CN103347878B - 丙型肝炎病毒抑制剂 - Google Patents

丙型肝炎病毒抑制剂 Download PDF

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Publication number
CN103347878B
CN103347878B CN201280008010.9A CN201280008010A CN103347878B CN 103347878 B CN103347878 B CN 103347878B CN 201280008010 A CN201280008010 A CN 201280008010A CN 103347878 B CN103347878 B CN 103347878B
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China
Prior art keywords
hcv
compound
mmol
interferon
acceptable salt
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Expired - Fee Related
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CN201280008010.9A
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English (en)
Chinese (zh)
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CN103347878A (zh
Inventor
J.A.本德
O.D.洛佩兹
G.王
M.贝乐玛
J.F.卡多
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D309/06—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
CN201280008010.9A 2011-02-07 2012-02-02 丙型肝炎病毒抑制剂 Expired - Fee Related CN103347878B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161440086P 2011-02-07 2011-02-07
US61/440,086 2011-02-07
US201161467602P 2011-03-25 2011-03-25
US61/467,602 2011-03-25
PCT/US2012/023595 WO2012109080A1 (en) 2011-02-07 2012-02-02 Hepatitis c virus inhibitors

Publications (2)

Publication Number Publication Date
CN103347878A CN103347878A (zh) 2013-10-09
CN103347878B true CN103347878B (zh) 2015-05-06

Family

ID=45688244

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280008010.9A Expired - Fee Related CN103347878B (zh) 2011-02-07 2012-02-02 丙型肝炎病毒抑制剂

Country Status (23)

Country Link
US (2) US8552047B2 (https=)
EP (1) EP2673271B1 (https=)
JP (1) JP5815746B2 (https=)
KR (1) KR20140048848A (https=)
CN (1) CN103347878B (https=)
AR (1) AR085327A1 (https=)
AU (1) AU2012214767B2 (https=)
BR (1) BR112013020042A2 (https=)
CA (1) CA2826774A1 (https=)
CL (1) CL2013002241A1 (https=)
CO (1) CO6761335A2 (https=)
EA (1) EA021538B1 (https=)
ES (1) ES2540052T3 (https=)
IL (1) IL227789A0 (https=)
MA (1) MA34896B1 (https=)
MX (1) MX2013008419A (https=)
PE (1) PE20140302A1 (https=)
PH (1) PH12013501543A1 (https=)
SG (1) SG192267A1 (https=)
TW (1) TWI542585B (https=)
UY (1) UY33897A (https=)
WO (1) WO2012109080A1 (https=)
ZA (1) ZA201306720B (https=)

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CN109456375B (zh) * 2018-12-11 2019-10-22 枣庄学院 一种抑制丙肝病毒的含单糖基杂环类化合物及制备方法
US11857827B2 (en) 2021-11-19 2024-01-02 Nautilus, Inc. Plate-sensing base for a connected adjustable free weight system
CN117105928B (zh) * 2023-08-22 2024-03-26 上海蓝木化工有限公司 一种蛋白酶抑制剂及其制备方法

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