HK1210467A1 - 作為 拮抗劑的吡唑化合物 - Google Patents

作為 拮抗劑的吡唑化合物

Info

Publication number
HK1210467A1
HK1210467A1 HK15111230.0A HK15111230A HK1210467A1 HK 1210467 A1 HK1210467 A1 HK 1210467A1 HK 15111230 A HK15111230 A HK 15111230A HK 1210467 A1 HK1210467 A1 HK 1210467A1
Authority
HK
Hong Kong
Prior art keywords
crth2
pyrazole compounds
antagonists
pyrazole
compounds
Prior art date
Application number
HK15111230.0A
Other languages
English (en)
Inventor
‧安德斯克維茲
‧馬蒂雷斯
‧奧斯特
‧里斯特
‧希瑟
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43799503&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1210467(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of HK1210467A1 publication Critical patent/HK1210467A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK15111230.0A 2011-01-24 2013-12-10 作為 拮抗劑的吡唑化合物 HK1210467A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP11151876 2011-01-24

Publications (1)

Publication Number Publication Date
HK1210467A1 true HK1210467A1 (zh) 2016-04-22

Family

ID=43799503

Family Applications (3)

Application Number Title Priority Date Filing Date
HK13113692.9A HK1186183A1 (zh) 2011-01-24 2013-12-10 作為 拮抗劑的吡唑化合物
HK16103130.7A HK1215247A1 (zh) 2011-01-24 2013-12-10 作為 拮抗劑的吡唑化合物
HK15111230.0A HK1210467A1 (zh) 2011-01-24 2013-12-10 作為 拮抗劑的吡唑化合物

Family Applications Before (2)

Application Number Title Priority Date Filing Date
HK13113692.9A HK1186183A1 (zh) 2011-01-24 2013-12-10 作為 拮抗劑的吡唑化合物
HK16103130.7A HK1215247A1 (zh) 2011-01-24 2013-12-10 作為 拮抗劑的吡唑化合物

Country Status (36)

Country Link
US (1) US8759386B2 (zh)
EP (1) EP2668181B1 (zh)
JP (1) JP5695216B2 (zh)
KR (2) KR101923365B1 (zh)
CN (4) CN104628705B (zh)
AP (1) AP3343A (zh)
AR (1) AR084916A1 (zh)
AU (1) AU2012210718B2 (zh)
BR (1) BR112013017570B1 (zh)
CA (1) CA2825458C (zh)
CL (1) CL2013001945A1 (zh)
CO (1) CO6801731A2 (zh)
CY (1) CY1116012T1 (zh)
DK (1) DK2668181T3 (zh)
EA (1) EA022559B1 (zh)
EC (1) ECSP13012832A (zh)
ES (1) ES2529452T3 (zh)
GE (1) GEP20156332B (zh)
HK (3) HK1186183A1 (zh)
HR (1) HRP20150069T1 (zh)
IL (1) IL226920A (zh)
MA (1) MA34838B1 (zh)
MX (1) MX342830B (zh)
MY (1) MY163012A (zh)
PE (1) PE20140860A1 (zh)
PH (1) PH12018501531A1 (zh)
PL (1) PL2668181T3 (zh)
PT (1) PT2668181E (zh)
RS (1) RS53785B1 (zh)
SG (1) SG192096A1 (zh)
SI (1) SI2668181T1 (zh)
TN (1) TN2013000280A1 (zh)
TW (1) TWI527809B (zh)
UA (1) UA109696C2 (zh)
UY (1) UY33873A (zh)
WO (1) WO2012101043A1 (zh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8759386B2 (en) * 2011-01-24 2014-06-24 Boehringer Ingelheim International Gmbh Pyrazole compounds as CRTH2 antagonists
EP2688882B1 (en) * 2011-03-25 2015-05-13 Boehringer Ingelheim International GmbH Pyrazole compounds as crth2 antagonists
US20140148484A1 (en) * 2012-11-23 2014-05-29 Boehringer Ingelheim International Gmbh Pyrazole compounds for treating hairloss
WO2014079803A1 (en) 2012-11-23 2014-05-30 Boehringer Ingelheim International Gmbh Bicyclosubstituted pyrazole compounds for treating hairloss
EP3768245A4 (en) * 2018-03-23 2023-10-18 Palatin Technologies, Inc. MELANOCORTIN RECEPTOR-SPECIFIC PEPTIDE FORMULATIONS AND METHODS OF ADMINISTRATION SPECIFIC TO THE GASTROINTESTINAL TRACT
CN113874015B (zh) 2018-12-21 2024-05-24 细胞基因公司 Ripk2的噻吩并吡啶抑制剂

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260322A (en) 1990-10-08 1993-11-09 Merck & Co., Inc. Angiotension II antagonists in the treatment of hyperuricemia
PL356487A1 (en) 1999-11-10 2004-06-28 Takeda Chemical Industries, Ltd. 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity
DE60303238T2 (de) 2003-04-25 2006-09-14 Actimis Pharmaceuticals, Inc., La Jolla Pyrimidin-Essigsäure Derivate geeignet zur Behandlung von CRTH2-bedingten Krankheiten
JP2007509104A (ja) * 2003-10-24 2007-04-12 グラクソ　グループ　リミテッド 複素環式化合物
CN101084209A (zh) * 2004-12-21 2007-12-05 德福根有限公司 具有Kv4离子通道活性的化合物
JP4950542B2 (ja) * 2006-04-07 2012-06-13 岩手東芝エレクトロニクス株式会社 固体撮像装置およびその製造方法
WO2007141267A1 (en) 2006-06-06 2007-12-13 Glaxo Group Limited N- (phenylmethyl) -2- (1h-pyraz0l-4-yl) acetamide derivatives as p2x7 antagonists for the treatment of pain, inflammation and neurodegeneration
EP2097407A1 (en) * 2006-11-27 2009-09-09 Pfizer Products Inc. Pyrazole analogs
MX2010003178A (es) * 2007-09-25 2010-04-30 Actimis Pharmaceuticals Inc Primidinas sustituidas con 2-s-bencilo como antagonistas de crth2.
TW200922587A (en) 2007-09-25 2009-06-01 Actimis Pharmaceuticals Inc Alkylthio pyrimidines as CRTH2 antagonists
JP2011088826A (ja) * 2008-01-31 2011-05-06 Astellas Pharma Inc 芳香族カルボン酸化合物
US20110144160A1 (en) * 2008-07-03 2011-06-16 Amira Pharmaceuticals, Inc. Antagonists of Prostaglandin D2 Receptors
GB2463788B (en) * 2008-09-29 2010-12-15 Amira Pharmaceuticals Inc Heteroaryl antagonists of prostaglandin D2 receptors
WO2010057118A2 (en) 2008-11-17 2010-05-20 Amira Pharmaceuticals, Inc. Heterocyclic antagonists of prostaglandin d2 receptors
WO2010089391A1 (en) * 2009-02-09 2010-08-12 Boehringer Ingelheim International Gmbh New pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
AP3360A (en) * 2010-01-27 2015-07-31 Boehringer Ingelheim Int Pyrazole compounds as CRTH2 antagonists
EP2598145A1 (en) * 2010-07-28 2013-06-05 Boehringer Ingelheim International GmbH Pharmaceutical composition for treatment of respiratory and inflammatory diseases
US8759386B2 (en) * 2011-01-24 2014-06-24 Boehringer Ingelheim International Gmbh Pyrazole compounds as CRTH2 antagonists

Also Published As

Publication number Publication date
JP5695216B2 (ja) 2015-04-01
UA109696C2 (xx) 2015-09-25
CN104961732B (zh) 2017-07-11
AP3343A (en) 2015-07-31
KR20140005931A (ko) 2014-01-15
CO6801731A2 (es) 2013-11-29
AU2012210718B2 (en) 2016-06-02
TWI527809B (zh) 2016-04-01
RS53785B1 (en) 2015-06-30
PH12018501531A1 (en) 2019-04-08
CA2825458C (en) 2021-01-26
CN103339125A (zh) 2013-10-02
BR112013017570B1 (pt) 2022-01-11
AU2012210718A1 (en) 2013-07-04
CN104628705B (zh) 2017-04-12
EP2668181A1 (en) 2013-12-04
HK1215247A1 (zh) 2016-08-19
MX342830B (es) 2016-10-14
BR112013017570A2 (pt) 2016-10-18
NZ611695A (en) 2015-04-24
PL2668181T3 (pl) 2015-04-30
CY1116012T1 (el) 2017-01-25
HK1186183A1 (zh) 2014-03-07
AP2013006942A0 (en) 2013-06-30
SI2668181T1 (sl) 2015-02-27
ES2529452T3 (es) 2015-02-20
CN103339125B (zh) 2015-07-15
CN107011332A (zh) 2017-08-04
CA2825458A1 (en) 2012-08-02
US20130023576A1 (en) 2013-01-24
EA022559B1 (ru) 2016-01-29
UY33873A (es) 2012-07-31
MA34838B1 (fr) 2014-01-02
EA201300857A1 (ru) 2013-12-30
GEP20156332B (en) 2015-07-27
TN2013000280A1 (en) 2014-11-10
IL226920A (en) 2016-11-30
CL2013001945A1 (es) 2013-10-25
PT2668181E (pt) 2015-02-05
DK2668181T3 (da) 2015-01-19
HRP20150069T1 (hr) 2015-02-27
CN104628705A (zh) 2015-05-20
CN104961732A (zh) 2015-10-07
KR101923365B1 (ko) 2018-11-30
PE20140860A1 (es) 2014-07-20
MY163012A (en) 2017-07-31
AR084916A1 (es) 2013-07-10
WO2012101043A1 (en) 2012-08-02
CN107011332B (zh) 2020-03-13
SG192096A1 (en) 2013-08-30
MX2013008082A (es) 2013-09-13
ECSP13012832A (es) 2013-09-30
KR102251939B1 (ko) 2021-05-14
KR20180129962A (ko) 2018-12-05
US8759386B2 (en) 2014-06-24
EP2668181B1 (en) 2014-11-05
TW201245184A (en) 2012-11-16
JP2014502986A (ja) 2014-02-06

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20230116