CN103339125A - 作为crth2拮抗剂的吡唑化合物 - Google Patents
作为crth2拮抗剂的吡唑化合物 Download PDFInfo
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- CN103339125A CN103339125A CN2012800063033A CN201280006303A CN103339125A CN 103339125 A CN103339125 A CN 103339125A CN 2012800063033 A CN2012800063033 A CN 2012800063033A CN 201280006303 A CN201280006303 A CN 201280006303A CN 103339125 A CN103339125 A CN 103339125A
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- Prior art keywords
- alkyl
- formula
- pyrazole compound
- compound
- cycloalkyl
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Classifications
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Abstract
Description
Claims (23)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
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CN201510362688.2A CN104961732B (zh) | 2011-01-24 | 2012-01-20 | 作为crth2拮抗剂的吡唑化合物 |
CN201410837969.4A CN104628705B (zh) | 2011-01-24 | 2012-01-20 | 作为crth2拮抗剂的吡唑化合物 |
CN201710440429.6A CN107011332B (zh) | 2011-01-24 | 2012-01-20 | 作为crth2拮抗剂的吡唑化合物 |
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EP11151876.7 | 2011-01-24 | ||
EP11151876 | 2011-01-24 | ||
PCT/EP2012/050830 WO2012101043A1 (en) | 2011-01-24 | 2012-01-20 | Pyrazole compounds as crth2 antagonists |
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CN201510362688.2A Division CN104961732B (zh) | 2011-01-24 | 2012-01-20 | 作为crth2拮抗剂的吡唑化合物 |
CN201710440429.6A Division CN107011332B (zh) | 2011-01-24 | 2012-01-20 | 作为crth2拮抗剂的吡唑化合物 |
CN201410837969.4A Division CN104628705B (zh) | 2011-01-24 | 2012-01-20 | 作为crth2拮抗剂的吡唑化合物 |
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CN103339125A true CN103339125A (zh) | 2013-10-02 |
CN103339125B CN103339125B (zh) | 2015-07-15 |
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CN201410837969.4A Expired - Fee Related CN104628705B (zh) | 2011-01-24 | 2012-01-20 | 作为crth2拮抗剂的吡唑化合物 |
CN201710440429.6A Expired - Fee Related CN107011332B (zh) | 2011-01-24 | 2012-01-20 | 作为crth2拮抗剂的吡唑化合物 |
CN201280006303.3A Expired - Fee Related CN103339125B (zh) | 2011-01-24 | 2012-01-20 | 作为crth2拮抗剂的吡唑化合物 |
CN201510362688.2A Expired - Fee Related CN104961732B (zh) | 2011-01-24 | 2012-01-20 | 作为crth2拮抗剂的吡唑化合物 |
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CN201410837969.4A Expired - Fee Related CN104628705B (zh) | 2011-01-24 | 2012-01-20 | 作为crth2拮抗剂的吡唑化合物 |
CN201710440429.6A Expired - Fee Related CN107011332B (zh) | 2011-01-24 | 2012-01-20 | 作为crth2拮抗剂的吡唑化合物 |
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CN201510362688.2A Expired - Fee Related CN104961732B (zh) | 2011-01-24 | 2012-01-20 | 作为crth2拮抗剂的吡唑化合物 |
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US (1) | US8759386B2 (zh) |
EP (1) | EP2668181B1 (zh) |
JP (1) | JP5695216B2 (zh) |
KR (2) | KR102251939B1 (zh) |
CN (4) | CN104628705B (zh) |
AP (1) | AP3343A (zh) |
AR (1) | AR084916A1 (zh) |
AU (1) | AU2012210718B2 (zh) |
BR (1) | BR112013017570B1 (zh) |
CA (1) | CA2825458C (zh) |
CL (1) | CL2013001945A1 (zh) |
CO (1) | CO6801731A2 (zh) |
CY (1) | CY1116012T1 (zh) |
DK (1) | DK2668181T3 (zh) |
EA (1) | EA022559B1 (zh) |
EC (1) | ECSP13012832A (zh) |
ES (1) | ES2529452T3 (zh) |
GE (1) | GEP20156332B (zh) |
HK (3) | HK1210467A1 (zh) |
HR (1) | HRP20150069T1 (zh) |
IL (1) | IL226920A (zh) |
MA (1) | MA34838B1 (zh) |
MX (1) | MX342830B (zh) |
MY (1) | MY163012A (zh) |
PE (1) | PE20140860A1 (zh) |
PH (1) | PH12018501531A1 (zh) |
PL (1) | PL2668181T3 (zh) |
PT (1) | PT2668181E (zh) |
RS (1) | RS53785B1 (zh) |
SG (1) | SG192096A1 (zh) |
SI (1) | SI2668181T1 (zh) |
TN (1) | TN2013000280A1 (zh) |
TW (1) | TWI527809B (zh) |
UA (1) | UA109696C2 (zh) |
UY (1) | UY33873A (zh) |
WO (1) | WO2012101043A1 (zh) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8759386B2 (en) * | 2011-01-24 | 2014-06-24 | Boehringer Ingelheim International Gmbh | Pyrazole compounds as CRTH2 antagonists |
WO2012130633A1 (en) * | 2011-03-25 | 2012-10-04 | Boehringer Ingelheim International Gmbh | Pyrazole compounds as crth2 antagonists |
US20140148492A1 (en) * | 2012-11-23 | 2014-05-29 | Boehringer Ingelheim International Gmbh | Bicyclosubstituted pyrazole compounds for treating hair loss |
US20140148484A1 (en) * | 2012-11-23 | 2014-05-29 | Boehringer Ingelheim International Gmbh | Pyrazole compounds for treating hairloss |
CN112188888A (zh) * | 2018-03-23 | 2021-01-05 | 帕拉丁科技公司 | 用于胃肠道特异性递送的黑皮质素受体特异性肽配制品和方法 |
AR117472A1 (es) | 2018-12-21 | 2021-08-11 | Celgene Corp | Inhibidores de tienopiridina de ripk2 |
Citations (3)
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CN1413207A (zh) * | 1999-11-10 | 2003-04-23 | 武田药品工业株式会社 | 含氮的五元杂环化合物 |
CN101541790A (zh) * | 2006-11-27 | 2009-09-23 | 辉瑞产品公司 | 吡唑类似物 |
WO2010057118A2 (en) * | 2008-11-17 | 2010-05-20 | Amira Pharmaceuticals, Inc. | Heterocyclic antagonists of prostaglandin d2 receptors |
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US5260322A (en) | 1990-10-08 | 1993-11-09 | Merck & Co., Inc. | Angiotension II antagonists in the treatment of hyperuricemia |
PT1471057E (pt) | 2003-04-25 | 2006-05-31 | Actimis Pharmaceuticals Inc | Derivados de acido pirimidinilacetico uteis para o tratamento de doencas mediadas por crth2 |
US20070060596A1 (en) * | 2003-10-24 | 2007-03-15 | Giblin Gerard M P | Heterocyclyl compounds |
CA2587664A1 (en) * | 2004-12-21 | 2006-06-29 | Devgen N.V. | Compounds with kv4 ion channel activity |
JP4950542B2 (ja) * | 2006-04-07 | 2012-06-13 | 岩手東芝エレクトロニクス株式会社 | 固体撮像装置およびその製造方法 |
DE602007010781D1 (de) | 2006-06-06 | 2011-01-05 | Glaxo Group Ltd | N- (phenylmethyl) -2- (1h-pyrazol-4-yl) acetamid-derivate als p2x7-antagonisten zur behandlung von schmerzen, entzündungen und neurodegeneration |
US8314116B2 (en) * | 2007-09-25 | 2012-11-20 | Actimis Pharmaceuticals, Inc. | 2-S-benzyl substituted pyrimidines as CRTH2 antagonists |
JP5524847B2 (ja) | 2007-09-25 | 2014-06-18 | アクチミス ファーマシューティカルズ インコーポレーテッド | Crth2アンタゴニストとしてのアルキルチオピリミジン |
JP2011088826A (ja) * | 2008-01-31 | 2011-05-06 | Astellas Pharma Inc | 芳香族カルボン酸化合物 |
WO2010003120A2 (en) * | 2008-07-03 | 2010-01-07 | Amira Pharmaceuticals, Inc. | Antagonists of prostaglandin d2 receptors |
GB2463788B (en) * | 2008-09-29 | 2010-12-15 | Amira Pharmaceuticals Inc | Heteroaryl antagonists of prostaglandin D2 receptors |
EP2393492A1 (en) * | 2009-02-09 | 2011-12-14 | Boehringer Ingelheim International GmbH | New pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
ES2545865T3 (es) * | 2010-01-27 | 2015-09-16 | Boehringer Ingelheim International Gmbh | Compuestos de pirazol como antagonistas de CRTH2 |
EP2598145A1 (en) * | 2010-07-28 | 2013-06-05 | Boehringer Ingelheim International GmbH | Pharmaceutical composition for treatment of respiratory and inflammatory diseases |
US8759386B2 (en) * | 2011-01-24 | 2014-06-24 | Boehringer Ingelheim International Gmbh | Pyrazole compounds as CRTH2 antagonists |
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1413207A (zh) * | 1999-11-10 | 2003-04-23 | 武田药品工业株式会社 | 含氮的五元杂环化合物 |
CN101541790A (zh) * | 2006-11-27 | 2009-09-23 | 辉瑞产品公司 | 吡唑类似物 |
WO2010057118A2 (en) * | 2008-11-17 | 2010-05-20 | Amira Pharmaceuticals, Inc. | Heterocyclic antagonists of prostaglandin d2 receptors |
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