 WO2012076989A1 (en) 2010-12-09 2011-02-03 Ketolide compounds

Publications (2)

Publication Number Publication Date
KR20130112911A KR20130112911A (ko) 2013-10-14
KR101657751B1 true KR101657751B1 (ko) 2016-09-19

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020137016527A Expired - Fee Related KR101657751B1 (ko) 2010-12-09 2011-02-03 케토라이드 화합물

Country Status (18)

Country Link
US (2) US9175031B2 (cg-RX-API-DMAC10.html)
EP (2) EP3216798A3 (cg-RX-API-DMAC10.html)
JP (2) JP5851516B2 (cg-RX-API-DMAC10.html)
KR (1) KR101657751B1 (cg-RX-API-DMAC10.html)
CN (2) CN103384676B (cg-RX-API-DMAC10.html)
AU (1) AU2011340204B2 (cg-RX-API-DMAC10.html)
BR (1) BR112013014392B1 (cg-RX-API-DMAC10.html)
CA (2) CA2820451C (cg-RX-API-DMAC10.html)
DK (1) DK2673285T3 (cg-RX-API-DMAC10.html)
ES (1) ES2642287T3 (cg-RX-API-DMAC10.html)
HU (1) HUE036658T2 (cg-RX-API-DMAC10.html)
MX (1) MX348084B (cg-RX-API-DMAC10.html)
NZ (1) NZ623574A (cg-RX-API-DMAC10.html)
PL (1) PL2673285T3 (cg-RX-API-DMAC10.html)
PT (1) PT2673285T (cg-RX-API-DMAC10.html)
RU (1) RU2601550C2 (cg-RX-API-DMAC10.html)
WO (1) WO2012076989A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA201304150B (cg-RX-API-DMAC10.html)

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NZ587490A (en) * 2010-08-20 2013-03-28 Greentide Ltd Anti-Microbial Compounds containing compounds with a sugar substituent
EP2688900B1 (en) * 2011-03-22 2016-09-28 Wockhardt Limited Process for preparation of ketolide compounds
US9346828B2 (en) 2013-06-07 2016-05-24 Wisconsin Alumni Research Foundation Forazolines, compositions thereof and uses thereof
NZ739211A (en) * 2015-07-27 2019-05-31 Chong Kun Dang Pharmaceutical Corp 1,3,4-oxadiazole amide derivative compound as histone deacetylase 6 inhibitor, and pharmaceutical composition containing same
BR112017027798B1 (pt) 2015-07-27 2023-12-19 Chong Kun Dang Pharmaceutical Corp Compostos de derivado de 1,3,4-oxadiazol sulfamida como inibidor de histona desacetilase 6 e a composição farmacêutica que compreende os mesmos
HRP20230052T1 (hr) 2015-07-27 2023-03-03 Chong Kun Dang Pharmaceutical Corp. Spojevi derivata 1,3,4-oksadiazol sulfonamida kao inhibitori histonske deacetilaze 6, i farmaceutski pripravak koji ih sadrži
HRP20220003T1 (hr) 2015-08-04 2022-04-01 Chong Kun Dang Pharmaceutical Corp. Spojevi derivata 1,3,4-oksadiazola kao inhibitori histonske deacetilaze 6, i farmaceutski pripravak koji ih sadrži
FI3362445T3 (fi) 2015-10-12 2023-03-21 Chong Kun Dang Pharmaceutical Corp Oksadiatsoliamiinijohdannaisyhdisteitä histonideasetylaasi 6:n inhibiittoreina ja niitä käsittävä farmaseuttinen koostumus
KR20180101509A (ko) * 2016-01-12 2018-09-12 욱크하르트 리미티드 약학 조성물
AU2017206671A1 (en) * 2016-01-12 2018-08-23 Wockhardt Limited Pharmaceutical compositions for the treatment of bacterial infections
WO2017122127A1 (en) * 2016-01-12 2017-07-20 Wockhardt Limited Pharmaceutical compositions
KR20190129863A (ko) * 2017-03-16 2019-11-20 욱크하르트 리미티드 케톨라이드 화합물의 제조 방법
KR102316234B1 (ko) 2018-07-26 2021-10-22 주식회사 종근당 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이를 포함하는 약제학적 조성물
CN113874369B (zh) 2019-05-31 2024-08-27 株式会社钟根堂 作为组蛋白脱乙酰酶6抑制剂的1,3,4-噁二唑高邻苯二甲酰亚胺衍生化合物及包含其的药物组合物
US20230029266A1 (en) 2019-11-05 2023-01-26 Dermira, Inc. MrgprX2 Antagonists for the Treatment of Inflammatory Disorders
AU2020380926B2 (en) * 2019-11-05 2026-07-16 Dermira, Inc. MrgprX2 antagonists and uses thereof

Citations (3)

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Publication number Priority date Publication date Assignee Title
JP2004531471A (ja) 2000-12-21 2004-10-14 グラクソ グループ リミテッド マクロライド抗生物質
WO2008023248A2 (en) 2006-08-24 2008-02-28 Wockhardt Research Centre Novel macrolides and ketolides having antimicrobial activity
WO2009137787A1 (en) 2008-05-09 2009-11-12 Enanta Pharmaceuticals, Inc. Processes for the preparation of 2-fluoro 6-11 bicyclic erythromycin derivatives

Family Cites Families (17)

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FR2473525A1 (fr) 1980-01-11 1981-07-17 Roussel Uclaf Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments
US4331803A (en) 1980-06-04 1982-05-25 Taisho Pharmaceutical Co., Ltd. Novel erythromycin compounds
YU43006B (en) 1981-03-06 1989-02-28 Pliva Pharm & Chem Works Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof
FR2719587B1 (fr) 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
DE69733439T2 (de) 1996-09-04 2006-05-04 Abbott Laboratories, Abbott Park 6-o-Substituierte Ketoliden mit antibakteriellen Wirkung
JP2004514643A (ja) * 1997-10-29 2004-05-20 大正製薬株式会社 エリスロマイシンa誘導体
HRP980189B1 (en) * 1998-04-06 2004-04-30 Pliva Pharm & Chem Works Novel 15-membered lactams ketolides
FR2777282B1 (fr) 1998-04-08 2001-04-20 Hoechst Marion Roussel Inc Nouveaux derives de la 2-fluoro 3-de((2,6-dideoxy 3-c-methyl 3-0-methyl-alpha-l-ribohexopyranosyl) oxyl) 6-o-methyl 3-oxo erythromycine, leur procede de preparation et leur application a la synthese de principes actifs de medicaments
MXPA03001607A (es) 2000-08-22 2003-06-04 Basilea Pharmaceutica Ag Nuevos macrolidos con actividad antibacteriana.
GB0031312D0 (en) 2000-12-21 2001-02-07 Glaxo Group Ltd Macrolides
GB0127349D0 (en) 2001-11-14 2002-01-02 Glaxo Group Ltd Macrolides
US6995143B2 (en) * 2002-02-28 2006-02-07 Basilea Pharmaceutica Ag Macrolides with antibacterial activity
US6727229B2 (en) 2002-08-19 2004-04-27 Enanta Pharmaceuticals, Inc. 11,12-substituted lactone ketolide derivatives having antibacterial activity
WO2004108744A2 (en) * 2003-05-19 2004-12-16 Prasad K Deshpande Azalides and azaketolides having antimicrobial activity
WO2006080954A1 (en) * 2004-07-28 2006-08-03 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
MX2010002932A (es) * 2007-09-17 2010-05-27 Enanta Pharm Inc Macrolidos de biarilo con puente en 6, 11.
EP2435460B1 (en) * 2009-05-27 2015-01-07 Wockhardt Limited Ketolide compounds having antimicrobial activity

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Publication number Priority date Publication date Assignee Title
JP2004531471A (ja) 2000-12-21 2004-10-14 グラクソ グループ リミテッド マクロライド抗生物質
WO2008023248A2 (en) 2006-08-24 2008-02-28 Wockhardt Research Centre Novel macrolides and ketolides having antimicrobial activity
WO2009137787A1 (en) 2008-05-09 2009-11-12 Enanta Pharmaceuticals, Inc. Processes for the preparation of 2-fluoro 6-11 bicyclic erythromycin derivatives

Also Published As

Publication number Publication date
EP3216798A3 (en) 2017-10-25
JP5851516B2 (ja) 2016-02-03
PT2673285T (pt) 2017-10-19
MX348084B (es) 2017-05-26
CA2820451C (en) 2017-12-12
EP3216798A2 (en) 2017-09-13
CN103384676B (zh) 2016-02-03
KR20130112911A (ko) 2013-10-14
BR112013014392A2 (pt) 2016-07-19
RU2601550C2 (ru) 2016-11-10
EP2673285A1 (en) 2013-12-18
MX2013006461A (es) 2013-10-01
JP2015172085A (ja) 2015-10-01
JP2013544877A (ja) 2013-12-19
ES2642287T3 (es) 2017-11-16
AU2011340204B2 (en) 2016-04-14
US20140005133A1 (en) 2014-01-02
HUE036658T2 (hu) 2018-07-30
NZ623574A (en) 2015-07-31
PL2673285T3 (pl) 2017-12-29
US9175031B2 (en) 2015-11-03
CN105669803A (zh) 2016-06-15
CN103384676A (zh) 2013-11-06
ZA201304150B (en) 2014-11-26
RU2013131234A (ru) 2015-01-20
DK2673285T3 (en) 2017-10-16
WO2012076989A1 (en) 2012-06-14
JP6102991B2 (ja) 2017-03-29
CA2820451A1 (en) 2012-06-14
US20160083412A1 (en) 2016-03-24
EP2673285B1 (en) 2017-07-19
BR112013014392B1 (pt) 2021-09-21
AU2011340204A1 (en) 2013-07-04
CA2964104A1 (en) 2012-06-14

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