TN2013000280A1 - Pyrazole compounds as crth2 antagonists - Google Patents

Pyrazole compounds as crth2 antagonists

Info

Publication number
TN2013000280A1
TN2013000280A1 TNP2013000280A TN2013000280A TN2013000280A1 TN 2013000280 A1 TN2013000280 A1 TN 2013000280A1 TN P2013000280 A TNP2013000280 A TN P2013000280A TN 2013000280 A TN2013000280 A TN 2013000280A TN 2013000280 A1 TN2013000280 A1 TN 2013000280A1
Authority
TN
Tunisia
Prior art keywords
compounds
pyrazole compounds
crth2 antagonists
pyrazole
crth2
Prior art date
Application number
TNP2013000280A
Other languages
English (en)
Inventor
Ralf Anderskewitz
Domnic Martyres
Thorsten Oost
Wolfgang Rist
Peter Seither
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43799503&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TN2013000280(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of TN2013000280A1 publication Critical patent/TN2013000280A1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/41551,2-Diazoles non condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/14Decongestants or antiallergics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TNP2013000280A 2011-01-24 2013-06-28 Pyrazole compounds as crth2 antagonists TN2013000280A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11151876 2011-01-24
PCT/EP2012/050830 WO2012101043A1 (fr) 2011-01-24 2012-01-20 Composés de pyrazole en tant qu'antagonistes de crth2

Publications (1)

Publication Number Publication Date
TN2013000280A1 true TN2013000280A1 (en) 2014-11-10

Family

ID=43799503

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2013000280A TN2013000280A1 (en) 2011-01-24 2013-06-28 Pyrazole compounds as crth2 antagonists

Country Status (36)

Country Link
US (1) US8759386B2 (fr)
EP (1) EP2668181B1 (fr)
JP (1) JP5695216B2 (fr)
KR (2) KR102251939B1 (fr)
CN (4) CN104628705B (fr)
AP (1) AP3343A (fr)
AR (1) AR084916A1 (fr)
AU (1) AU2012210718B2 (fr)
BR (1) BR112013017570B1 (fr)
CA (1) CA2825458C (fr)
CL (1) CL2013001945A1 (fr)
CO (1) CO6801731A2 (fr)
CY (1) CY1116012T1 (fr)
DK (1) DK2668181T3 (fr)
EA (1) EA022559B1 (fr)
EC (1) ECSP13012832A (fr)
ES (1) ES2529452T3 (fr)
GE (1) GEP20156332B (fr)
HK (3) HK1210467A1 (fr)
HR (1) HRP20150069T1 (fr)
IL (1) IL226920A (fr)
MA (1) MA34838B1 (fr)
MX (1) MX342830B (fr)
MY (1) MY163012A (fr)
PE (1) PE20140860A1 (fr)
PH (1) PH12018501531A1 (fr)
PL (1) PL2668181T3 (fr)
PT (1) PT2668181E (fr)
RS (1) RS53785B1 (fr)
SG (1) SG192096A1 (fr)
SI (1) SI2668181T1 (fr)
TN (1) TN2013000280A1 (fr)
TW (1) TWI527809B (fr)
UA (1) UA109696C2 (fr)
UY (1) UY33873A (fr)
WO (1) WO2012101043A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8759386B2 (en) * 2011-01-24 2014-06-24 Boehringer Ingelheim International Gmbh Pyrazole compounds as CRTH2 antagonists
WO2012130633A1 (fr) * 2011-03-25 2012-10-04 Boehringer Ingelheim International Gmbh Composés pyrazoles comme antagonistes du crth2
US20140148492A1 (en) * 2012-11-23 2014-05-29 Boehringer Ingelheim International Gmbh Bicyclosubstituted pyrazole compounds for treating hair loss
US20140148484A1 (en) * 2012-11-23 2014-05-29 Boehringer Ingelheim International Gmbh Pyrazole compounds for treating hairloss
CN112188888A (zh) * 2018-03-23 2021-01-05 帕拉丁科技公司 用于胃肠道特异性递送的黑皮质素受体特异性肽配制品和方法
AR117472A1 (es) 2018-12-21 2021-08-11 Celgene Corp Inhibidores de tienopiridina de ripk2

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260322A (en) 1990-10-08 1993-11-09 Merck & Co., Inc. Angiotension II antagonists in the treatment of hyperuricemia
ATE271049T1 (de) * 1999-11-10 2004-07-15 Takeda Chemical Industries Ltd Fünfgliedrige n-heterocyclen mit hypoglykämischer und hypolipidemischer wirkung
PT1471057E (pt) 2003-04-25 2006-05-31 Actimis Pharmaceuticals Inc Derivados de acido pirimidinilacetico uteis para o tratamento de doencas mediadas por crth2
US20070060596A1 (en) * 2003-10-24 2007-03-15 Giblin Gerard M P Heterocyclyl compounds
CA2587664A1 (fr) * 2004-12-21 2006-06-29 Devgen N.V. Composes inter-reagissant avec des canaux ioniques, en particulier avec des canaux ioniques de la famille kv
JP4950542B2 (ja) * 2006-04-07 2012-06-13 岩手東芝エレクトロニクス株式会社 固体撮像装置およびその製造方法
DE602007010781D1 (de) 2006-06-06 2011-01-05 Glaxo Group Ltd N- (phenylmethyl) -2- (1h-pyrazol-4-yl) acetamid-derivate als p2x7-antagonisten zur behandlung von schmerzen, entzündungen und neurodegeneration
AU2007327004A1 (en) * 2006-11-27 2008-06-05 Pfizer Products Inc. Pyrazole analogs
US8314116B2 (en) * 2007-09-25 2012-11-20 Actimis Pharmaceuticals, Inc. 2-S-benzyl substituted pyrimidines as CRTH2 antagonists
JP5524847B2 (ja) 2007-09-25 2014-06-18 アクチミス ファーマシューティカルズ インコーポレーテッド Crth2アンタゴニストとしてのアルキルチオピリミジン
JP2011088826A (ja) * 2008-01-31 2011-05-06 Astellas Pharma Inc 芳香族カルボン酸化合物
WO2010003120A2 (fr) * 2008-07-03 2010-01-07 Amira Pharmaceuticals, Inc. Antagonistes des récepteurs de la prostaglandine d<sb>2</sb>
GB2463788B (en) * 2008-09-29 2010-12-15 Amira Pharmaceuticals Inc Heteroaryl antagonists of prostaglandin D2 receptors
WO2010057118A2 (fr) 2008-11-17 2010-05-20 Amira Pharmaceuticals, Inc. Antagonistes hétérocycliques des récepteurs de la prostaglandine d2
EP2393492A1 (fr) * 2009-02-09 2011-12-14 Boehringer Ingelheim International GmbH Nouvelles compositions pharmaceutiques destinées au traitement de troubles respiratoires et gastro-intestinaux
ES2545865T3 (es) * 2010-01-27 2015-09-16 Boehringer Ingelheim International Gmbh Compuestos de pirazol como antagonistas de CRTH2
EP2598145A1 (fr) * 2010-07-28 2013-06-05 Boehringer Ingelheim International GmbH Composition pharmaceutique pour le traitement de maladies respiratoires et inflammatoires
US8759386B2 (en) * 2011-01-24 2014-06-24 Boehringer Ingelheim International Gmbh Pyrazole compounds as CRTH2 antagonists

Also Published As

Publication number Publication date
CN104628705B (zh) 2017-04-12
CO6801731A2 (es) 2013-11-29
KR102251939B1 (ko) 2021-05-14
EA022559B1 (ru) 2016-01-29
HK1186183A1 (en) 2014-03-07
HRP20150069T1 (hr) 2015-02-27
ES2529452T3 (es) 2015-02-20
NZ611695A (en) 2015-04-24
AP2013006942A0 (en) 2013-06-30
MX342830B (es) 2016-10-14
KR101923365B1 (ko) 2018-11-30
US8759386B2 (en) 2014-06-24
KR20180129962A (ko) 2018-12-05
PT2668181E (pt) 2015-02-05
UA109696C2 (xx) 2015-09-25
DK2668181T3 (da) 2015-01-19
CN107011332B (zh) 2020-03-13
UY33873A (es) 2012-07-31
CL2013001945A1 (es) 2013-10-25
RS53785B1 (en) 2015-06-30
TWI527809B (zh) 2016-04-01
HK1210467A1 (en) 2016-04-22
CN104628705A (zh) 2015-05-20
BR112013017570A2 (pt) 2016-10-18
AR084916A1 (es) 2013-07-10
AU2012210718B2 (en) 2016-06-02
CN104961732A (zh) 2015-10-07
JP5695216B2 (ja) 2015-04-01
CN103339125B (zh) 2015-07-15
CN107011332A (zh) 2017-08-04
EA201300857A1 (ru) 2013-12-30
BR112013017570B1 (pt) 2022-01-11
GEP20156332B (en) 2015-07-27
PH12018501531A1 (en) 2019-04-08
IL226920A (en) 2016-11-30
WO2012101043A1 (fr) 2012-08-02
MX2013008082A (es) 2013-09-13
EP2668181B1 (fr) 2014-11-05
SI2668181T1 (sl) 2015-02-27
CA2825458A1 (fr) 2012-08-02
CY1116012T1 (el) 2017-01-25
US20130023576A1 (en) 2013-01-24
JP2014502986A (ja) 2014-02-06
CA2825458C (fr) 2021-01-26
PE20140860A1 (es) 2014-07-20
AU2012210718A1 (en) 2013-07-04
KR20140005931A (ko) 2014-01-15
SG192096A1 (en) 2013-08-30
MA34838B1 (fr) 2014-01-02
HK1215247A1 (zh) 2016-08-19
PL2668181T3 (pl) 2015-04-30
CN103339125A (zh) 2013-10-02
MY163012A (en) 2017-07-31
EP2668181A1 (fr) 2013-12-04
CN104961732B (zh) 2017-07-11
ECSP13012832A (es) 2013-09-30
AP3343A (en) 2015-07-31
TW201245184A (en) 2012-11-16

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