CN104961732A - 作为crth2拮抗剂的吡唑化合物 - Google Patents
作为crth2拮抗剂的吡唑化合物 Download PDFInfo
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- CN104961732A CN104961732A CN201510362688.2A CN201510362688A CN104961732A CN 104961732 A CN104961732 A CN 104961732A CN 201510362688 A CN201510362688 A CN 201510362688A CN 104961732 A CN104961732 A CN 104961732A
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Classifications
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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Abstract
Description
Claims (10)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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EP11151876.7 | 2011-01-24 | ||
EP11151876 | 2011-01-24 | ||
CN201280006303.3A CN103339125B (zh) | 2011-01-24 | 2012-01-20 | 作为crth2拮抗剂的吡唑化合物 |
Related Parent Applications (1)
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CN201280006303.3A Division CN103339125B (zh) | 2011-01-24 | 2012-01-20 | 作为crth2拮抗剂的吡唑化合物 |
Publications (2)
Publication Number | Publication Date |
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CN104961732A true CN104961732A (zh) | 2015-10-07 |
CN104961732B CN104961732B (zh) | 2017-07-11 |
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Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
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CN201410837969.4A Expired - Fee Related CN104628705B (zh) | 2011-01-24 | 2012-01-20 | 作为crth2拮抗剂的吡唑化合物 |
CN201710440429.6A Expired - Fee Related CN107011332B (zh) | 2011-01-24 | 2012-01-20 | 作为crth2拮抗剂的吡唑化合物 |
CN201280006303.3A Expired - Fee Related CN103339125B (zh) | 2011-01-24 | 2012-01-20 | 作为crth2拮抗剂的吡唑化合物 |
CN201510362688.2A Expired - Fee Related CN104961732B (zh) | 2011-01-24 | 2012-01-20 | 作为crth2拮抗剂的吡唑化合物 |
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CN201410837969.4A Expired - Fee Related CN104628705B (zh) | 2011-01-24 | 2012-01-20 | 作为crth2拮抗剂的吡唑化合物 |
CN201710440429.6A Expired - Fee Related CN107011332B (zh) | 2011-01-24 | 2012-01-20 | 作为crth2拮抗剂的吡唑化合物 |
CN201280006303.3A Expired - Fee Related CN103339125B (zh) | 2011-01-24 | 2012-01-20 | 作为crth2拮抗剂的吡唑化合物 |
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US (1) | US8759386B2 (zh) |
EP (1) | EP2668181B1 (zh) |
JP (1) | JP5695216B2 (zh) |
KR (2) | KR102251939B1 (zh) |
CN (4) | CN104628705B (zh) |
AP (1) | AP3343A (zh) |
AR (1) | AR084916A1 (zh) |
AU (1) | AU2012210718B2 (zh) |
BR (1) | BR112013017570B1 (zh) |
CA (1) | CA2825458C (zh) |
CL (1) | CL2013001945A1 (zh) |
CO (1) | CO6801731A2 (zh) |
CY (1) | CY1116012T1 (zh) |
DK (1) | DK2668181T3 (zh) |
EA (1) | EA022559B1 (zh) |
EC (1) | ECSP13012832A (zh) |
ES (1) | ES2529452T3 (zh) |
GE (1) | GEP20156332B (zh) |
HK (3) | HK1210467A1 (zh) |
HR (1) | HRP20150069T1 (zh) |
IL (1) | IL226920A (zh) |
MA (1) | MA34838B1 (zh) |
MX (1) | MX342830B (zh) |
MY (1) | MY163012A (zh) |
PE (1) | PE20140860A1 (zh) |
PH (1) | PH12018501531A1 (zh) |
PL (1) | PL2668181T3 (zh) |
PT (1) | PT2668181E (zh) |
RS (1) | RS53785B1 (zh) |
SG (1) | SG192096A1 (zh) |
SI (1) | SI2668181T1 (zh) |
TN (1) | TN2013000280A1 (zh) |
TW (1) | TWI527809B (zh) |
UA (1) | UA109696C2 (zh) |
UY (1) | UY33873A (zh) |
WO (1) | WO2012101043A1 (zh) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8759386B2 (en) * | 2011-01-24 | 2014-06-24 | Boehringer Ingelheim International Gmbh | Pyrazole compounds as CRTH2 antagonists |
WO2012130633A1 (en) * | 2011-03-25 | 2012-10-04 | Boehringer Ingelheim International Gmbh | Pyrazole compounds as crth2 antagonists |
US20140148492A1 (en) * | 2012-11-23 | 2014-05-29 | Boehringer Ingelheim International Gmbh | Bicyclosubstituted pyrazole compounds for treating hair loss |
US20140148484A1 (en) * | 2012-11-23 | 2014-05-29 | Boehringer Ingelheim International Gmbh | Pyrazole compounds for treating hairloss |
CN112188888A (zh) * | 2018-03-23 | 2021-01-05 | 帕拉丁科技公司 | 用于胃肠道特异性递送的黑皮质素受体特异性肽配制品和方法 |
AR117472A1 (es) | 2018-12-21 | 2021-08-11 | Celgene Corp | Inhibidores de tienopiridina de ripk2 |
Citations (4)
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WO2005040128A1 (en) * | 2003-10-24 | 2005-05-06 | Glaxo Group Limited | Heterocyclyl compounds |
CN100541790C (zh) * | 2006-04-07 | 2009-09-16 | 株式会社东芝 | 固体摄像装置及其制造方法 |
WO2010057118A2 (en) * | 2008-11-17 | 2010-05-20 | Amira Pharmaceuticals, Inc. | Heterocyclic antagonists of prostaglandin d2 receptors |
CN102164894A (zh) * | 2008-09-29 | 2011-08-24 | 艾米拉制药公司 | 前列腺素d2受体的杂芳基拮抗剂 |
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US5260322A (en) | 1990-10-08 | 1993-11-09 | Merck & Co., Inc. | Angiotension II antagonists in the treatment of hyperuricemia |
ATE271049T1 (de) * | 1999-11-10 | 2004-07-15 | Takeda Chemical Industries Ltd | Fünfgliedrige n-heterocyclen mit hypoglykämischer und hypolipidemischer wirkung |
PT1471057E (pt) | 2003-04-25 | 2006-05-31 | Actimis Pharmaceuticals Inc | Derivados de acido pirimidinilacetico uteis para o tratamento de doencas mediadas por crth2 |
CA2587664A1 (en) * | 2004-12-21 | 2006-06-29 | Devgen N.V. | Compounds with kv4 ion channel activity |
DE602007010781D1 (de) | 2006-06-06 | 2011-01-05 | Glaxo Group Ltd | N- (phenylmethyl) -2- (1h-pyrazol-4-yl) acetamid-derivate als p2x7-antagonisten zur behandlung von schmerzen, entzündungen und neurodegeneration |
AU2007327004A1 (en) * | 2006-11-27 | 2008-06-05 | Pfizer Products Inc. | Pyrazole analogs |
US8314116B2 (en) * | 2007-09-25 | 2012-11-20 | Actimis Pharmaceuticals, Inc. | 2-S-benzyl substituted pyrimidines as CRTH2 antagonists |
JP5524847B2 (ja) | 2007-09-25 | 2014-06-18 | アクチミス ファーマシューティカルズ インコーポレーテッド | Crth2アンタゴニストとしてのアルキルチオピリミジン |
JP2011088826A (ja) * | 2008-01-31 | 2011-05-06 | Astellas Pharma Inc | 芳香族カルボン酸化合物 |
WO2010003120A2 (en) * | 2008-07-03 | 2010-01-07 | Amira Pharmaceuticals, Inc. | Antagonists of prostaglandin d2 receptors |
EP2393492A1 (en) * | 2009-02-09 | 2011-12-14 | Boehringer Ingelheim International GmbH | New pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
ES2545865T3 (es) * | 2010-01-27 | 2015-09-16 | Boehringer Ingelheim International Gmbh | Compuestos de pirazol como antagonistas de CRTH2 |
EP2598145A1 (en) * | 2010-07-28 | 2013-06-05 | Boehringer Ingelheim International GmbH | Pharmaceutical composition for treatment of respiratory and inflammatory diseases |
US8759386B2 (en) * | 2011-01-24 | 2014-06-24 | Boehringer Ingelheim International Gmbh | Pyrazole compounds as CRTH2 antagonists |
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2012
- 2012-01-19 US US13/353,621 patent/US8759386B2/en active Active
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- 2012-01-20 PE PE2013001586A patent/PE20140860A1/es active IP Right Grant
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2013
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- 2013-07-26 CO CO13177740A patent/CO6801731A2/es active IP Right Grant
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- 2013-12-10 HK HK15111230.0A patent/HK1210467A1/zh not_active IP Right Cessation
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Patent Citations (4)
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WO2005040128A1 (en) * | 2003-10-24 | 2005-05-06 | Glaxo Group Limited | Heterocyclyl compounds |
CN100541790C (zh) * | 2006-04-07 | 2009-09-16 | 株式会社东芝 | 固体摄像装置及其制造方法 |
CN102164894A (zh) * | 2008-09-29 | 2011-08-24 | 艾米拉制药公司 | 前列腺素d2受体的杂芳基拮抗剂 |
WO2010057118A2 (en) * | 2008-11-17 | 2010-05-20 | Amira Pharmaceuticals, Inc. | Heterocyclic antagonists of prostaglandin d2 receptors |
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